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Neurología (Barc., Ed. impr.) ; 23(8): 499-502, oct. 2008. tab, ilus
Article in Spanish | IBECS | ID: ibc-76039

ABSTRACT

Introducción. Diversos estudios han demostrado unamayor prevalencia de lesiones de sustancia blanca (LSB) enresonancia magnética (RM) cerebral de pacientes con migraña.También se ha comunicado mayor frecuencia deshunt derecha-izquierda (SDI) en pacientes con migrañacon aura (MCA) que en población general. El objetivo denuestro estudio es explorar una eventual asociación entre laexistencia de LSB y la presencia o no de SDI en pacientescon migraña.Métodos. Se revisaron los pacientes con MCA o migrañasin aura (MSA) con estudio de RM, a los que se había determinadopreviamente SDI mediante doppler transcraneal(DTC). Se determinaron LSB (alteraciones de señal de sustanciablanca hiperintensas en secuencias ponderadas en T2y FLAIR sin alteración de señal en T1). Se relaciona la presenciade LSB con el tipo de migraña y presencia o no de SDImediante estadística univariante.Resultados. Cuarenta y cuatro pacientes con migraña(31 mujeres y 13 hombres); edad media: 39 años (23-66).Doce pacientes con MSA y 32 con MCA. Catorce pacientesmostraron LSB (31,8 %). Veintinueve pacientes (65,9 %) presentaronSDI. Los pacientes con LSB presentaron SDI tan sóloen un 26,7% y los pacientes con SDI presentaron LSB enun 34,5 %. No se apreciaron diferencias estadísticamentesignificativas (p=0,738).Conclusiones. No hemos podido demostrar una relaciónentre el SDI y la aparición de LSB en la RM cerebral ennuestra serie. Desconocemos la naturaleza de la asociaciónentre LSB y migraña, pero estos hallazgos sugieren que elmecanismo no sería el embolismo paradójico (AU)


Introduction. Previous studies have described a higherprevalence of white matter lesions (WML) in thebrain magnetic tesonance imaging (MRI) in patients withmigraine. A higher frequency of right-to-left shunt (RLS)in patients with migraine with aura (MA) than in generalpopulation has been reported. This study has aimed toinvestigate a possible association between the existenceof WML and the presence or non-presence of RLS in patientswith migraine.Methods. We have reviewed migraine patients sufferingMA or migraine without aura (MWA) with an MRIstudied in whom left-right shunt had been determinedpreviously by transcranial doppler (TCD). The presenceof WML was determined (white matter hyperintensitiesin T2-weighted MR images (T2WI) and FLAIR, withoutsignal alteration in T1WI). The presence of WML was relatedwith the type of migraine and presence or non-presenceof RLS by univariate statistics.Results. Forty four patients with migraine, 13 maleand 31 female, mean age 39 years (23-66) were studied.Twelve patients had MA and 32 MWA. Fourteen patientshad WML (31.8%), 29 patients (65.9%) RLS; 26.7% ofthe patients with WML also had RLS, and 34.5% of thepatients with RLS had WML. Non-statistically significantdifferences were observed (p=0.738).Conclusions. We could not demonstrate a relationshipbetween RLS and WML in the brain MRI of ourpatients. We do not know the nature of the associationbetween is the association between WML and migraine,but these findings suggest that the link would not be byparadoxical embolism (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Foramen Ovale, Patent/complications , Migraine Disorders/etiology , Foramen Ovale, Patent/diagnosis , Migraine Disorders/diagnosis , Magnetic Resonance Spectroscopy , Ultrasonography, Doppler, Transcranial
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