Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors.

Soy protein favorably alters serum lipids and lipoproteins in hypercholesterolemic individuals, thereby reducing cardiovascular disease risk. The primary purpose was to determine the effect of soy protein (40 g/d) on circulating lipids and lipoproteins or coagulation and fibrinolytic factors in normocholesterolemic and mildly hypercholesterolemic perimenopausal women. We also determined the contribution of coagulation and fibrinolytic and other factors (e.g., body size and composition; serum estrogens, ferritin, iron; dietary intake) to lipid profiles. Subjects were randomly assigned to treatment: isoflavone-rich soy (n = 24), isoflavone-poor soy (n = 24), or whey control (n = 21) protein. We measured circulating lipids and lipoproteins at baseline, wk 12 and wk 24, and coagulation/fibrinolytic factors at baseline and wk 24. Coagulation and fibrinolytic factors were not adversely affected by treatment. Treatment did not alter lipid profiles in mildly hypercholesterolemic (n = 30) or in all subjects combined. Time significantly (P < 0.001) affected serum total cholesterol, triacylglycerol, LDL cholesterol and HDL cholesterol concentrations. We could not attribute changes over time to various factors, but at baseline accounted for 57% of the variability in HDL cholesterol (P < or = 0.0001) and for 50% in the total to HDL cholesterol ratio (P < or = 0.0001). Dietary vitamin E and % energy from fat had positive effects, whereas plasma plasminogen activator inhibitor-1, fibrinogen, body weight and serum ferritin had negative effects on HDL and total to HDL cholesterol. Isoflavone-rich or isoflavone-poor soy protein had no effect on lipid profiles or coagulation and fibrinolytic factors, whereas the effect of time suggested that the hormonal milieu during the menopausal transition may have overridden any detectable treatment effect on lipids. The relationship between coagulation factors and serum lipids should be examined further as indices of cardiovascular disease risk in midlife women.

Office management of the acute ankle sprain.

Ankle injuries occur frequently in an athletic population. Understanding the anatomy, biomechanics, pathomechanics, differential diagnosis, and special pediatric considerations allows an accurate diagnosis. Treatment with a nonoperative aggressive goal-oriented therapy program has been successful at the United States Military Academy.

Effects of Gravity-Facilitated Traction on lntervertebral Dimensions of the Lumbar Spine*.

The purpose of this study was to determine the effects of gravity-facilitated traction (inversion) on intervertebral dimensions of the lumbar spine. Fifteen normal male subjects were fully inverted for a period of 10 minutes. Vertebral separation was measured on lateral roentgenograms both pre- and postinversion by outlining the margins of the intervertebral bodies both anteriorly and posteriorly and the greatest vertical heights of the intervertebral foramina. Fine point engineering calipers were used to facilitate measurements. A student t-test for paired data was used to determine significance of separation between lumbar segments, following 10 minutes of inversion. The alpha level was set at 0.05 for statistical significance. Gravity-facilitated traction produced increased separation at all levels measured. Significant increases in total mean anterior separation, total mean posterior separation, and total mean intervertebral foraminal separation were determined. Mean anterior separation was significant at all levels except L3-L4. Mean posterior separation was significant at all levels except L1-L2 and L5-S1. Mean intervertebral foraminal separation was significant at all levels but L5-S1. If increases in intervertebral dimensions play a role in the relief of low back syndrome, then gravity-facilitated traction may be an effective moda1i;y in the treatment of this condition. J Orthop Sports Phys Ther 1985;6(5):281-288.