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1.
J Med Eng Technol ; 33(6): 481-7, 2009.
Article in English | MEDLINE | ID: mdl-19484686

ABSTRACT

In order to conduct fast screening of passengers with infections such as severe acute respiratory syndrome (SARS) or pandemic influenza at a quarantine depot, we developed a non-contact screening system with self-produced program to conduct a human screening within five seconds, via a linear discriminant function from non-contact derived variables, i.e. palmer pulse derived from a laser Doppler blood-flow meter, respiration rate determined by a 10-GHz microwave radar, and facial temperature measured by thermography. The system evaluation was conducted on seven healthy male subjects (23 +/- 1 years). In order to achieve a pseudo-infection condition, the subjects maintained an ergometer exercise load (100 W, 10 minutes). Before (normal condition) and after (pseudo-infection condition) exercise, a significant linear discriminant function (p < 0.001) was determined to distinguish pseudo-infection condition from normal condition (Mahalanobis D-square = 20.3, classification error rate <5%). The proposed system appears promising for future application in fast screening of infection at a quarantine depot.


Subject(s)
Influenza, Human/diagnosis , Laser-Doppler Flowmetry , Mass Screening , Quarantine , Radar , Severe Acute Respiratory Syndrome/diagnosis , Thermography , Adult , Body Temperature , Diagnostic Imaging/instrumentation , Disease Outbreaks/prevention & control , Heart Rate , Humans , Infection Control/instrumentation , Infection Control/methods , Infrared Rays , Male , Mass Screening/instrumentation , Mass Screening/methods , Microwaves , Respiratory Rate , Time Factors , Young Adult
2.
J Med Eng Technol ; 33(5): 403-9, 2009.
Article in English | MEDLINE | ID: mdl-19440915

ABSTRACT

In order to conduct fast screening of passengers with infections such as severe acute respiratory syndrome (SARS) or pandemic influenza at a quarantine depot, we developed a non-contact screening system with a self-produced program to conduct a human screening within five seconds, via a linear discriminant function from non-contact derived variables, i.e. palmer pulse derived from a laser Doppler blood-flow meter, respiration rate determined by a 10-GHz microwave radar, and facial temperature measured by a thermography. The system evaluation was conducted on seven healthy male subjects (23+1 years). In order to achieve a pseudo-infection condition, the subjects maintained an ergo-meter exercise load (100 W, 10 minutes). Before (normal condition) and after (pseudo-infection condition) exercise, a significant linear discriminant function (p50.001) was determined to distinguish the pseudo-infection condition from the normal condition (Mahalanobis D-square 1/4 20.3, classification error rate55%). The proposed system appears promising for future application in fast screening of infection at a quarantine depot.


Subject(s)
Infrared Rays , Laser-Doppler Flowmetry/methods , Mass Screening , Microwaves , Thermography/methods , Data Interpretation, Statistical , Discriminant Analysis , Disease Outbreaks/prevention & control , Face/physiology , Heart Rate/physiology , Humans , Image Processing, Computer-Assisted/methods , Mass Screening/instrumentation , Mass Screening/methods , Respiration , User-Computer Interface
3.
Rev. ciênc. farm. básica apl ; 26(1): 29-37, 2005. tab
Article in Portuguese | LILACS | ID: lil-425721

ABSTRACT

Com o aumento significativo na incidência de infecções fúngicas invasivas durante a última década, principalmente em pacientes com câncer, AIDS, ou hospitalizados por período prolongado em unidades de terapia intensiva, há a necessidade da pesquisa de novos agentes antifúngicos com qualidade superior aos existentes. Esta pesquisa objetivou a procura de um microrganismo produtor de substâncias antibacterianas e antifúngicas. Microrganismos das amostras de solo da região de Araraquara, Brasil, foram coletados e analisados quanto ao seu potencial antimicrobiano contra microrganismos padrões (Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus oryzae). Das 64 cepas isoladas, 34 apresentaram atividade antimicrobiana. A cepa Ar 4014 foi escolhida para dar continuidade ao trabalho por apresentar boa atividade antimicrobiana contra Candida albicans. Estudos fermentativos mostraram que os Meios 608-K e 602-B foram os melhores para produção e extração de substâncias antifúngicas de Ar 4014. Após cromatografia em coluna de sílica do extrato bruto, as frações ativas obtidas mostraram picos de absorção UV-VIS característicos de pentaenos normais. O antibiótico foi denominado provisoriamente Ara 4014-75


Subject(s)
Animals , Antifungal Agents , Anti-Bacterial Agents/metabolism , Antifungal Agents/isolation & purification , Antifungal Agents/metabolism , Streptomycin/isolation & purification , Streptomyces/isolation & purification , Streptomyces/metabolism , Aspergillus oryzae/isolation & purification , Candida albicans/isolation & purification , Escherichia coli/isolation & purification , Staphylococcus aureus/isolation & purification
4.
Rev Latinoam Microbiol ; 38(3-4): 185-91, 1996.
Article in English | MEDLINE | ID: mdl-10932709

ABSTRACT

An actinomycete strain (Ar386) was isolated from the soil of the Araraquara region, SP, Brazil. The strain, named Streptomyces jacareensis, formed irregular rayed, rugose, grayish-white mycelium with sinuous, branched hyphae carrying rare isolated spores; assimilated glucose, galactose, inositol, ribose, maltose, sucrose, melibiose and starch but not mannitol, rhamnose, arabinose, xylose, lactose and raffinose; and contained LL-diaminopimelic acid in its cell wall. An antibiotic active against Gram-positive bacteria, which was characterized as being 26-deoxylaidlomycin and which may have application against poultry coccidiosis, was isolated from cultures of the strain. This was the first isolation of this antibiotic from a microorganism of the genus Streptomyces and also the first isolation of this antibiotic in Brazil.


Subject(s)
Monensin/analogs & derivatives , Brazil , Monensin/biosynthesis , Monensin/isolation & purification , Soil Microbiology , Streptomyces/isolation & purification , Streptomyces/metabolism
5.
An. farm. quím. Säo Paulo ; 22(1/2): 88-93, 1982.
Article in Portuguese | LILACS | ID: lil-12469

ABSTRACT

Prospecto atual e futuro da tecnologia de fermentacao. Os produtos obtidos por fermentacao foram agrupados em 1) farmacos, 2) alimentos, 3) produtos agro-industriais e 4) produtos quimicos. Outros processos que utilizam a fermentacao foram citados Entre as possibilidades breves de aplicacao foram relatadas as producoes do interferon, da insulina, dos hormonios proteicos e dos anticorpos monoclonais por fermentacao. As vastas possibilidades do emprego da Engenharia Genetica e da Cultura de Celulas nas fermentacoes industriais foram discutidas


Subject(s)
Antibodies, Monoclonal , Fermentation , Genetic Engineering
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