ABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Adolescent , Middle Aged , Colitis/diagnosis , Cysts/diagnosis , Gastrointestinal Hemorrhage/etiology , Intestinal Mucosa/pathology , Rectal Neoplasms/diagnosis , Diagnosis, Differential , Follow-Up StudiesSubject(s)
Colitis/diagnosis , Colorectal Neoplasms/diagnosis , Cysts/diagnosis , Diagnostic Errors , Adolescent , Colitis/drug therapy , Colitis/pathology , Colitis/surgery , Colitis, Ulcerative/complications , Cysts/drug therapy , Cysts/pathology , Cysts/surgery , Female , Follow-Up Studies , Gastrointestinal Hemorrhage/etiology , Humans , Immunosuppressive Agents/therapeutic use , Male , Mesalamine/therapeutic use , Middle Aged , Rectal Diseases/etiology , Recurrence , Unnecessary ProceduresABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Pleural Effusion/diagnosis , Pancreatic Fistula/diagnosis , Pancreatitis, Chronic/complications , Dyspnea/etiology , Asymptomatic DiseasesSubject(s)
Pancreatic Fistula/complications , Pancreatitis, Chronic/complications , Pleural Diseases/complications , Pleural Effusion/etiology , Respiratory Tract Fistula/complications , Asymptomatic Diseases , Calcinosis/diagnostic imaging , Calcinosis/etiology , Cholangiopancreatography, Endoscopic Retrograde , Cholangiopancreatography, Magnetic Resonance , Constriction, Pathologic , Humans , Male , Middle Aged , Pancreatic Ducts/pathology , Pancreatic Ducts/surgery , Pancreatic Pseudocyst/etiology , Pancreatitis, Chronic/diagnostic imaging , Pleural Effusion/diagnostic imaging , Stents , Tomography, X-Ray ComputedABSTRACT
Polycystic liver disease (PLD) is a hereditary disease inherited by autosomal dominant trait that occurs as a frequent extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). We report a case of a 59-year-old woman diagnosed with ADPKD associated with PLD. End-stage chronic renal failure with a secondary Budd-Chiari syndrome developed during the patient's clinical course. She underwent combined liver and kidney transplantation, with a successful response over a 9-year follow-up period.
ABSTRACT
Primary sclerosing cholangitis is an infrequent extraintestinal manifestation of ulcerative colitis. Damage to bile ducts is irreversible and medical therapies to prevent progression of the disease are usually ineffective. We describe a patient with long-standing ulcerative colitis, which was refractory to corticosteroid therapy who developed primary sclerosing cholangitis (biochemical stage II/IV) in the course of his pancolitis. Treatment with infliximab (5 mg/kg as an induction dose followed by maintenance doses every two months) was indicated because of steroid-dependent disease associated to primary sclerosing cholangitis as well as sacroiliitis and uveitis and previous episode of severe azathioprine-related hepatic toxicity. At present, after two years of follow-up, the patient is asymptomatic with normal liver tests and complete resumption of daily life activities. This case draws attention to the usefulness of anti-tumor necrosis factor-alpha therapy for the management of primary sclerosing cholangitis as extraintestinal manifestation of inflammatory bowel disease.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Cholangitis, Sclerosing/drug therapy , Colitis, Ulcerative/drug therapy , Drug Resistance , Immunosuppressive Agents/therapeutic use , Steroids/therapeutic use , Aged , Cholangitis, Sclerosing/diagnosis , Cholangitis, Sclerosing/etiology , Colitis, Ulcerative/complications , Colitis, Ulcerative/diagnosis , Humans , Infliximab , Male , Treatment OutcomeABSTRACT
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiopathogenesis and increasing incidence in recent years. Perianal complications of ulcerative colitis are rare and seem to be associated with higher extent of inflammation and a more severe course of the disease. The cases of two male patients with severe corticoid-dependent ulcerative colitis of protracted clinical course who developed perianal fistulas and abscesses successfully treated with infliximab are reported. Treatment with infliximab was followed by perianal fistula closure with marked improvement in the quality of life over 2-year follow-up period.