Scale-free correlations in the dynamics of a small (N∼10000) cortical network.

The advent of novel optogenetics technology allows the recording of brain activity with a resolution never seen before. The characterization of these very large data sets offers new challenges as well as unique theory-testing opportunities. Here we discuss whether the spatial and temporal correlations of the collective activity of thousands of neurons are tangled as predicted by the theory of critical phenomena. The analysis shows that both the correlation length ξ and the correlation time τ scale as predicted as a function of the system size. With some peculiarities that we discuss, the analysis uncovers evidence consistent with the view that the large-scale brain cortical dynamics corresponds to critical phenomena.

Self-tuned criticality: Controlling a neuron near its bifurcation point via temporal correlations.

Previous work showed that the collective activity of large neuronal networks can be tamed to remain near its critical point by a feedback control that maximizes the temporal correlations of the mean-field fluctuations. Since such correlations behave similarly near instabilities across nonlinear dynamical systems, it is expected that the principle should control also low-dimensional dynamical systems exhibiting continuous or discontinuous bifurcations from fixed points to limit cycles. Here we present numerical evidence that the dynamics of a single neuron can be controlled in the vicinity of its bifurcation point. The approach is tested in two models: a two-dimensional generic excitable map and the paradigmatic FitzHugh-Nagumo neuron model. The results show that in both cases, the system can be self-tuned to its bifurcation point by modifying the control parameter according to the first coefficient of the autocorrelation function.

Finite-size correlation behavior near a critical point: A simple metric for monitoring the state of a neural network.

In this article, a correlation metric κ_{c} is proposed for the inference of the dynamical state of neuronal networks. κ_{C} is computed from the scaling of the correlation length with the size of the observation region, which shows qualitatively different behavior near and away from the critical point of a continuous phase transition. The implementation is first studied on a neuronal network model, where the results of this new metric coincide with those obtained from neuronal avalanche analysis, thus well characterizing the critical state of the network. The approach is further tested with brain optogenetic recordings in behaving mice from a publicly available database. Potential applications and limitations for its use with currently available optical imaging techniques are discussed.

Similar local neuronal dynamics may lead to different collective behavior.

This report is concerned with the relevance of the microscopic rules that implement individual neuronal activation, in determining the collective dynamics, under variations of the network topology. To fix ideas we study the dynamics of two cellular automaton models, commonly used, rather in-distinctively, as the building blocks of large-scale neuronal networks. One model, due to Greenberg and Hastings (GH), can be described by evolution equations mimicking an integrate-and-fire process, while the other model, due to Kinouchi and Copelli (KC), represents an abstract branching process, where a single active neuron activates a given number of postsynaptic neurons according to a prescribed "activity" branching ratio. Despite the apparent similarity between the local neuronal dynamics of the two models, it is shown that they exhibit very different collective dynamics as a function of the network topology. The GH model shows qualitatively different dynamical regimes as the network topology is varied, including transients to a ground (inactive) state, continuous and discontinuous dynamical phase transitions. In contrast, the KC model only exhibits a continuous phase transition, independently of the network topology. These results highlight the importance of paying attention to the microscopic rules chosen to model the interneuronal interactions in large-scale numerical simulations, in particular when the network topology is far from a mean-field description. One such case is the extensive work being done in the context of the Human Connectome, where a wide variety of types of models are being used to understand the brain collective dynamics.