ABSTRACT
UNLABELLED: For the last thirty years immunotherapy has become an integral part of treatment of some cancers. The most effective approach in this context would be the use of complex immunostimulatory factors including tumor antigen in different forms, interleukins that stimulate differentiation. BACKGROUND: The aim of the study was to compare cellular immune response on specific and combined immunotherapy in patients with cervical cancer. PATIENTS AND METHODS: 76 cervical cancer patients undergoing combined radiotherapy were included into the study. Plus to basic radiation treatment two types of immunotherapy was performed: first--autolymphocytes reinfusion after in vitro incubation with tumor antigen (tumor tissue homogenate) and interleukin-2, second--combination of above mentioned immunotherapy, interleukin-2 and systemic enzyme. RESULTS: This has resulted in increase of cellular immunity parameters in the main group with combined immunotherapy an excess of cells with killer activity to ensure an effective antitumor immune response and, accordingly, the clinical efficacy of specific methods and adoptive immunotherapy in patients with cervical cancer. CONCLUSION: Immunotherapy usage in the form of a preparation of interleukin-2 and a system enzymotherapy in a combination with a specific immunotherapy is possible. This way of treatment is recommended in cases of decreasing of cellular immunity indicators.
Subject(s)
Antigens, Neoplasm , Desensitization, Immunologic/methods , Enzyme Therapy/methods , Interleukin-2 , Uterine Cervical Neoplasms , Adult , Aged , Antigens, Neoplasm/immunology , Antigens, Neoplasm/therapeutic use , Antineoplastic Protocols , Female , Humans , Immunity, Cellular/immunology , Interleukin-2/immunology , Interleukin-2/therapeutic use , Monitoring, Immunologic/methods , Neoplasm Staging , Treatment Outcome , Uterine Cervical Neoplasms/immunology , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/therapyABSTRACT
The aim of investigation is to reveal dependence of indicators of a phagocytes-macrophageal link and cytokine regulation at the operated patients with malignant new growths from a way of anesthesia. 274 patients with a gastroenteric cancer which was exposed to radical operative interventions with use of various ways of anesthesia (total intravenous, inhalation and intravenous-epidural) are surveyed. Existence of dependence of indicators of a phagocytes link of immunity and cytokine regulation from a way of surgical anesthesia at oncological patients is revealed. Most the imbalance of the studied phagocytes and cytokine mechanisms was shown at total intravenous, in the smallest--at combined intravenous epidural anesthesia that serves one of factors for the recommendation of its priority use in oncosurgical practice.