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2.
Cureus ; 14(3): e23322, 2022 Mar.
Article in English | MEDLINE | ID: mdl-35464596

ABSTRACT

Purpose This retrospective study aims to analyze the clinical and functional results obtained over a seven-year period of performing reverse total shoulder arthroplasty (RTSA) and the subsequent postoperative rehabilitation protocol. Methods We analyzed data from 80 patients who were evaluated at a preoperative, as well as monthly postoperative outpatient consultation, until the discharge from the rehabilitation program, using Constant Score (CS). Results A comparison of preoperative and postoperative (after rehabilitation protocol) results revealed an improved functional score of absolute CS (20.8 increase), normal relative CS (29.1 increase), and individual relative CS (31.7 increase) with statistical significance (p<0.05). From the analysis of CS subscores, there was a positive evolution of the pain subscore, as well as flexion, abduction, and external rotation combined with abduction range of motion (ROM). Contrarily, there was a negative evolution of the combined internal rotation, extension, and adduction ROM, as well as deltoid muscle strength. No statistically significant correlations were found between age and postoperative CS, as well as between the time interval from surgery to the beginning of outpatient rehabilitation and CS evolution. Conclusion Our study demonstrates that RTSA is an effective therapeutic option that, if combined with a well-structured rehabilitation program, can improve pain, mobility, and upper limb functionality.

3.
Am J Phys Med Rehabil ; 101(5): e76-e79, 2022 05 01.
Article in English | MEDLINE | ID: mdl-35067557

ABSTRACT

ABSTRACT: Congenital facial palsy is a rare condition, usually related to a traumatic event during birth or as a feature of a syndrome. In this report, two cases of infants with peripheral facial palsy since birth are described, in which magnetic resonance imaging demonstrated unilateral aplasia of the facial nerve. There are only a few cases with similar findings described in the literature. A multidisciplinary approach is recommended to provide the best care. Although no reinnervation of the facial muscles is likely to occur, rehabilitative therapies may be valuable as complementary treatments.


Subject(s)
Facial Paralysis , Facial Nerve , Facial Paralysis/etiology , Humans , Infant , Magnetic Resonance Imaging , Syndrome
4.
J Chem Ecol ; 46(9): 871-880, 2020 Sep.
Article in English | MEDLINE | ID: mdl-32691372

ABSTRACT

Weeds have been a major threat in agriculture for several generations as they lead to decreases in productivity and cause significant economic losses. Parasitic plants are a specific type of weed causing losses in crops of great relevance. A new strategy has emerged in the fight against parasitic plants, which is called 'suicidal germination' or the 'honey-pot strategy'. Regarding the problem of weed control from an ecological point of view, it is interesting to investigate new natural compounds with allelopathic activity with the aim of developing new natural herbicides that can inhibit the growth of weeds without damaging the environment. Safflower crops have been affected by parasitic plants and weeds and, as a consequence, the secondary metabolites exuded by safflower roots have been studied. The sesquiterpene lactone dehydrocostuslactone was isolated and characterised, and the structurally related costunolide was identified by UHPLC-MS/MS in safflower root exudates. These sesquiterpene lactones have been shown to stimulate germination of Phelipanche ramosa and Orobanche cumana seeds. In addition, these compounds were phytotoxic on three important weeds in agriculture, namely Lolium perenne, Lolium rigidum and Echinochloa crus-galli. The exudation of the strigolactones solanacol and fabacyl acetate have also been confirmed by UHPLC-MS/MS. The study reported here contributes to our knowledge of the ecological role played by some secondary metabolites. Moreover, this knowledge could help identify new models for the development of future agrochemicals based on natural products.


Subject(s)
Carthamus tinctorius/parasitology , Germination/drug effects , Plant Roots/parasitology , Plant Weeds/drug effects , Weed Control/methods , Allelopathy , Chromatography, Liquid , Lactones/isolation & purification , Lactones/pharmacology , Lolium/drug effects , Lolium/growth & development , Orobanche/drug effects , Orobanche/growth & development , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Plant Exudates/isolation & purification , Plant Exudates/pharmacology , Plant Roots/chemistry , Seeds/drug effects , Sesquiterpenes/isolation & purification , Sesquiterpenes/pharmacology , Tandem Mass Spectrometry
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