Perception of unfamiliar caregivers during sickness - Using the new Caregiver Perception Task (CgPT) during experimental endotoxemia.

Social withdrawal is a well-established part of sickness behavior, but in some contexts sick animals might gain from keeping close instead of keeping away. For instance, sick individuals are more willing to be near known individuals who can provide care and safety (close others) compared to when healthy. Yet, interactions with some strangers might also be beneficial (i.e., healthcare professionals), but it is not known how sickness interplay with social behavior towards such individuals. Here, we assessed if sickness affects perception of caregivers, and developed a new task, the Caregiver Perception Task (CgPT). Twenty-six participants performed the CgPT, once after an injection of lipopolysaccharide (LPS, 0.8 ng/kg body weight, n = 24), and once after an injection of saline (n = 25), one hour and forty-five minutes post-injection. During the task, participants watched short video clips of three types of caregivers: a healthcare professional taking care of a sick individual, a healthcare professional not taking care of a sick individual, and a non-healthcare professional taking care of their sick adult child or partner. After each video clip, the likability, trustworthiness, professionalism, and willingness to interact with and receive care from the caregiver were rated on visual analogue scales. Results showed that participants injected with saline rated healthcare professionals who did not take care of a sick individual less positively on all aspects compared to healthcare professionals who took care of a sick individual. Moreover, compared to saline, LPS increased the participants' willingness to receive care from healthcare professionals and non-healthcare professionals providing care, but not from healthcare professionals not providing care. Thus, our results indicate that sick individuals may approach unknown individuals with potential to provide care and support.

The walking sick: Perception of experimental sickness from biological motion.

Identification of sick conspecifics allows for avoidance of infectious threats, and is therefore an important behavioral defense against diseases. Here, we investigated if humans can identify sick individuals solely from biological motion and posture (using point-light displays). Additionally, we sought to determine which movements and sickness parameters would predict such detection. We collected video clips and derived point-light displays (one stride presented in a loop) of sick walkers (injected with lipopolysaccharide at 2.0 ng/kg body weight) and the same walkers when healthy (injected with saline). We then presented these displays to two groups, one group classified each walker as sick or healthy (study 1, n = 106), and the other group scored the walkers' health on a visual analogue scale (study 2, n = 106). The raters were able to identify sick individuals above chance, and rated sick walkers as having worse health, both from observing video clips and point-light displays. Furthermore, both sickness detection and worse apparent health were predicted by inflammation-induced increase in rigidity and slower walking, but not other cues. Altogether, these findings indicate that biological motion can serve as a sickness cue, possibly allowing humans to identify sick conspecifics from a distance, and thereby allowing for disease avoidance.

A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss.

BACKGROUND: Sudden smell loss is a specific early symptom of COVID-19, which, prior to the emergence of Omicron, had estimated prevalence of ~40% to 75%. Chemosensory impairments affect physical and mental health, and dietary behavior. Thus, it is critical to understand the rate and time course of smell recovery. The aim of this cohort study was to characterize smell function and recovery up to 11 months post COVID-19 infection. METHODS: This longitudinal survey of individuals suffering COVID-19-related smell loss assessed disease symptoms and gustatory and olfactory function. Participants (n=12,313) who completed an initial survey (S1) about respiratory symptoms, chemosensory function and COVID-19 diagnosis between April and September 2020, were invited to complete a follow-up survey (S2). Between September 2020 and February 2021, 27.5% participants responded (n=3,386), with 1,468 being diagnosed with COVID-19 and suffering co-occurring smell and taste loss at the beginning of their illness. RESULTS: At follow-up (median time since COVID-19 onset ~200 days), ~60% of women and ~48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered. Prevalence of parosmia and phantosmia was ~10% of participants in S1 and increased substantially in S2: ~47% for parosmia and ~25% for phantosmia. Persistent smell impairment was associated with more symptoms overall, suggesting it may be a key marker of long-COVID illness. The ability to smell during COVID-19 was rated slightly lower by those who did not eventually recover their pre-illness ability to smell at S2. CONCLUSIONS: While smell ability improves for many individuals who lost it during acute COVID-19, the prevalence of parosmia and phantosmia increases substantially over time. Olfactory dysfunction is associated with broader persistent symptoms of COVID-19, and may last for many months following acute COVID-19. Taste loss in the absence of smell loss is rare. Persistent qualitative smell symptoms are emerging as common long-term sequelae; more research into treatment options is strongly warranted given that even conservative estimates suggest millions of individuals may experience parosmia following COVID-19. Healthcare providers worldwide need to be prepared to treat post COVID-19 secondary effects on physical and mental health.

Case report of a combined oncocytoma and type 1 papillary renal cell carcinoma: a rare entity.

An extremely rare renal hybrid tumor composed of papillary renal cell carcinoma (PRCC) and renal oncocytoma (RO) within the same tumor is described. Only eight previous cases are documented in the literature.A 44-year-old man showed a 3.5 cm renal mass composed by areas with tubulo-papillary structures made up with small cells with scanty cytoplasm adjacent to polygonal cells forming solid sheet and tubules with abundant eosinophilic cytoplasm and uniform, round central nuclei without mitoses. Complete immunohistochemical panel suggested a diagnosis of type 1 PRCC combined with RO. Contrary to previous cases of hybrid renal tumors reported in the literature, no pseudocapsule divided the two histotypes of tumors. Our patient is the youngest among the previous reports being 44.Collision tumours have previously been described, although mixed renal tumours composed of oncocytoma and PRCC is extremely rare. There is no evidence to suggest a relationship between oncocytoma and papillary RCC since they originate from different cells and have different prognoses.Given the possibility of oncocytomas to harbour other tumours, we suggest careful examination of the samples to exclude the presence of an associated malignant neoplasm, which might have a significantly worse prognosis than oncocytoma. Differential diagnosis is needed, and immunohistochemical stains are of great help in distinguishing between the two histological components.

Systematic Review of fMRI Compatible Devices: Design and Testing Criteria.

Functional Magnetic Resonance Imaging (fMRI) is at present one of the most used methodologies for functional brain exploration, both in clinical and research settings. fMRI can noninvasively measure neural activity by using specific experimental paradigms. Often, these paradigms require the stimulation of the subject to perform sensorimotor tasks: in the past, the stimuli have been administered manually for investigating fundamental aspects of tactile perception and somatosensory processing. Nowadays, the use of mechatronic devices to stimulate the subject during fMRI studies is growing, also to assure reproducibility, control, and monitoring of task performances. For these reasons, researchers are interested in designing interfaces to be used inside the MRI environment during fMRI studies. For the design of every new device safety and compatibility constraints, imposed by the presence of high static magnetic field, switching magnetic gradients and radiofrequency electromagnetic pulses, must be satisfied. Moreover, it should be considered that functional imaging sequences are even more sensitive to perturbations of the magnetic field than MRI standard diagnostic sequences. Despite several existing devices for use in fMRI studies, an extensive review is still lacking. Our survey aims to introduce into the challenges imposed on the development of fMRI-compatible devices. The current state of the art of compatible devices in fMRI will be presented, pointing out the functionalities and peculiarities of various kinds of device. A particular emphasis will be placed on the tests for the evaluation of fMRI compatibility. This review will be useful both for designers of devices to be used in fMRI studies and for neuroscientists that are having to design fMRI experimental paradigm, and therefore require an overview of existing instruments, but also a knowledge of the benefits and criticism arising from their use.

Assortative mating based on cooperativeness and generosity.

Cooperative behaviour and generosity towards nonkin represent costly and risky behaviour that could be used as a signal of mate quality. Therefore, cooperative traits could serve as criteria in mate choice, leading to assortative mating for those traits. There is evidence of similarity in couples for altruistic traits. However, the literature is based on self-reports and does not provide conclusive proof of either a convergence across time or mating preferences. Here, we report a field experiment, conducted in rural villages in Senegal, showing that husbands and wives are similar with respect to their contributions to a public good and their charity donations. Further analyses suggest that this similarity is due to initial assortment rather than convergence of phenotypes.

Daily-life monitoring of stroke survivors motor performance: the INTERACTION sensing system.

The objective of the INTERACTION Eu project is to develop and validate an unobtrusive and modular system for monitoring daily life activities, physical interactions with the environment and for training upper and lower extremity motor function in stroke subjects. This paper describes the development and preliminary testing of the project sensing platform made of sensing shirt, trousers, gloves and shoes. Modular prototypes were designed and built considering the minimal set of inertial, force and textile sensors that may enable an efficient monitoring of stroke patients. The single sensing elements are described and the results of their preliminary lab-level testing are reported.

SoC CMOS UWB Pulse Radar Sensor for Contactless Respiratory Rate Monitoring.

An ultra wideband (UWB) system-on-chip radar sensor for respiratory rate monitoring has been realized in 90 nm CMOS technology and characterized experimentally. The radar testchip has been applied to the contactless detection of the respiration activity of adult and baby. The field operational tests demonstrate that the UWB radar sensor detects the respiratory rate of person under test (adult and baby) associated with sub-centimeter chest movements, allowing the continuous-time non-invasive monitoring of hospital patients and other people at risk of obstructive apneas such as babies in cot beds, or other respiratory diseases.

Wearable monitoring of lumbar spine curvature by inertial and e-textile sensory fusion.

This paper describes the design, the development and the preliminary testing of a wearable system able perform a real time estimation of the local curvature and the length of the spine lumbar arch. The system integrate and fuse information gathered from textile based piezoresistive sensor arrays and tri-axial accelerometers. E-textile strain sensing garments suffer from non-linearities, hysteresis and long transient, while accelerometers, used as inclinometers, present biased values and are affected by the system acceleration due to subject movements. In this work, focused on the wearability and comfort of the user, we propose a fusion of the information deriving from the two class of sensors to reduce their intrinsic errors affecting measurements. Comparative evaluation of system performances with stereophotogrammetric techniques shows a 2% error in lumbar arch length reconstruction.

Heart rate and accelerometer data fusion for activity assessment of rescuers during emergency interventions.

The current state of the art in wearable electronics is the integration of very small devices into textile fabrics, the so-called ¿smart garment.¿ The ProeTEX project is one of many initiatives dedicated to the development of smart garments specifically designed for people who risk their lives in the line of duty such as fire fighters and Civil Protection rescuers. These garments have integrated multipurpose sensors that monitor their activities while in action. To this aim, we have developed an algorithm that combines both features extracted from the signal of a triaxial accelerometer and one ECG lead. Microprocessors integrated in the garments detect the signal magnitude area of inertial acceleration, step frequency, trunk inclination, heart rate (HR), and HR trend in real time. Given these inputs, a classifier assigns these signals to nine classes differentiating between certain physical activities (walking, running, moving on site), intensities (intense, mild, or at rest) and postures (lying down, standing up). Specific classes will be identified as dangerous to the rescuer during operation, such as, ¿subject motionless lying down¿ or ¿subject resting with abnormal HR.¿ Laboratory tests were carried out on seven healthy adult subjects with the collection of over 4.5 h of data. The results were very positive, achieving an overall classification accuracy of 88.8%.

Extranodal Rosai-Dorfman disease of bone and nose: a case report and review of literature.

Rosai-Dorfman disease (RDD) is a rare benign condition of unknown origin, which was first described in 1969. By histopathology, the disease is composed of sinusoidal lymph node hyperplasia and abundant histiocytes with haemophagocytosis, particularly lymphocytes. It commonly affects lymph nodes, and rarely has an exclusively extra-nodal clinical presentation. Among the so-called "extranodal" sites, the head and neck region, and in particular the nose and paranasal sinuses, are frequently affected. RDD shows a highly variable clinical course that can be partly modified by medical therapy. We present of a case of extra-nodal RDD, with nasal and osseous involvement, which has been followed-up for 19 years. We also discuss its presentation, the most relevant radiographic findings, treatment options and histological findings.

Wearable system-on-a-chip UWB radar for contact-less cardiopulmonary monitoring: present status.

The present status of the project aimed at the realization of an innovative wearable system-on-chip UWB radar for the cardiopulmonary monitoring is presented. The overall system consists of a wearable wireless interface including a fully integrated UWB radar for the detection of the heart beat and breath rates, and a IEEE 802.15.4 ZigBee low-power radio interface. The principle of operation of the UWB radar for the monitoring of the heart wall is summarized. With respect to the prior art, this paper reports the results of the experimental characterization of the intra-body channel loss, which has been carried out successfully in order to validate the theoretical model employed for the radar system analysis. Moreover, the main building blocks of the radar have been manufactured in 90 nm CMOS technology by ST-Microelectronics and the relevant performance are resulted in excellent agreement with those expected by post-layout simulations.

Wearable microwave radiometers for remote fire detection: System-on-Chip (SoC) design and proof of the concept.

The paper reports the present status of the project aimed at the realization of a wearable low-cost low-power System-on-Chip (SoC) 13-GHz passive microwave radiometer in CMOS 90 nm technology. This sensor has been thought to be inserted into the firemen jacket in order to help them in the detection of a hidden fire behind a door or a wall, especially where the IR technology fail. With respect of the prior art, the SoC is further developed and a proof of the concept is provided by means of a discrete-component prototype.

Wearable system-on-a-chip radiometer for remote temperature sensing and its application to the safeguard of emergency operators.

The remote sensing and the detection of events that may represent a danger for human beings have become more and more important thanks to the latest advances of the technology. A microwave radiometer is a sensor capable to detect a fire or an abnormal increase of the internal temperature of the human body (hyperthermia), or an onset of a cancer, or even meteorological phenomena (forest fires, pollution release, ice formation on road pavement). In this paper, the overview of a wearable low-cost low-power system-on-a-chip (SoaC) 13 GHz passive microwave radiometer in CMOS 90 nm technology is presented. In particular, we focused on its application to the fire detection for civil safeguard. In detail, this sensor has been thought to be inserted into the fireman jacket in order to help the fireman in the detection of a hidden fire behind a door or a wall. The simulation results obtained by Ptolemy system simulation have confirmed the feasibility of such a SoaC microwave radiometer in a low-cost standard silicon technology for temperature remote sensing and, in particular, for its application to the safeguard of emergency operators.

Value of image fusion in the staging of prostatic carcinoma.

PURPOSE: We assessed the value of image fusion in the staging of prostatic cancer in a series of 32 patients who underwent preoperative evaluation with transrectal colour-Doppler ultrasonography (TRUS) and magnetic resonance imaging (MRI). MATERIALS AND METHODS: Colour-Doppler TRUS exams were performed using a 7.5-MHz biplanar probe. MRI exams were done with a scanner operating at 1.5 Tesla (T) using an endorectal coil. All patients underwent radical prostatectomy within 2 weeks from the imaging assessment. Whole-mount sections were prepared from the surgical specimens and were subsequently digitised by using a high-resolution scanner. The Digital Imaging and Communications in Medicine (DICOM) TRUS and MR images as well as the digitised pathological images were transferred to a graphic workstation to perform image fusion. RESULTS: Image fusion was technically possible in 25/32 cases in which axial TRUS images were available. The following fusion images were obtained: TRUS + pathological sections; MRI + pathological sections; TRUS + MRI + pathological sections. The final pathological staging concerning the T status was: four pT2b, fourteen pT2c, three pT3a and four pT3b. The three types of image fusion led to the following results: TRUS + pathological sections, correct staging in 20/25 cases (accuracy 80%); MRI + pathological sections, correct staging in 22/25 cases (accuracy 88%); TRUS + MRI + pathological sections, correct staging in 23/25 cases (accuracy 92%). CONCLUSIONS: Our study suggests that by using image fusion between colour-Doppler TRUS and endorectal MRI, it is possible to improve the accuracy of pathological staging in patients who are candidates for radical prostatectomy.

Artificial kinesthetic systems for telerehabilitation.

Artificial sensory motor systems are now under development in a truly wearable form using an innovative technology based on electroactive polymers. The integration of electroactive polymeric materials into wearable garments endorses them with strain sensing and mechanical actuation properties. The methodology underlying the design of haptic garments has necessarily to rely on knowledge of biological perceptual and motor processes which is, however, scattered and fragmented. Notwithstanding, the combined use of new polymeric electroactive materials in the form of fibers and fabrics with emerging concepts of biomimetic nature in sensor data analysis, pseudomuscular actuator control and biomechanical design may not only provide new avenues toward the realization of truly wearable kinesthetic and haptic interfaces, but also clues and instruments to better comprehend human manipulative and gestual functions. In this talk the conception, early stage implementation and preliminary testing of a fabric-based wearable interface endowed with spatially redundant strain sensing and distributed actuation are illustrated with reference to a wearable upper limb artificial kinesthesia system, intended to be used in telerehabilitation of post stroke patient.

Strain sensing fabric for hand posture and gesture monitoring.

Monitoring body kinematics and analyzing posture and gesture is an area of major importance in bioengineering and several other connected disciplines such as rehabilitation, sport medicine and ergonomics. Recent developments of new smart materials consent the realization of a new generation of garments with distributed sensors. What we present here is a sensing glove able to detect the posture and movements of the hand.

Rare case of inflammatory fibrous polyp of the esophagus.

Esophageal inflammatory fibrous polyps are extremely rare benign neoplasms. The manuscript illustrates a case of a man complaining of pyrosis and gastroesophageal reflux symptoms. Diagnostic work-up showed an expansive lesion of the distal esophagus simulating malignancy but with negative, repeated, multiple biopsies. The considerable size of the lesion, and the suspicion of a malignant tumor because of the presence of ulceration, indicated esophagectomy with extensive lymphadenectomy and intrathoracic esophagogastroplasty. The diagnosis of inflammatory polyp of the esophagus was achieved postoperatively. The Discussion deals with a review of the literature and considers the performed operation a good choice considering the hypothesis of a malign neoplastic evolution of this lesion.

Churg-Strauss syndrome: clinical and serological features of 19 patients from a single Italian centre.

OBJECTIVE: Churg-Strauss syndrome is a rare multisystem vasculitis of unknown aetiology. Due to the rarity of the disease, few single-centre case series have been described. The aim of this study was to evaluate a small series from a single Italian centre in order to describe the clinical features of the disease, the treatment and long-term follow-up. METHODS: Nineteen Churg-Strauss syndrome patients were selected from the medical records of all vasculitis patients attending the Immunology Unit at the Department of Internal Medicine of the University of Pisa in the decade between 1989 and 2000. Data were obtained retrospectively. RESULTS: All the patients had asthma and hypereosinophilia. As in other case series, the lungs, skin and peripheral nervous system were the most commonly involved organs. The majority of our patient received i.v. pulses of methylprednisolone followed by i.v. pulses of cyclophosphamide. The outcome and long-term follow-up were good. There were no fatalities observed in this series during the follow-up period. CONCLUSIONS: Churg-Strauss syndrome is a systemic vasculitis occurring in patients with a history of asthma and allergic rhinitis. The positive results of the treatment protocol used in this preliminary study deserve to be tested in controlled multicentre studies.