Functional connectivity via the dorsolateral prefrontal cortex in the late phase of rest periods predicts offline learning.

The relationship between offline learning gains and functional connectivity (FC) has been investigated in several studies. They have focused on average motor task performance and resting-state FC across subjects. Generally, individual differences are seen in both offline learning gain and neurophysiological profiles in resting-state FC. However, few studies have focused on the relationship between individual differences in offline learning gain and temporal characteristics of resting-state FC. The present study aimed to clarify this relationship between the two profiles. Thirty-four healthy right-handed participants performed a force-controlled motor task. Electroencephalography was performed during the 15-minute wakeful rest period between tasks. The results revealed a significant correlation between offline learning gain and FC between the contralateral dorsolateral prefrontal cortex (DLPFC) and contralateral primary motor cortex (M1), and ipsilateral primary somatosensory cortex (S1) during late phase of the rest interval. These results are consistent with the findings of previous studies showing the FC between M1, which is necessary for awake offline learning, and DLPFC, which is related to motor control. Additionally, sensory feedback related to force control may be caused by the interaction between contralateral DLPFC and ipsilateral S1. Our study shed light on the temporal profiles of resting-state FC associated with individual differences in offline learning.

Sequential motor learning transfers from real to virtual environment.

BACKGROUND: Skill acquisition of motor learning between virtual environments (VEs) and real environments (REs) may be related. Although studies have previously examined the transfer of motor learning in VEs and REs through the same tasks, only a small number of studies have focused on studying the transfer of motor learning in VEs and REs by using different tasks. Thus, detailed effects of the transfer of motor skills between VEs and REs remain controversial. Here, we investigated the transfer of sequential motor learning between VEs and REs conditions. METHODS: Twenty-seven healthy volunteers performed two types of sequential motor learning tasks; a visually cued button-press task in RE (RE task) and a virtual reaching task in VE (VE task). Participants were randomly assigned to two groups in the task order; the first group was RE task followed by VE task and the second group was VE task followed by RE task. Subsequently, the response time in RE task and VE task was compared between the two groups respectively. RESULTS: The results showed that the sequential reaching task in VEs was facilitated after the sequential finger task in REs. CONCLUSIONS: These findings suggested that the sequential reaching task in VEs can be facilitated by a motor learning task comprising the same sequential finger task in REs, even when a different task is applied.