1.
Bioorg Med Chem Lett
; 16(9): 2525-7, 2006 May 01.
Article
in English
| MEDLINE
| ID: mdl-16464581
ABSTRACT
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.
Subject(s)
Adenosine A3 Receptor Agonists , Adenosine/chemical synthesis , Adenosine/pharmacology , Adenosine/analogs & derivatives , Humans , Molecular Conformation , Solubility , Stereoisomerism , Structure-Activity Relationship , Water/chemistry
2.
J Med Chem
; 46(3): 353-5, 2003 Jan 30.
Article
in English
| MEDLINE
| ID: mdl-12540233
ABSTRACT
Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.