ABSTRACT
The authors report the follow-up of a 68-year-old lady with bilateral anterior uveitis secondary to erlotinib. Erlotinib was started and stopped after symptoms and signs suggestive of severe bilateral anterior uveitis were noted. The patient developed signs of a non-ST elevation myocardial infarction, 12 days after stopping the erlotinib, and recovered without major problems. The patient also reported intermittent low-grade fever since starting erlotinib which resolved after stopping this drug. No further symptoms of uveitis were noted up to 6 month follow-up. The patient reported improved well being, resolution of ocular symptoms and intermittent low-grade fever at last follow-up (6 months after stopping erlotinib).
Subject(s)
Adenocarcinoma/drug therapy , Lung Neoplasms/drug therapy , Protein Kinase Inhibitors/adverse effects , Quinazolines/adverse effects , Uveitis/chemically induced , Aged , Diagnosis, Differential , Erlotinib Hydrochloride , Female , Humans , Uveitis/diagnosis , Visual AcuitySubject(s)
Gastrointestinal Hemorrhage/etiology , Portal Vein , Somatostatinoma/diagnostic imaging , Vascular Neoplasms/diagnostic imaging , Venous Thrombosis/diagnostic imaging , Esophageal and Gastric Varices/diagnostic imaging , Esophageal and Gastric Varices/etiology , Humans , Male , Middle Aged , Pancreatic Neoplasms/pathology , Portal Vein/diagnostic imaging , Radiography , Somatostatinoma/complications , Somatostatinoma/secondary , Vascular Neoplasms/complications , Vascular Neoplasms/secondary , Venous Thrombosis/etiologyABSTRACT
The authors report the case of a 68-year-old woman with secondary adenocarcinoma of the lungs from an unknown primary. Erlotinib was started which produced symptoms suggestive of uveitis. Erlotinib was stopped and restarted a month later at a lower dose, which resulted in severe bilateral anterior uveitis. The uveitis settled after stopping erlotinib and treatment with topical steroids and cycloplegics. To the best of the authors' knowledge, this is the first case of erlotinib-related anterior uveitis.