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1.
Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters.
Collier, Ai-Ris Y; Miller, Jessica; Hachmann, Nicole P; McMahan, Katherine; Liu, Jinyan; Bondzie, Esther A; Gallup, Lydia; Rowe, Marjorie; Schonberg, Eleanor; Thai, Siline; Barrett, Julia; Borducchi, Erica N; Bouffard, Emily; Jacob-Dolan, Catherine; Mazurek, Camille R; Mutoni, Audrey; Powers, Olivia; Sciacca, Michaela; Surve, Nehalee; VanWyk, Haley; Wu, Cindy; Barouch, Dan H.
N Engl J Med ; 388(6): 565-567, 2023 02 09.
Article in English | MEDLINE | ID: mdl-36630611

Subject(s)
COVID-19 , Immunogenicity, Vaccine , Humans , Antibodies, Neutralizing , Antibodies, Viral , Vaccines, Combined/immunology , Vaccines, Combined/therapeutic use , Vaccines, Synthetic/immunology , Vaccines, Synthetic/therapeutic use , Immunogenicity, Vaccine/immunology , COVID-19/genetics , COVID-19/immunology , COVID-19/prevention & control , COVID-19/virology , mRNA Vaccines
2.
Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters.
Collier, Ai-Ris Y; Miller, Jessica; Hachmann, Nicole P; McMahan, Katherine; Liu, Jinyan; Apraku Bondzie, Esther; Gallup, Lydia; Rowe, Marjorie; Schonberg, Eleanor; Thai, Siline; Barrett, Julia; Borducchi, Erica N; Bouffard, Emily; Jacob-Dolan, Catherine; Mazurek, Camille R; Mutoni, Audrey; Powers, Olivia; Sciacca, Michaela; Surve, Nehalee; VanWyk, Haley; Wu, Cindy; Barouch, Dan H.
bioRxiv ; 2022 Oct 25.
Article in English | MEDLINE | ID: mdl-36324798

ABSTRACT

Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.

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