ABSTRACT
AIM: To determine the role of histological diagnosis of lymphadenopathy (LAP) associated with clinico-laboratory picture in patients with HIV infection/AIDS. MATERIAL AND METHODS: Target biopsy of the peripheral lymph node was made in 80 HIV-infected patients from 2002 to 2005. Histological diagnosis was made in all the patients with light microscopy, in some patients at immunohistological examination. RESULTS: Most of the patients had peripheral blood CD4 lymphocytes under 200 cell/mcl. Viral load was hundred thousands copies in mcl. Tuberculosis was diagnosed in 33 (41%) patients, lymphomas--in 23(29%), lymphogranulomatosis--in 5 (6%), reactive lymphadenopathy--in 15 (19%), germinogenic tumors--in 3 (4%), sarcoidosis--in 1 (1%). Histologically, LAP was represented by follicular hyperplasia (n = 9), involution (n = 2), bacterial lymphadenitis with necrosis (n = 4). CONCLUSION: Biopsy of peripheral lymph nodes is an early, safe, reliable and cost-effective method of LAP diagnosis in patients with AIDS.
Subject(s)
Lymph Nodes/pathology , Lymphoma, AIDS-Related/diagnosis , Adolescent , Adult , Biopsy , CD4 Lymphocyte Count , DNA, Viral/analysis , Diagnosis, Differential , HIV/genetics , HIV/immunology , HIV Antibodies/analysis , Humans , Middle Aged , Polymerase Chain Reaction , Retrospective Studies , Viral LoadABSTRACT
The authors present their own observation of a patient suffering from drug-induced agranulocytosis, cured with filgastrim-neupogen, a recombinant colony-stimulating human granulocyte factor.