ABSTRACT
Peaton virus (PEAV; family Peribunyaviridae, genus Orthobunyavirus) appears to be capable of producing congenital malformations in ruminants; however, its pathogenicity remains unknown given its relatively low incidence. We evaluated the relationship between congenital abnormalities of calves and PEAV infection by serologic, epidemiologic, pathologic, and virologic investigations using specimens from 31 malformed calves in the years 1996-2016 in Japan. Antibody testing was carried out for known teratogenic viruses, including Akabane, Aino, Chuzan, and bovine viral diarrhea viruses, in the precolostral sera of these abnormal calves, but all results were negative. However, all 31 malformed calves were positive for antibodies against PEAV. A PEAV-specific gene was amplified from central nervous system tissues from a stillborn calf delivered in April 2007, and its nucleotide sequence was identical with that of PEAV isolated from healthy sentinel cattle in September 2006. These findings indicate that PEAV can cause bovine congenital anomalies.
Subject(s)
Bunyaviridae Infections/veterinary , Cattle Diseases/pathology , Cattle/abnormalities , Congenital Abnormalities/veterinary , Orthobunyavirus/physiology , Animals , Antibodies, Viral/blood , Bunyaviridae Infections/pathology , Bunyaviridae Infections/virology , Cattle Diseases/virology , Congenital Abnormalities/pathology , Congenital Abnormalities/virology , JapanABSTRACT
A 6-month-old male Nubian goat suddenly showed dullness, tachypnea, recumbency and opisthotonus in August 2011 in Okinawa, Japan. The goat was consequently necropsied: gross lesions in the brain included slightly swollen foci of yellowish discoloration on the cerebral hemisphere. Histopathologically, necrosis of the cortex with ischemic changes of neuronal cells was present, and swelling of the vascular endothelium, thickening of the basement membrane and diffuse infiltration of macrophages were observed in the cerebral lesion. Autofluorescence of the cerebral cortex was confirmed by an ultraviolet light test. The thiamine levels of the blood serum and tissue samples (brain, liver and heart) of the goat were low compared with goats from the same herd. The goat was diagnosed with cerebrocortical necrosis (CCN). This is the first case report of caprine CCN in Japan.
