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1.
Mil Med ; 2024 Jan 09.
Article in English | MEDLINE | ID: mdl-38195202

ABSTRACT

INTRODUCTION: Ventral hernia repair cost the U.S. healthcare system nearly 3 billion dollars annually. Surgical repair is a critical competency for residents yet hernia recurrence rates following mesh-based repair range from 0.8% to 24%. Improving surgical techniques using cadavers is often cost-prohibited for many education programs and limited research exists using simulation models with a corresponding hernia repair curriculum in the graduate medical education setting. This pilot project aimed to develop a low cost, easily reproducible novel abdominal wall reconstruction model and pilot-test the ventral hernia repair curriculum to inform further refinement prior to formal evaluation. MATERIAL AND METHODS: This descriptive study pilot-tested the newly refined Abdominal Wall Surgical Skills Operative Model (AWSSOM) simulator for ventral hernia repair with mesh and its corresponding 2-h training curriculum for use at all levels of general surgery graduate medical education. The AWSSOM is a 3D printed synthetic anatomically realistic abdominal wall model consisting of silicone cured layers of skin, fat, rectus abdominis and a posterior rectus sheath fascia, and silicone tubules to simulate lateral neurovascular bundles. The curriculum incorporated didactic content reflecting surgical practice guidelines, hands-on practice, and faculty guidance promoting interactive critical thinking development during task performance. A pre-/post-assessment included a 10-item knowledge test, a 19-item psychomotor assessment, and 4-items confidence survey to examine changes in performance, knowledge, and confidence in competently completing the ventral hernia repair technique. Descriptive statistics were used to report the limited results of six military surgical resident participants and inform further model and curriculum refinement prior to formal evaluation. RESULTS: The five-layer AWSSOM model was manufactured in 65 h at a material cost of $87 per model frame, is reusable model, and secure base. Six surgical residents were recruited; only four completed both pre- and post-tests due to resident schedule conflicts. The average increase in knowledge was 25%, although variable changes in confidence were observed over the four program year participants. A larger sample size and a control group are needed to demonstrate curriculum effectiveness at improving knowledge, performance, and confidence in ventral hernia repair with mesh and better delineate if high scores translate to better operative skills. A key improvement requested by residents was a more secure model base for dissection and performance of the hernia repair. CONCLUSIONS: The novel abdominal wall surgical skills operative model fills an important proof of concept gap in simulation training. It is low cost with the potential to improve cognitive and psychomotor skills, as well as confidence to competently complete ventral hernia repair with mesh in the graduate medical education setting. Prior to formal effectiveness testing, our lessons learned should be addressed in both the model and curriculum. Future studies must include an adequately powered statistical evaluation with a larger sample across all levels of training.

2.
Surgery ; 169(5): 1228-1233, 2021 05.
Article in English | MEDLINE | ID: mdl-33583604

ABSTRACT

BACKGROUND: After the American Board of Surgery announcement of the Flexible Endoscopy Curriculum requirement in 2014, we implemented a dedicated endoscopy rotation at the post graduate year (PGY)2 level including a simulation curriculum for Fundamentals of Endoscopic Surgery skills. Here we evaluate the outcomes of this implementation. METHODS: Beginning in 2015, we developed a clinical endoscopy and simulation-based rotation to prepare for Fundamentals of Endoscopic Surgery testing. Originally, our curriculum was based on the published Texas Association of Surgical Skills Laboratories curriculum using the GI Mentor and transitioned to a mastery learning curriculum using the Endoscopy Training System in 2016. We evaluated the success of the curriculum in terms of first-time pass rates, training time required, and comparison to previously published benchmarks based on clinical experience. RESULTS: Since 2015, a total of 37 general surgery residents in our program were Fundamentals of Endoscopic Surgery tested (PGY2 = 24, PGY3 = 4, PGY5 = 9); 84% (31) completed the Endoscopy Training System curriculum. At the time of testing, 73% (27) had performed <25 esophagogastroduodenoscopies, and 46% had performed <25 colonoscopies. Ninety-two percent (34) spent 10 hours or less completing the curriculum. The first-time pass rate for those completing the Endoscopy Training System curriculum was 97% vs 67% for those not completing the Endoscopy Training System curriculum (P = .01). For residents completing the Endoscopy Training System curriculum, total Fundamentals of Endoscopic Surgery scores were discernibly higher (472 vs 389, P < .01), as were 3/5 task scores (Nav1 80 vs 67, P = .02; Loop2 36 vs 8, P = .02; Retro3 89 vs 71, P = .02). Despite clinical inexperience (<25 esophagogastroduodenoscopies and <50 colonoscopies), PGY2s yielded a mean score of 454 and a pass rate of 92%. This was similar to PGY5s (427, 89%; P = .3) and compares to benchmark data of endoscopists with >300 cases. CONCLUSION: Early implementation of flexible endoscopy training with a simulation-based curriculum results in Fundamentals of Endoscopic Surgery performance equal to a clinical experience not often gained during surgical residency. Often requiring <10 hours, this represents a fantastic return on investment for this training.


Subject(s)
Curriculum/statistics & numerical data , Endoscopy/education , General Surgery/education , Simulation Training , Humans , Internship and Residency
3.
Mil Med ; 185(9-10): e1794-e1802, 2020 09 18.
Article in English | MEDLINE | ID: mdl-32313930

ABSTRACT

INTRODUCTION: Anorectal diseases, among the most common surgical conditions, are underrepresented in medical training. The Fundamentals of Anorectal Technical Skills course was developed to provide cost-effective formal training in diagnosis of common anorectal conditions and in commonly performed anorectal procedures using the theories of deliberative practice and perceptual and adaptive learning. MATERIALS AND METHODS: First- through third-year general surgery and internal medicine residents and third- and fourth-year medical students participated in a course consisting of didactic instruction and hands on skills stations. The course covered common anorectal conditions, including internal and external hemorrhoids, fissures, condylomata, abscesses, fistula-in-ano, rectal prolapse, pilonidal disease, pruritis ani, and anal and rectal cancer, as well as common procedures such as anoscopy, excision of thrombosed external hemorrhoids, banding of internal hemorrhoids, rigid proctoscopy, incision and drainage of an abscess, administration of local anesthesia, and reduction of rectal prolapse. Before the course, participants completed a questionnaire consisting of demographics; previous anorectal experience, as measured by procedural case volume; confidence diagnosing and treating anorectal conditions; and a clinical knowledge multiple-choice quiz. Immediately following the course, participants took an additional survey reassessing their confidence and testing their clinical knowledge. This study was granted an educational exception by the Institutional Review Board at Walter Reed National Military Medical Center. RESULTS: Forty-three learners participated in this course. Forty-six percent of participants had not participated in any anorectal cases, 26% had participated in 1 to 5 cases, 17% had participated in 6 to 10 cases, 6% had been involved with 11 to15 cases, and 6% had been involved with more than 15 cases. For learners who had no prior experience, 1 to 5 prior cases, or 6 to 10 cases, there were statistically and educationally significant increases in confidence for all diagnoses and procedures. Additionally, there were statistically and educationally significant increases between pre-course and post-course quiz scores for learners who had no prior experience (7.8 ± 2.0 vs. 11.8 ± 2.5, P < 0.01, Cohen's d = 1.8) and for those who had only participated in 1 to 5 cases (11.0 ± 3.7 vs. 14.2 ± 2.0, P = 0.04, Cohen's d = 1.1). The changes in quiz scores for learners who previously had been involved with six or more cases were not statistically significant. CONCLUSION: This course provides a cost-effective training that significantly boosts learners' confidence in diagnosis of common anorectal procedures and confidence in performance of common anorectal procedures, in addition to improving objectively measured anorectal clinical knowledge.


Subject(s)
Rectal Diseases , Abscess , Drainage , Hemorrhoids , Humans , Rectal Fistula
4.
J Surg Educ ; 76(6): e49-e55, 2019.
Article in English | MEDLINE | ID: mdl-31492639

ABSTRACT

INTRODUCTION: The attrition rate in civilian general surgery Graduate Medical Education (GME) is estimated at 20%, while estimates of attrition in military general surgery (MGS) GME programs using the same methodology are nearly twice that. We sought to identify the true attrition rate in MGS GME, identify factors influencing attrition, and examine the relationship between attrition and quality of MGS GME. METHODS: Deidentified data were collected on categorical general surgery residents matriculating from 2010 to 2013 from all 12 MGS residency programs. Information gathered included gender, medical degree, marital status, location of program, presence of a military-related interruption in training, and age at start of the categorical contract. For those who did not graduate, data on postgraduate year at time of attrition, reasons for attrition, and deficiencies in core competencies were solicited. To assess the effect of true attrition rate on graduate performance, we compared the published 5-year American Board of Surgery qualifying exam/certifying exam first time pass rates between military and civilian programs. RESULTS: One hundred eighty-four categorical residents matriculated from 2010 to 2013. Fifty six (31.5 %) were women, 151 (62.1%) were MD's, 103 (56%) were married, 172 (93.5%) were less than 35 years old, and 33 (17.9%) had a military-related interruption in training. Nineteen individuals left residency prior to graduation (15 resigned, 2 resigned in lieu of termination, 2 terminated) for an overall attrition rate of 10.3%. The most common year for attrition was PGY-3 (31.6%) and most common reason for resignation was changing to a different subspecialty (73.3%). Men and women had equal attrition rates (10.3%), and there was no meaningful difference between MD's and DO's (9.9% vs 12.1%, p = 0.71) or region of training (10.6% East vs 9.1% West, p = 0.73). However, those who were not married, had a militarily mandated interruption in training and started their categorical training over the age of 35 had higher attrition rates (married 5.6%, not married 15%, p = 0.04, interruption 16% vs no interruption 9%, p = 0.1; Age ≥ 35 33.3% vs age < 35 6.7%, p < 0.01). Comparison of American Board of Surgery (ABS) first time pass rates over a similar time period showed that military programs performed statistically discernibly better than civilian programs (82% ± 12 vs 75% ± 13, p = 0.047). CONCLUSIONS: Previous used methodology over estimates the attrition rate in MGS GME. The lower rate in MGS programs results in a high level of graduate performance as measured by ABS pass rates. Interruption in training and especially marital status and age ≥ 35 appear to be potential predictors of attrition. Components of MGS GME training and selection processes might inform efforts to reduce attrition and improve performance in civilian surgical GME.


Subject(s)
General Surgery/education , Internship and Residency/statistics & numerical data , Military Personnel/statistics & numerical data , Student Dropouts/statistics & numerical data , Adult , Female , Humans , Internship and Residency/standards , Male , United States
5.
J Surg Educ ; 76(4): 1139-1145, 2019.
Article in English | MEDLINE | ID: mdl-30952458

ABSTRACT

OBJECTIVE: Newly-graduated military general surgeons often find themselves isolated at sea, solely responsible for all surgical care of several thousand sailors, regardless of the surgical specialty training required for any individual procedure. This educational need assessment explored trends in afloat surgical care over the last 25 years, and assessed trainees' preparedness for their expected role as an isolated surgeon. DESIGN: A sample of deidentified US Navy Ship's Surgeon case logs were reviewed to determine afloat case load trends in 5 common afloat case categories (urologic/gynecologic, anorectal, hernia, appendectomy, and hand/orthopedic/trauma) from 1990s to 2017. Individual procedures were mapped to American College of Surgeons/Military Health System Knowledge, Skills, and Attitudes line items to ensure afloat-relevant skills were identified. Recent military resident case logs were then compared with afloat cases to evaluate relevant trainee experience. SETTING: US Navy ships at sea from 1995 to 2017. PARTICIPANTS: US Navy afloat-deployed surgeons, totaling 1340 cases within the study period. RESULTS: Case log analysis of 1340 surgeries, comprising >200 months at sea, reflected 46 named procedures; 34 of 46 (74%) correlated to an intraoperative knowledge, skills, and attitudes item. The most common surgeries were vasectomy, (304 of 1340, 23%). No difference in case mix was apparent comparing pre- and post-2000 deployments (representing afloat laparoscopic integration) in 4 of 5 categories, while hernias proportionally declined. Case volume per deployment markedly declined overall (p < 0.001) and in each category. Resident case log analysis from 2012 to 2016 showed experience was limited in urologic/gynecologic, orthopedic, and open appendectomy categories. CONCLUSIONS: No formal case repository exists for afloat surgery, making detailed analysis problematic. Current training provides excellent surgical education but minimal exposure to rare-but-real cases expected on deployments, which may not translate to competency for the isolated, afloat surgeon. Military surgical leadership should embrace training for these cases and assertively invest in the development of the military's newest surgeons.


Subject(s)
Career Choice , Clinical Competence , Mobile Health Units/organization & administration , Naval Medicine/education , Specialties, Surgical/education , Adult , Cohort Studies , Education, Medical, Graduate/methods , Female , Humans , Internship and Residency/methods , Male , Military Personnel , Retrospective Studies , Ships , United States
6.
J Surg Educ ; 76(5): 1303-1308, 2019.
Article in English | MEDLINE | ID: mdl-30910499

ABSTRACT

BACKGROUND: Many injuries from recent wars involve extremity trauma secondary to blasts, which predispose patients to developing extremity compartment syndrome. In military studies, 17% of fasciotomies required revision on arrival to a Role 4 hospital, and 41% of these had missed compartments, which is similar to that seen in civilian centers. While training has decreased this rate to 8%, this number is still too high. We conducted a focused needs assessment to guide the development of lower-extremity fasciotomy training. METHODS: In a predeployment assessment, 42 military surgeons performed a 2-incision, 4-compartment, lower-extremity fasciotomy on simulated lower leg models. Models were assessed for standardized and objectively-assessed major (inadequate skin or fascial incisions, missed compartments) and minor (failure to make an H-shaped incision over the lateral compartments, division of the greater saphenous vein) errors based on joint Trauma System clinical practice guidelines and approved training curricula. RESULTS: Four of 42 (9.5%) models contained no errors. Models averaged 4.3 ± 2.6 major and 0.3 ± 0.5 minor errors. 11 models (26.2%) had at least one missed compartment. The most common missed compartments were the deep posterior (17%) and anterior (14%). 29 (69%) had inadequate or poorly-placed skin incisions, with the most common being inadequate distal extension of the medial (10, 24%) and lateral (14, 33%) incisions, inadequate proximal extension of the lateral incision (6, 14%), medial incision too close to the tibia (7, 17%), and lateral incision over or behind the fibula (12, 29%). A total of 36 (86%) had inadequate fascial incisions. Inadequate fasciotomies were seen in the anterior (57%), lateral (55%), superficial (52%), and deep (34%) posterior compartments CONCLUSIONS: Performance on the models approximates what has been seen in military and civilian settings. This needs assessment will inform development of a simulation curriculum based on error-management and mastery learning theory to reduce the morbidity of lower-extremity compartment syndrome.


Subject(s)
Compartment Syndromes/surgery , Fasciotomy/education , Lower Extremity/surgery , Medical Errors/prevention & control , Needs Assessment , Simulation Training , Fasciotomy/standards , Humans , Models, Anatomic
7.
J Gastrointest Surg ; 20(11): 1891-1898, 2016 11.
Article in English | MEDLINE | ID: mdl-27561636

ABSTRACT

BACKGROUND: There is a paucity of data demonstrating the effect race and insurance status have on postoperative outcomes for patients with rectal cancer. We evaluated factors impacting short-term outcomes following rectal cancer surgery. DESIGN: Patients who underwent surgery for rectal cancer using the University Health System Consortium database from 2011 to 2012 were studied. Univariate and multivariable analyses were used to identify patient related risk factors for 30-day outcomes after proctectomy: complication rate, 30-day readmission, ICU stay, and length of hospital stay (LOS). RESULTS: A total of 9272 proctectomies were identified in this cohort. After adjustment for potential confounders, black patients were more likely to have 30-day readmissions (OR 1.51, 95 % CI 1.26-1.81), ICU stays (OR 1.25, 95 % CI 1.03-1.51), and longer LOS (+1.67 days, 95 % CI 1.21-2.13) when compared to whites. Compared to those with private insurance, patients with public or military insurance or who were self-pay had a higher likelihood of having postoperative complications. CONCLUSIONS: In patients who undergo elective proctectomy for rectal cancer, non-white and non-privately insured status are associated with significantly worse short-term outcomes. Further studies are needed to determine the implications with respect to receipt of adjuvant therapy and survival.


Subject(s)
Digestive System Surgical Procedures/adverse effects , Insurance Coverage/statistics & numerical data , Length of Stay/statistics & numerical data , Patient Readmission/statistics & numerical data , Rectal Neoplasms/surgery , Aged , Black People/statistics & numerical data , Critical Care/economics , Critical Care/statistics & numerical data , Databases, Factual/statistics & numerical data , Digestive System Surgical Procedures/economics , Digestive System Surgical Procedures/statistics & numerical data , Female , Humans , Insurance Coverage/economics , Intensive Care Units/economics , Intensive Care Units/statistics & numerical data , Length of Stay/economics , Male , Middle Aged , Patient Readmission/economics , Postoperative Complications/economics , Postoperative Complications/epidemiology , Postoperative Complications/ethnology , Rectal Neoplasms/economics , Rectal Neoplasms/ethnology , Risk Factors , Treatment Outcome , United States/epidemiology , White People/statistics & numerical data
8.
J Gastrointest Surg ; 20(2): 335-42, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26487333

ABSTRACT

BACKGROUND: Volume has been shown to be an important determinant of quality and cost outcomes. METHODS: We performed a retrospective study of patients who underwent surgery for diverticulitis using the University HealthSystem Consortium database from 2008­2012. Outcomes evaluated included minimally invasive approach, stoma creation, intensive-care admission, post-operative complications, length of stay, and total direct hospital costs by surgeon volume. Surgeon volume was categorized into four categories by mean annual volumes: very-high (VHVS) (>31), high (HVS) (13­31), medium (MVS) (6­12), and low (LVS) (≤5). RESULTS: A total of 19,212 patients with a mean age of 59 years, 54 % female makeup, and 55 % rate of private insurance were included. Similar to the unadjusted analysis, multivariable analysis revealed decreasing odds of stoma creation, complications, ICU admission, reoperation, readmission, and inpatient mortality with increasing surgeon volume. Additionally, compared with LVS, a higher surgeon volume was associated with higher rates of the minimally invasive approach. Median length of stay and costs were also notably lower with increasing surgeon volume. CONCLUSION: Quality and the use of minimally invasive technique are tightly associated with surgeon volume. Further studies are necessary to validate the direct association of volume with outcomes in surgery for diverticulitis.


Subject(s)
Colectomy/statistics & numerical data , Colonic Diseases/surgery , Diverticulitis/surgery , Adult , Aged , Colectomy/adverse effects , Colectomy/economics , Colonic Diseases/economics , Colonic Diseases/mortality , Critical Care , Diverticulitis/economics , Diverticulitis/mortality , Female , Hospital Mortality , Hospitalization/economics , Hospitals, High-Volume , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures/adverse effects , Minimally Invasive Surgical Procedures/economics , Minimally Invasive Surgical Procedures/statistics & numerical data , Outcome Assessment, Health Care , Quality Improvement , Retrospective Studies
9.
Int J Surg ; 12(12): 1295-9, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25448648

ABSTRACT

INTRODUCTION: Pre-operative restaging CT scans are often performed routinely following neoadjuvant chemoradiotherapy for locally advanced rectal cancer. There is a paucity of data on the utility of this common practice. We sought to determine how often restaging CTs identified disease progression or regression that altered management. METHODS: We performed a single-institution retrospective study. From 2007 to 2011, 182 patients had newly-diagnosed, non-metastatic rectal adenocarcinoma, of which 96 were surgical candidates with clinical stage II/III disease. Ninety-one of these patients (95%) completed neoadjuvant chemoradiation. RESULTS: Eighty-three out of 91 patients (91%) had restaging CTs. Four patients (5%) had new lesions suspicious for distant metastasis (2 lung, 2 liver) on restaging CT scan reports (1 of these was present on initial staging CT but not reported). All 4 patients had node-positive disease. In no case did restaging CT result in a change in surgical management. DISCUSSION: Because of the financial costs and established risks of intravenous contrast and cumulative radiation exposure, it may be advisable to take a more selective approach to preoperative imaging. Larger, prospective studies may enable identification of an at-risk cohort who would benefit most from restaging CT. CONCLUSION: Routine restaging CT scans are low yield in the management of locally advanced rectal cancer.


Subject(s)
Adenocarcinoma/diagnostic imaging , Adenocarcinoma/therapy , Chemoradiotherapy, Adjuvant , Rectal Neoplasms/diagnostic imaging , Rectal Neoplasms/therapy , Adenocarcinoma/pathology , Aged , Female , Humans , Male , Middle Aged , Neoadjuvant Therapy , Neoplasm Staging/methods , Rectal Neoplasms/pathology , Retrospective Studies , Tomography, X-Ray Computed
10.
Dis Colon Rectum ; 57(12): 1421-9, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25380009

ABSTRACT

BACKGROUND: After passage of the Affordable Care Act, 30 -day hospital readmissions have come under greater scrutiny. Excess readmissions for certain medical conditions and procedures now result in penalizations on all Medicare reimbursements. OBJECTIVE: The purpose of this work was to define the risk factors, outcomes, and costs of 30-day readmissions after colorectal surgery. DESIGN: Adults undergoing colorectal surgery were studied using data from the University HealthSystem Consortium. Univariate and multivariable analyses were used to identify patient-related risk factors for, and 30-day outcomes of, readmission after colorectal surgery. SETTINGS: This study was conducted at an academic hospital and its affiliates. PATIENTS: Adults ≥18 years of age who underwent colorectal surgery for cancer, diverticular disease, IBD, or benign tumors between 2008 and 2011 were included in this study. MAIN OUTCOME MEASURES: Readmission within 30 days of index discharge was the main outcome measured. RESULTS: A total of 70,484 patients survived the index hospitalization after colorectal surgery; 9632 (13.7%) were readmitted within 30 days of discharge. The strongest independent predictors of readmission were length of stay ≥4 days (OR 1.44; 95% CI 1.32-1.57), stoma (OR 1.54; 95% CI 1.46-1.51), and discharge to skilled nursing (OR 1.62; 95% CI 1.49-1.76) or rehabilitation facility (OR 2.93; 95% CI 2.53-3.40). Of those readmitted, half of the readmissions occurred within 7 days, 13% required the intensive care unit, 6% had a reoperation, and 2% died during the readmission stay. The median combined total direct hospital cost was more than 2 times higher ($26,917 vs $13,817; p < 0.001) for readmitted than for nonreadmitted patients. LIMITATIONS: Follow-up was limited to 30 days after initial discharge. CONCLUSIONS: Readmissions after colorectal resection occur frequently and incur a significant financial burden on the health-care system. Future studies aimed at targeted interventions for high-risk patients may reduce readmissions and curb escalating health-care costs.


Subject(s)
Colectomy , Intestinal Diseases , Patient Readmission , Postoperative Complications , Cohort Studies , Colectomy/adverse effects , Colectomy/economics , Colectomy/methods , Colectomy/statistics & numerical data , Comorbidity , Cost of Illness , Female , Hospital Costs/statistics & numerical data , Humans , Intestinal Diseases/economics , Intestinal Diseases/epidemiology , Intestinal Diseases/physiopathology , Intestinal Diseases/surgery , Length of Stay , Male , Middle Aged , Outcome Assessment, Health Care , Patient Discharge , Patient Readmission/economics , Patient Readmission/statistics & numerical data , Postoperative Complications/diagnosis , Postoperative Complications/epidemiology , Postoperative Complications/therapy , Reoperation/economics , Reoperation/methods , Reoperation/statistics & numerical data , Risk Factors , Severity of Illness Index , Time Factors , United States/epidemiology
11.
Int J Colorectal Dis ; 29(12): 1527-34, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25331030

ABSTRACT

BACKGROUND: Postoperative ileus is a significant clinical challenge lacking effective management strategies. Ghrelin-receptor stimulation has promotility effects in the upper and lower gastrointestinal tract. OBJECTIVE: This proof-of-concept, phase 2, randomized study evaluated the safety and efficacy of the ghrelin-receptor agonist ipamorelin in the treatment of postoperative ileus following abdominal surgery (ClinicalTrials.gov NCT00672074). DESIGN: The design was a multicenter, double-blind, placebo-controlled, clinical trial. SETTINGS: The settings include hospital inpatients. PATIENTS: The patients were adults undergoing small and large bowel resection by open or laparoscopic surgery. INTERVENTION: The intervention was intravenous infusions of 0.03-mg/kg ipamorelin vs placebo twice daily, on postoperative day 1 to 7 or hospital discharge. MAIN OUTCOME MEASURES: Safety was assessed by monitoring adverse events and laboratory tests. The key efficacy endpoint was time from first dose of study drug to tolerance of a standardized solid meal. RESULTS: One hundred seventeen patients were enrolled, of whom 114 patients composed the safety and modified intent-to-treat populations. Demographic and disease characteristics were balanced between groups. Overall incidence of any treatment-emergent adverse events was 87.5 % in the ipamorelin group and 94.8 % in placebo group. Median time to first tolerated meal was 25.3 and 32.6 h in the ipamorelin and placebo groups, respectively (p = 0.15). LIMITATIONS: This proof of concept study was small and enrolled patients with a broad range of underlying conditions. CONCLUSIONS: Ipamorelin 0.03-mg/kg twice daily for up to 7 days was well tolerated. There were no significant differences between ipamorelin and placebo in the key and secondary efficacy analyses.


Subject(s)
Gastrointestinal Agents/therapeutic use , Ileus/drug therapy , Intestines/surgery , Oligopeptides/therapeutic use , Postoperative Complications/drug therapy , Receptors, Ghrelin/agonists , Double-Blind Method , Female , Gastrointestinal Agents/adverse effects , Humans , Ileus/etiology , Male , Middle Aged , Nausea/chemically induced , Oligopeptides/adverse effects , Prospective Studies , Vomiting/chemically induced
12.
J Gastrointest Surg ; 18(10): 1804-11, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25091840

ABSTRACT

BACKGROUND: The incidence and virulence of Clostridium difficile infection (CDI) are on the rise. The characteristics of patients who develop CDI following colorectal resection have been infrequently studied. MATERIALS AND METHODS: We utilized the University HealthSystem Consortium database to identify adult patients undergoing colorectal surgery between 2008 and 2012. We examined the patient-related risk factors for CDI and 30-day outcomes related to its occurrence. RESULTS: A total of 84,648 patients met our inclusion criteria, of which the average age was 60 years and 50% were female. CDI occurred in 1,266 (1.5%) patients during the years under study. The strongest predictors of CDI were emergent procedure, inflammatory bowel disease (IBD), and major/extreme APR-DRG severity of illness score. CDI was associated with a higher rate of complications, intensive care unit (ICU) admission, longer preoperative inpatient stay, 30-day readmission rate, and death within 30 days compared to non-CDI patients. Cost of the index stay was, on average, $14,130 higher for CDI patients compared with non-CDI patients. CONCLUSION: Emergent procedures, higher severity of illness, and inflammatory bowel disease are significant risk factors for postoperative CDI in patients undergoing colorectal surgery. Once established, CDI is associated with worse outcomes and higher costs. The poor outcomes of these patients and increased costs highlight the importance of prevention strategies targeting high-risk patients.


Subject(s)
Clostridioides difficile/isolation & purification , Colorectal Surgery/adverse effects , Enterocolitis, Pseudomembranous/epidemiology , Hospital Costs/trends , Risk Assessment/methods , Surgical Wound Infection/epidemiology , Adolescent , Adult , Cost-Benefit Analysis , Enterocolitis, Pseudomembranous/economics , Enterocolitis, Pseudomembranous/microbiology , Female , Follow-Up Studies , Humans , Length of Stay/trends , Male , Middle Aged , Prevalence , Prognosis , Retrospective Studies , Risk Factors , Surgical Wound Infection/economics , Surgical Wound Infection/microbiology , Time Factors , United States/epidemiology , Young Adult
13.
J Am Coll Surg ; 218(6): 1223-30, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24768291

ABSTRACT

BACKGROUND: Surgeon volume may be an important predictor of quality and cost outcomes. We evaluated the association between surgeon volume and quality and cost of surgical care in patients with colon cancer. STUDY DESIGN: We performed a retrospective study of patients who underwent resection for colon cancer, using data from the University HealthSystem Consortium from 2008 to 2011. Outcomes evaluated included use of laparoscopy, ICU admission, postoperative complications, length of stay, and total direct hospital costs by surgeon volume. Surgeon volume was categorized according to high (HVS), medium (MVS), and low (LVS) average annual volumes. RESULTS: A total of 17,749 patients were included in this study. The average age of the cohort was 65 years and 51% of patients were female. After adjustment for potential confounders, compared with LVS, HVS and MVS were more likely to use laparoscopy (HVS, odds ratio [OR] 1.27, 95% CI 1.15, 1.39; MVS, OR 1.16 95% CI 1.65, 1.26). Postoperative complications were significantly lower in patients operated on by HVS than LVS (OR 0.77 95% CI 0.76, 0.91). The HVS patients were less likely to require reoperation than those in the LVS group (OR 0.70, 95% CI 0.53, 0.92) Total direct costs were $927 (95% CI -$1,567 to -$287) lower in the HVS group compared with the LVS group. CONCLUSIONS: Higher quality, lower cost care was achieved by HVS in patients undergoing surgery for colon cancer. An assessment of differences in processes of care by surgeon volume may help further define the mechanism for this observed association.


Subject(s)
Colectomy/statistics & numerical data , Colonic Neoplasms/surgery , Colorectal Surgery/statistics & numerical data , Elective Surgical Procedures/statistics & numerical data , Laparoscopy/statistics & numerical data , Outcome Assessment, Health Care , Aged , Colonic Neoplasms/economics , Costs and Cost Analysis , Elective Surgical Procedures/economics , Female , Humans , Laparoscopy/economics , Male , Postoperative Complications/epidemiology , Retrospective Studies
14.
J Trauma Acute Care Surg ; 73(2): 469-73; discussion 473, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22846958

ABSTRACT

BACKGROUND: Nonprofessionals routinely perform high-risk home maintenance activities otherwise regulated by the Occupational Health and Safety Administration when professionals perform the same work. Reducing the risks taken by these "weekend warriors" has not been the focus of injury prevention efforts. This study describes injury patterns and outcomes for nonprofessionals attempting home roof and tree maintenance. METHODS: We queried our trauma registry for all adult patients (age, ≥18 years) with injury codes for "fall-from-height" or "struck-by-tree" (2005-present) and reviewed charts to determine injuries sustained during home roof or tree work. Patients injured during occupational duties (indicated by Workman's Compensation) were excluded. Descriptive statistics were used to determine patient demographics, injury patterns, and outcomes. RESULTS: A total of 129 patients were injured performing roof and tree maintenance during the study period. Of these patients, 90 (69.8%) were fall from height and 39 (30.2%) were struck by tree. Mean (SD) age was 45 (14) years. The majority were male (124, 96.1%) and white (116, 89.9%). Nearly half (59, 45.7%) were privately insured; a quarter (32, 24.8%) had no insurance. Mean (SD) Injury Severity Score was 12.7 (9.3). Injury distributions were as follows: head injury, 48.8%; facial fractures, 10.1%; cervical spine fractures, 3.9%; thoracic, lumbar, and sacral spine fractures, 28.1%; rib fractures, 27.3%; intrathoracic injuries, 22.5%; liver/spleen injuries, 6.2%; pelvic fractures, 15.6%; upper-extremity fractures, 27.3%; and lower-extremity fractures, 14.7%. Of the patients, 19 (14.7%) had one or more regions with Abbreviated Injury Scale score of higher than 3. Mean (SD) length of stay was 5.3 (7.6) days. Except for 2 deaths (1.6%), discharge dispositions were as follows: home, 64.2%; home with services, 10.1%; rehabilitation, 17.8%; and skilled nursing, 5.4%. CONCLUSION: Weekend warriors performing home roof and tree maintenance sustain serious injuries with a potential for a long-term disability at young ages. Injury prevention efforts should educate the public about the hazards of high-risk home maintenance, possibly encouraging Occupational Health and Safety Administration-regulated protective measures or deferral to trained professionals.


Subject(s)
Accident Prevention/methods , Accidental Falls/statistics & numerical data , Accidents, Home/prevention & control , Accidents, Home/statistics & numerical data , Wounds and Injuries/epidemiology , Accidental Falls/prevention & control , Adult , Age Distribution , Chi-Square Distribution , Cohort Studies , Craniocerebral Trauma/epidemiology , Craniocerebral Trauma/etiology , Female , Fractures, Bone/epidemiology , Fractures, Bone/etiology , Hobbies , Humans , Incidence , Leisure Activities , Male , Middle Aged , Primary Prevention , Registries , Retrospective Studies , Risk Assessment , Sex Distribution , Spinal Fractures/epidemiology , Spinal Fractures/etiology , Time Factors , Trauma Centers , Wounds and Injuries/etiology
16.
Clin Colon Rectal Surg ; 25(3): 127-33, 2012 Sep.
Article in English | MEDLINE | ID: mdl-23997667

ABSTRACT

Teaching the discipline of surgery to medical students depends on the practicing clinical surgeon assuming the role of educator. The amount of surgical knowledge to impart and technical skill to train are ever increasing as the duration of time students spend on surgical rotations is decreasing. The intent of this article is to assist those surgeons with minimal formal training in educational methods to enhance their teaching skills. Traditional large-group lecture, small-group sessions, and mentoring are reviewed with special emphasis on medical simulation.

17.
AJR Am J Roentgenol ; 193(5): 1291-5, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19843744

ABSTRACT

OBJECTIVE: The purpose of this study was to determine the discrepancy between CT colonography (CTC) and optical colonoscopy (OC) measurements for both anus-to-cecum length and anus-to-polyps distance and then determine whether a conversion factor could be generated to equate these CTC and OC distances. MATERIALS AND METHODS: We retrospectively reviewed CTC and OC reports from patients who had undergone both procedures as part of an established protocol. The anus-to-cecum measurement recorded on a single proprietary CTC workstation was compared with the OC cecal length for each patient. Likewise, anus-to-polyp distances were compared as measured by the radiologist and endoscopist. RESULTS: Three hundred thirty-eight patients and 437 polyps were identified with complete data from both CTC and same-day OC. The average anus-to-cecum distance measured at CTC was 189 cm (range, 75-257 cm) and at OC, 108 cm (range, 65-150 cm). For polyps proximal to the splenic flexure (n = 145), the CTC anus-to-polyp measurement was on average 1.7 times that measured at OC. For left-sided polyps (n = 292), the CTC measurement was, on average, within 12 cm or 1.3 times that of the OC anus-to-polyp measurement. All the differences between CTC and OC measurements of cecal length and polyp distances were found to be statistically significant using a paired Student's t test of means (p < 0.001). CONCLUSION: Anus-to-cecum and anus-to-polyp distances are disparate but comparable using a conversion factor of 0.57 for the CTC anus-to-cecum measurement and 0.59 for right-sided CTC anus-to-polyp or 0.78 for left-sided CTC anus-to-polyp measurements. These anus-to-polyp conversion factors could potentially augment current CTC guidelines for accurate and precise polyp localization and removal at endoscopy.


Subject(s)
Colonic Polyps/diagnosis , Colonography, Computed Tomographic/methods , Colonoscopy/methods , Adult , Aged , Anal Canal/diagnostic imaging , Anal Canal/pathology , Colon/diagnostic imaging , Colon/pathology , Colonic Polyps/diagnostic imaging , Colonic Polyps/pathology , Female , Humans , Male , Middle Aged , Radiographic Image Interpretation, Computer-Assisted , Retrospective Studies
18.
Dis Colon Rectum ; 52(2): 222-9, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19279416

ABSTRACT

PURPOSE: Colorectal cancer screening has decreased mortality through early disease detection. In 1995, the United States Preventative Services Task Force recommended commencing screening at age 50 for average-risk people. We assessed trends in colorectal resection for neoplasia in the interval following these recommendations. METHODS: The Nationwide Inpatient Sample was queried to identify patient discharges for colorectal resection of neoplastic disease, 1998-2005. Univariate analyses were performed using Rao-Scott chi-squared tests and survey-weighted analysis of variance. Trends were analyzed by the Mantel-Haenszel chi-squared test. RESULTS: There were 212,389 patient discharges following resection for colorectal neoplasia. The number of resections for each age group were as follows: less than 50 years ranged from 11.8 to 13.3 percent, around 12.5 percent for ages 50 to 70 years, and 13.5 to 11.6 percent for ages greater than 70, with overall P < 0.0001. In-hospital mortality was 0.6 percent for patients aged less than 50 years, 1.5 percent for those aged 50 to 70 years, and 4.6 percent for those aged greater than 70 years. Right colectomy was the most common procedure among all age groups (42.5 percent). CONCLUSIONS: Although the national incidence of colorectal cancer has been fairly stable, the increase in colorectal resection for neoplasia in patients less than age 50, combined with their low in-hospital mortality rate, strengthens the argument for screening before age 50. The predominance of right-sided procedures supports the use of full colonoscopy as the primary screening method.


Subject(s)
Colorectal Neoplasms/epidemiology , Age Factors , Aged , Colectomy/statistics & numerical data , Colonoscopy , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/surgery , Early Detection of Cancer , Female , Hospital Mortality , Humans , Male , Middle Aged , United States/epidemiology
19.
Clin Colon Rectal Surg ; 22(1): 3, 2009 Feb.
Article in English | MEDLINE | ID: mdl-20119549
20.
J Trauma ; 64(4): 1043-7, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18404073

ABSTRACT

BACKGROUND: Management of penetrating colorectal injuries in the civilian trauma population has evolved away from diversionary stoma into primary repair or resection and primary anastomosis. With this in mind, we evaluated how injuries to the colon and rectum were managed in the ongoing war in Iraq. METHODS: The records of Operation Iraqi Freedom patients evacuated to National Naval Medical Center (NNMC) from March 2004 until November 2005 were retrospectively reviewed. Patients with colorectal injuries were identified and characterized by the following: (1) injury type; (2) mechanism; (3) associated injuries; (4) Injury Severity Score; (5) levels of medical care involved in patient treatment; (6) time interval(s) between levels of care; (7) management; and (8) outcomes. RESULTS: Twenty-three patients were identified as having either colon or rectal injury. The average ISS was 24.4 (range, 9-54; median 24). On average, patients were evaluated and treated at 2.5 levels of surgically capable medical care (range, 2-3; median 2) between time of injury and arrival at NNMC, with a median of 6 days from initial injury until presentation at NNMC (range, 3-11). Management of colorectal injuries included 7 primary repairs (30.4%), 3 resections with anastomoses (13.0%), and 13 colostomies (56.6%). There was one death (4.3%) and three anastomotic leaks (30%). Total complication rate was 48%. CONCLUSIONS: Based upon injury severity, the complex nature of triage and medical evacuation, and the multiple levels of care involved for injured military personnel, temporary stoma usage should play a greater role in military casualties than in the civilian environment for penetrating colorectal injuries.


Subject(s)
Colectomy/methods , Colon/injuries , Surgical Stomas/statistics & numerical data , Warfare , Wounds, Penetrating/surgery , Adult , Anastomosis, Surgical , Cohort Studies , Colectomy/adverse effects , Colorectal Surgery/methods , Colostomy/methods , Colostomy/statistics & numerical data , Follow-Up Studies , Hospitals, Military , Humans , Incidence , Injury Severity Score , Iraq , Male , Postoperative Complications/epidemiology , Rectum/injuries , Retrospective Studies , Risk Assessment , Survival Rate , Treatment Outcome , Wounds, Penetrating/mortality
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