High-Density, Nonvolatile, Flexible Multilevel Organic Memristor Using Multilayered Polymer Semiconductors.

Nonvolatile organic memristors have emerged as promising candidates for next-generation electronics, emphasizing the need for vertical device fabrication to attain a high density. Herein, we present a comprehensive investigation of high-performance organic memristors, fabricated in crossbar architecture with PTB7/Al-AlOx-nanocluster/PTB7 embedded between Al electrodes. PTB7 films were fabricated using the Unidirectional Floating Film Transfer Method, enabling independent uniform film fabrication in the Layer-by-Layer (LbL) configuration without disturbing underlying films. We examined the charge transport mechanism of our memristors using the Hubbard model highlighting the role of Al-AlOx-nanoclusters in switching-on the devices, due to the accumulation of bipolarons in the semiconducting layer. By varying the number of LbL films in the device architecture, the resistance of resistive states was systematically altered, enabling the fabrication of novel multilevel memristors. These multilevel devices exhibited excellent performance metrics, including enhanced memory density, high on-off ratio (>108), remarkable memory retention (>105 s), high endurance (87 on-off cycles), and rapid switching (∼100 ns). Furthermore, flexible memristors were fabricated, demonstrating consistent performance even under bending conditions, with a radius of 2.78 mm for >104 bending cycles. This study not only demonstrates the fundamental understanding of charge transport in organic memristors but also introduces novel device architectures with significant implications for high-density flexible applications.

Enhancement in Capacitance of Ionic Type of EAP-Based Strain Sensors.

This paper aims to enhance the capacitance of electroactive polymer (EAP)-based strain sensors. The enhancement in capacitance was achieved by using a free-standing stretchable polymer film while introducing conducting polymer to fabricate a hybrid dielectric film with controlled conductivity. In this work, styrene-ethylene-butylene-styrene (SEBS) rubber was used as the base material, and dodecyl benzene sulfonate anion (DBSA)-doped polyaniline (PANI) was used as filler to fabricate a hybrid composite conducting film. The maleic anhydride group of the SEBS Rubber and DBSA, the anion of the polyaniline dopant, make a very stable dispersion in Toluene and form a free-standing stretchable film by solution casting. DBSA-doped polyaniline increased the conductivity and dielectric constant of the dielectric film, resulting in a significant enhancement in the capacitance of the EAP-based strain sensor. The sensor presented in this article exhibits capacitance values ranging from 24.7 to 100 µF for strain levels ranging from 0 to 100%, and sensitivity was measured 3 at 100% strain level.

Variable-Sensitivity Force Sensor Based on Structural Modification.

Force sensors are used in a wide variety of fields. They require different measurement ranges and sensitivities depending on the operating environment because there is generally a trade-off between measurement range and sensitivity. In this study, we developed a variable-sensitivity, variable-measurement-range force sensor that utilizes structural modification, namely changes in the distance between the force application point and the detection area, and changes in the cross-sectional area. The use of shape-memory materials allows the sensor structure to be easily changed and fixed by controlling the temperature. First, we describe the theory of the proposed sensor. Then, we present prototypes and the experimental methods used to verify the performance of the sensor. We fabricated the prototypes by attaching two strain gauges to two sides of a shape-memory alloy and shape-memory polymer plates. Experiments on the prototypes show that the relationship between the applied force and the detected strain can be changed by bending the plate. This allows the sensitivity and measurement range of the sensor to be changed.

Evaluation of Contact Force between Aneurysm Model and Coil for Embolization of Intracranial Aneurysms.

Objective: To ensure safe coil embolization for intracranial aneurysms, it is important to investigate the contact force between the coil and the aneurysm wall. However, it is unclear how the catheter tip position and the diameter of the secondary loop of the coil influence the contact force. In this study, we measured the contact force between a coil and an aneurysm biomodel under different conditions. Methods: A commercially available coil was inserted through a microcatheter into a silicone rubber aneurysm model at a constant speed (1 mm/s) using an automatic stage, and the contact force between the coil and the aneurysm wall was measured by a force sensor attached on the aneurysm model. The inner diameter of the spherical aneurysm was 5 mm. The effects of varying the position of the catheter tip (near dome, center, near neck) and the diameter of the secondary coil (4.5 mm) were evaluated. Results: When the catheter tip was inserted more deeply into the aneurysm (especially near the dome), the contact force increased. The contact force also increased as the secondary coil diameter was increased with the catheter tip near and in the center of the dome. Conclusion: These results suggest that the catheter tip position and the secondary coil diameter affect the contact force. In particular, the contact force should be considered large with the catheter tip near the dome to ensure safe coil deployment.

Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models.

Tube-shaped blood vessel models that mimic their geometries and mechanical properties can deliver reliable and realistic behavioral information such as deformation and rupture during procedures such as insertion of medical devices. Thickness of vessel walls is an important parameter for fabricating the blood vessel models owing to their strong influence on the model behavior, especially during deformation. The dip-coating method is used to fabricate blood vessel models; however, non-uniform wall thicknesses are observed using this method. This study aimed at finding the characteristics of stereo "angular control dip-coating" (ACDC) system to develop a dip-coating system that can produce tubular models with uniformed wall thickness. The system developed here enables an observation of the substrate behavior from two different views. The conditions of dip-coating used in this study produce 1.36-1.82 mm in the maximum and 0.188-0.435 mm in minimum wall thickness and the fabricated walls cover the realistic range of carotid arterial dimensions. The characteristics of the ACDC system indicate that ACDC is effective for fabricating the uniform wall thickness particularly in the strong curved parts.

Numerical analysis and experimental observation of guidewire motion in a blood vessel model.

We have developed a computer-based system to simulate a guidewire in blood vessels for surgical planning, intra-operative assistance, and to facilitate the design of new guidewires. In this study, we compared simulation results with experimental results for validation of the simulation system. First, we inserted a commercial guidewire into a poly (vinyl alcohol) hydrogel blood vessel model using a two-axis automatic stage and measured the position of the guidewire tip and the contact force between the guidewire and the vessel. The experimental apparatus can be used not only for the validation of numerical analyses, but also as a simulation system. Second, similarly to the experiment, the motion of the guidewire in the blood vessel model was calculated when the proximal part of the guidewire model was pushed and twisted. The model of the guidewire is constructed with viscoelastic springs and segments, and the proximal part of the guidewire model is constrained by the fixed catheter model. Collisions between the guidewire and the vessel are calculated, and the contact forces are determined according to the stiffness of the vessel wall. The same tendency was seen in the trajectories and the contact force of both the experimental and simulated guidewire tips.

Simulation and experimental observation of contact conditions between stents and artery models.

Treatment of coronary artery stenosis with percutaneous coronary angioplasty and stenting is sometimes complicated by neointimal hyperplasia, possibly due to interaction of the stent with the arterial wall within a specific contact area. Therefore, we characterized the stress distribution at the contacts between the stent and the artery using mathematical and experimental modeling (an arterial cylinder model with a tube-like structure and an arterial stenosis model, consisting of a tube and plaque portion) and two kinds of link stents with different numbers of cells and links. First, the contact condition was investigated using a finite element method (FEM). Second, experimental visualization of the contact area between the stent and the artery models was performed. Comparison of the experimental results with the FEM analysis revealed that the contact area between the stent (with a high number of cells and links) and the artery model was distributed over the total surface of the stent. Further, values obtained from the experimental distribution and the calculated distribution were similar. These data indicate that experimental modeling and FEM analysis are useful methods for analyzing the relationship between stent structure and stent/wall stress distributions and may help guide the design of new stents.