ABSTRACT
The outcomes of patients with acute lymphoblastic leukaemia (ALL) presenting relapse after allogeneic stem cell transplant (allo-SCT) are poor, with few data available in this setting. OBJECTIVE AND METHODS: To evaluate the outcomes of patients with ALL presenting relapsed after allo-SCT, we performed a retrospective study including 132 from 11 centres in Spain. RESULTS: Therapeutic strategies consisted of palliative treatment (n = 22), chemotherapy (n = 82), tyrosine kinase inhibitors (n = 26), immunotherapy with inotuzumab and/or blinatumumab (n = 19), donor lymphocyte infusions (n = 29 pts), second allo-SCT (n = 37) and CAR T therapy (n = 14). The probability of overall survival (OS) at 1 and 5 years after relapse was 44% (95% confidence interval [CI]: 36%; 52%) and 19% (95% CI: 11%; 27%). In the 37 patients undergoing a second allo-SCT, the 5-year estimated OS probability was 40% [22%; 58%]. Younger age, recent allo-SCT, late relapse, 1st complete remission at 1st allo-SCT and chronic graft-versus-host disease confirmed their positive impact on survival in the multivariable analysis. CONCLUSION: Despite the poor prognosis of patients with ALL presenting relapse after a first allo-SCT, some can be satisfactorily rescued and a second allo-SCT still remains a valid option for selected patients. Moreover, emerging therapies really might improve ALL patients outcome when relapsing after an allo-SCT.
Subject(s)
Hematopoietic Stem Cell Transplantation , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Humans , Retrospective Studies , Transplantation, Homologous , Neoplasm Recurrence, Local , Hematopoietic Stem Cell Transplantation/adverse effects , Stem Cell Transplantation , Prognosis , Acute Disease , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology , RecurrenceABSTRACT
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Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Hematologic Diseases/diagnosis , Coronavirus Infections/epidemiology , Pneumonia, Viral/epidemiology , Pandemics , Hematologic Diseases/complications , Prognosis , Lymphoma/therapy , Spain/epidemiology , BetacoronavirusSubject(s)
Betacoronavirus , Coronavirus Infections/prevention & control , Delayed Diagnosis , Health Care Rationing , Health Services Accessibility , Hematologic Neoplasms/diagnosis , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Severity of Illness Index , Acute Disease , Adult , Aged , COVID-19 , Female , Hematologic Neoplasms/epidemiology , Humans , Male , Middle Aged , Prognosis , SARS-CoV-2 , SpainABSTRACT
No disponible
