ABSTRACT
In experiment there were studied changes of the tissue blood circulation and microcirculation during postischemic reperfusion of skeletal muscles with various density of capillaries. It was established that reactive hyperemia, caused mainly by enhancement of extracapillary tissue blood flow. While persistence of durable arterial hypertension the capillaries quantity and potential volume of microcirculatory bed are reducing, negatively influencing the blood circulation restoration process during postischemic reperfusion. In chronic ischemia the potential volume of microcirculation is increasing, securing complete restoration of blood circulation in postischemic reperfusion.
Subject(s)
Disease Models, Animal , Ischemia/surgery , Muscle, Skeletal/blood supply , Muscle, Skeletal/surgery , Reperfusion Injury/surgery , Animals , Microcirculation/physiology , Surgical Procedures, Operative , SwineABSTRACT
Postischemic changes of central and regional hemodynamic while various reperfusion regimens have been studied on animal experimental model. We had revealed that despite vasodilatation, peripheral vascular resistance in the postischemic extremity rises, as a result of reperfusion by the lowered perfusion volume. Such phenomenon has been named as "reperfusion-collapse". In spite of the microcirculation disorders progression there have been no significant rising of the peripheral vascular resistance as well as worsening of the regional hemodynamic indexes in the postischemic limb during reperfusion by either normal or increased perfusion volume.
Subject(s)
Reperfusion Injury/surgery , Acute Disease , Animals , Extremities/blood supply , Hemodynamics , Ischemia/complications , Reperfusion Injury/diagnosis , Reperfusion Injury/etiology , SwineSubject(s)
Amputation, Surgical/methods , Leg/surgery , Amputation Stumps , Humans , Reoperation , ThighABSTRACT
In 95 patients with atherosclerotic occlusion of aorto-iliac and femoro-popliteal arterial segments and II-IV grade of ischemia (according to Fontaine) the concentration of malonic dialdehyde and general antioxidant activity of the blood plasma in ischemia period of time and in various terms of revascularization period were determined. The processes rising of peroxide clearance of lipids (PCL) in injured limb and lowering of antioxidant (AO) activity of blood plasma was discovered. In the revascularization period further significant activation of PCL processes (maximally during the first day) and gradual rising of AO activity of blood plasma (maximally on the 3-5th day) was revealed. The magnitude of these processes depended on the tissue ischemia extension and its severity.
Subject(s)
Antioxidants/analysis , Arteriosclerosis Obliterans/surgery , Leg/blood supply , Lipid Peroxidation , Adolescent , Adult , Aged , Aged, 80 and over , Arteriosclerosis Obliterans/metabolism , Humans , Middle Aged , Postoperative PeriodABSTRACT
Luminescent investigation data of the tissue blood circulation and microcirculation in the limbs in 29 patients (in 25 of them with the main arteries occlusion) were adduced. Significance of the luminescent investigation of the limbs blood circulation in the diagnosis of the tissue blood circulation and microcirculation infringement degree was determined.
Subject(s)
Arterial Occlusive Diseases/physiopathology , Ischemia/physiopathology , Leg/blood supply , Luminescent Measurements , Adolescent , Adult , Aged , Aged, 80 and over , Arterial Occlusive Diseases/diagnosis , Blood Flow Velocity , Case-Control Studies , Contrast Media , Humans , Ischemia/diagnosis , Microcirculation , Middle Aged , Regional Blood FlowABSTRACT
Complex investigation of 122 patients with various degree ischemia of lower limbs was conducted. The site of the blood flow disorder in local arterial basins, the type of lesion (stenosis, occlusion, aneurysm or their combination), the degree of collateral blood flow compensation and the trophic changes of ischemized tissues were truthfully established with the help of radionuclide investigation.
Subject(s)
Ischemia/diagnostic imaging , Leg/blood supply , Radionuclide Angiography , Aged , Evaluation Studies as Topic , Humans , Ischemia/etiology , Middle AgedABSTRACT
The data from literature on the problem of urolithiasis pathogenesis have been analyzed. A physico-chemical theory (hypothesis) of the possible mechanism of lithogenesis in urinary tracts is suggested on the basis of results from studies of surface tension, light transmission and crystallization of urine depending on the concentration of exogenous calcium chloride in it.