Uncovering key molecular mechanisms in the early and late-stage of papillary thyroid carcinoma using association rule mining algorithm.

OBJECTIVE: Thyroid Cancer (TC) is the most frequent endocrine malignancy neoplasm. It is the sixth cause of cancer in women worldwide. The treatment process could be expedited by identifying the controlling molecular mechanisms at the early and late stages, which can contribute to the acceleration of treatment schemes and the improvement of patient survival outcomes. In this work, we study the significant mRNAs through Machine Learning Algorithms in both the early and late stages of Papillary Thyroid Cancer (PTC). METHOD: During the course of our study, we investigated various methods and techniques to obtain suitable results. The sequence of procedures we followed included organizing data, using nested cross-validation, data cleaning, and normalization at the initial stage. Next, to apply feature selection, a t-test and binary Non-Dominated Sorting Genetic Algorithm II (NSGAII) were chosen to be employed. Later on, during the analysis stage, the discriminative power of the selected features was evaluated using machine learning and deep learning algorithms. Finally, we considered the selected features and utilized Association Rule Mining algorithm to identify the most important ones for improving the decoding of dominant molecular mechanisms in PTC through its early and late stages. RESULT: The SVM classifier was able to distinguish between early and late-stage categories with an accuracy of 83.5% and an AUC of 0.78 based on the identified mRNAs. The most significant genes associated with the early and late stages of PTC were identified as (e.g., ZNF518B, DTD2, CCAR1) and (e.g., lnc-DNAJB6-7:7, RP11-484D2.3, MSL3P1), respectively. CONCLUSION: Current study reveals a clear picture of the potential candidate genes that could play a major role not only in the early stage, but also throughout the late one. Hence, the findings could be of help to identify therapeutic targets for more effective PTC drug developments.

Unraveling the link between PTBP1 and severe asthma through machine learning and association rule mining method.

Severe asthma is a chronic inflammatory airway disease with great therapeutic challenges. Understanding the genetic and molecular mechanisms of severe asthma may help identify therapeutic strategies for this complex condition. RNA expression data were analyzed using a combination of artificial intelligence methods to identify novel genes related to severe asthma. Through the ANOVA feature selection approach, 100 candidate genes were selected among 54,715 mRNAs in blood samples of patients with severe asthmatic and healthy groups. A deep learning model was used to validate the significance of the candidate genes. The accuracy, F1-score, AUC-ROC, and precision of the 100 genes were 83%, 0.86, 0.89, and 0.9, respectively. To discover hidden associations among selected genes, association rule mining was applied. The top 20 genes including the PTBP1, RAB11FIP3, APH1A, and MYD88 were recognized as the most frequent items among severe asthma association rules. The PTBP1 was found to be the most frequent gene associated with severe asthma among those 20 genes. PTBP1 was the gene most frequently associated with severe asthma among candidate genes. Identification of master genes involved in the initiation and development of asthma can offer novel targets for its diagnosis, prognosis, and targeted-signaling therapy.

Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches.

Objective: Wilms tumor (WT) and Rhabdoid tumor (RT) are pediatric renal tumors and their differentiation is based on histopathological and molecular analysis. The present study aimed to introduce the panels of mRNAs and microRNAs involved in the pathogenesis of these cancers using deep learning algorithms. Methods: Filter, graph, and association rule mining algorithms were applied to the mRNAs/microRNAs data. Results: Candidate miRNAs and mRNAs with high accuracy (AUC: 97%/93% and 94%/97%, respectively) could differentiate the WT and RT classes in training and test data. Let-7a-2 and C19orf24 were identified in the WT, while miR-199b and RP1-3E10.2 were detected in the RT by analysis of Association Rule Mining. Conclusion: The application of the machine learning methods could identify mRNA/miRNA patterns to discriminate WT from RT. The identified miRNAs/mRNAs panels could offer novel insights into the underlying molecular mechanisms that are responsible for the initiation and development of these cancers. They may provide further insight into the pathogenesis, prognosis, diagnosis, and molecular-targeted therapy in pediatric renal tumors.

Key therapeutic targets implicated at the early stage of hepatocellular carcinoma identified through machine-learning approaches.

Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Early-stage detection plays an essential role in making treatment decisions and identifying dominant molecular mechanisms. We utilized machine learning algorithms to find significant mRNAs and microRNAs (miRNAs) at the early and late stages of HCC. First, pre-processing approaches, including organization, nested cross-validation, cleaning, and normalization were applied. Next, the t-test/ANOVA methods and binary particle swarm optimization were used as a filter and wrapper method in the feature selection step, respectively. Then, classifiers, based on machine learning and deep learning algorithms were utilized to evaluate the discrimination power of selected features (mRNAs and miRNAs) in the classification step. Finally, the association rule mining algorithm was applied to selected features for identifying key mRNAs and miRNAs that can help decode dominant molecular mechanisms in HCC stages. The applied methods could identify key genes associated with the early (e.g., Vitronectin, thrombin-activatable fibrinolysis inhibitor, lactate dehydrogenase D (LDHD), miR-590) and late-stage (e.g., SPRY domain containing 4, regucalcin, miR-3199-1, miR-194-2, miR-4999) of HCC. This research could establish a clear picture of putative candidate genes, which could be the main actors at the early and late stages of HCC.

A diagnostic miRNA panel to detect recurrence of ovarian cancer through artificial intelligence approaches.

BACKGROUND: Ovarian Cancer (OC) is the deadliest gynecology malignancy, whose high recurrence rate in OC patients is a challenging object. Therefore, having deep insights into the genetic and molecular mechanisms of OC recurrence can improve the target therapeutic procedures. This study aimed to discover crucial miRNAs for the detection of tumor recurrence in OC by artificial intelligence approaches. METHOD: Through the ANOVA feature selection method, we selected 100 candidate miRNAs among 588 miRNAs. For their classification, a deep-learning model was employed to validate the significance of the candidate miRNAs. The accuracy, F1-score (high-risk), and AUC-ROC of classification test data based on the 100 miRNAs were 73%, 0.81, and 0.65, respectively. Association rule mining was used to discover hidden relations among the selected miRNAs. RESULT: Five miRNAs, including miR-1914, miR-203, miR-135a-2, miR-149, and miR-9-1, were identified as the most frequent items among high-risk association rules. The identified miRNAs may target genes/proteins involved in epithelial-mesenchymal transition (EMT), resistance to therapy, and cancer stem cells; being responsible for the heterogeneity and plasticity of the tumor. Our conclusion presents mir-1914 as the significant candidate miRNA and the most frequent item. Current knowledge indicates that the dysregulated miR-1914 may function as a tumor suppressor or oncogene in the development of cancer. CONCLUSION: These candidate miRNAs can be considered a powerful tool in the diagnosis of OC recurrence. We hypothesize that mir-1914 might open a new line of research in the realm of managing the recurrence of OC and could be a significant factor in triggering OC recurrence.

Panels of mRNAs and miRNAs for decoding molecular mechanisms of Renal Cell Carcinoma (RCC) subtypes utilizing Artificial Intelligence approaches.

Renal Cell Carcinoma (RCC) encompasses three histological subtypes, including clear cell RCC (KIRC), papillary RCC (KIRP), and chromophobe RCC (KICH) each of which has different clinical courses, genetic/epigenetic drivers, and therapeutic responses. This study aimed to identify the significant mRNAs and microRNA panels involved in the pathogenesis of RCC subtypes. The mRNA and microRNA transcripts profile were obtained from The Cancer Genome Atlas (TCGA), which were included 611 ccRCC patients, 321 pRCC patients, and 89 chRCC patients for mRNA data and 616 patients in the ccRCC subtype, 326 patients in the pRCC subtype, and 91 patients in the chRCC for miRNA data, respectively. To identify mRNAs and miRNAs, feature selection based on filter and graph algorithms was applied. Then, a deep model was used to classify the subtypes of the RCC. Finally, an association rule mining algorithm was used to disclose features with significant roles to trigger molecular mechanisms to cause RCC subtypes. Panels of 77 mRNAs and 73 miRNAs could discriminate the KIRC, KIRP, and KICH subtypes from each other with 92% (F1-score ≥ 0.9, AUC ≥ 0.89) and 95% accuracy (F1-score ≥ 0.93, AUC ≥ 0.95), respectively. The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively. This study found new panels of mRNAs and miRNAs to distinguish among RCC subtypes, which were able to provide new insights into the underlying responsible mechanisms for the initiation and progression of KIRC and KIRP. The proposed mRNA and miRNA panels have a high potential to be as biomarkers of RCC subtypes and should be examined in future clinical studies.

Hyper-Parameter Optimization of Stacked Asymmetric Auto-Encoders for Automatic Personality Traits Perception.

In this work, a method for automatic hyper-parameter tuning of the stacked asymmetric auto-encoder is proposed. In previous work, the deep learning ability to extract personality perception from speech was shown, but hyper-parameter tuning was attained by trial-and-error, which is time-consuming and requires machine learning knowledge. Therefore, obtaining hyper-parameter values is challenging and places limits on deep learning usage. To address this challenge, researchers have applied optimization methods. Although there were successes, the search space is very large due to the large number of deep learning hyper-parameters, which increases the probability of getting stuck in local optima. Researchers have also focused on improving global optimization methods. In this regard, we suggest a novel global optimization method based on the cultural algorithm, multi-island and the concept of parallelism to search this large space smartly. At first, we evaluated our method on three well-known optimization benchmarks and compared the results with recently published papers. Results indicate that the convergence of the proposed method speeds up due to the ability to escape from local optima, and the precision of the results improves dramatically. Afterward, we applied our method to optimize five hyper-parameters of an asymmetric auto-encoder for automatic personality perception. Since inappropriate hyper-parameters lead the network to over-fitting and under-fitting, we used a novel cost function to prevent over-fitting and under-fitting. As observed, the unweighted average recall (accuracy) was improved by 6.52% (9.54%) compared to our previous work and had remarkable outcomes compared to other published personality perception works.

Rational Design of Field-Effect Sensors Using Partial Differential Equations, Bayesian Inversion, and Artificial Neural Networks.

Silicon nanowire field-effect transistors are promising devices used to detect minute amounts of different biological species. We introduce the theoretical and computational aspects of forward and backward modeling of biosensitive sensors. Firstly, we introduce a forward system of partial differential equations to model the electrical behavior, and secondly, a backward Bayesian Markov-chain Monte-Carlo method is used to identify the unknown parameters such as the concentration of target molecules. Furthermore, we introduce a machine learning algorithm according to multilayer feed-forward neural networks. The trained model makes it possible to predict the sensor behavior based on the given parameters.

An overview of artificial intelligence techniques for diagnosis of Schizophrenia based on magnetic resonance imaging modalities: Methods, challenges, and future works.

Schizophrenia (SZ) is a mental disorder that typically emerges in late adolescence or early adulthood. It reduces the life expectancy of patients by 15 years. Abnormal behavior, perception of emotions, social relationships, and reality perception are among its most significant symptoms. Past studies have revealed that SZ affects the temporal and anterior lobes of hippocampus regions of the brain. Also, increased volume of cerebrospinal fluid (CSF) and decreased volume of white and gray matter can be observed due to this disease. Magnetic resonance imaging (MRI) is the popular neuroimaging technique used to explore structural/functional brain abnormalities in SZ disorder, owing to its high spatial resolution. Various artificial intelligence (AI) techniques have been employed with advanced image/signal processing methods to accurately diagnose SZ. This paper presents a comprehensive overview of studies conducted on the automated diagnosis of SZ using MRI modalities. First, an AI-based computer aided-diagnosis system (CADS) for SZ diagnosis and its relevant sections are presented. Then, this section introduces the most important conventional machine learning (ML) and deep learning (DL) techniques in the diagnosis of diagnosing SZ. A comprehensive comparison is also made between ML and DL studies in the discussion section. In the following, the most important challenges in diagnosing SZ are addressed. Future works in diagnosing SZ using AI techniques and MRI modalities are recommended in another section. Results, conclusion, and research findings are also presented at the end.

A self-organizing deep neuro-fuzzy system approach for classification of kidney cancer subtypes using miRNA genomics data.

Kidney cancer is a dangerous disease affecting many patients all over the world. Early-stage diagnosis and correct identification of kidney cancer subtypes play an essential role in the patient's survival; therefore, its subtypes diagnosis and classification are the main challenges in kidney cancer treatment. Medical studies have proved that miRNA dysregulation can increase the risk of cancer. Thus, in this paper, we propose a new machine learning approach for significant miRNAs identification and kidney cancer subtype classification to design an automatic diagnostic tool. The proposed method contains two main steps: feature selection and classification. First, we apply the feature selection algorithm to choose the candidate miRNAs for each subtype. The feature selection algorithm utilizes the AMGM measure to select significant miRNAs with high discriminant power. Next, the candidate miRNAs are fed to a classifier to evaluate the candidate features. In the classification step, the proposed self-organizing deep neuro-fuzzy system is employed to classify kidney cancer subgroups. The new deep neuro-fuzzy system consists of a deep structure in the rule layer and novel architecture in the fuzzifier layer. The proposed self-organizing deep neuro-fuzzy system can help us to overcome the main obstacles in the field of neuro-fuzzy system applications, such as the curse of dimensionality. The goal of this paper is to illustrate that the neuro-fuzzy system can very useful in high dimensional data, such as genomics data, using the proposed deep neuro-fuzzy system. The obtained results illustrated that our proposed method has succeeded in classifying kidney cancer subtypes with high accuracy based on the selected miRNAs.

Machine learning as new promising technique for selection of significant features in obese women with type 2 diabetes.

Background The global trend of obesity and diabetes is considerable. Recently, the early diagnosis and accurate prediction of type 2 diabetes mellitus (T2DM) patients have been planned to be estimated according to precise and reliable methods, artificial networks and machine learning (ML). Materials and methods In this study, an experimental data set of relevant features (adipocytokines and anthropometric levels) obtained from obese women (diabetic and non-diabetic) was analyzed. Machine learning was used to select significant features [by the separability-correlation measure (SCM) algorithm] for classification of women with the best accuracy and the results were evaluated using an artificial neural network (ANN). Results According to the experimental data analysis, a significant difference (p < 0.05) was found between fasting blood sugar (FBS), hemoglobin A1c (HbA1c) and visfatin level in two groups. Moreover, significant correlations were determined between HbA1c and FBS, homeostatic model assessment (HOMA) and insulin, total cholesterol (TC) level and body mass index (BMI) in non-diabetic women and insulin and HOMA, FBS and HbA1c, insulin and HOMA, systolic blood pressure (SBP) and diastolic blood pressure (DBP), BMI and TC and HbA1c and TC in the diabetic group. Furthermore, there were significant positive correlations between adipocytokines except for the resistin and leptin levels for both groups. The excellent (FBS and HbA1c), good (HOMA) and fair (visfatin, adiponectin and insulin) discriminators of diabetic women were determined based on specificities and sensitivities level. The more selected features in the ML method were FBS, apelin, visfatin, TC, HbA1c and adiponectin. Conclusions Thus, the subset of features involving FBS, apelin, visfatin and HbA1c are significant features and make the best discrimination between groups. In this study, based on statistical and ML results, the useful biomarkers for discrimination of diabetic women were FBS, HbA1c, HOMA, insulin, visfatin, adiponectin and apelin. Eventually, we designed useful software for identification of T2DM and the healthy population to be utilized in clinical diagnosis.

Presenting a Neuroid model of wind-up based on dynamic synapse.

The treatment of chronic pain depends mainly on our understanding of the mechanisms such as central sensitization which is involved in it. Wind-up of spinal cord is one of the most important phenomena in the study of central sensitization which has received considerable attention in recent years. Wind-up is a form of short-term synaptic plasticity (STP) that can lead to central sensitivity. Although several models have been proposed for wind-up, none of them are based on the experimental evidence. In this study, a new network model is introduced according to the gate control theory of pain. Neuroids are used as neuron models in which their parameters are captured from available experimental data. Adjusting the weights of the network is based on the short-term synaptic plasticity. The results of the time and frequency domain show that the model can well simulate wind-up behavior. This model can be used for analyzing, predicting and controlling chronic pain in the future.

Cancers classification based on deep neural networks and emotional learning approach.

In the present era, enormous factors contribute to causing cancer. So cancer classification cannot rely only on doctor's thoughts. As a result, intelligent algorithms concerning doctor's help are inevitable. Therefore, the authors are motivated to suggest a novel algorithm to classify three cancer datasets; colon, ALL-AML, and leukaemia cancers. Their proposed algorithm is based on the deep neural network and emotional learning process. First of all, by applying the principal component analysis, they had a feature reduction. Then, they used deep neural as a feature extraction. Then, they implemented different classifiers; multi-layer perceptron, support vector machine (SVM), decision tree, and Gaussian mixture model. In the end, because in the real world, especially when working on systems biology, unpredictable events, and uncertainties are undeniable, the robustness of their model against uncertainties is important. So they added Gaussian noise to the input features of the first encoder in each dataset, then, they applied the stacked denoising method. Experimental results disclosed that, generally, using emotional learning increased the accuracy. In addition, the highest accuracy was gained by SVM, 91.66, 92.27, and 96.56% for colon, ALL-AML, and leukaemia, respectively. However, GMM led to the lowest accuracy. The best accuracy gained by GMM was 60%.

Modeling the connections of brain regions in children with autism using cellular neural networks and electroencephalography analysis.

The brain connections in the different regions demonstrate the characteristics of brain activities. In addition, in various conditions and with neuropsychological disorders, the brain has special patterns in different regions. This paper presents a model to show and compare the connection patterns in different brain regions of children with autism (53 boys and 36 girls) and control children (61 boys and 33 girls). The model is designed by cellular neural networks and it uses the proper features of electroencephalography. The results show that there are significant differences and abnormalities in the left hemisphere, (p < 0.05) at the electrodes AF3, F3, P7, T7, and O1 in the children with autism compared with the control group. Also, the evaluation of the obtained connections values between brain regions demonstrated that there are more abnormalities in the connectivity of frontal and parietal lobes and the relations of the neighboring regions in children with autism. It is observed that the proposed model is able to distinguish the autistic children from the control subjects with an accuracy rate of 95.1% based on the obtained values of CNN using the SVM method.

Designing a model to detect the brain connections abnormalities in children with autism using 3D-cellular neural networks.

In neuropsychological disorders, the significant abnormalities in the brain connections in some regions are observed. This paper presents a novel model to demonstrate the connections between different regions in children with autism. The proposed model first conducts the wavelet decomposition of electroencephalography signals by wavelet transform then the features are extracted, such as relative energy and entropy. These features are fed to the 3D-cellular neural network model as inputs to indicate the brain connections. The results showed that there are significant differences and abnormalities in the left hemisphere, (p<0.05) at the electrodes AF3, F3, P7, T7 and O1 in alpha band, AF3, F7, T7 and O1 in beta band, T7 and P7 in gamma band for children with autism compared with the control children. Also, the evaluation of the obtained connections values between brain regions indicated that there are more abnormalities in the connectivity of frontal and parietal lobes and the relations of the neighboring regions in all three bands especially in gamma band for autistic children. Evaluation of the analysis demonstrated that alpha frequency band had the best distinction level of 96.6% based on the obtained values of the cellular neural network using support vector machine method.

Designing and Implementation of Stable Sinusoidal Rough-Neural Identifier.

A rough neuron is defined as a pair of conventional neurons that are called the upper and lower bound neurons. In this paper, the sinusoidal rough-neural networks (SR-NNs) are used to identify the discrete dynamic nonlinear systems (DDNSs) with or without noise in series-parallel configuration. In the identification of periodic nonlinear systems, sinusoidal activation functions provide more efficient neural networks than the sigmoidal activation functions. Based on the Lyapunov stability theory, an online learning algorithm is developed to train the SR-NNs. The asymptotically convergence of the identification error to zero and the boundedness of parameters as well as predictions are proved. SR-NNs are used to identify some DDNSs and the cement rotary kiln (CRK). CRK is a complex nonlinear system in the cement factory, which produces the cement clinker. The experiments show that the SR-NNs in the identification of nonlinear systems have better performances than multilayer perceptrons (MLPs), sinusoidal neural networks, and rough MLPs, particularly in the presence of noise.

Adaptive variable structure hierarchical fuzzy control for a class of high-order nonlinear dynamic systems.

In this paper, a novel adaptive hierarchical fuzzy control system based on the variable structure control is developed for a class of SISO canonical nonlinear systems in the presence of bounded disturbances. It is assumed that nonlinear functions of the systems be completely unknown. Switching surfaces are incorporated into the hierarchical fuzzy control scheme to ensure the system stability. A fuzzy soft switching system decides the operation area of the hierarchical fuzzy control and variable structure control systems. All the nonlinearly appeared parameters of conclusion parts of fuzzy blocks located in different layers of the hierarchical fuzzy control system are adjusted through adaptation laws deduced from the defined Lyapunov function. The proposed hierarchical fuzzy control system reduces the number of rules and consequently the number of tunable parameters with respect to the ordinary fuzzy control system. Global boundedness of the overall adaptive system and the desired precision are achieved using the proposed adaptive control system. In this study, an adaptive hierarchical fuzzy system is used for two objectives; it can be as a function approximator or a control system based on an intelligent-classic approach. Three theorems are proven to investigate the stability of the nonlinear dynamic systems. The important point about the proposed theorems is that they can be applied not only to hierarchical fuzzy controllers with different structures of hierarchical fuzzy controller, but also to ordinary fuzzy controllers. Therefore, the proposed algorithm is more general. To show the effectiveness of the proposed method four systems (two mechanical, one mathematical and one chaotic) are considered in simulations. Simulation results demonstrate the validity, efficiency and feasibility of the proposed approach to control of nonlinear dynamic systems.

Patterns with different phases but same statistics.

Many successful methods in various vision tasks rely on statistical analysis of visual patterns. However, we are interested in covering the gap between the underlying mathematical representation of the visual patterns and their statistics. With this general trend, in this paper a relationship between phase structure of a class of patterns and their moments after and before filtering have been considered. First, a general formula between the phase structure and moments of the images is obtained. Second, a theorem is developed that states under which conditions two visual patterns with the same frequencies but different phases have the same moments up to a certain moment. Finally, a theorem is developed that explains, given a set of filters, under which conditions two visual patterns with both different frequencies and different phases have the same subband statistics.

Breast cancer classification based on advanced multi dimensional fuzzy neural network.

Breast cancer is the cause of the most common cancer death in women. Early detection of the breast cancer is an effective method to reduce mortality. Fuzzy Neural Networks (FNN) comprises an integration of the merits of neural and fuzzy approaches, enabling one to build more intelligent decision-making systems. But increasing the number of inputs causes exponential growth in the number of parameters in Fuzzy Neural Networks (FNN) and computational complexity increases accordingly. This phenomenon is named as "curse of dimensionality". The Hierarchical Fuzzy Neural Network (HFNN) and the Fuzzy Gaussian Potential Neural Network (FGPNN) are utilized to deal this problem. In this study, the HFNN and FGPNN by using new training algorithm, are applied to the Wisconsin Breast Cancer Database to classify breast cancer into two groups; benign and malignant lesions. The HFNN consists of hierarchically connected low-dimensional fuzzy neural networks. It can use fewer rules and parameters to model nonlinear system. Moreover, the FGPNN consists of Gaussian Potential Function (GPF) used in the antecedent as the membership function. When the number of inputs increases in FGPNN, the number of fuzzy rules does not increase. The performance of HFNN and FGPNN are evaluated and compared with FNN. Simulation results show the effectiveness of these methods even with less rules and parameters in performance result. These methods maintain the accuracy of original fuzzy neural system and have high interpretability by human in diagnosis of breast cancer.

Analysis of the noise reduction property of type-2 fuzzy logic systems using a novel type-2 membership function.

In this paper, the noise reduction property of type-2 fuzzy logic (FL) systems (FLSs) (T2FLSs) that use a novel type-2 fuzzy membership function is studied. The proposed type-2 membership function has certain values on both ends of the support and the kernel and some uncertain values for the other values of the support. The parameter tuning rules of a T2FLS that uses such a membership function are derived using the gradient descend learning algorithm. There exist a number of papers in the literature that claim that the performance of T2FLSs is better than type-1 FLSs under noisy conditions, and the claim is tried to be justified by simulation studies only for some specific systems. In this paper, a simpler T2FLS is considered with the novel membership function proposed in which the effect of input noise in the rule base is shown numerically in a general way. The proposed type-2 fuzzy neuro structure is tested on different input-output data sets, and it is shown that the T2FLS with the proposed novel membership function has better noise reduction property when compared to the type-1 counterparts.