Evaluation of First Treatment Timing, Fatal Disease Onset, and Days from First Treatment to Death Associated with Bovine Respiratory Disease in Feedlot Cattle.

Bovine respiratory disease (BRD) is a frequent beef cattle syndrome. Improved understanding of the timing of BRD events, including subsequent deleterious outcomes, promotes efficient resource allocation. This study's objective was to determine differences in timing distributions of initial BRD treatments (Tx1), days to death after initial treatment (DTD), and days after arrival to fatal disease onset (FDO). Individual animal records for the first BRD treatment (n = 301,721) or BRD mortality (n = 19,332) were received from 25 feed yards. A subset of data (318-363 kg; steers/heifers) was created and Wasserstein distances were used to compare temporal distributions of Tx1, FDO, and DTD across genders (steers/heifers) and the quarter of arrival. Disease frequency varied by quarter with the greatest Wasserstein distances observed between Q2 and Q3 and between Q2 and Q4. Cattle arriving in Q3 and Q4 had earlier Tx1 events than in Q2. Evaluating FDO and DTD revealed the greatest Wasserstein distance between cattle arriving in Q2 and Q4, with cattle arriving in Q2 having later events. Distributions of FDO varied by gender and quarter and typically had wide distributions with the largest 25-75% quartiles ranging from 20 to 80 days (heifers arriving in Q2). The DTD had right-skewed distributions with 25% of cases occurring by days 3-4 post-treatment. Results illustrate temporal disease and outcome patterns are largely right-skewed and may not be well represented by simple arithmetic means. Knowledge of typical temporal patterns allows cattle health managers to focus disease control efforts on the correct groups of cattle at the appropriate time.

A pooled analysis of six large-pen feedlot studies: effects of a noncoated initial and terminal implant compared with a single initial and delayed-release implant on arrival in feedlot heifers.

Randomized complete block design experiments (n = 6 experiments) evaluating steroidal implants (all from Merck Animal Health, Madison, NJ) were conducted in large-pen feedlot research facilities between 2015 and 2018 comparing an 80 mg trenbolone acetate (TBA) and 8 mg estradiol-17ß (E2) initial implant (Revalor-IH) and reimplanted with 200 mg TBA and 20 mg E2 (Revalor-200; REPEATED) to a single 80 mg TBA and 8 mg E2 uncoated; 120 mg TBA and 12 mg E2 coated implant (Revalor-XH) at arrival (SINGLE) on growth and carcass responses in finishing heifers. Experiments occurred in Nebraska, Oklahoma, Washington, and Texas. Similar arrival processing was used across experiments where 17,675 heifers [initial body weight = 333 kg SEM (4.1)] were enrolled into 180 pens (90 pens per treatment with 65-240 heifers per pen) and fed for 145-222 d. Only REPEATED heifers were removed from their pen at reimplant. Diets contained monensin and tylosin, consisted of ingredients common to each region, and contained greater than 90% concentrate. Ractopamine hydrochloride was fed for a minimum of 28 d prior to harvest. Linear mixed models were used for all analyses; model-adjusted means for each implant group and the corresponding SEM were generated. Distributions of U.S. Department of Agriculture (USDA) quality grade (QG) and yield grade (YG) were analyzed as ordinal outcomes. No differences (P ≥ 0.11) were detected for any performance parameters except dry matter intake (DMI), where SINGLE had greater (P = 0.02) DMI (9.48 vs. 9.38 ± 0.127 kg) compared with REPEATED. Heifers implanted with REPEATED had greater (P ≤ 0.02) hot carcass weight (HCW; 384 vs. 382 ± 2.8 kg), dressing percentage (64.54 vs. 64.22 ± 0.120%), and ribeye area (91.87 vs. 89.55 ± 0.839 cm2) but less (P ≤ 0.01) rib fat (1.78 vs. 1.83 ± 0.025 cm) and calculated YG (2.82 vs. 2.97 ± 0.040) and similar (P = 0.74) marbling scores (503 vs. 505 ± 5.2) compared with SINGLE heifers. Distributions of USDA YG and QG were impacted (P ≤ 0.03) by treatment such that REPEATED had fewer USDA Prime and YG 4 and 5 carcasses. Heifer growth performance did not differ between implant regimens, but HCW and muscling did, perhaps indicating that REPEATED may be suited for grid-based marketing, and SINGLE might be suited for heifers sold on a live basis depending upon market conditions and value-based grid premiums and discounts. However, these decisions are operational dependent and also may be influenced by factors including animal and employee safety, stress on animals, processing facilities, time of year, labor availability, and marketing strategies.

Effects of various ractopamine hydrochloride withdrawal periods on performance, health, and carcass characteristics in yearling steers.

Ractopamine hydrochloride (RAC) is a ß-adrenergic agonist approved for feeding during the last 28 to 42 d prior to cattle slaughter to improve feedlot performance and carcass characteristics. Three thousand crossbred yearling steers (527 ± 2.4 kg; AVG ± SD) were used in two periods to evaluate the effects of various RAC withdrawal times on feedlot performance, health, and carcass characteristics. In Period 1, 6 blocks of 30 pens totaling 1,500 steers were utilized, which was repeated for Period 2. In a randomized complete block design, cattle were assigned to 1 of 5 treatments consisting of 1) No RAC fed (CON), 2) 12-h RAC withdrawal (12-hRAC), 3) 2-d RAC withdrawal (2-dRAC), 4) 4-d RAC withdrawal (4-dRAC), and 5) 7-d RAC withdrawal (7-dRAC). Cattle were fed for a total of 62 d, and applicable treatments were supplemented with 30.0 ppm (dry matter basis) of RAC (average dose = 322 mg per steer per day) for 33 d at the end of the feeding period, corresponding to their respective withdrawal times. Initial body weight (BW) displayed a quadratic curve, with 2-dRAC and 4-dRAC withdrawal periods having the greatest BW. Accordingly, dry matter intake (DMI) responded quadratically (P = 0.034), with 2-dRAC and 4-dRAC treatments demonstrating the greatest DMI. No significant treatment differences (P ≥ 0.641) were observed in final live BW, average daily gain (ADG), or feed efficiency. Alternatively, when using a common dressing percentage to calculate live BW, cattle on RAC treatments exhibited 7.6 kg additional live BW (P < 0.001) compared to CON cattle. Furthermore, carcass-adjusted ADG and feed efficiency did not differ (P > 0.10) between RAC treatments but were improved compared to the CON treatment (P ≤ 0.002). Hot carcass weight (HCW) was on average 4.9 kg greater (P < 0.001) for RAC treatments vs. CON, and no differences were detected (P > 0.10) among RAC treatments. Within RAC treatments, carcass cutability responded quadratically (P ≤ 0.005) to withdrawal period, with the 2-dRAC and 4-dRAC treatments containing more Yield Grade 4 and 5 and fewer Yield Grade 1 and 2 carcasses than the other RAC treatments. On the basis of the results of this experiment, feeding RAC improves dressing percentage, HCW, and carcass-adjusted BW, ADG, and feed efficiency. Furthermore, extending the RAC withdrawal period to 7 d does not have a significant impact on cattle performance or health and has minimal effects on carcass characteristics.

Influence of therapeutic use of feedgrade tetracyclines in combination with tulathromycin metaphylaxis on animal health and performance of Holstein steer calves.

Feedgrade chlortetracycline (CTC) and oxytetracycline (OTC) are approved for use in beef cattle diets for the control of bovine respiratory disease (BRD). The objectives of this experiment were to compare CTC and OTC, administered according to label, for the treatment of BRD in Holstein calves and to characterize the influence of tulathromycin metaphylaxis in combination with tetracycline treatment. Summer-placed Holstein steer calves (n = 6,800) were randomly assigned to one of four treatments (11 blocks; initial BW = 140 ± 18 kg) as they passed through the squeeze chute at initial processing in a commercial feedlot. Treatments consisted of: (i) CTC and tulathromycin metaphylaxis (CTC+TUL), (ii) OTC and tulathromycin metaphylaxis (OTC+TUL), (iii) tulathromycin metaphylaxis only (TUL), or (iv) CTC only (CTC). Cattle were fed for an average of 118 d. Tetracycline feeding was instituted based on visual assessment of the attending veterinarian in accordance with the veterinary feed directive. When applicable, CTC was fed as a top-dress at a rate of 4 g CTC·steer-1·d-1 for 5 consecutive days, beginning on 6 d on feed (DOF). Three 5-d pulses were delivered to CTC+TUL and CTC cattle, with a 48-h time lapse between pulses. Cattle on OTC+TUL were administered 4 g OTC·steer-1·d-1 as part of a complete diet for 14 consecutive days beginning on 10 DOF. Within the first 30 d of the feeding period, BRD first pulls were reduced (P = 0.001) for CTC+TUL, OTC+TUL, and TUL relative to CTC alone. Percentage of BRD first pulls and total morbidity were lowest (P = 0.001) for CTC+TUL across the feeding period, with OTC+TUL and TUL being intermediate, and CTC alone exhibiting the highest percentage. Death loss and railers were not influenced (P ≥ 0.58) by treatment. Dry matter intake was greater (P = 0.001) for CTC+TUL than all other treatments. Final BW and ADG were greatest for CTC+TUL, lowest for TUL alone, and intermediate for the remaining treatments (P < 0.05) on a deads-and-railers-out basis. Deads-and-railers-in ADG was greatest (P < 0.05) for CTC+TUL compared to all other treatments. Feed conversion was not influenced (P ≥ 0.22) by treatment. In the current study, supplementation of OTC in combination with tulathromycin metaphylaxis did not benefit health over tulathromycin alone. Results suggest that CTC in combination with tulathromycin metaphylaxis reduces morbidity in Holstein steers calves, which may lead to improved performance.