From developmental neuroscience to policy: A novel framework based on participatory research.

Insights from developmental neuroscience are not always translated to actionable policy decisions. In this review, we explore the potential of bridging the gap between developmental neuroscience and policy through youth participatory research approaches. As the current generation of adolescents lives in an increasingly complex and rapidly changing society, their lived experiences are crucial for both research and policy. Moreover, their active involvement holds significant promise, given their heightened creativity and need to contribute. We therefore advocate for a transdisciplinary framework that fosters collaboration between developmental scientists, adolescents, and policy makers in addressing complex societal challenges. We highlight the added value of adolescents' lived experiences in relation to two pressing societal issues affecting adolescents' mental health: performance pressure and social inequality. By integrating firsthand lived experiences with insights from developmental neuroscience, we provide a foundation for progress in informed policy decisions.

Can adolescents be game changers for 21st-century societal challenges?

Adolescents growing up in the 21st century face novel challenges that affect today's adolescents differently compared with previous generations. Adolescents' prosocial values and social engagement can contribute in unique ways to combatting societal challenges. Participatory research provides tools to transform adolescents' prosocial motivations into drivers for societal change.

Adolescents' trust and reciprocity toward friends, unknown peers, and community members.

Using a newly developed version of the Trust Game among 196 adolescents aged 11-20 years, this study examined whether adolescents distinguish between trust and reciprocity to unknown peers, friends, and community members. We also tested for effects of age, gender, and individual differences in attending to others' emotions, emotional support to friends, societal contributions, and institutional and interpersonal trust beliefs. Results indicated that adolescents showed the least trust and reciprocity to unknown peers, more to a community member, and most to friends. Reciprocity increased with age, and individual differences in societal contributions and interpersonal trust were positively related to trust and reciprocity. This study was the first to show that community members are a specific target in adolescents' social world.

Neural Mechanisms Underlying Trust to Friends, Community Members, and Unknown Peers in Adolescence.

Trust plays an important role during adolescence for developing social relations. Although prior developmental studies give us insight into adolescents' development of differentiation between close (e.g., friends) and unknown (e.g., unknown peers) targets in trust choices, less is known about the development of trust to societal targets (e.g., members of a community organization) and its underlying neural mechanisms. Using a modified version of the Trust Game, our preregistered fMRI study examined the underlying neural mechanisms of trust to close (friend), societal (community member), and unknown others (unknown peer) during adolescence in 106 participants (aged 12-23 years). Adolescents showed most trust to friends, less trust to community members, and the least trust to unknown peers. Neural results show that target differentiation in adolescents' trust behavior is associated with activity in social brain regions implicated during mentalizing, reward processing, and cognitive control. Recruitment of the medial prefrontal cortex (mPFC) and OFC was higher for closer targets (i.e., friend and community member). For the mPFC, this effect was most pronounced during no trust choices. Trust to friends was additionally associated with increased activity in the precuneus and bilateral temporal parietal junction. In contrast, bilateral dorsolateral prefrontal cortex and anterior cingulate cortex were most active for trust to unknown peers. The mPFC showed increased activity with age and consistent relations with individual differences in feeling needed/useful.

Variability and change in adolescents' prosocial behavior across multiple time scales.

We examined variability and change in adolescents' prosocial behaviors directed to peers and friends across four time scales: two-years, one-year, two-monthly, and daily. Data from three longitudinal datasets with a total of 569 adolescents (55.7% girl, Mage  = 15.23, SD = 3.90) were included. The overall time-related stability of prosocial behavior across time scales was moderate to excellent. Variability did not differ between early (age 10-15) and late (age 16-21) adolescence, but late adolescence was associated with higher mean levels of prosociality. Finally, results indicated that prosocial behaviors measured over longer periods (i.e., two-years and one-year) were positively associated with cognitive processes (perspective taking), whereas prosocial behaviors measured over shorter periods (i.e., two-monthly) were positively associated with affective processes (empathy).

A perspective on enhancing representative samples in developmental human neuroscience: Connecting science to society.

Marginalized groups are often underrepresented in human developmental neuroscientific studies. This is problematic for the generalizability of findings about brain-behavior mechanisms, as well as for the validity, reliability, and reproducibility of results. In the present paper we discuss selection bias in cohort studies, which is known to contribute to the underrepresentation of marginalized groups. First, we address the issue of exclusion bias, as marginalized groups are sometimes excluded from studies because they do not fit the inclusion criteria. Second, we highlight examples of sampling bias. Recruitment strategies are not always designed to reach and attract a diverse group of youth. Third, we explain how diversity can be lost due to attrition of marginalized groups in longitudinal cohort studies. We provide experience- and evidence-based recommendations to stimulate neuroscientists to enhance study population representativeness via science communication and citizen science with youth. By connecting science to society, researchers have the opportunity to establish sustainable and equal researcher-community relationships, which can positively contribute to tackling selection biases.

Pathways for engaging in prosocial behavior in adolescence.

Adolescent development is often regarded as a period of social sensitivities, given that brain development continues into the early 20s in interplay with social experiences. In this review, we present adolescence as a unique window for prosocial development; that is, behavior that benefits others. We present evidence for multiple pathways of neural sensitivity that contribute to key developmental processes related to prosocial behaviors, including valuing, perspective taking, and goal-flexibility. Yet, these processes are dependent on several contextual factors including recipients, audience effects, and strategic motivations. Next, we present intervention findings suggesting that prosocial experiences within these various contexts are crucial for adolescents developing into engaged and contributing members of society. These findings suggest a new interpretation of the elevated socio-affective sensitivity and emerging socio-cognitive development in adolescence, focusing on opportunities rather than risks.

Positive and Negative Risk-Taking in Adolescence and Early Adulthood: A Citizen Science Study During the COVID-19 Pandemic.

Sensation seeking is an important underlying factor of both positive and negative forms of risk-taking during adolescence and early adulthood. However, macro-factors such as the global COVID-19 pandemic may influence sensation seeking opportunities and risk-taking behaviors that are considered negative and positive. Therefore, the primary aim of this study was to examine the associations between sensation seeking and behaviors that are considered positive or negative forms of risk-taking during the Covid-19 pandemic in a sample of adolescents and early adults (N = 660, M age = 22.91, SD = 3.14). Using citizen science methods, negative risk-taking was defined as taking unaccepted risks, such as falsifying vaccination reports or deliberately contracting COVID-19. Positive risk-taking was defined as taking socially accepted risks, such as balancing between the risk to infect elderly people and the need to socialize with peers. Results showed that participants with higher levels of sensation seeking took more positive and negative COVID-19 related risks. An additional finding was that sensation seeking was positively associated with the need to contribute to society. This indicates that during adolescence and early adulthood, sensation seeking may be a driving factor for both positive (i.e., socially accepted) and negative (i.e., socially unaccepted) risk-taking in the context of a high-stake global pandemic, arguing against a one-direction negative relation between sensation seeking and risk-taking.

Daily prosocial actions during the COVID-19 pandemic contribute to giving behavior in adolescence.

Prosocial actions are a building block for developing mature and caring social relations. However, the global pandemic may hamper adolescents' prosocial actions. In this preregistered study, we examined the extent to which adolescents provided daily emotional support during the COVID-19 pandemic. In total, 10-25-year-old high school and university students participated at three timepoints (N = 888 at the first timepoint (May 2020); 494 at the second timepoint (Nov 2020) and 373 at the third timepoint (May 2021)). At the first and second timepoint, participants completed 2 weeks of daily diaries on providing emotional support. At all timepoints, participants performed Dictator Games to measure giving to peers, friends and COVID-19 targets (medical doctors, COVID-19 patients, individuals with a poor immune system). Across the three timepoints, adolescents gave more to COVID-19 targets than peers and friends, but giving to COVID-19 target was highest in the beginning of the pandemic (first timepoint relative to second and third timepoint). Results from the first timepoint showed that emotional support directed to friends peaked in mid-adolescence, whereas emotional support towards family members showed a gradual increase from childhood to young adulthood. Furthermore, daily emotional support increased between the first and second timepoint. Daily emotional support to friends predicted giving behavior to all targets, whereas emotional support to family was specifically associated with giving to COVID-19 targets. These findings elucidate the relation between daily actions and prosocial giving to societally-relevant targets in times of crisis, underlying the importance of prosocial experiences during adolescence.

Emotion regulation training as a treatment element for externalizing problems in adolescence: A randomized controlled micro-trial.

Improving interventions for externalizing problems in adolescence may require determining which treatment elements actually produce change. In this micro-trial, we tested a treatment element addressing one widely-hypothesized mechanism underlying externalizing problems: emotion regulation. We tested whether emotion regulation could be improved via training, whether adolescents who received such training would subsequently show reduced externalizing problems, and which training approach and sequence was most effective. We randomized 108 adolescents with elevated externalizing problems (71.3% boys, Mage = 13.66, SD = 1.10) to a control condition or an experimental condition teaching emotion regulation through either a cognitive or behavioral approach, in alternated sequences. Effects of the modules were assessed before and after the modules, and with weekly assessments. The results showed a positive effect of the experimental training on self-reported use of adaptive emotion regulation strategies. However, self-reported externalizing problems decreased more in the control condition than in the experimental condition. No mediation, approach (cognitive versus behavioral) or sequence (cognitive-behavioral versus behavioral-cognitive sequence) effects were found. These findings illustrate that change in a proposed mechanism may not be accompanied by change in targeted problems; this highlights the importance of testing the hypothesized impact of specific treatment elements on targeted mental health problems. TRIAL REGISTRATION: This trial was registered in the Dutch Trial Register (NTR7334, July 10th, 2018) and the study protocol was published (te Brinke, Schuiringa, Menting, Dekovic, & de Castro, 2018).

Emotion regulation and angry mood among adolescents with externalizing problems and intellectual disabilities.

BACKGROUND AND AIMS: Cognitive behavior therapy targeting emotion regulation is found to be effective in decreasing externalizing problems, but little is known about the emotion regulation capacities of adolescents with externalizing problems and Mild Intellectual Disabilities or Borderline Intellectual Functioning (MID-BIF). Therefore, the aim of this study was to compare emotion (i.e., anger) regulation capacities, angry mood level and angry mood variability between two groups: adolescents with externalizing problems and MID-BIF and adolescents with externalizing problems and average intelligence (AIQ). METHODS AND PROCEDURES: Participants in the MID-BIF (n = 42, Mage = 15.52, SD = 1.43) and AIQ (n = 39, Mage = 13.67, SD = 1.06) group completed questionnaires about emotion regulation difficulties, emotion regulation strategies, and angry mood. OUTCOMES AND RESULTS: Adolescents in the MID-BIF group reported fewer emotion regulation difficulties, fewer maladaptive regulation strategies, and lower levels of angry mood than adolescents in the AIQ group. No between-group differences in angry mood variability were found. Lastly, adolescents in the MID-BIF group reported to use more behavioral than cognitive regulation strategies. CONCLUSIONS AND IMPLICATIONS: These findings provide a starting point in understanding emotion regulation and angry mood of adolescents with externalizing problems and MID-BIF and show that it is important to consider differences between cognitive and behavioral regulation processes.

The Role of Perspective Taking and Self-Control in a Preventive Intervention Targeting Childhood Disruptive Behavior.

Prevention studies typically focus on outcome variables such as reductions in problem behavior, rather than targeted factors (e.g., cognitions), or the relation between change in targeted factors and outcomes. Therefore, the current study examined the effect of a targeted prevention program for childhood disruptive behavior on targeted factors (i.e., perspective taking and self-control) and associations between change in targeted factors and outcomes (i.e., aspects of disruptive behavior). The sample consisted of 173 children (Mage = 10.2 years) who were randomly assigned to an intervention condition (n = 70) or waitlist control condition (n = 103). Assessment took place at pre-, post- and follow-up measurements. For ethical considerations, follow-up data was not available for children on the waitlist. Findings revealed a direct intervention effect on self-control. From pre-test to follow-up, children who received the intervention improved in perspective taking and self-control. Moreover, improvements in self-control were associated with and predicted reductions in teacher-reported symptoms of oppositional defiant disorder. No associations were found between changes in perspective taking and disruptive behavior. These findings suggest that self-control may be an important target factor in reducing childhood disruptive behavior in targeted prevention.

Bidirectional Effects between Parenting and Aggressive Child Behavior in the Context of a Preventive Intervention.

Over time, developmental theories and empirical studies have gradually started to adopt a bidirectional viewpoint. The area of intervention research is, however, lagging behind in this respect. This longitudinal study examined whether bidirectional associations between (changes in) parenting and (changes in) aggressive child behavior over time differed in three conditions: a child intervention condition, a child + parent intervention condition and a control condition. Participants were 267 children (74 % boys, 26 % girls) with elevated levels of aggression, their mothers and their teachers. Reactive aggression, proactive aggression and perceived parenting were measured at four measurement times from pretest to one-year after intervention termination. Results showed that associations between aggressive child behavior and perceived parenting are different in an intervention context, compared to a general developmental context. Aggressive behavior and perceived parenting were unrelated over time for children who did not receive an intervention. In an intervention context, however, decreases in aggressive child behavior were related to increases in perceived positive parenting and decreases in perceived overreactivity. These findings underscore the importance of addressing child-driven processes in interventions aimed at children, but also in interventions aimed at both children and their parents.