ABSTRACT
Background: Gastric cancer (GC) is the fourth leading cause of cancer deaths globally. There is a paucity of real-life data on GC in Brazil. Our study aimed to evaluate survival trends in gastric adenocarcinoma (GA) in a large cancer center in Brazil during 2000-2017. Methods: Based on our Hospital Cancer Registry Database, all individuals diagnosed with GA between 2000 and 2017, and treated at A.C. Camargo Cancer Center, were retrospectively included. The primary objectives were to describe the patient demographics, clinicopathological characteristics, treatment modalities and survival trends during four separate periods of diagnosis (2000-2004; 2005-2009; 2010-2014 and 2015-2017). χ2 test was performed between two specified periods (2000-2004 and 2015-2017) to compare categorical variables. Overall survival (OS) curves were stratified by four separate periods and compared with log-rank tests. Results: This analysis included 1,406 individuals. Across all periods, most patients were men aged 50-69 and presented with Lauren's intestinal subtype. The frequency of stage IV disease significantly decreased between 2000-2004 and 2015-2017 (43.6% to 32.8%, p < 0.001). In contrast, we observed a rise in stage II (9.4% to 24.8%, p < 0.001) in the same comparison. We noticed an increased utilization of a combined approach involving chemotherapy and surgery (12% in 2000-2004 and 36.3% in 2015-2017, p < 0.001). The predicted 5-year OS of patients with GA in 2000-2004 was 27.8%, which increased to 53.9% in 2015-2017 (p < 0.001). Conclusion: Our retrospective cohort showed an upward trend in survival rates during the period. We observed that 5-year OS almost doubled among men and women during 2000-2017. Mini Abstract: The present retrospective cohort showed an upward trend in survival rates during the period from 2000 to 2017, in which the OS almost doubled among men and women.
ABSTRACT
Relata-se o trauma contuso de baço em jovem atendida no Hospital UniversitárioRisoleta Tolentino Neves, em Belo Horizonte, Minas Gerais. Essa lesão é encontrada,frequentemente, em traumas contusos do abdômen. O intuito é discutir a terapêuticadessa lesão, sua abordagem não cirúrgica como primeira escolha na maioria dos casos.Justifica-se a escolha do manejo não operatório, em paciente com lesão esplênicagrau IV, segundo critérios da American Association for the Surgery of Trauma.
We report a case of blunt splenic trauma in a young patient served by the urgency of the University Hospital Risoleta Tolentino Neves Belo Horizonte-MG. This kind of injury is often found in blunt abdominal trauma. The aim is to discuss the approach of the blunt splenic injuries and address the non-surgical treatment as first choice in most cases. Justi-fied this approach by reporting non-surgical therapy, even in a patient with splenic injury grade IV, according to the American Association for the Surgery of Trauma.