ABSTRACT
An 11-year-old castrated male rabbit presented with a subcutaneous mass in the right hind limb. The mass comprised solid and myxoid areas. Solid areas were characterized by a storiform or interlacing pattern of spindle cells, strap cells, multinucleated giant cells and round cells with eccentrically located nuclei, whereas the myxoid areas were composed predominantly of elongated fusiform cells with hyperchromatic nuclei embedded in Alcian Blue-positive myxoid stroma. Immunohistochemically, tumor cells in both areas were positive for desmin and vimentin. Ultrastructurally, the tumor cells in the solid areas had abundant myofilaments with electron dense Z-band structures. Based on these pathological findings, this case was diagnosed as rhabdomyosarcoma in a rabbit.
Subject(s)
Muscle Neoplasms/veterinary , Rabbits/anatomy & histology , Rhabdomyosarcoma/veterinary , Animals , Male , Muscle Neoplasms/diagnosis , Muscle Neoplasms/pathology , Muscle, Skeletal/pathology , Rhabdomyosarcoma/diagnosis , Rhabdomyosarcoma/pathologyABSTRACT
A 13-year-old castrated male Labrador retriever dog presented with a mass caudal to the first molar of his left mandible. Although the tumor was excised, a recurrent tumor was detected one month later and resected. Both tumors displayed invasive growth and were composed of neoplastic proliferation arranged in irregular lobules, nests and cords continuous with mucosal epithelium. The most prominent feature of the tumors was the presence of many proliferating spindle cells admixed with palisading basal-like cells, acanthocytes and stellate cells. In immunohistochemical examinations, the spindle cells were found to be positive for vimentin; cytokeratin AE1/AE3, 5/6, 14 and 19; and p63. The other neoplastic cells were positive for all of these markers shown above except vimentin. Based on these findings, the tumors were diagnosed as spindle cell ameloblastic carcinoma.
Subject(s)
Ameloblastoma/veterinary , Carcinoma/veterinary , Dog Diseases/metabolism , Dog Diseases/pathology , Jaw Neoplasms/veterinary , Neoplasm Recurrence, Local/veterinary , Ameloblastoma/metabolism , Ameloblastoma/pathology , Animals , Carcinoma/metabolism , Carcinoma/pathology , Dogs , Immunohistochemistry/veterinary , Jaw Neoplasms/metabolism , Jaw Neoplasms/pathology , Keratins/metabolism , Male , Vimentin/metabolismABSTRACT
We examined calcium channel blockers (CCBs) and angiotensin receptor II blockers in low-risk hypertensives to evaluate renal, vascular function and left ventricular mass (LVM) from the viewpoint of salt intake (SI). Low-risk hypertensives who had not met blood pressure (BP) goals with CCB were administered telmisaltan. Office and home BP, urinary albumin excretion (uAE), brachial ankle pulse wave velocity (baPWV) and LVM were significantly reduced. uAE and baPWV correlated with SI. It is therefore necessary to evaluate the organ-protecting effects from the viewpoint of SI. In low-risk hypertensives, telmisartan with CCB improves renal, vascular function and LVM.
Subject(s)
Albuminuria/drug therapy , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Benzimidazoles/administration & dosage , Benzoates/administration & dosage , Calcium Channel Blockers/therapeutic use , Hypertension/drug therapy , Hypertrophy, Left Ventricular/drug therapy , Aged , Aged, 80 and over , Albuminuria/epidemiology , Blood Pressure/drug effects , Drug Therapy, Combination , Female , Hemodynamics/drug effects , Humans , Hypertension/epidemiology , Hypertrophy, Left Ventricular/epidemiology , Incidence , Male , Middle Aged , Risk Factors , Sodium Chloride/urine , Telmisartan , Treatment OutcomeABSTRACT
A solitary mass of 6 x 6 x 5 cm was found in the smooth muscle layer of the pyloric part in the stomach of a Shetland sheepdog. The excised mass was solid, gray-white in color, and had central necrosis with hemorrhages. Microscopically, the neoplasm was composed of irregular bundles of spindle-shaped tumor cells and round tumor cells. A few multinucleated cells and gangliocyte-like cells were observed. The nuclei exhibited a high degree of atypia and many cells contained mitotic figures. Immunohistochemically, tumor cells were positive for vimentin and desmin, but negative for c-kit antibody. Ultrastructurally, tumor cells contained cytoplasmic myofilaments and pinocytotic vesicles. Based on these pathological findings, the tumor was diagnosed as gastric pleomorphic leiomyosarcoma.