ABSTRACT
One of the major factors that limits the widespread use of ultrafast titanium sapphire (Ti:S) lasers in life science is its expensive and complex pump source. Broad area diode laser (BA-DL) based pump sources have high potential to solve this problem, since they are compact, inexpensive and very efficient. However, their non-diffraction limited beam profile makes it challenging to achieve high powers in Kerr-lens mode-locked (KLM) operation of Ti:S lasers. In this work, we show that the ideal way to beam shape two spectrally combined BA-DLs with different beam qualities is to aim for a compromise between matching to the cavity mode diameter and the cavity mode Rayleigh range. We furthermore conclude that the relative intensity noise (RIN) of the BA-DL pumped Ti:S laser, another important parameter for imaging applications, is sufficiently low for a wide range of life science applications. However, for applications that are highly sensitive to noise, new laser diode designs are likely necessary to reduce inherent noise originating within the laser diode.
ABSTRACT
Objectives Blood stream infections (BSIs) are the main cause of morbidity and mortality in children worldwide. The present study was carried out to determine the prevalence of BSI with a focus on the identification of the causative agent of BSI, and to further evaluate the antibiotic susceptibility profile of the causing bacterial pathogens.Methods A cross-section study was carried out at the tertiary care hospital in Peshawar, Pakistan from January to December, 2018. Blood samples were collected in BACTEC