ABSTRACT
BACKGROUND: The efficacy of coronavirus disease 2019 (COVID-19) vaccines in preventing SARS-CoV-2 infection in patients with hepatocellular carcinoma (HCC) is not clear. METHODS: From January 2022 to October 2022, patients diagnosed with HCC in a prospective, multicenter, observational cohort were analyzed. RESULTS: One hundred and forty-one patients with (n = 107) or without COVID-19 vaccination (n = 34) were included. The number of patients with severe or very severe infection was relatively lower in the vaccinated group (3.7% vs. 11.8%, p = 0.096). Median infection-free survival in the vaccinated group (14.0 vs. 8.3 months, p = 0.010) was significantly longer than that in the unvaccinated group. COVID-19 vaccination (hazard ratio (HR) HR = 0.47), European Cooperative Oncology Group performance score = 0 (HR = 2.06), and extrahepatic spread (HR = 0.28) were found to be the independent predictive factors for infection-free survival. CONCLUSION: COVID-19 vaccines could effectively reduce the SARS-Cov-2 infection in patients with HCC.
Subject(s)
COVID-19 Vaccines , COVID-19 , Carcinoma, Hepatocellular , Liver Neoplasms , SARS-CoV-2 , Humans , Carcinoma, Hepatocellular/mortality , Carcinoma, Hepatocellular/virology , Liver Neoplasms/mortality , Liver Neoplasms/virology , COVID-19 Vaccines/administration & dosage , COVID-19 Vaccines/therapeutic use , Female , Male , COVID-19/prevention & control , COVID-19/complications , Prospective Studies , Middle Aged , Aged , Prognosis , SARS-CoV-2/immunologyABSTRACT
The admire activity, selective and corrosion resistance electrocatalysts for oxygen evolution reaction (OER) are the bottleneck restricting seawater electrolysis owing to the side reactions of chloride ions (Cl-). Herein, we developed a local amorphous S-modified NiFe-LDH ultrathin nanosheets with large spacing on NiFe foam (la-S-NiFe-LDH/NFF) in-situ via the fast H2O2 assisted etching-anion regulation, resulting in a superior OER catalytic activity for seawater electrolysis. Benefitting from the local amorphous architecture induced by S, enhanced the metal-oxygen covalency, triggered lattice oxygen activity, and reduced the desorption energy of O2, the la-S-NiFe-LDH/NFF accelerated the OER progress via the lattice-oxygen-mediated (LOM) mechanism. Additionally, the preferential adsorbed OH- and reconstructed SO42- cooperated to prevent the proximity and erosion of Cl- and enhanced the corrosion resistance for seawater electrolysis. The assembled electrolyzer of Pt/C || la-S-NiFe-LDH/NFF possessed an industrial level of 500 mA cm-2 at 1.83 V potential for seawater electrolysis, and sustained response for 100 h.
ABSTRACT
Ultraviolet micro-LEDs show great potential as a light source for maskless photolithography. However, there are few reports on micro-LED based maskless photolithography systems, and the studies on the effects of system parameters on exposure patterns are still lacking. Hence, we developed a maskless photolithography system that employs micro-LEDs with peak wavelength 375â nm to produce micrometer-sized exposure patterns in photoresists. We also systematically explored the effects of exposure time and current density of micro-LED on static direct writing patterns, as well as the effects of stage velocity and current pulse width on dynamic direct writing patterns. Furthermore, reducing the size of micro-LED pixels enables obtaining high-resolution exposure patterns, but this approach will bring technical challenges and high costs. Therefore, this paper proposes an oblique direct writing method that, instead of reducing the micro-LED pixel size, improves the pattern resolution by changing the tilt angle of the sample. The experimental results show that the linewidths of the exposed lines decreased by 4.0% and 15.2%, respectively, as the sample tilt angle increased from 0° to 15° and 30°, which confirms the feasibility of the proposed method to improve the pattern resolution. This method is also expected to correct the exposure pattern error caused by optical distortion of the lens in the photolithography system. The system and method reported can be applied in various fields such as PCBs, photovoltaics, solar cells, and MEMS.
ABSTRACT
Temperature-dependent electroluminescence (TDEL) measurements have been employed to investigate the carrier transport and recombination processes of InGaN red micro-LED based on dual-wavelength InGaN/GaN MQWs structure. EL peak energy and carrier transport of the red micro-LED both show temperature dependence, due to temperature-induced changes in defect activation. In addition, the current density at which the blue peak of the low-In-content appears in the EL spectrum varies with temperature. As the temperature increases, the blue peak of the low In component tends to appear at higher current densities, which may be attributed to the increase in thermally activated defects hindering the injection of holes into the low-In-content MQWs further away from p-GaN. Furthermore, the IQEs of the high-In-content MQWs are estimated from the TDEL method and then reveal the temperature-dependent efficiency droop. The IQE decreases as temperature increases, particularly above 50 K, where it drops sharply due to temperature-dependent nonradiative recombination. And the two different variation trends in IQE of MQWs with high and low In content reveal a competitive mechanism in carrier distribution, implying that more escaping holes from high-In-content MQWs will further reduce red emission efficiency but enhance carrier injection and blue emission in low-In-content MQWs.
ABSTRACT
To optimize proteins for particular traits holds great promise for industrial and pharmaceutical purposes. Machine Learning is increasingly applied in this field to predict properties of proteins, thereby guiding the experimental optimization process. A natural question is: How much progress are we making with such predictions, and how important is the choice of regressor and representation? In this paper, we demonstrate that different assessment criteria for regressor performance can lead to dramatically different conclusions, depending on the choice of metric, and how one defines generalization. We highlight the fundamental issues of sample bias in typical regression scenarios and how this can lead to misleading conclusions about regressor performance. Finally, we make the case for the importance of calibrated uncertainty in this domain.
Subject(s)
Computational Biology , Machine Learning , Protein Engineering , Protein Engineering/methods , Regression Analysis , Computational Biology/methods , Proteins/chemistry , AlgorithmsABSTRACT
Recently, signatures of superconductivity with critical temperature from 20 to 30 K have been reported in pressured trilayer nickelate La4Ni3O10through a pressure-induced structure transition. Here we explore the evolution of electronic structures and electronic correlations in different phases of La4Ni3O10under corresponding pressure regions, by using density functional theory (DFT) combined with dynamical mean-field theory (DMFT). Similar to bilayer superconductor La3Ni2O7, the electronic bands in superconducting La4Ni3O10are dominated by Ni-3dx2-y2and 3dz2orbits near the Fermi level, in contrast, the inner Ni-O plane in La4Ni3O10generates a doublet hole-pocket Fermi surfaces around the Brillouin-zone corner, meanwhile one branch of the Ni-3dz2bands is pushed very close above the Fermi level, which can induce an electron pocket through small electron doping. The DFT+DMFT simulations suggest that the electronic correlations only give minor modification to the Fermi surfaces, meanwhile the Ni-3dz2and 3dx2-y2states on outer Ni-O layers have considerable greater mass enhancements than on the inner layer. The sensitiveness of electronic structure under doping and unique layer dependence of correlation suggest a distinct superconducting mechanism with respect to bilayer La3Ni2O7. Based on the DFT and DFT+DMFT simulations, we eventually derive a trilayer effective tight-binding model, which can produce rather precise electronic bands and Fermi surfaces, hence can serve as an appropriate model to further study the superconducting mechanism and paring symmetry in trilayer La4Ni3O10.
ABSTRACT
The rational design of efficient and economical bifunctional electrocatalysts remained a challenge for overall water electrolysis. In this work, the Ni-boride/ phosphide particles anchored amorphous B-doped carbon layer with hierarchical porous characteristics in Ni foam (Ni3P/Ni3B/B-C/NF) was fabricated for overall water splitting. The Boroncarbide (B4C) power was filled and fixed in the NF interspace through the electroplating and electroless plating, and then annealed in vacuum high temperature. The amorphous B-C layer derived from the B4â C not only speeded up the electron transport, but also cooperate with Ni-boride/phosphide to enhance the electrocatalytic activity for HER and OER synergistically. Furthermore, the hierarchical porous architecture of Ni3P/Ni3B/B-C/NF increased space utilization to load more active materials. The self-supported Ni3P/Ni3B/B-C/NF electrode possessed a low overpotential of 212 and 280â mV to deliver 100â mA cm-2 for HER and OER, respectively, and high stability for 48â h. In particular, the electrolyzer constituted with the Ni3P/Ni3B/B-C/NF bifunctional electrocatalyst only required a voltage of 1.59â V at 50â mA cm-2 for water electrocatalysis under alkaline medium, and demonstrated long-term stability for 48â h. This study provides a new technical path for the development of bifunctional of transition metal borides to promote the application of hydrogen production from water splitting.
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Global emission reductions still must address winter fine particulate matter (PM2.5) pollution in urban basins with enclosed terrains and frequent cold air pool (CAP) events when the temperatures within the basin are colder than above it. The effects of urban basin aerosol-boundary layer interactions on PM2.5 pollution during CAP events remain unclear. Intensive boundary layer observations in January 2021 and numerical models were used to investigate this issue in the semi-arid urban Lanzhou Basin of China. The results showed that CAPs formed because of the synoptic weather system that exacerbated the warming over the basin. The CAPs in this experiment were characterized by stronger temperature inversion (TI) layers in the vertical direction and lower relative humidity, lower wind speed, and weaker turbulence at the bottom of the basin compared to other conditions. The strong TI layers below the top of the basin inhibited the vertical dispersion of pollutants in the basin and concentrated the PM2.5 within a height of 0.3 km from the bottom of the basin. During CAP events, the proportion of elemental carbon in PM2.5 increased, whereas that of secondary inorganic species decreased. Aerosol absorption increased faster than scattering during CAP events. Therefore, the mean single scattering albedo decreased from 0.85 during non-CAP periods to 0.81 during CAP events. Radiosonde-sounding observations and numerical simulations indicated that aerosols accumulating in the lower basin heated the atmosphere during the daytime and facilitated boundary layer development via the "stove effect" (absorption aerosol heats lower atmosphere to promote boundary layer development). No significant "dome effect" (absorption aerosol heats the upper boundary layer to suppress boundary layer development) occurred during the two CAP events. These findings provide a theoretical basis for scientifically-guided PM2.5 pollution control in winter in isolated urban basins.
ABSTRACT
OBJECTIVE: To compare the efficacy and safety of preoperative localization of small pulmonary nodules (SPNs) with 4-hook anchor device and hook-wire before video-assisted thoracoscopic surgery. METHODS: Patients with SPNs scheduled for computed tomography-guided nodule localization before video-assisted thoracoscopic surgery between May 2021 and June 2021 at our center were randomized to either 4-hook anchor group or hook-wire group. The primary end point was intraoperative localization success. RESULTS: After randomization, 28 patients with 34 SPNs were assigned to the 4-hook anchor group and 28 patients with 34 SPNs to the hook-wire group. The operative localization success rate was significantly greater in the 4-hook anchor group than in the hook-wire group (94.1% [32/34] vs 64.7% [22/34]; P = .007). All lesions in the 2 groups were successfully resected under thoracoscopy, but 4 patients in the hook-wire group who required transition from wedge resection to segmentectomy or lobectomy because of unsuccessful localization. Total localization-related complication rate was significantly lower in the 4-hook anchor group than in the hook-wire group (10.3% [3/28] vs 50.0% [14/28]; P = .004). The rate of chest pain requiring analgesia after the localization procedure was significantly lower in the 4-hook anchor group than in the hook-wire group (0 vs 5/28, 17.9%; P = .026). There were no significant differences in localization technical success rate, operative blood loss, hospital stay length and hospital cost between the 2 groups (all P > .05). CONCLUSIONS: The use of the 4-hook anchor device for SPN localization offers advantages over the traditional hook-wire technique.
Subject(s)
Lung Neoplasms , Multiple Pulmonary Nodules , Solitary Pulmonary Nodule , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/surgery , Lung Neoplasms/pathology , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/surgery , Multiple Pulmonary Nodules/pathology , Retrospective Studies , Solitary Pulmonary Nodule/diagnostic imaging , Solitary Pulmonary Nodule/surgery , Solitary Pulmonary Nodule/pathology , Thoracic Surgery, Video-Assisted/methods , Tomography, X-Ray Computed/methodsABSTRACT
Chronic hypoxia and ischemia make diabetic wounds non-healing. Cellular functions of diabetic chronic wounds are inhibited under a pathological environment. Therefore, this work develops a composite hydrogel system to promote diabetic wound healing. The composite hydrogel system consists of ε-poly-lysine (EPL), calcium peroxide (CP), and borosilicate glass (BG). The hydrogel supplies continuous dissolved oxygen molecules to the wound that can penetrate the skin tissue to restore normal cellular function and promote vascular regeneration. Biofunctional ions released from BGs can recruit more macrophages through neovascularization and modulate macrophage phenotypic transformation. Combining oxygen-mediated vascular regeneration and ion-mediated inflammatory regulation significantly accelerated diabetic wound healing. These findings indicate that this composite hydrogel system holds promise as a novel tissue engineering material.
Subject(s)
Diabetes Mellitus , Wound Healing , Humans , Hydrogels/pharmacology , Hypoxia , IonsABSTRACT
Sidewall defects play a key role in determining the efficiency of GaN-based micro-light emitting diodes (LEDs) for next generation display applications, but there still lacks direct observation of defects-related recombination at the affected area. In this Letter, we proposed a direct technique to investigate the recombination mechanism and size effect of sidewall defects for GaN blue micro-LEDs. The results show that mesa etching will produce stress release near the sidewall, which can reduce the quantum confinement Stark effect (QCSE) to improve the radiative recombination. Meanwhile, the defect-related non-radiative recombination generated by the sidewall defects plays a leading role under low-power injection. In addition, the effective area of the mesas affected by the sidewall defects can be directly observed according to the fluorescence lifetime imaging microscope (FLIM) characterization. For example, the effective area of the mesa with 80 µm is affected by 23% while the entire area of the mesa with 10 µm is almost all affected. This study provides guidance for the analysis and repair of sidewall defects to improve the quantum efficiency of micro-LEDs display at low current density.
ABSTRACT
Mineral dust can accelerate secondary aerosol formation under humid conditions. However, it is unclear whether it can promote secondary aerosol formation under dry conditions. To investigate this issue, two years of comprehensive observations was conducted at a semi-arid site, near the dust source regions. Three types of episodes were selected: dust, anthropogenic-dominated, and mixed (mixed with dust and anthropogenic aerosols). Compared to anthropogenic-dominated episodes under humid conditions, rapid nitrate formation was still observed in mixed episodes under dry conditions, suggesting that active metallic oxides in dust, such as titanium dioxide, could promote photochemical reactions of nitrogen dioxide. The detailed evolutionary processes are further illustrated by a typical dust-to-mixed episode. After the arrival of the dust, titanium sharply increased ten-fold and rapid nitrate formation was observed, together with a rapid increase in the two most important photochemical pollutants, ozone and peroxyacetyl nitrate. The increased secondary organic carbon further illustrated that the suspended dust particles accelerated the atmospheric oxidative capacity, thereby enhancing secondary aerosol formation and eventually leading to haze pollution. These results differ from those in humid regions and therefore expand the scientific understanding of the impact of dust aerosols on haze pollution under dry conditions.
Subject(s)
Air Pollutants , Dust , Aerosols/analysis , Air Pollutants/analysis , China , Dust/analysis , Environmental Monitoring/methods , Nitrates/analysis , Organic Chemicals , Particulate Matter/analysisABSTRACT
InGaN-based micro-LEDs can detect and emit optical signals simultaneously, owing to their overlapping emission and absorption spectra, enabling color detection. In this paper, we fabricated a green InGaN-based micro-LED array with integrated emission and detection functions. On the back side of the integrated device, when the 80 µm micro-LED emitted light, the 200 µm LED could receive reflected light to accomplish color detection. The spacing between the 80 µm and the 200 µm micro-LEDs was optimized to be 1 mm to reduce the effect of the direct light transmitted through the n-GaN layer without reflection. The integrated device shows good detection performance for different colors and skin colors, even in a dark environment. In addition, light can be emitted from the top side of the device. Utilization of light from both sides of the integrated device provides the possibility of its application in display, communication, and detection on the different sides.
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In this paper, we fabricated a 3×3 violet series-biased micro-LED array with high-output optical power and applied it in high-speed and long-distance visible light communication. By employing the orthogonal frequency division multiplexing modulation scheme, distance adaptive pre-equalization, and a bit-loading algorithm, record data rates of 10.23 Gbps, 10.10 Gbps, and 9.51 Gbps were achieved at 0.2 m, 1 m, and 10 m, respectively, below the forward error correction limit of 3.8×10-3. To the best of our knowledge, these are the highest data rates achieved by violet micro-LEDs in free space and the first communication demonstration beyond 9.5 Gbps at 10 m using micro-LEDs.
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Seasonal algal blooms produce a high risk for water supply safety. To explore the mechanism of seasonal algal blooms in northern eutrophic stratified reservoirs, the combination of taxonomic and functional classifications, local weighted regression (LOWESS), and Boundary line analysis (BLA) were employed to obtain the succession features and environmental thresholds of seasonal (e.g., spring and summer) algal blooms, based on the long-term and high-frequency monitoring from 2017 to 2020 in Lijiahe Reservoir. The results showed that:â the succession and response mechanisms of algal blooms were different in spring and summer. In detail, Chlorophyta, Bacillariophyta, and Dinoflagellates (e.g., low-temperature, small, high surface-to-volume genera) dominated in spring, whereas Chlorophyta, Bacillariophyta, and Cyanobacteria (e.g., high-temperature, large or colonial, low surface-to-volume genera) dominated in summer. The differences in physiological and morphological characteristics of algae were the internal cause triggering seasonal algal blooms. â¡ The main drivers of algal blooms were different in spring and summer. Spring blooms were controlled by water temperature (WT), mixing depth (i.e., Zmix), and light availability (i.e., Zeu/Zmix), whereas summer blooms were jointly influenced by WT, Zmix, Zeu/Zmix, and total phosphorus (TP). The differences in the changes of the major drivers were external causes triggering seasonal algal blooms. ⢠The water environment thresholds starting seasonal algal blooms were different in spring and summer. The thresholds of WT, Zmix, and Zeu/Zmix in spring were>9.4â, <10.9 m, and>0.24, respectively, whereas the thresholds of WT, Zmix, Zeu/Zmix, and TP in summer were>16.0â, <11.6 m, >0.16, and>0.011 mg·L-1, respectively. Based on the research on the mechanism of seasonal algal blooms and related thresholds, this work will provide a reference for the control of subsequent algal blooms.
Subject(s)
Eutrophication , Fresh Water , Seasons , Temperature , Sunlight , Phosphorus/analysis , China , Fresh Water/chemistry , Environmental MonitoringABSTRACT
The regeneration of alveolar bone is still clinical challenge, particularly accompanied with diabetes, causing metabolic disorder with a protracted low-grade inflammatory phenotype. As a result, the anticipated loading of biomaterials is highly suspicious in spontaneous modulation of cells function, which is mostly disturbed by constant inflammation. In this study, we developed glucose and hydrogen peroxide dual-responsive borosilicate glass (BSG) scaffolds loaded with epigallocatechin gallate (EGCG) to synergistically modulate the abnormal inflammation of diabetic alveolar bone defects. It was found that the release of EGCG by BSG could directly regulate the shift of macrophages from M1 to the M2 phenotype by promoting autophagy and lessening the inhibition of autophagic flux. Moreover, EGCG can also indirectly regulate the polarization phenotype of macrophages by reducing the activation of NF-κb in stem cells and restoring its immunoregulatory capacity. Therefore, the addition of EGCG to BSG scaffold in diabetes allows for a more striking modulation of the macrophage phenotype in a timely manner. The altered macrophage phenotype reduces local inflammation and thus increases the ability to repair diabetic alveolar bone, showing promise for the treatment of alveolar defect in diabetic patients.
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Activation of coagulation cascades, especially FX and prothrombin, prevents blood loss and reduces mortality from hemorrhagic shock. Inorganic salts are efficient but cannot stop bleeding completely in hemorrhagic events, and rebleeding carries a significant mortality risk. The coagulation mechanism of biominerals has been oversimplified in the past two decades, limiting the creation of novel hemostats. Herein, at the interface, the affinity of proteins, the protease activity, fibrinolysis, hydration shell, and dynamic microenvironment are monitored at the protein level. Proteomic analysis reveals that fibrinogen and antithrombin III's affinity for kaolin's interface causes a weak thrombus and rebleeding during hemostasis. Inspiringly, amorphous bioactive glass (BG) with a transient-dynamic ion microenvironment breaches the hydration layer barrier and selectively and slightly captures procoagulant components of kiniogen-1, plasma kallikrein, FXII, and FXI proteins on its interface, concurrently generating a continuous biocatalytic interface to rapidly activate both intrinsic and extrinsic coagulation pathways. Thus, prothrombin complexes are successfully hydrolyzed to thrombin without platelet membrane involvement, speeding production of high-strength clots. This study investigates how the interface of inorganic salts assists in coagulation cascades from a more comprehensive micro-perspective that may help elucidate the clinical application issues of kaolin-gauze and pave the way to new materials for managing hemorrhage.
Subject(s)
Prothrombin , Thrombosis , Humans , Kaolin , Proteomics , Salts , Blood Coagulation , HemorrhageABSTRACT
CsPbBr3 perovskite quantum dots (PQDs) as promising color conversion materials have been widely used in display and visible light communication (VLC), but most CsPbBr3 PQDs for VLC are randomly selected without optimization. Thereby the exploration of fundamental experimental parameters of QDs is essential to better employ their performance advantages. Herein, we investigated the concentration and solvent effects on photoluminescence (PL) properties and communication performance of CsPbBr3 PQDs. The PL, time-resolved PL characterization and communication measurements of CsPbBr3 PQDs all exhibit concentration dependence, suggesting that there exists an optimum concentration to take advantages of performance merits. CsPbBr3 PQDs with a concentration of 0.5 mg/ml show the shortest carrier lifetime and achieve the highest -3 dB bandwidth (168.03 MHz) as well as the highest data rate (660 Mbps) comparing to other concentrations. And in terms of the optimal concentration, we further explored the approach to improve the communication performance, investigating the effect of polarity solvent on the communication performance of CsPbBr3 PQDs. Original 0.5 mg/ml CsPbBr3 PQDs (1 ml) with 55 µL ethanol added in obtain a higher -3 dB bandwidth of 363.68 MHz improved by â¼116.4% and a record data rate of 1.25 Gbps improved by â¼89.4% but weaker PL emission due to energy transfer. The energy transfer assisted improvement may open up a promising avenue to improve the communication performance of QDs, but more feasible energy transfer path needs to be explored to ensure the stability of QDs.
ABSTRACT
The current understanding regarding the potential influence of aerosol chemistry on the optical properties does not satisfy accurate evaluation of aerosol radiative effects and precise determination of aerosol sources. We conducted a comprehensive study of the potential influence of aerosol chemistry on the optical properties in a semi-arid region based on various observations. Organic matter was the main contributor to the scattering coefficients followed by secondary inorganic aerosols in all seasons. We further related aerosol absorption to elemental carbon, organic matter, and mineral dust. Results showed that organic matter and mineral dust contributed to >40% of the aerosol absorption in the ultraviolet wavelengths. Therefore, it is necessary to consider the absorption of organic matter and mineral dust in addition to that of elemental carbon. We further investigated the potential influence of chemical composition, especially of organic matter and mineral dust on the optical parameters. Mineral dust contributed to higher absorption efficiency and lower scattering efficiency in winter. The absorption Ångström exponent (AAE) was mostly sensitive to organic matter and mineral dust in winter and spring, respectively; it was relatively high (i.e., 1.68) in winter and moderate (i.e., 1.42) in spring. Unlike in the other seasons, mineral dust contributed to higher mass absorption efficiency in winter. This work reveals the complexity of the relationship between aerosol chemistry and optical properties, and especially the influence of organic matter and mineral dust on aerosol absorption. The results are highly important regarding both regional air pollution and climate.
Subject(s)
Air Pollutants , Air Pollutants/analysis , Environmental Monitoring , Aerosols/analysis , Dust/analysis , Seasons , Carbon , Particulate Matter/analysisABSTRACT
In this work, we demonstrated a convenient and reliable method to realize the vertical stack integration of the blue and yellow InGaN micro-LED arrays. The standard white and color-tunable micro-light sources can be achieved by adjusting the current densities injection of the micro-LEDs. The spectra cover violet, standard white, cyan, etc., showing an excellent color-tunable property. And the mixed standard white light can be separated into red-green-blue three primary colors through the color filters to realize full-color micro-LED display with a color gamut of 75% NTSC. Besides, the communication capability of the integrated micro-LED arrays as visible light communication (VLC) transmitters is demonstrated with a maximum total data rate of 2.35 Gbps in the wavelength division multiplexing (WDM) experimental set-up using orthogonal frequency division multiplexing modulation. In addition, a data rate of 250 Mbps is also realized with the standard white light using on-off keying (OOK) modulation. This integrated device shows great potential in full-color micro-LED display, color-tunable micro-light sources, and high-speed WDM VLC multifunctional applications.