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Bioorg Med Chem Lett
; 13(11): 1891-5, 2003 Jun 02.
Article
in English
| MEDLINE
| ID: mdl-12749892
ABSTRACT
A series of isonicotinoyl-(L)-aminophenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. These compounds exhibit subnanomolar binding affinity to VLA-4 and significant off-rates. The interplay between off-rate, protein binding and pharmacokinetics is discussed.