ABSTRACT
The aim of the study was to reduce perioperative blood loss in patients with giant uterine myoma. As a result of studies have provided evidence that the use of anti fibrinolytic therapy as intravenous infusion of tranexamic acid for 30 minutes before the surgery in a dose of 20 mg/kg followed by infusion of 5 mg/kg per hour for the first postoperative day, helped to reduce perioperative blood loss by 29%. Hemoglobin level was higher by 10% (p < 0,05), blood loss was lower by 29% (p < 0,05), the length of stay in hospital was reduced by 24% (p < 0,05) in patients of the second group on the second postoperative day.
Subject(s)
Antifibrinolytic Agents/therapeutic use , Leiomyoma/surgery , Postoperative Hemorrhage , Tranexamic Acid/therapeutic use , Uterine Myomectomy/adverse effects , Uterine Neoplasms/surgery , Antifibrinolytic Agents/administration & dosage , Drug Administration Schedule , Female , Humans , Leiomyoma/blood , Middle Aged , Perioperative Period , Postoperative Hemorrhage/diagnosis , Postoperative Hemorrhage/drug therapy , Thrombelastography , Tranexamic Acid/administration & dosage , Uterine Neoplasms/bloodABSTRACT
The aim of the study was to examine the state of endothelial system in healthy pregnant women in the third trimester and in pregnant women with severe preeclampsia by determining the number of circulating endothelial cells desquamated at different stages of apoptosis, the method of J. Hladoveka at baseline and after the test with the test stimulus. Data obtained from studies were processed using standard software packages "MedStat" and Microsoft Excel, their analysis.
Subject(s)
Endothelial Cells/pathology , Endothelium, Vascular/pathology , Hypoxia/pathology , Pre-Eclampsia/pathology , Adaptation, Physiological , Adult , Apoptosis , Blood Pressure , Case-Control Studies , Cell Count , Female , Humans , Hypoxia/diagnosis , Pre-Eclampsia/diagnosis , Pregnancy , Pregnancy Trimester, Third , Severity of Illness IndexABSTRACT
The instrumental method of the integral assessment of functional state of the hemostasis system using piezoelectric hemoviscosigraphy was elaborated.