Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials.

Background: The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis of randomized controlled trials (RCTs). Methods: Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web of Science and Embase. RCTs assessing mortality, intensive care unit (ICU) admission, mechanical ventilation (MV), length of hospitalization (LOH), and inflammatory markers containing C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), lactate dehydrogenase (LDH) were included. 19 RCTs were involved in the analysis and were conducted subgroup analyses on the baseline COVID-19 severity and vitamin D administration. Results: In the severity subgroup, statistically significant effects in moderate to severe group were observed in ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008), MV (OR 0.44, 95% CI 0.27, 0.72; p = 0.001) and LOH (SMD -0.49, 95% CI -0.92, -0.06; p = 0.027). In the administration subgroup, effects of ICU admission (OR 0.39, 95% CI 0.16, 0.97; p = 0.044), MV (OR 0.18, 95% CI 0.07, 0.46; p = 0.000) and LOH (SMD -0.50, 95% CI -0.96, -0.04; p = 0.034) were more pronounced in patients supplied with multiple-dose vitamin D than single-dose. Although the result of mortality showed no statistically significant effect, it indicated a reduced trend (OR 0.87, 95% CI 0.63, 1.12; p > 0.05). The results of inflammatory markers reached no statistical differences. Conclusion: This meta-analysis revealed that moderate to severe COVID-19 patients supplied with multiple doses of vitamin D were less apt to need ICU admission, mechanical ventilation and have shorter hospital stays.

In Situ Electrochemical Polymerization of Cathode Electrolyte Interphase Enabling High-Performance Lithium Metal Batteries.

Lithium metal batteries (LMBs) with high-voltage nickel-rich cathodes show great potential as energy storage devices due to their exceptional capacity and power density. However, the detrimental parasitic side reactions at the cathode electrolyte interface result in rapid capacity decay. Herein, a polymerizable electrolyte additive, pyrrole-1-propionic acid (PA), which can be in situ electrochemically polymerized on the cathode surface and involved in forming cathode electrolyte interphase (CEI) film during cycling is proposed. The formed CEI film prevents the formation of microcracks in LiNi0.8Co0.1Mn0.1O2 (NCM811) secondary particles and mitigates parasitic reactions. Additionally, the COO- anions of PA promote the acceleration of Li+ transport from cathode particles and increase charging rates. The Li||NCM811 batteries with PA in the electrolyte exhibit a high capacity retention of 83.83% after 200 cycles at 4.3 V, and maintain 80.88% capacity after 150 cycles at 4.6 V. This work provides an effective strategy for enhancing interface stability of high-voltage nickel-rich cathodes by forming stable CEI film.

Synergistic Construction of Sub-Nanometer Channel Membranes through MOF-Polymer Composites: Strategies and Nanofiltration Applications.

The selective separation of small molecules at the sub-nanometer scale has broad application prospects in the field, such as energy, catalysis, and separation. Conventional polymeric membrane materials (e.g., nanofiltration membranes) for sub-nanometer scale separations face challenges, such as inhomogeneous channel sizes and unstable pore structures. Combining polymers with metal-organic frameworks (MOFs), which possess uniform and intrinsic pore structures, may overcome this limitation. This combination has resulted in three distinct types of membranes: MOF polycrystalline membranes, mixed-matrix membranes (MMMs), and thin-film nanocomposite (TFN) membranes. However, their effectiveness is hindered by the limited regulation of the surface properties and growth of MOFs and their poor interfacial compatibility. The main issues in preparing MOF polycrystalline membranes are the uncontrollable growth of MOFs and the poor adhesion between MOFs and the substrate. Here, polymers could serve as a simple and precise tool for regulating the growth and surface functionalities of MOFs while enhancing their adhesion to the substrate. For MOF mixed-matrix membranes, the primary challenge is the poor interfacial compatibility between polymers and MOFs. Strategies for the mutual modification of MOFs and polymers to enhance their interfacial compatibility are introduced. For TFN membranes, the challenges include the difficulty in controlling the growth of the polymer selective layer and the performance limitations caused by the "trade-off" effect. MOFs can modulate the formation process of the polymer selective layer and establish transport channels within the polymer matrix to overcome the "trade-off" effect limitations. This review focuses on the mechanisms of synergistic construction of polymer-MOF membranes and their structure-nanofiltration performance relationships, which have not been sufficiently addressed in the past.

Manipulation of Charge Transport in MoS2/MoTe2 Field Effect Transistors and Heterostructure by Propagating the Surface Acoustic Wave.

Two-dimensional (2D) materials with atomic-scale thickness are promising candidates to develop next-generation electronic and optoelectronic devices with multiple functions due to their widely tunable physical properties by various stimuli. The surface acoustic wave (SAW) produced at the surface of the piezoelectrical substrate can generate electrical and strain fields simultaneously with micro/nanometer resolution during propagation. It provides a stable and wireless platform to manipulate the rich and fascinating properties of 2D materials. However, the interaction mechanisms between the SAW and 2D materials remain unclear, preventing further development and potential applications of SAW-integrated 2D devices. This work studied the acoustoelectric (AE) charge transport mechanism in 2D materials thoroughly by characterizing the performances of the n-type MoS2 and p-type MoTe2 field effect transistors (FETs) and the MoS2/MoTe2 p-n junction driven by the SAW. As compared to the case driven by the static electrical field alone, the SAW drove the electron and hole transport along the same direction as its propagation, and the generated AE current always had the opposite direction to the AE voltage. In the device level, the 2D FETs showed a significantly reduced subthreshold swing up to around 67% when the SAW was used to drive the channel carriers, indicating that the SAW enhanced the on/off switching speed. Moreover, the MoTe2/MoS2 p-n junction showed a tunable photoresponsivity by the power and propagation direction of the SAW. These findings provide a solid foundation to promote future research and potential applications of SAW-driven multifunctional devices based on 2D materials.

Conductive nanofiltration membranes via in situ PEDOT-polymerization for electro-assisted membrane fouling mitigation.

Nanofiltration (NF) membranes play a pivotal role in water treatment; however, the persistent challenge of membrane fouling hampers their stable application. This study introduces a novel approach to address this issue through the creation of a poly(3,4-ethylenedioxythiophene) (PEDOT)-based conductive membrane, achieved by synergistically coupling interfacial polymerization (IP) with in situ self-polymerization of EDOT. During the IP reaction, the concurrent generation of HCl triggers the protonation of EDOT, activating its self-polymerization into PEDOT. This interwoven structure integrates with the polyamide network to establish a stable selective layer, yielding a remarkable 90 % increase in permeability to 20.4 L m-2 h-1 bar-1. Leveraging the conductivity conferred by PEDOT doping, an electro-assisted cleaning strategy is devised, rapidly restoring the flux to 98.3 % within 5 min, outperforming the 30-minute pure water cleaning approach. Through simulations in an 8040 spiral-wound module and the utilization of the permeated salt solution for cleaning, the electro-assisted cleaning strategy emerges as an eco-friendly solution, significantly reducing water consumption and incurring only a marginal electricity cost of 0.055 $ per day. This work presents an innovative avenue for constructing conductive membranes and introduces an efficient and cost-effective electro-assisted cleaning strategy to effectively combat membrane fouling.

Quantity of questing black-legged ticks and associated micro-scale environmental data collected from four Suburban Parks near New York City.

During 2017 and 2018, we collected the quantity of questing black-legged ticks (Ixodes scapularis), also known as deer ticks, in 124 sampling sites of 5m by 5m in four state parks-Caumsett State Historic Park, Connetquot River State Park, Rockefeller State Park, and Fire Island National Seashore-around New York City. The black-legged tick is the primary vector for the spirochete Borrelia burgdorferi, the pathogen of Lyme disease, in Northeastern United States. Using the flagging method, we collected and counted the numbers of adult and nymphal black-legged ticks at each stie. Along with these quantities, we also recorded the geographic coordinates, ambient temperature, and relative humidity at the sampling sites. Using high-resolution aerial imagery and LiDAR data, we further derived land cover composition, ecotone boundary length, normalized difference vegetation index (NDVI), elevation, solar radiation, and other environmental factors. The data could be used to conduct longitudinal analysis at the same sampling sites as well as comparison with other sites. Ecologists and environmental scientists can use the data for spatiotemporal and statistical analyses of tick ecology at the local scale.

Dry torrefaction and continuous thermochemical conversion for upgrading agroforestry waste into eco-friendly energy carriers: Current progress and future prospect.

Agroforestry Waste (AW) is seen as a carbon neutral resource. However, the poor quality of AW reduced its potential application value. Even more unfortunately, chlorine in AW led to the formation of organic pollutants such as dioxins under higher temperatures. Alkali and alkaline earth metals (AAEMs) in ash may deepen the reaction degree. Co-pretreatment of dry torrefaction and de-ashing followed by thermochemical conversion is a promising technology, which can improve raw material quality, inhibit the release of organic pollutants and transform AW into eco-friendly energy carriers. In order to better understand the process, theoretical basis such as the structural characteristics, thermal properties and separation methods of structural components of AW are described in detail. In addition, dry torrefaction related reactors, process parameters, kinetic analysis models as well as the evaluation methods of torrefaction degree and environmental impact are systematically reviewed. The problem of ash accumulation caused by dry torrefaction can be well solved by de-ashing pretreatment. This paper provides a comprehensive discussion on the role of the two- and three-stage conversion technologies around dry torrefacion, de-ashing pretreatment and thermochemical conversion in products quality enhancement. Finally, the existing technical challenges, including suppression of gaseous pollutant release, harmless treatment and reuse of torrefaction liquid product (TPL) and reduction of torrefaction operating costs, are summarized and evaluated. The future research directions, such as vitrification of the reused TPL (after de-ashing or acid catalysis) and integration of oxidative torrefaction with thermochemical conversion technologies, are proposed.

Neutrophil extracellular traps contributing to atherosclerosis: From pathophysiology to clinical implications.

Neutrophil extracellular traps (NETs) are network-like structures of chromatin filaments decorated by histones, granules, and cytoplasmic-derived proteins expelled by activated neutrophils under multiple pathogenic conditions. NETs not only capture pathogens in innate immunity but also respond to sterile inflammatory stimuli in atherosclerosis, such as lipoproteins and inflammatory cytokines. Atherosclerosis is a lipid-driven chronic inflammatory disease characterized by the accumulation and transformation of inflammatory cells, and smooth muscle cells in the intimal space. NETs-derived extracellular components possess toxic and proinflammatory properties leading to cellular dysfunction and tissue damage, which may establish a link among lipid metabolism, inflammatory immunity, and atherosclerosis. In this review, we discuss recent advances regarding the role of NETs engaged in the pathogenesis of atherosclerosis, particularly focusing on the interaction with lipids and inflammasomes, crosstalk with smooth muscle cells and inflammatory cells, and the association with aging. We also evaluate the current knowledge on the potential of NETs as biomarkers and therapeutic targets for atherosclerosis and its related diseases in clinical practice.

Authentication of Single Herbal Powders Enabled by Microscopy-Guided In Situ Auto-sampling Combined with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

In the long history of investigation of herbal products, microscopic examination has greatly contributed to the authentication of herbs in a powder form. However, it cannot provide the chemical profiles of herbal powders and thus is limited to morphological identification. In this work, we present a label-free and automatic approach for the characterization and identification of single herbal powders and their adulterants, enabled through the combination of microscopy-guided auto-sampling and matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). To meet the demand for automatic and highly efficient in situ extraction, the glass slide was coated with gelatin to immobilize dried herbal powders that cannot stick to the glass slide like fresh and hydrated cells. The gelatin coating also facilitated the pump-out of chemical components and prevented diffusion across the interface enabled by the formation of a tight contact at the probe tip and surface. Optical microscopy was applied to acquire the microstructure and position of the herbal powders immobilized on the gelatin-coated slide. The candidate single herbal powders were picked out by a software for subsequent auto-sampling and MALDI MS identification. The combination of microstructure features and chemical profiles significantly improved the authentication capability of microscopic examination.

Locking Patterned Carbon Nanotube Cages by Nanofibrous Mats to Construct Cucurbituril[n]-Based Ultrapermselective Dye/Salt Separation Membranes.

Surface patterning is a promising strategy to overcome the trade-off effect of separation membranes. Herein, a bottom-up patterning strategy of locking micron-sized carbon nanotube cages (CNCs) onto a nanofibrous substrate is developed. The strongly enhanced capillary force triggered by the abundant narrow channels in CNCs endows the precisely patterned substrate with excellent wettability and antigravity water transport. Both are crucial for the preloading of cucurbit[n]uril (CB6)-embeded amine solution to form an ultrathin (∼20 nm) polyamide selective layer clinging to CNCs-patterned substrate. The CNCs-patterning and CB6 modification result in a 40.2% increased transmission area, a reduced thickness, and a lowered cross-linking degree of selective layer, leading to a high water permeability of 124.9 L·m-2 h-1 bar-1 and a rejection of 99.9% for Janus Green B (511.07 Da), an order of magnitude higher than that of commercial membranes. The new patterning strategy provides technical and theoretical guidance for designing next-generation dye/salt separation membranes.

Roles and gains of coordination chemistry in nanofiltration membrane: A review.

The nanofiltration (NF) membranes with the specific separation accuracy for molecules with the size of 0.5-2 nm have been applied in various industries. However, the traditional polymeric NF membranes still face problems like the trade-off effect, organic solvent consumption, and weak durability in harsh conditions. The participation of coordination action or metal-organic coordination compounds (MOCs) brings the membrane with uniform pores, better antifouling properties, and high hydrophilicity. Some of the aqueous-phase reactions also help to introduce a green fabrication process to NF membranes. This review critically summarizes the recent research progress in coordination chemistry relevant NF membranes. The participation of coordination chemistry was classified by the various functions in NF membranes like additives, interlayers, selective layers, coating layers, and cross-linkers. Then, the effect and mechanism of the coordination chemistry on the performance of NF membranes are discussed in depth. Perspectives are given for the further promotion that coordination chemistry can make in NF processes. This review also provides comprehensive insight and constructive guidance on high-performance NF membranes with coordination chemistry.

Encrypted information reading technology at the micro/nano scale based on surface plasma-driven reactions.

The plasma exciton induced photocatalytic reaction has considerable potential in terms of controllability and selectivity. In this paper, with the advantage of Raman fingerprinting, the localized photocatalytic reaction driven by surface plasmons is realized by the writing and reading process of encrypted information at the micro/nano scale. A layer of probe molecules (4-nitrobenzenethiol, 4-NBT) was assembled on a gold nanoporous array grown on porous anodic aluminium oxide (AAO) membranes. The focused Raman spot is manipulated in a two-dimensional micro/nano manipulation technique to control the movement of the spot at an excitation wavelength of 633 nm. Probe molecules within the spot trajectory will undergo a photocatalytic reaction to produce p,p'-dimercaptoazobenzene (DMAB) molecules, thereby writing the specific information required. The use of Raman mapping to image the characteristic peaks of formed DMAB under excitation light with a longer wavelength of 785 nm enables the readout of 2D micro/nano cryptograms. Combined with finite-difference time-domain (FDTD) simulations, it was found that the presence of a large number of regularly arranged hot spots on the surface of the array is the key to achieving the efficient photocatalytic reaction. This study enables real-time, lossless recording/reading of encrypted information with the aid of 2D Raman technology. This would be a very interesting research area with broad application in confidential information storage.

Removing miscellaneous heavy metals by all-in-one ion exchange-nanofiltration membrane.

The composition of wastewater containing heavy metal mixtures is often complex and poses a serious threat to human and environmental health. Effective removal of a variety of heavy metal ions with a single technology is challenging, and the conventional split integrated technologies require multi-step processing and a massive footprint. For the first time, we achieve hierarchically integrating ion exchange and nanofiltration into all-in-one "iNF" membranes. The iNF membrane has a hierarchical structure with an interfacial polymerization layer and an ion exchange layer, which can achieve highly efficient indiscriminate heavy metal ion removal, overcoming the defect that traditional nanofiltration membranes can only remove single metal cations or oxyanions. The ion exchange layer can remove heavy metal ions through sulfonic acid groups and quaternary amine groups. In addition, the ion exchange layer can be regenerated by electro-deionization, which is meaningful for sustainable membrane usage. This facile, scalable, and compact integrated process shows outstanding potential and universal applicability in complex wastewater treatment.

Relevance of Ferroptosis to Cardiotoxicity Caused by Anthracyclines: Mechanisms to Target Treatments.

Anthracyclines (ANTs) are a class of anticancer drugs widely used in oncology. However, the clinical application of ANTs is limited by their cardiotoxicity. The mechanisms underlying ANTs-induced cardiotoxicity (AIC) are complicated and involve oxidative stress, inflammation, topoisomerase 2ß inhibition, pyroptosis, immunometabolism, autophagy, apoptosis, ferroptosis, etc. Ferroptosis is a new form of regulated cell death (RCD) proposed in 2012, characterized by iron-dependent accumulation of reactive oxygen species (ROS) and lipid peroxidation. An increasing number of studies have found that ferroptosis plays a vital role in the development of AIC. Therefore, we aimed to elaborate on ferroptosis in AIC, especially by doxorubicin (DOX). We first summarize the mechanisms of ferroptosis in terms of oxidation and anti-oxidation systems. Then, we discuss the mechanisms related to ferroptosis caused by DOX, particularly from the perspective of iron metabolism of cardiomyocytes. We also present our research on the prevention and treatment of AIC based on ferroptosis. Finally, we enumerate our views on the development of drugs targeting ferroptosis in this emerging field.

Plasmon-driven photocatalytic reaction based on gold microsphere array.

Plasma-driven photocatalytic reactions have great research value in the fields of energy utilization, environmental pollution treatment and micro-nano information encryption. In most cases, the substrates used to study photocatalytic reactions are dispersed and disordered, which leads to poor signal reproducibility and makes it difficult to realize applications in the field of quantitative analysis. In this paper, two different sizes of polystyrene (PS) microspheres were used as templates to prepare gold microsphere arrays (Au MA) with homogeneous particle size and regular arrangement. The p-Aminothiophenol (PATP) was selected as the probe molecule to systematically investigate the photocatalytic reaction on Au MA, and the dependence of the photocatalytic reaction on the particle size of the spheres was discussed. It was found that the smaller size of Au MA has higher catalytic activity. In addition, using conventional gold films as a comparison, no significant photocatalytic reaction was found under the same experimental conditions. The reason is the existence of strong surface plasma "hot spots" in the interstices of the particles on the surface of the Au MA, which promotes the reaction. The above experimental results are of theoretical and practical significance for the in-depth study of the photocatalytic effect of micro-nano array catalytic substrates.

Voltage-Gated Membranes Incorporating Cucurbit[n]uril Molecular Containers for Molecular Nanofiltration.

Smart voltage-gated nanofiltration membranes have enormous potential for on-demand and precise separation of similar molecules, which is an essential element of sustainable water purification and resource recovery. However, the existing voltage-gated membranes are hampered by limited selectivity, stability, and scalability due to electroactive monomer dimerization. Here, for the first time, the host-guest recognition properties of cucurbit[7]uril (CB[7]) are used to protect the viologen derivatives and promote their assembly into the membrane by interfacial polymerization. Viologen functions as a voltage switch, whereas CB[7] complexation prevents its dimerization and improves its redox stability. The inhibited diffusion of the CB[7]-viologen complex enables the precise patterning of the surface structure. The resultant voltage-gated membrane displays 80% improved rejection performance, excellent recovery accuracy for similar molecules, and anti-fouling properties. This work not only provides an innovative strategy for the preparation of voltage-gated smart nanofiltration membranes but also opens up new avenues for ion-selective transmission in water treatment, bionic ion channels, and energy conversion.

Plasmon-driven photocatalytic properties based on the surface of gold nanostar particles.

Surface plasmon resonance (SPR) generated in gold nanoparticles can induce the conversion of p-Aminothiophenol (PATP) molecules into p,p'-dimercaptoazobenzene (DMAB) molecules by coupling reaction under the action of excitation light. Molecular detection of samples by surface enhanced Raman spectroscopy (SERS) techniques allows the study of their plasma-driven photocatalytic reaction processes. In this study, we used gold nanostars (GNS) as the substrate to study its catalytic performance and sensitivity. On this basis, catalytic substrates of gold nanospheres (GNPs) were prepared for comparison. The catalytic reactions of PATP molecules on each of the above two substrates were systematically investigated under 633 nm laser irradiation. The reduction process was subsequently observed by introducing NaBH4 solution. The results show that photocatalytic reactions can be achieved on both substrates under laser excitation at the same wavelength. However, the catalytic and reduction reaction rates on GNSs as a substrate are much faster than those of GNPs. This phenomenon may be due to the abundant nano-branched microstructures on the surface of GNSs, which will generate more and stronger local surface plasma hot spots under the irradiation of excitation light. In order to test the above hypothesis, the surface electromagnetic field distribution of two nanostructures was numerically simulated using the finite-difference time domain (FDTD) method. It is found that the star-like nanostructures not only have the same inter-particle hot spot system as the spherical nanostructures, but also have a large number of high-intensity single-particle hot spot systems arising from the abundance of branched nanostructures on their own surfaces. Compared with the spherical nanostructures, they are characterized by a dual hot spot system, which accelerates the photocatalytic reaction rate. The above experiments are of some reference significance for the in-depth study of multi-branched nanostructures and surface plasma distribution properties and their applications.

How Phantom Networks, Provider Qualities, and Poverty Sway Medicaid Dental Care Access: A Geospatial Analysis of Manhattan.

Access to general dental care is essential for preventing and treating oral diseases. To ensure adequate spatial accessibility for the most vulnerable populations, New York State mandates a ratio of one general dentist to 2000 Medicaid recipients within 30 min of public transportation. This study employed geospatial methods to determine whether the requirement is met in Manhattan by verifying the online directories of ten New York managed care organizations (MCOs), which collectively presented 868 available dentists from 259 facilities. Our survey of 118 dental facilities representing 509 dentists revealed that significantly fewer dentists are available to treat Medicaid recipients compared to MCO directories. The average dentist-to-patient ratio derived from the MCO listings by the Two-Step Floating Catchment Area (2SFCA) method was 1:315, while the average verified ratio was only 1:1927. "Phantom networks", or inaccurate provider listings, substantially overstated Medicaid dental accessibility. Surprisingly, our study also discovered additional Medicaid providers unlisted in any MCO directory, which we coined "hidden networks". However, their inclusion was inconsequential to the overall dental supply. We further scrutinized dental care access by uniquely applying six "patient-centered characteristics", and these criteria vastly reduced accessibility to an average ratio of merely 1:4587. Our novel evaluation of the spatial association between poverty, dental care access, and phantom networks suggests that Medicaid dental providers wish to be located in wealthier census tracts that are in proximity to impoverished areas for maximum profitability. Additionally, we discovered that poverty and phantom networks were positively correlated, and phantom providers masked a lack of dental care access for Medicaid recipients.

Influence of air oxidative and non-oxidative torrefaction on the chemical properties of corn stalk.

The non-structural components (extractives and ash) in biomass can affect the torrefaction characteristics. The objective of this study was to investigate the applicability of air oxidative and non-oxidative torrefaction for corn stalk, which has higher organic extractives and lower ash contents. The raw materials were torrefied with air and nitrogen in a fluidized bed reactor at 180℃~235℃ and 200℃~280℃ for 1 h, respectively. The proximate and ultimate analysis results demonstrated that the lower ash content (3.89%) was not favorable for deoxygenation. The organic extractives, extracted materials and mixture were torrefied with nitrogen at 260℃. The results indicated that the addition of organic extractives reduced the deoxidation efficiency of structural components during torrefaction. Compared to raw materials, the moderate and severe removal of hemicellulose can be achieved through torrefaction under air and nitrogen, respectively.

Encapsulated Polyethyleneimine Enables Synchronous Nanostructure Construction and In Situ Functionalization of Nanofiltration Membranes.

Highly permselective nanostructured membranes are desirable for the energy-efficient molecular sieving on the subnanometer scale. The nanostructure construction and charge functionalization of the membranes are generally carried out step by step through the conventional layer-by-layer coating strategy, which inevitably brings about a demanding contradiction between the permselective performance and process efficiency. For the first time, we report the concurrent construction of the well-defined molecular sieving architectures and tunable surface charges of nanofiltration membranes through precisely controlled release of the nanocapsule decorated polyethyleneimine and carbon dioxide. This novel strategy not only substantially shortens the fabrication process but also leads to impressive performance (permeance up to 37.4 L m-2 h-1 bar-1 together with a rejection 98.7% for Janus Green B-511 Da) that outperforms most state-of-art nanofiltration membranes. This study unlocks new avenues to engineer next-generation molecular sieving materials simply, precisely, and cost efficiently.