The effectiveness of physical activity interventions in Asian children and adolescents: a systematic review.

OBJECTIVE: The objective of this review is to investigate the effectiveness of interventions to promote physical activity (PA) among children and adolescents in Asian countries. STUDY DESIGN: Systematic review. METHODS: A systematic search of eight electronic databases was performed to retrieve articles published between January 1990 and August 2019, in English language, including any interventions to promote PA outcomes among children (aged 3-12 years) and adolescents (aged 13-18 years) in Asian countries. RESULTS: Thirty studies met the eligibility criteria and were included. Most studies were school-based (70%, n = 21), and half were cluster randomized controlled trials (53%, n = 16). Twelve of 30 included studies were among children, 15 among adolescents, and three among both children and adolescents. Only four studies (13%) used device-based measures of PA. The duration of intervention ranged from one day to 60 months (median 4.5 months). Twenty-one studies were of moderate-to-high quality, of which 15 demonstrated significant increases in PA behavior or physical fitness. Evidence was found that school-based, short-term (up to six months) interventions with a single or multicomponent approach including PA sessions, physical education, health education, and/or educational materials may increase overall PA in Asian children and adolescents. CONCLUSIONS: The present review provides some evidence supporting the effectiveness of interventions in promoting PA-related outcomes. However, the findings are inconsistent due to the low number of studies, low-methodological quality, and/or small sample size. Well-designed interventions are needed to inform strategies to enhance PA engagements among children and adolescents in Asia.

Durable benefit of rituximab maintenance post-autograft in patients with relapsed follicular lymphoma: 12-year follow-up of the EBMT lymphoma working party Lym1 trial.

We report the 12-year follow-up of the prospective randomized EBMT LYM1 trial to determine whether the benefit of brief duration rituximab maintenance (RM) on progression-free survival (PFS) in patients with relapsed follicular lymphoma (FL) receiving an autologous stem cell transplant (ASCT) is sustained. One hundred and thirty-eight patients received RM with or without purging. The median follow-up after random assignment is 12 years (range 10-13) for the whole series. The 10-year PFS after ASCT is 47% (95% CI 40-54) with only 4 patients relapsing after 7.5 years. RM continues to significantly improve 10-year PFS after ASCT in comparison with NM [P = 0.002; HR 0.548 (95% CI 0.38-0.80)]. Ten-year non-relapse mortality (NRM) was not significantly different between treatment groups (7% overall). 10-year overall survival (OS) after ASCT was 75% (69-81) for the whole series, with no significant differences according to treatment sub-groups. 10-year OS for patients who progressed within 24 months (POD24T) was 60%, in comparison with 85% for patients without progression. Thus the benefit of rituximab maintenance after ASCT on relapse prevention is sustained at 12 years, suggesting that RM adds to ASCT-mediated disease eradication and may enhance the curative potential of ASCT.

Parental and peer supports are associated with an active lifestyle of adolescents: evidence from a population-based survey.

OBJECTIVES: Parental and peer support can foster adolescents' activity behaviours; however, little is known about how such support are linked with adolescents' active lifestyle in non-Western settings. The study aimed to explore associations of parental and peer support with an active lifestyle of adolescents in Malaysia. STUDY DESIGN: This is a cross-sectional study. METHODS: We used data from the 2012 Malaysian Global School-based Student Health Survey, which covered adolescents aged 11-17 years (51% girls). Adolescents were asked about their physical activity, sitting time, and levels of parental and peer support. Participants with ≥60 min of moderate to vigorous physical activity per day and ≤2 h of sitting time per day were categorised as having an 'active lifestyle'. Binary logistic regression was used to examine the relationships by gender and age group (11-14 and 15-17 years). RESULTS: Of the participating adolescents (n = 12,081), 15.3% reported to have an active lifestyle (boys: 22.0%; girls: 8.8%). About 31% reported to have higher levels of parental support, whereas 47% reported higher levels of peer support. Higher parental and peer support were significantly associated with an active lifestyle of boys across both age groups. Girls with higher parental support had higher odds of reporting an active lifestyle in both age groups, whereas higher peer support was significantly associated with an active lifestyle among girls aged 11-14 years. CONCLUSIONS: This study uniquely extends the current evidence by examining the associations of parental and peer support with physical activity and sitting time combined. More research is needed to understand how different types of social support can influence adolescents' active lifestyle.

Physical activity and sedentary behaviour in Bangladesh: a systematic scoping review.

OBJECTIVES: Lack of physical activity (PA) contributes to increasing prevalence of non-communicable diseases (NCDs) globally. However, little is known about PA and sedentary behaviour (SB) among populations in low- and middle-income countries (LMICs). This systematic review examined prevalence of PA and SB in Bangladesh. STUDY DESIGN: Systematic review of the literature. METHODS: A systematic electronic search in eight databases and a manual search of retrieved articles' references were conducted. Original research conducted in Bangladesh with PA- and/or SB-related outcome(s) were included. RESULTS: Out of 1,162 retrieved titles, 33 articles (32 cross-sectional and one case-control study) met the inclusion criteria. Twenty-nine studies were with healthy populations: adults (n = 19); children and adolescents (n = 7); and children, adolescents and adults (n = 3). Five studies used nationally representative samples of adults and one of adolescents. Most studies (n = 26) assessed PA only; three only SB, and four both PA and SB. All studies used self-reported measures. Among healthy adults, prevalence of insufficient PA ranged from 5% to 83%. Occupational and transport-related PA contributed the most towards total PA with negligible contribution of recreational PA. Among children and adolescents, the prevalence of insufficient PA ranged between 20% and 67%. Females engaged in less PA compared to males. Limited evidence currently exists about the prevalence of SB, especially among adults. CONCLUSIONS: PA and SB research has received little attention in Bangladesh. Critical knowledge gaps identified in this review should be taken into account when designing new research and programmes in Bangladesh and other LMICs with similar socio-economic and cultural settings.

Ethanol-responsive genes: identification of transcription factors and their role in metabolomics.

Transcription factors (TFs) and their combinatorial control on cis-regulatory elements play critical role in the co-expression of genes. This affects the interaction of genes in the transcriptome and thus may affect signals that cascade through cellular pathways. Using a combination of bioinformatic approaches, we sought to identify such common combinations of TFs in a set of ethanol-responsive (ER) genes and assess the role of ethanol in affecting multiple pathways through their co-regulation. Our results show that the metallothionein genes are regulated by TF motifs cAMP responsive element binding protein (CREB) and metal-activated transcription factor 1 and primarily involved in zinc ion homeostasis. We have also identified new target genes, Synaptojanin 1 and tryptophan hydroxylase 1, potentially regulated by this module. Altered arrangement of TF-binding sites in the module may direct the action of these and other target genes in intracellular signaling cascades, cell growth and/or maintenance. In addition to CREB, other key TFs identified are ecotropic viral integration site-1 and SP1. These modulate the contribution of the target ER genes in cell cycle regulation and apoptosis or programmed cell death. Multiple lines of evidence confirm the above findings and indicate that different groups of ER genes are involved in different biological processes and their co-regulation most likely results from different sets of regulatory modules. These findings associate the role of the ER genes studied and their potential TF modules with alcohol response pathways and phenotypes.

Pithedulosides A-G, oleanane glycosides from Pithecellobium dulce.

Seven saponins named pithedulosides A-G were isolated from the seeds of Pithecellobium dulce. Their structures were established through spectral analyses as echinocystic acid 3-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside, echinocystic acid and oleanolic acid 3-O-alpha-L-arabinopyranosyl- (1-->2)-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranosides and 3-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl -(1-->6)-beta-D-glucopyranosides, oleanolic acid 3-O-alpha-L-arabinopyranosy-(1-->2)-alpha-L- arabinopyranosyl-(1-->6)-[beta-D-glucopyranosyl-(1-->2)]-beta- D-glucopyranoside, and 3-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6) -[beta-D-glucopyranosyl-(1-->2)]--beta-D-glucopyranoside.

Studies on heavy metals in the ground waters of the city of Aligarh U.P. (India).

A study was conducted to determine the levels of heavy metals Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn along with physico-chemical parameters in ground waters of Aligarh city, U.P. (India). Twenty seven samples of hand pump water and twenty three samples of municipal water supply were collected from different localities of the Aligarh city, five times during the period of two months at intervals of 12 days. The samples were analysed for physico-chemical characteristics (pH, electrical conductivity, chlorides, sulphates, total hardness, total alkalinity, nitrate-nitrogen, fluoride, calcium and magnesium) and heavy metal contents. The concentrations of heavy metals in the hand pump water samples were found in the ranges of Cd (ND-5.00); Cr (ND-30.00); Cu (ND-82.50); Fe (16.80-460.00); Mn (ND-425.00); Ni (ND-25.00); Pb (ND-25.00) and Zn (28.60-775.00) µg l(-1). The heavy metal concentrations in the municipal water supply samples were found to be Cd (ND-5.00); Cr (ND-25.00); Cu (ND-37.50); Fe (8.00-37.50); Mn (ND-320.00); Ni (ND-25.00); Pb (ND-25.00) and Zn (2.00-271.87) µg l(-1).It appears from the results of these studies the concentrations of Cd, Cr, Cu, Ni, Pb, and Zn in the ground waters of the Aligarh City were found to be lower than the prescribed limits of World Health Organisation (1984), whereas the values of Fe and Mn were found above the prescribed limits in some localities. The chloride total hardness and nitrate-nitrogen were comparatively higher in the hand pump water than the municipal supply water. The reason of higher values of these parameters may be ascribed to the surface disposal of sewage wastes, wastes from metal processing industries and other house hold refuses.

Quality of drinking water in the Aligarh Muslim University Campus, Aligarh, U.P. (India) with respect to heavy metals.

The physico-chemical characteristics of the drinking water in nine residential halls of the Aligarh Muslim University, Aligarh, U.P. (India), were studied. Nine samples each of running and standing water were taken four times over a period of one month at weekly intervals from all of the residential halls and were analysed for physico-chemical characteristics and heavy metal contents. The temperature, pH and electrical conductivity of water samples ranged between 20.0-26.0°C; 7.00-8.00 and 116.00-199.04 micromhos cm(-1) respectively whereas the values of total alkalinity, total hardness, Cl(-), SO 4 (-) , F(-), NH3-N, NO2-N; NO3-N were found between 261.00-396.00; 128.00-200.00; 8.00-69.00; 12.00-46.00; 0.90-1.35; 0.20-0.44; ND; 1.60-6.50 mg l(-1) respectively. The ranges of heavy metal concentrations in the running water samples were as follows: Cd (0.70-3.75); Cr (ND-5.00); Co (9.50-18.75); Cu (0.75-15.00); Fe (ND-13.50); Mn (3.50-51.00); Ni (7.00-17.50); Pb (0.50-2.50) and Zn (10.00-176.50) µg l(-1). The heavy metal concentrations in standing water samples were found to be: Cd (1.20-4.90); Cr (ND-10.00); Co (10.25-19.00); Cu (1.75-20.00); Fe (ND-18.00); Mn (5.00-66.50); Ni (8.75-19.75); Pb (0.75-5.50) and Zn (28.60-364.00) µg l(-1). The concentrations of heavy metals in drinking water supplies of the Aligarh Muslim University campus were well below the guidelines for drinking water quality as prescribed by World Health Organisation (1984). It is evident from the results that the drinking water may not cause any significant health hazard to water consumers due to heavy metals but these may be hazardous if they get accumulated in the body due to continuous consumption of water.