Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Emerg Infect Dis ; 30(6): 1203-1213, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38782023

ABSTRACT

Major dengue epidemics throughout Nicaragua's history have been dominated by 1 of 4 dengue virus serotypes (DENV-1-4). To examine serotypes during the dengue epidemic in Nicaragua in 2022, we performed real-time genomic surveillance in-country and documented cocirculation of all 4 serotypes. We observed a shift toward co-dominance of DENV-1 and DENV-4 over previously dominant DENV-2. By analyzing 135 new full-length DENV sequences, we found that introductions underlay the resurgence: DENV-1 clustered with viruses from Ecuador in 2014 rather than those previously seen in Nicaragua; DENV-3, which last circulated locally in 2014, grouped instead with Southeast Asia strains expanding into Florida and Cuba in 2022; and new DENV-4 strains clustered within a South America lineage spreading to Florida in 2022. In contrast, DENV-2 persisted from the formerly dominant Nicaragua clade. We posit that the resurgence emerged from travel after the COVID-19 pandemic and that the resultant intensifying hyperendemicity could affect future dengue immunity and severity.


Subject(s)
COVID-19 , Dengue Virus , Dengue , Phylogeny , SARS-CoV-2 , Serogroup , Dengue Virus/genetics , Dengue Virus/classification , Nicaragua/epidemiology , Humans , Dengue/epidemiology , Dengue/virology , COVID-19/epidemiology , COVID-19/virology , SARS-CoV-2/genetics , Pandemics
SELECTION OF CITATIONS
SEARCH DETAIL