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1.
Oncol Lett ; 28(5): 516, 2024 Nov.
Article in English | MEDLINE | ID: mdl-39268169

ABSTRACT

Soft tissue sarcomas are rare cancers and most cases are metastatic at the time of diagnosis. Although the chances of survival are good with surgical treatment in the early stages, systemic treatment in the advanced stages is only associated with a survival duration of ~12 months. Alterations in the anaplastic lymphoma kinase (ALK) gene are becoming increasingly recognized as pan-cancer indicators in solid tumors. However, little is known regarding the molecular spectrum of ALK-positive histiocytosis. Molecular treatments, including ALK inhibitors, are potential treatment options. The present case report describes an aggressive ALK-positive soft tissue sarcoma with intracardiac metastases and severe leukocytosis responding to ALK inhibitors. The patient initially responded to crizotinib but required alectinib due to central nervous system progression. The patient has shown a near-complete response and remained stable for 2 years; however, there has been recent lymph node progression.

2.
Medicine (Baltimore) ; 103(26): e38379, 2024 Jun 28.
Article in English | MEDLINE | ID: mdl-38941440

ABSTRACT

BACKGROUND: This study aimed to evaluate the clinical and radiological features of the patella fixation technique using Toggleloc suspension system in a single ellipsoidal blind patellar tunnel during medial patellofemoral ligament (MPFL) reconstruction. METHODS: This study included 52 patients (25 men, 27 women) who underwent MPFL reconstruction using a semitendinosus tendon graft. The graft was fixed to the ellipsoidal single blind tunnel opened on the medial side of the patella with an endobutton and was fixed to the femoral tunnel by using bioabsorbable screw. Clinical scores (Kujala score, Lysholm score, Tegner activity score and the visual analog scale [VAS] score) were evaluated preoperatively and at the end-follow up. Preoperative and postoperative radiological measurements (trochlea depth, sulcus angle, patellar height, patellar congruence angle, patellar tilt angle and lateral patellofemoral angle) were evaluated with X-ray (Merchant X-ray, anteroposterior and lateral radiography) and computed tomography (CT) of the knee. RESULTS: Postoperative patellar redislocation or subluxation was not observed in any patient. Patellar congruence angle, patellar tilt angle and lateral patellofemoral angle mean values were found to return to normal values in the postoperative period and the results were statistically significant. Also statistically significant improvement in all clinical scores postoperatively. According to the Insall-Salvati index (ISI) and Caton-Deschamps index (CDI) on lateral radiography of the knee at 30° flexion, patellar height decreased in the postoperative period statistically significant. The CDI was above 1.3 in 17 (%32) of our patients. Thirteen of these values decreased to normal values. No radiological progression of patellofemoral osteoarthritis was observed in all patients at the final follow-up evaluation. CONCLUSION: In cases of patellofemoral instability, fixation of the tendon graft in blind ellipsoid tunnel using the Toggleloc suspension system provides satisfactory patellar graft fixation strength, significant functional improvement and a low failure rate.


Subject(s)
Patella , Patellofemoral Joint , Humans , Female , Male , Adult , Patellofemoral Joint/surgery , Patellofemoral Joint/diagnostic imaging , Follow-Up Studies , Patella/surgery , Plastic Surgery Procedures/methods , Young Adult , Ligaments, Articular/surgery , Treatment Outcome , Adolescent
3.
Medicine (Baltimore) ; 101(12): e29142, 2022 Mar 25.
Article in English | MEDLINE | ID: mdl-35357356

ABSTRACT

ABSTRACT: Plantar fasciitis is the most common cause of heel pain. Pain can be persistent in some patients and interrupt daily activities and sportive activities. There are a lot of treatment options available for plantar fasciitis. We hypothesized that patients with chronic persistent plantar fasciitis can be successfully treated with radiofrequency nerve ablation (RFNA).Two hundred sixty-one patients with plantar fasciitis (378 feet) treated with RFNA from February 2017 to January 2019 were retrospectively assessed. All the patients had plantar heel pain for at least 6months. Based on their body mass index (BMI), the enrolled patients were divided into obese (BMI ≥ 30kg/m2) and non-obese (BMI < 30kg/m2) groups. The patients were asked to complete a questionnaire just before and after the procedure and during the final follow-up. The BNS Radiofrequency Lesion Generator was used during a single session. The patients' information, including their visual analogue scale (VAS) score and American Orthopaedic Foot and Ankle Society (AOFAS) score, was assessed. During their final follow-up, the patients were asked to rate the success of their treatment by choosing one of the following options: completely successful, very successful, moderately successful, marginally successful, or not successful.The VAS and AOFAS scores of all the patients were evaluated pre-procedure, in the first month after procedure, and during the final follow-up (8-24 months). There was a statistically significant difference between the pre-procedure and postprocedure VAS scores (P < .001), there was no statistically significant difference between the VAS scores in the first month postprocedure and during the final follow-up.There was a statistically significant difference between the pre-procedure and postprocedure AOFAS scores (P < .001), there was no statistically significant difference between the AOFAS scores in the first month postprocedure and during the final follow-up.RFNA can be used as an alternative method to surgical procedures for treating plantar fasciitis because it is safe and effective. The advantages of RFNA are that patients can quickly return to their work and resume weight-bearing activities.


Subject(s)
Catheter Ablation , Fasciitis, Plantar , Catheter Ablation/methods , Fasciitis, Plantar/surgery , Humans , Pain/surgery , Pain Measurement , Retrospective Studies , Treatment Outcome
5.
Medicine (Baltimore) ; 100(13): e25328, 2021 Apr 02.
Article in English | MEDLINE | ID: mdl-33787628

ABSTRACT

ABSTRACT: Different methods have been used throughout the years for syndesmotic injury but there is no consensus on the ideal treatment. Some methods are expensive and some have more complications. The aim of this study is to compare single suture endobutton with double suture endobutton and screw fixation for syndesmotic injury.Sixty nine patients with syndesmotic injury with fibular fractures whom were treated with a single interosseous suture endobutton system (ZipTightTM, Zimmer Biomet), a double interosseous suture endobutton system (ZipTightTM, Zimmer Biomet) and 1 syndesmotic screw (TST, Istanbul, Turkey) were included in this study. Functional and radiological results from patient records between 2015 and 2018 were retrospectively evaluated.Twenty patients were treated with the double interosseous suture endobutton, 23 were treated with the single interosseous suture endobutton, and 26 were treated with traditional AO screw fixation. Three patients from the screw fixation group (11.5%) required revision surgery (P < .05). All the radiologic and clinical outcomes were statistical similar in all 3 groups.Our findings showed that the interosseous suture endobutton system is at least as safe as the screw fixation technique for treatment of syndesmosis joint injuries and can be used as an alternative to the screw method. The interosseous suture endobutton system eliminates the need for a second surgery to remove the hardware, which minimizes the probability of re-diastasis. Since our results showed no statistical difference between single and double interosseous suture endobutton systems, the less costly single endobutton system may be the better alternative.


Subject(s)
Ankle Injuries/surgery , Bone Screws/adverse effects , Fracture Fixation, Internal/methods , Postoperative Complications/epidemiology , Suture Techniques/adverse effects , Adult , Ankle Injuries/diagnosis , Ankle Joint/diagnostic imaging , Ankle Joint/surgery , Female , Fracture Fixation, Internal/adverse effects , Fracture Fixation, Internal/instrumentation , Humans , Male , Middle Aged , Postoperative Complications/etiology , Retrospective Studies , Treatment Outcome , Young Adult
6.
Acta Orthop Traumatol Turc ; 54(4): 453-460, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32812878

ABSTRACT

OBJECTIVE: This study aimed to determine the effects of a novel biodegradable implant releasing platelet-derived growth factor (PDGF) at the fracture site on fracture healing in a rat tibia fracture model. METHODS: In this study, 35 male Sprague-Dawley rats weighing between 300 and 350 g were used. The rats were divided into four groups: Group A (control group without any treatment, n=10), Group B (spacer without PDGF Group, n=10), Group C (spacer with PDGF group, n=10), and Group D (healthy rat Group, n=5). Standardized fractures were created in the right tibias of rats, and then biodegradable implants made of poly-ß-hydroxybutyrate-co-3-hydroxy valerate were implanted at the fracture sites in Groups B and C. In Group C, implants were loaded with 600 ng of PDGF. Animals were sacrificed 30 days after the operation, and fracture healing in each group was assessed radiologically based on the Goldberg score. Furthermore, the anteroposterior (AP) and mediolateral (ML) callus diameters were measured macroscopically, and fracture sites were mechanically tested. RESULTS: In the radiological assessment, Group C showed higher fracture healing rate than Groups A and B (p=0.001), whereas no significant difference was found between group C and Group D (p>0.05). In the macroscopic assessment, while Group C exhibited the thickest AP callus diameter (p=0.02), no significant differences in ML callus diameters existed among the groups (p>0.05). Mechanical testing revealed that Group C had higher torsional strength (p=0.001) and stiffness than Groups A and B (p=0.001) while there was no significant difference between Groups C and D (p>0.05). CONCLUSION: Biodegradable implant releasing PDGF may have positive effects on fracture healing.


Subject(s)
Absorbable Implants , Fracture Healing/drug effects , Platelet-Derived Growth Factor/pharmacokinetics , Tibial Fractures/therapy , Animals , Drug Liberation , Male , Models, Anatomic , Rats , Rats, Sprague-Dawley , Treatment Outcome
7.
Medicine (Baltimore) ; 98(29): e16552, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31335737

ABSTRACT

We report the outcomes of mechanical prophylaxis and chemoprophylaxis in patients who underwent elective surgery for idiopathic adolescent scoliosis (AIS).We retrospectively studied the patients who underwent posterior spinal instrumentation for AIS. The patients were divided into three groups: Group A low-molecular-weight heparin (LMWH) started at 8 hours after surgery; Group B LMWH started at 24 hr after surgery; Group C did not receive chemoprophylaxis. The data about wound oozing, need for transfusion, preoperative and postoperative hemoglobin level, length of stay in hospital, interval from the surgery to removal of closed suction drainage tube, postoperative blood loss from closed suction drain, deep venous thrombosis (DVT), and pulmonary embolism (PE) were investigated.The mean age and Lenke classification for all the groups were similar. No DVT or PE was detected in any group. The mean blood loss from the drain was higher in Group A (400 mL) and Group B (450 mL) when compared to Group C (150 mL) (P = .001). There were more wound oozing in Groups A (5) and B (6) than in Group C (3) (P = .585). Three patients in Group B, 3 patients in Group A, and no patient in Group C had superficial infections. However, there was no statistical difference between the groups (P = .182). Postoperative hospital stay was significantly longer in Groups A (6 days) and B (6 days) then in Group C (5 days) (P = .001).Our current study claims that chemoprophylaxis is not necessary for the patients without risk factors after AIS surgery. Early mobilization and mechanoprophylaxis represents adequate prophylaxis in addition to pain management and well hydration in patients' routine treatment. The complications of chemoprophylaxis are not correlated to the initiation time of prophylaxis.


Subject(s)
Anticoagulants/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Pulmonary Embolism/prevention & control , Scoliosis/surgery , Venous Thrombosis/prevention & control , Adolescent , Anticoagulants/adverse effects , Blood Transfusion , Drug Administration Schedule , Early Ambulation , Elective Surgical Procedures/adverse effects , Female , Hemoglobins/metabolism , Heparin, Low-Molecular-Weight/adverse effects , Humans , Length of Stay , Male , Postoperative Complications/prevention & control , Postoperative Hemorrhage/therapy , Retrospective Studies , Risk Factors , Stockings, Compression , Suction , Surgical Wound Infection , Unnecessary Procedures
8.
Eklem Hastalik Cerrahisi ; 30(1): 10-6, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30885103

ABSTRACT

OBJECTIVES: This study aims to evaluate proximal, shaft, and distal tibial fractures treated with suprapatellar (SP) tibial intramedullary nailing (IMN) in terms of alignment, healing, and patellofemoral (PF) pain. PATIENTS AND METHODS: The study included 58 patients (41 males, 17 females; mean age 42.9 years; range, 18 to 75 years) treated via the SP approach in semiextention. Suprapatellar IMN surgeries were performed by two surgeons. After a minimum of 12 months of follow-up, patients' genders, ages, limb sides, fracture types, and classifications were recorded. Fracture reduction accuracy, angulation, PF arthritis, healing time, complications, and nonunions were analyzed. Anterior knee pain, visual analog scale (VAS), and Lysholm knee scoring scale were used as clinical measurements. RESULTS: Seventeen fractures were in the proximal third, while 22 were in the middle third and 19 were in the distal third of the tibia. The mean healing time was 7.14 months (range, 4 to 13 months); differences in healing time between fracture locations were not statistically significant (p=0.83). The mean follow-up duration was 19.83 months (range, 12 to 30 months); there were no statistically significant differences in follow-up times in terms of fracture sites (p=0.51). The VAS score for the knee was 0 in 49 patients (84.5%) and <3 in nine patients (15.5%). The Lysholm score differences between the fracture location groups were not statistically significant (p=0.33). CONCLUSION: Suprapatellar tibial IMN can be applicable to extra-articular tibial fractures in all locations. Providing easy anatomic reduction in semiextention, convenient fluoroscopic imaging, safety for the PF joint, acceptable anterior knee pain, and satisfactory functional outcomes render SP approach more feasible.


Subject(s)
Fracture Fixation, Intramedullary/methods , Fracture Healing , Tibial Fractures/surgery , Adolescent , Adult , Aged , Arthralgia/etiology , Bone Nails , Female , Follow-Up Studies , Fracture Fixation, Intramedullary/adverse effects , Humans , Lysholm Knee Score , Male , Middle Aged , Patellofemoral Joint , Prospective Studies , Tibia , Tibial Fractures/complications , Tibial Fractures/diagnostic imaging , Time Factors , Visual Analog Scale , Young Adult
9.
Gene ; 688: 140-150, 2019 Mar 10.
Article in English | MEDLINE | ID: mdl-30529510

ABSTRACT

Moringa oleifera (Moringaceae) is a plant known for having high antioxidant potency, anticancer, hepatoprotective, cardioprotective etc. and many more activities. Besides these, Moringaceae has the potential for attenuating the male sexual dysfunction. Reactive oxygen species/ROS were increased in cryptorchidism and therefore cause infertility by damaging sperm DNA and germ cell apoptosis. There was an increase in heat shock proteins (HSP) in cells, which is affected by heat shock. In the present study, the antioxidant effects of two different doses of M. oleifera Lam Extract (MOLE) on experimentally induced cryptorchid testes of rats was investigated. Forty two male rats (16 days old) were divided into four groups: a normal control group, a cryptorchidism-induced control group and two cryptorchidism-induced groups treated orally with either 400 or 800 mg/kg MOLE for 2 weeks. Our study showed that there were ruptures from interstitial spaces, separation of the germ cells from basal membrane, falling of the germ cells into the lumen, perivascular fibrosis, oedema, increased level of HSP70, apoptosis, malondialdehyde (MDA) and decrease in the level of superoxide dismutase (SOD) after the cryptorchidism. We found that pathological damages, oxidative stress, expression of the HSP70 and germ cell apoptosis were decreased in treated groups with MOLE. In brief, we can say that aqueous extract of M. oleifera reduces the oxidative stress in a unilateral cryptorchidism induced rats, and it might attenuate histopathological damages, HSP expression and germ cell apoptosis.


Subject(s)
Apoptosis/drug effects , Germ Cells/drug effects , HSP70 Heat-Shock Proteins/metabolism , Moringa oleifera/chemistry , Plant Extracts/pharmacology , Animals , Antioxidants/pharmacology , Cryptorchidism/metabolism , Germ Cells/metabolism , Male , Malondialdehyde/metabolism , Models, Animal , Oxidative Stress/drug effects , Rats , Rats, Sprague-Dawley , Spermatozoa/drug effects , Spermatozoa/metabolism , Superoxide Dismutase/metabolism
10.
J Orthop Surg (Hong Kong) ; 26(3): 2309499018799769, 2018.
Article in English | MEDLINE | ID: mdl-30235975

ABSTRACT

PURPOSE: Changes in weight-bearing patterns after partial foot amputations may lead to new localized high-pressure points and keratosis due to ulcerations in patients with neuropathies and hypovascular limbs. As a result, diabetic foot ulcers (DFUs) after partial foot amputations are very complex. The aim of this study was to compare the effectiveness of vacuum-assisted closure (VAC) therapy with conventional moist wound dressings in the treatment of diabetic wound ulcers after partial foot amputations. METHODS: Sixty-five diabetic patients with a DFU, who had previously undergone partial foot amputation surgery, were assigned to treatment with VAC (group A: 31 patients) or conventional wound moist dressing (group B: 34 patients). The final results were considered as failed treatment if reamputation was required. Conversely, reaching 90% of wound granulation was considered to be a successful endpoint. RESULTS: The average time to reach 90% granulation tissue was significantly lower in group A (7.8 ± 1.2 weeks vs. 11.1 ± 1.2 weeks; p < 0.001). However, there was no significant difference regarding the reamputation requirements; 38.7% (12 patients) in group A and 41.2% (14 patients) in group B, ( p = 0.839). CONCLUSION: The results of this study allowed us to conclude that VAC therapy system appears to be an effective treatment for patients with complex DFUs who had previously undergone partial foot amputation.


Subject(s)
Amputation, Surgical , Bandages , Diabetic Foot/therapy , Negative-Pressure Wound Therapy , Adult , Aged , Aged, 80 and over , Debridement , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome
11.
Eklem Hastalik Cerrahisi ; 29(2): 104-9, 2018 Aug.
Article in English | MEDLINE | ID: mdl-30016610

ABSTRACT

OBJECTIVES: This study aims to compare the three most commonly used fixation techniques: tension-band wire fixation, partially threaded cannulated screws, and fully threaded cannulated headless compression screws. PATIENTS AND METHODS: Ninety patients with medial malleolus fractures were included in the study. Patients were divided into three groups. Group A included patients who underwent tension-band wire fixation (n=26), Group B partially threaded cannulated compression screws (n=32), and Group C fully threaded cannulated headless compression screws (n=32). The type of medial malleolus fracture, healing rates, implant-related complications, rate of infection, hardware removal, weight-bearing restrictions, mean interval time from the injury to the surgery, and Body Mass Indexes (BMIs) were investigated. The patients' radiographs (standard anteroposterior, lateral, and mortise) were reviewed. The American Orthopedic Foot and Ankle Society (AOFAS) scoring system was used for clinical evaluation. RESULTS: No significant difference was observed between the three groups in terms of age, gender, BMI, follow-up period, and fracture type. Union rate for group C was significantly shorter than groups A and B. There was no implant failure or irritation in group C and this was statistically significant comparing to group A and B (p=0.037). However, there was no significant difference between group A and B (p=0.41). There were no significant differences in the three groups according to AOFAS. Patients with low BMI in groups A and B had a high rate of implant-related complications. There was a significant correlation between low BMI and implant-related complication (p<0.001). CONCLUSION: Union rate in the group who were operated with fully threaded cannulated headless compression screws was significantly shorter than the other groups. This study has shown that tension band wiring and partially threaded cannulated compression screws can cause irritation of soft tissues and pain over the hardware implantation site. Patients with low BMI are vulnerable for implant-related complications.


Subject(s)
Ankle Fractures/surgery , Fracture Fixation, Internal/instrumentation , Fracture Fixation, Internal/methods , Fracture Healing , Adult , Body Mass Index , Female , Humans , Male , Middle Aged , Orthopedic Fixation Devices , Postoperative Complications , Retrospective Studies , Young Adult
12.
J Orthop Surg Res ; 13(1): 132, 2018 May 31.
Article in English | MEDLINE | ID: mdl-29855332

ABSTRACT

BACKGROUND: This biomechanical study evaluates the effect of N-acetylcysteine alone and in combination with the most commonly used antibiotic-loaded bone cement mixtures. METHODS: We mixed eight bone cement mixture groups including combinations of N-acetylcysteine, gentamicin, teicoplanin, and vancomycin and applied a four-point bending test individually to each sample on days 1 and 15 using an MTS Acumen test device. RESULTS: The result was less than 50 MPa-the limit declared by the ISO (International Standards Organization)-in only the "gentamicin + bone cement + N-acetylcysteine" group. Mechanical fatigue resistance of the bone cement decreased significantly with the addition of N-acetylcysteine both on day 1 and day 15 (p <  0.001). With the addition of N-acetylcysteine into the "gentamicin + bone cement" and "vancomycin + bone cement" mixtures, a significant decrease in mechanical fatigue resistance was observed both on day 1 and day 15 (p <  0.001). In contrast, with the addition of N-acetylcysteine into the "teicoplanin + bone cement" mixture, no significant difference in mechanical fatigue resistance was observed on days 1 and 15 (p = 0.093, p = 0.356). CONCLUSION: Preliminary results indicate that adding N-acetylcysteine to teicoplanin-loaded bone cement does not significantly affect the cement's mechanical resistance, potentially leading to a new avenue for preventing and treating peri-prosthetic joint infection. N-acetylcysteine may, therefore, be considered as an alternative agent to be added to antibiotic-loaded bone cement mixtures used in the prevention of peri-prosthetic joint infection.


Subject(s)
Acetylcysteine/administration & dosage , Anti-Bacterial Agents/administration & dosage , Bone Cements/standards , Materials Testing/standards , Stress, Mechanical , Bone Cements/therapeutic use , Materials Testing/methods , Prosthesis-Related Infections/prevention & control
13.
Acta Orthop Traumatol Turc ; 52(4): 272-276, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29705297

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the effects of PLIF and TLIF on sagittal spinopelvic balance and to compare radiological results of two surgical procedures with regard to spinopelvic parameters. METHODS: Thirty-five patients (34 female and 1 male; mean age: 52.29 ± 13.08 (range: 35-75)) with degenerative spondylolisthesis cases were included in the study. Patients were divided into two groups according to surgical technique: PLIF and TLIF. The level and the severity of listhesis according to Meyerding classification were assessed and spinopelvic parameters including sacral slope, pelvic tilt, pelvic incidence (PI), lumbar lordosis, and segmental lumbar lordosis were measured on digital X-rays. All preoperative and postoperative parameters and the results were compared between two groups. RESULTS: The age distribution was similar in both groups (p = 0.825) and there was no difference between the mean PI of the groups (p = 0.616). In 15 patients, spondylolisthesis level were at the L5-S1 level (PLIF: 8, TLIF: 7), in 16 patients at the L4-L5 level (PLIF: 6, TLIF: 10) and in 4 patients at the L3-L4 level (PLIF: 2, TLIF: 2). According to Meyerding classification, before the operation, the sliding grades were 0 in 4 patients, 1 in 21 patients, 2 in 7 patients, and 3 in 3 patients. The grades changed into 0 in 28 patients, 1 in 5 patients, and 2 in 2 patients after surgery. There were no differences in the grade of listhesis between PLIF and TLIF groups preoperatively (p = 0.190) and postoperatively (p = 0.208). In both groups, the spondylolisthesis-related deformities of patients were significantly corrected after surgery (p < 0.001). CONCLUSION: PLIF and TLIF techniques have similar radiological results in restoring the sagittal spinopelvic balance in patients with degenerative spondylolisthesis. Both techniques are good options to achieve reduction and fusion in patients with degenerative spondylolisthesis, but have no advantage over each other for restoring spinopelvic balance. LEVEL OF EVIDENCE: Level III, Therapeutic study.


Subject(s)
Lumbar Vertebrae/surgery , Pelvis/diagnostic imaging , Sacrum/surgery , Spinal Fusion/methods , Spondylolisthesis/surgery , Adult , Age Distribution , Aged , Female , Humans , Lumbar Vertebrae/diagnostic imaging , Male , Middle Aged , Pelvis/surgery , Postoperative Period , Radiography , Sacrum/diagnostic imaging , Spondylolisthesis/diagnostic imaging
14.
Eklem Hastalik Cerrahisi ; 27(1): 9-15, 2016.
Article in English | MEDLINE | ID: mdl-26874629

ABSTRACT

OBJECTIVES: This study aims to investigate the effects of zoledronate therapy on histological and biomechanical properties of bone healing via a fracture model generated on osteoporotic rat tibiae. MATERIALS AND METHODS: Ovariectomized 40 Wistar-Dawley female rats weighing 300 g to 350 g were used in the study. After one week, 2 IU/g heparin injection was started subcutaneously. After four weeks of daily injections, osteoporosis was ensued proven with bone mineral density measurements. Osteoporotic rats were separated into four equal groups randomly as group A (control), group B (calcium and vitamin D), group C (0.1 mg/kg subcutaneous zoledronic acid), and group D (calcium and vitamin D / 0.1 mg/kg subcutaneous zoledronic acid). Six weeks later, all rats were sacrificed, their tibiae were resected, and histopathologic and biomechanical studies were performed. RESULTS: Group C (30.2±1 Nm) and group D (33.3±3 Nm) had significantly higher peak torque values than group A (21.6±6 Nm) and group B (23.6±4 Nm) (p=0.007 and p=0.005, respectively). Group C (1.8) and group D (2.0) had higher stiffness values than group A (1.4) and group B (1.7); however, the difference was not statistically significant (p>0.05 for all). CONCLUSION: According to histopathological and biomechanical test results, single dose zoledronic acid treatment improves fracture healing in an osteoporotic rat fracture model. Orally administered daily calcium and vitamin D treatment had no effect on fracture healing. There was no additional improvement in fracture healing when calcium and vitamin D treatment was added to zoledronic acid treatment. Positive effects of zoledronic acid treatment on osteoporotic fracture healing and callus quality should be shown by future clinical studies.


Subject(s)
Diphosphonates/pharmacology , Fracture Healing/drug effects , Imidazoles/pharmacology , Osteoporosis , Osteoporotic Fractures , Animals , Biomechanical Phenomena , Bone Density/drug effects , Bone Density Conservation Agents/pharmacology , Bone Regeneration , Bony Callus/drug effects , Female , Osteoporosis/complications , Osteoporotic Fractures/drug therapy , Osteoporotic Fractures/pathology , Osteoporotic Fractures/physiopathology , Rats , Rats, Wistar , Tibia/pathology , Treatment Outcome , Vitamin D/pharmacology , Zoledronic Acid
15.
Knee Surg Sports Traumatol Arthrosc ; 23(1): 246-50, 2015 Jan.
Article in English | MEDLINE | ID: mdl-23443330

ABSTRACT

PURPOSE: Spontaneous subchondral osteonecrosis of the knee joint confined to a localized area of one condyle can occur after arthroscopic procedures. Meniscal tears, arthroscopic meniscectomy, and radiofrequency chondroplasty are aetiological factors in the development of osteonecrosis. The aim of this study was to investigate whether the incidence of osteonecrosis increased when mechanical or radiofrequency chondroplasty was used in conjunction with arthroscopic meniscectomy. METHODS: In this prospective clinical trial, arthroscopic meniscectomy was the primary treatment in 75 patients (mean age 40 ± 13) with stage II and III degenerative changes on the articular cartilage. Patients had to meet the following criteria: 1) have preoperative MRI and plain film radiographs showing no evidence of osteonecrosis; 2) be symptomatic for at least 6 weeks before the preoperative MRI; and 3) have arthroscopically confirmed stage II or III chondral lesion. A preoperative MRI was performed for all patients. For treatment of chondral lesions, debridement with a shaver or chondroplasty with a monopolar RF energy system was used. Patients were divided into three treatment groups. Partial meniscectomy of the medial or lateral (or both) menisci was performed on all patients, but patients in group 2 additionally received mechanical debridement of the chondral lesion, and those in group 3 were additionally treated with RF chondroplasty. Patients in group 1 were treated with partial meniscectomy alone. Patients were re-examined after 6 months, at which time a repeat MRI was performed. RESULTS: Development of osteonecrosis was detected during the postoperative MRIs of five patients: two in group 1, two in group 2, and one in group 3. CONCLUSION: The addition of mechanical or RF chondroplasty to meniscectomy did not increase the number of patients with osteonecrosis. Also, RF chondroplasty, which is commonly proposed to be an aetiological factor, resulted in a decrease in the number of patients that developed osteonecrosis. LEVEL OF EVIDENCE: II.


Subject(s)
Arthroplasty/adverse effects , Cartilage Diseases/surgery , Knee Injuries/surgery , Knee Joint/pathology , Menisci, Tibial/surgery , Osteonecrosis/diagnosis , Adult , Arthroscopy/adverse effects , Cartilage, Articular/surgery , Female , Humans , Incidence , Knee Injuries/diagnosis , Knee Joint/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Osteonecrosis/etiology , Prospective Studies
16.
Eur J Orthop Surg Traumatol ; 24(7): 1101-5, 2014 Oct.
Article in English | MEDLINE | ID: mdl-23934502

ABSTRACT

The very rare isolated medial humeral condyle fractures in children and adolescents pose significant problems to orthopedic surgeons such as ulnar nerve injury, trochlear irregularities, fishtail deformity and motion loss. Six adolescent boys with displaced medial humeral condyle fractures with an average age of 14.8 (range 12-17) were included in this study. Patients were followed-up with a mean of 39.8 months (range 21-72). In three patients, there were clinical signs of ulnar nerve dysfunction at initial presentation. Of these, two had only mild hypoesthesia on the ulnar side. The other patient had sensory and motor loss of ulnar nerve at initial presentation complicated by hypothenar atrophy and anhydrosis during follow-up. Complete recovery was seen in this patient only at 2 years. One patient without a neurologic compliant at initial presentation developed mild hypoesthesia on the ulnarly innervated areas postoperatively with complete resolution. Medial skin incision was used for open reduction and internal fixation. No signs of gross morphologic damage were seen on the nerve. The symptoms resolved postoperatively in 3 months time in three of the patients, but in the remaining one, it took 2 years for complete resolution of the symptoms. Also, trochlear irregularity and fishtail deformity were seen on radiographs of two different patients. In all but one patients, motion loss ranging from 10° to 20° was evident on physical examination. The most important finding of this study revealed that transient ulnar nerve dysfunction was seen two-thirds of the patients in this series than any other series reported previously. In three series, only one case of ulnar nerve injury was reported from a total of 19 patients. A possible explanation for such a difference may be the older age in this series.


Subject(s)
Elbow Joint/physiopathology , Humeral Fractures/physiopathology , Humeral Fractures/therapy , Intra-Articular Fractures/therapy , Muscle, Skeletal/pathology , Ulnar Nerve/physiopathology , Adolescent , Atrophy/etiology , Bone Wires , Child , Follow-Up Studies , Fracture Fixation, Internal , Hand , Humans , Humeral Fractures/complications , Hypesthesia/etiology , Immobilization , Intra-Articular Fractures/complications , Intra-Articular Fractures/physiopathology , Male , Neuromuscular Diseases/etiology , Neuromuscular Diseases/physiopathology , Orthotic Devices , Range of Motion, Articular , Recovery of Function , Ulnar Nerve/injuries , Elbow Injuries
17.
Eur J Orthop Surg Traumatol ; 24(1): 117-22, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23412254

ABSTRACT

BACKGROUND: Distal Achilles tendon avulsions are in the form of either bony and nonbony avulsion of Achilles tendon from its calcaneal insertion. METHODS: Four patients with distal Achilles tendon avulsions or ruptures which were treated with tendon to bone repair using suture anchors are presented here. Operated leg was immobilized in above-knee cast for 4 weeks while the patient walked non-weight-bearing. Then, cast was changed to below knee, and full weight-bearing was allowed. Patients underwent gait analysis minimum at first postoperative year. RESULTS: Mean American Orthopedics Foot Ankle Society ankle/hindfoot score of patients at last visit was 88.75 (range 85-100), and Achilles tendon total rupture score was 77.75 (range 58-87). Mean passive dorsiflexion of injured ankles (14° ± 5°) was lower than uninjured ankles (23° ± 9°). All the kinematic parameters of gait analysis were comparable to the uninjured side. Maximum plantar flexion power of injured ankle was 1.40 W/kg, and this was significantly lower than the contralateral side value 2.38 W/kg; (P = 0.0143). CONCLUSIONS: There were no visually altered gait or problems in daily life. Suture anchor tenodesis technique of distal Achilles tendon avulsions was successful in achieving durable osteotendinous repairs.


Subject(s)
Achilles Tendon/injuries , Suture Anchors , Tendon Injuries/surgery , Tenodesis/methods , Achilles Tendon/surgery , Adolescent , Adult , Ankle/surgery , Biomechanical Phenomena , Female , Gait/physiology , Humans , Male , Range of Motion, Articular , Treatment Outcome , Young Adult
18.
Eur J Orthop Surg Traumatol ; 24(7): 1139-44, 2014 Oct.
Article in English | MEDLINE | ID: mdl-23959034

ABSTRACT

INTRODUCTION: At first presentation of paediatric humeral lateral condyle fractures, radiological methods such as computerised tomography, ultrasonography, magnetic resonance imaging, arthrography, and internal oblique radiography are used to determine stability. Very few studies show which radiological method should be used to evaluate displacement at follow-up for conservatively treated patients. This study aimed to show that internal oblique radiography is a simple, effective method to determine the subsequent development of fracture displacement in patients with an initially non-displaced or minimally displaced fracture. MATERIALS AND METHODS: In this retrospective study, 27 paediatric patients with non-displaced or minimally displaced (<2 mm) humerus lateral condyle fracture were evaluated by elbow anteroposterior radiograph. The degree of fracture displacement was evaluated by anteroposterior then by internal oblique radiographs. The first follow-up was made between the 5th and 8th day and thereafter at intervals of 7-10 days. RESULTS: Of the 27 patients identified with non-displaced or minimally displaced (<2 mm) fracture from the initial anteroposterior radiograph, 16 were accepted as displacement >2 mm as a result of the evaluation of the internal oblique radiography and underwent surgery. At follow-up, 2 of 11 patients were defined with displacement from anteroposterior and internal oblique radiographs and 4 from the internal oblique radiographs and underwent surgery. Conservative treatment was applied to 5 patients. CONCLUSIONS: Internal oblique radiography is the best imaging showing subsequent fracture displacement in initially non-displaced or minimally displaced humerus lateral condyle fractures. At the first week follow-up, anteroposterior and particularly internal oblique radiographs should be taken of conservatively treated patients.


Subject(s)
Elbow Joint/diagnostic imaging , Humeral Fractures/diagnostic imaging , Humeral Fractures/therapy , Immobilization , Intra-Articular Fractures/diagnostic imaging , Intra-Articular Fractures/therapy , Casts, Surgical , Child , Child, Preschool , Female , Fracture Healing , Humans , Humeral Fractures/surgery , Intra-Articular Fractures/surgery , Male , Radiography , Retrospective Studies , Elbow Injuries
19.
J Hand Surg Am ; 38(4): 666-71, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23433940

ABSTRACT

PURPOSE: To compare the decrease in ulnar nerve strains using a modification of medial epicondylectomy by removing the distal half of the medial epicondyle with in situ decompression and partial medial epicondylectomy. METHODS: Using 20 elbows of 10 fresh human cadavers, we measured the strain on the ulnar nerve using a microstrain gauge before and after in situ decompression. Then, we repeated the measurements after partial medial epicondylectomy on left elbows, and after distal medial epicondylectomy on right elbows. We compared the mean strain values with 2-way analysis of variance. RESULTS: The decrease in mean ulnar nerve strain with in situ decompression from 5.4% to 5.2% on the right side and 5.4% to 5.0% on the left was not statistically significant. The decrease to 2.9% on the left elbows after partial and to 1.9% on the right elbows after distal medial epicondylectomy was statistically significant. In addition, the remaining ulnar nerve strain after distal medial epicondylectomy was significantly less compared with that after partial medial epicondylectomy. We observed nerve subluxation only with partial medial epicondylectomy. CONCLUSIONS: In situ decompression alone does not change ulnar nerve strains. The significant change in ulnar nerve strain with partial or distal medial epicondylectomy underlines the role of medial epicondyle on stretching of the ulnar nerve. Excision of the distal half of the medial epicondyle sets the contact point of the nerve with the bone proximally and decreases the strain on ulnar nerve more effectively than partial epicondylectomy. However, its efficacy and complications need to be studied clinically. CLINICAL RELEVANCE: The results of the present cadaveric study suggest that excision of the distal half of the medial epicondyle in cubital tunnel syndrome may decrease ulnar nerve strain effectively. The clinical effect of decrease in nerve strain and the indications for the procedure need to be investigated.


Subject(s)
Decompression, Surgical/methods , Humerus/surgery , Orthopedic Procedures/methods , Stress, Mechanical , Ulnar Nerve/surgery , Aged , Biomechanical Phenomena , Cadaver , Cubital Tunnel Syndrome/surgery , Elbow Joint/surgery , Female , Humans , Male , Sensitivity and Specificity , Ulnar Nerve/physiology
20.
J Arthroplasty ; 28(1): 117-25, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22868069

ABSTRACT

Midterm results of cementless total hip arthroplasty in patients with Crowe type IV congenital dislocation of the hip were evaluated. A modified oblique subtrochanteric shortening osteotomy was used in all patients. A cylindrical femoral stem was used in all patients to stabilize the osteotomy. Mean follow-up was 82 months in 20 hips of 16 patients. Mean Merle D'Aubigné pain score increased from 2.52 to 5.65 points, function score improved from 4.0 to 5.3 points, and mobility score improved from 3.95 to 5.35. Mean greater trochanter height relative to the estimated hip center was 6.8 ± 2.0 cm preoperatively and -1 ± 0.2 cm postoperatively. Complications were dislocations in 3 patients, which were successfully managed without redislocation and fracture of greater trochanter in 3 patients, which healed uneventfully in 2 but with residual Trendelenburg gait in one. Total hip arthroplasty with modified oblique subtrochanteric shortening osteotomy is an effective technique for the treatment for Crowe type IV hip dislocation.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Femur/surgery , Hip Dislocation, Congenital/surgery , Osteotomy/methods , Adult , Female , Hip Dislocation, Congenital/diagnostic imaging , Hip Joint/diagnostic imaging , Hip Prosthesis , Humans , Male , Middle Aged , Osteotomy/adverse effects , Radiography
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