Does occupational air pollution threaten the lung health of indoor workers more than those of bus drivers?: a cross-sectional study.

AIM: This study aimed to evaluate the lung health between professional bus drivers and white collar workers in metropolis municipality from Turkey. MATERIAL AND METHODS: Out of 126 bus drivers and 1100 office employees, data were analyzed from 243 indoor employees and 57 bus drivers. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, forced expiratory flow (FEF) 25-75% were measured, some data were collected with a questionnaire (work and environmental anamnesis, symptoms, smoking). RESULTS: The mean (±SD) values for FVC, FVC percent predicted value, FEV1, FEV1 percent predicted value, FEV1/FVC were 4.33 ± 0.99L, 96.5 ± 18.2%, 3.31 ± 0.87L, 84.5 ± 18.2%, 76.30 ± 9.23%, respectively. Sixty-six participants (22%) had FEV1/FVC proportions of less than 70%. After weighing for the propensity scores, there was a significant difference between bus drivers and indoor workers concerning FEV1/FVC grouping; while 65 (26.1%) indoor workers had FEV1/FVC proportions less than 70%, there were only two (3.9%) bus drivers (Chi-Square = 12.009, p = .001). The mean spirometry values were significantly different between the two groups in favor of the bus drivers (p < .05). Night cough was much more seen in the indoor workers (Chi-Square test = 9.019, p = .003). CONCLUSION: We conclude that there are no health risks associated with bus driving in a metropolitan city, concerning lung functions.

Fibulins: a new biomarker for pulmonary thromboembolism?

OBJECTIVES: Fibulin-1, -2, -4, and -5 have important role in several vascular diseases. We aimed to investigate if fibulin-4 and -5 can be used as a biomarker for pulmonary thromboembolism (PTE). METHODS: This is a prospective case control study. Thirthy patients diagnosed with PTE and 31 in the control group. Data on demographic characteristics, length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases, radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) requirement, and loss of life were recorded for the patients group. Serum Fibulin-4 and Fibulin-5 levels were measured. RESULTS: Fibulin 4 levels correlated positively with female gender (p < .01, r = 0.433). Positive results were found in 14 (46.7%) patients for PESI.0.1; in 7 (23.3%) patients for D-dimer; in 7 (23.3%) patients for troponin-I; in 7(23.3%) patients for BNP. Median values for Fibulin 4 level were significantly higher in patients positive for BNP. Fibulin-5 level was found to be correlated with the presence of embolism (p = .041, r = 0.263). CONCLUSIONS: Fibulin-4 and -5 have been shown to be relevant to cardiovascular biology and diseases. Experimental studies and observations in humans show that they may play a role in several cardiovascular diseases particularly pulmonary embolism.