Atypical diabetes in children: ketosis-prone type 2 diabetes.

Ketosis-prone type 2 diabetes mellitus also known as atypical or flatbush diabetes is being increasingly recognised worldwide. These patients are typically obese, middle-aged men with a strong family history of type 2 diabetes. The aetiology and pathophysiological mechanism is still unclear but some initial research suggests that patients with ketosis-prone type 2 diabetes have a unique predisposition to glucose desensitisation. These patients have negative autoantibodies typically associated with type 1 diabetes but have shown to have human leucocyte antigen (HLA) positivity. At initial presentation, there is an impairment of both insulin secretion and action. ß Cell function and insulin sensitivity can be markedly improved by initiating aggressive diabetes management to allow for discontinuation of insulin therapy within a few months of treatment. These patients can be maintained on oral hypoglycaemic agents and insulin therapy can be safely discontinued after few months depending on their ß cell function.

Subaponeurotic or subgaleal fluid collections in infancy: an unusual but distinct cause of scalp swelling in infancy.

Subaponeurotic or subgaleal fluid collection is a rare but important cause of scalp swelling in young infants. Fluid in the subaponeurotic or subgaleal space presents as soft, ill-defined, fluctuant, highly mobile scalp swelling and is not limited by suture lines, which makes it clinically very distinct from other scalp swellings. However, the aetiology of such swelling still remains uncertain but may be related to traumatic labour that manifests after the first few weeks of life. There is no indication for imaging if the condition is diagnosed clinically with confidence. The late subaponeurotic or subgaleal fluid collection resolves spontaneously without any intervention, hence conservative management is the treatment of choice.