ABSTRACT
Metastatic prostatic carcinoma commonly involves bones and extra pelvic lymph nodes. CNS involvement is unusual and particularly the occurence of leptomeningeal metastasis is extremely rare, with few cases described in the literature.1 The reported incidence at autopsy vary from 0.6 to 4.4 percent.2 We report a 65 year old male who presented with multiple cranial nerve palsies due to leptomeningeal metastasis in carcinoma prostate treated with orchidectomy and planned for radiotherapy and antiandrogen therapy.
Subject(s)
Adenocarcinoma/complications , Cranial Nerve Diseases/etiology , Meningeal Neoplasms/complications , Prostatic Neoplasms/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/secondary , Aged , Humans , Male , Meningeal Neoplasms/diagnosis , Meningeal Neoplasms/secondary , Prostatic Neoplasms/diagnosisABSTRACT
Parry-Romberg syndrome is a rare clinical entity characterised by progressive hemifacial atrophy with appearance of 'saber'. Various neurological and otorhinolaryngological disorders are associated with this syndrome. The association of Parry -Romberg syndrome with Spasmodic dysphonia has rarely been reported. A 37 year old female presented with progressive atrophy of tissues of left side of face for 10 years and change in voice for 1 year. On examination, wasting and atrophy of tissues including tongue was noted on left side of the face. ENT examination revealed adductor spasmodic dysphonia. We report the rare association of Parry -Romberg syndrome with spasmodic dysphonia.
Subject(s)
Dysphonia/etiology , Facial Hemiatrophy/complications , Facial Hemiatrophy/diagnosis , Adult , Dysphonia/diagnosis , Female , HumansSubject(s)
Abducens Nerve/abnormalities , Duane Retraction Syndrome/complications , Lacrimal Apparatus Diseases/complications , Lacrimal Apparatus/innervation , Tears/metabolism , Abducens Nerve/pathology , Child , Cranial Nerve Diseases/diagnosis , Eating , Humans , Lacrimal Apparatus Diseases/congenital , Magnetic Resonance Imaging , Male , Oculomotor Nerve/abnormalities , Oculomotor Nerve/physiopathology , Ophthalmoplegia/complicationsABSTRACT
The familial episodic ataxia type II is a rare, dominantly inherited disease characterized by episodes of ataxia of early onset, often with completely normal cerebellar function between attacks. We report a family with affected members who had features of episodic ataxia type II and cerebellar atrophy on MRI imaging. All the affected members were successfully treated with acetazolamide, a carbonic anhydrase inhibitor. They are asymptomatic at 2 year follow-up.
