Almagate interference in breath test results for the diagnosis of Helicobacter pylori infection.

BACKGROUND: Infection by Helicobacter pylori is common and affects both genders at any age. The 13C-urea breath test is a widely used test for the diagnosis of this infection. However, multiple drugs used for the treatment of Helicobacter pylori infection symptoms have interactions with this breath test that generate false negative results. This observational study was to assess the potential interaction between almagate and the breath test. METHODS: Thirty subjects on almagate therapy who underwent a breath test were included. If the result was negative, almagate was withdrawn for a month and the breath test was then repeated. RESULTS: In general, 51.9 % of assessed subjects had a negative result after the first test, and 100 % of these also had a negative result after the second test. CONCLUSIONS: It was concluded that the use of almagate does not interfere in breath test results. These results provide a drug therapy option for the treatment of symptoms associated with Helicobacter pylori infection during the diagnostic process.

Interferencia del almagato con el resultado del test del aliento para el diagnóstico de la infección por Helicobacter pylori / Almagate interference in breath test results for the diagnosis of Helicobacter pylori infection

Introducción: la infección por Helicobacter pylori es muy frecuente y afecta a cualquier edad y sexo. El test del aliento con urea 13C es una prueba ampliamente utilizada para el diagnóstico de esta infección. Sin embargo, múltiples fármacos utilizados para tratar los síntomas de la infección por Helicobacter pylori presentan interacciones con la realización del test del aliento dando como resultado falsos negativos. Este estudio observacional tiene como objetivo evaluar la posible interacción entre el uso de almagato y el test del aliento. Métodos: se incluyeron 30 participantes en tratamiento con almagato y se les realizó el test del aliento. En caso de resultado negativo, se les retiró la administración de almagato durante un mes y se les repitió el test del aliento. Resultados: el 51,9 % de los participantes analizados presentaron un resultado negativo en el primer test y el 100 % de estos se les confirmó el resultado negativo en el segundo test. Conclusiones: se concluyó que el uso de almagato no interfiere con el resultado del test del aliento. Estos resultados aportan una alternativa farmacológica para tratar la sintomatología de la infección por Helicobacter pylori durante el periodo de su diagnóstico (AU)

Background: Infection by Helicobacter pylori is common and affects both genders at any age. The 13C-urea breath test is a widely used test for the diagnosis of this infection. However, multiple drugs used for the treatment of Helicobacter pylori infection symptoms have interactions with this breath test that generate false negative results. This observational study was to assess the potential interaction between almagate and the breath test. Methods: Thirty subjects on almagate therapy who underwent a breath test were included. If the result was negative, almagate was withdrawn for a month and the breath test was then repeated. Results: In general, 51.9 % of assessed subjects had a negative result after the first test, and 100 % of these also had a negative result after the second test. Conclusions: It was concluded that the use of almagate does not interfere in breath test results. These results provide a drug therapy option for the treatment of symptoms associated with Helicobacter pylori infection during the diagnostic process (AU)