ABSTRACT
Data in the literature support the existence of a state of limited metastases or oligometastases. Favorable outcomes have been observed in selected patients with such oligometastases that are treated with local ablative therapies, which include surgical extirpation, stereotactic body radiation therapy (SBRT), and radiofrequency ablation. The role of SBRT in the setting of lymph node oligometastases is still emerging but the early results for local control are promising. However, the biggest challenge is to identify patients who will benefit from treatment of their oligometastatic disease with local aggressive therapy. Patients are initially categorized based upon examination of the initial biopsy, location, stage, and previous treatments received. Appropriate patient management with SBRT requires an understanding of several clinicopathological features that help to identify several subsets of patients with more responsive tumors and a good tolerance to SBRT. In an effort to incorporate the most recent evidence, here the Spanish Society of Radiation Oncology presents guidelines for using SBRT in lymph node oligometastases (AU)
No disponible
Subject(s)
Humans , Male , Female , Radiosurgery/instrumentation , Radiosurgery/methods , Radiosurgery , Lymph Nodes/pathology , Lymph Nodes/radiation effects , Lymphatic Metastasis/radiotherapy , Neoplasm Metastasis/radiotherapy , Societies, Medical/organization & administration , Societies, Medical/standardsABSTRACT
El carcinoma epidermoide primario de mama esuna entidad muy poco frecuente. Típicamente sepresenta como un tumor cístico en la mama de grantamaño y evolución rápida. (También se caracterizapor diseminación a distancia y escasa afectaciónmetastásica en ganglios). En la mayoría de los casos,los receptores hormonales son negativos y loshallazgos radiológicos son inespecíficos. Los tratamientosdescritos en la literatura consisten en lacombinación de cirugía, quimioterapia y radioterapia
Breast primary squamous carcinoma is an infrequententity. It appears typically as a voluminousbreast cystic tumour of rapid evolution. It is characteristicthe development of a systemic disseminationgenerally in the absence of regional lymph nodemetastases. In most cases hormone receptors arelacking, and radiological findings are not specific.The treatments described in the medical literatureconsist of a combination of surgery, chemotherapyand radiotherapy
Subject(s)
Female , Middle Aged , Humans , Carcinoma, Squamous Cell/pathology , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Biomarkers, Tumor/analysisABSTRACT
El incremento de las indicaciones de la Radioterapia (RT) como tratamiento de primera línea en determinadosprocesos oncológicos, la necesidad de aumentar la intensidad de dosis para un adecuadocontrol local y una mayor sensibilización social del valor de la Calidad de Vida de los pacientes,han impulsado la búsqueda de tratamientos de soporte para prevenir y tratar sus complicaciones deuna forma más eficaz y a un coste razonable.La Oxigenoterapia Hiperbárica (OHB), técnica introducida hace unos 80 años en el tratamiento delos accidentes de buceo, también ha sido utilizada en procesos relacionados con isquemia/necrosis.Estos antecedentes han supuesto que los investigadores y clínicos que tratamos a los pacientescon cáncer, hayamos abierto una línea de trabajo de la cual podría beneficiarse un grupo de pacientesseleccionado.En esta revisión describimos las bases físicas, técnicas y fisiopatológicas en relación con la Radioterapia(RT). Además hacemos una revisión básica de las indicaciones de la OHB, en función del áreaanatómica afecta
The increasing indications of radiation therapy (RT) as treatment of choice in specific oncologicalprocesses, the need to increase the intensity for an adequate tumor control, and a greater socialsensitivity about the value of the patients quality of life, impelled the search of supportive treatmentsto prevent and treat the radiotherapy complications in a more effective manner, and at a reasonablecost.The technique of the hyperbaric oxygen (HBO) therapy was introduced 80 years ago for thetreatment of diving accidents, and has also been used in processes related to ischemia/necrosis.These background drove the researchers and clinicians treating cancer patients to open a workingline that could benefit a group of selected patients.We describe in this review the physical, technical and physiological bases of radiation therapy(RT). We also make a basic review of the indications of HBO therapy according to the affectedanatomical area