ABSTRACT
BACKGROUND: The ORBE II study aimed to describe the characteristics and clinical outcomes of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting in Spain. METHODS: ORBE II (NCT04648839) was an observational, retrospective cohort study in adult SEA patients who had been prescribed benralizumab. Demographic and clinical data of 204 SEA patients were collected 12 months prior to benralizumab initiation (baseline) and at follow-up. Exacerbation rate, asthma symptoms, maintenance oral corticosteroid (OCS) use and lung function were evaluated, among other variables. RESULTS: A total of 204 SEA patients were evaluated. Mean (standard deviation, SD) age of the study population was 56.4 (12.4) years, 62.3% were women and mean (SD) duration of asthma was 15.1 (12.7) years. Median (Q1-Q3) follow-up duration was 19.5 (14.2-24.2) months. At baseline, 72.6% of the overall population (OP) presented blood eosinophil counts ≥ 300 cells/µL; 36.8% had comorbid chronic rhinosinusitis with nasal polyps (CRSwNP); 84.8% reported at least one severe exacerbation, and 29.1% were OCS-dependent. At 1 year of follow-up, patients receiving benralizumab treatment had a 85.6% mean reduction in exacerbations from baseline, and 81.4% of patients achieved zero exacerbations. We also found a clinically relevant mean (SD) increase in pre-bronchodilator (BD) FEV1 of 331 (413) mL, with 66.7% of patients achieving a pre-BD FEV1 increase ≥ 100 mL, and 46.3% of patients achieving a pre-BD FEV1 ≥ 80% of predicted. Regarding symptom control, 73.8% of the OP obtained an ACT score ≥ 20 points. After 1 year of follow-up, mean reduction in the daily OCS dose was 70.5%, and complete OCS withdrawal was achieved by 52.8% of the OCS-dependent patients. Almost half (43.7%) of the OP on benralizumab met all four criteria for clinical remission. Patients with concomitant CRSwNP obtained similar or enhanced outcomes. CONCLUSIONS: These data support the real-world benefits of benralizumab in SEA patients, and particularly in those with concomitant CRSwNP. TRIAL REGISTRATION: NCT04648839.
Subject(s)
Anti-Asthmatic Agents , Asthma , Pulmonary Eosinophilia , Sinusitis , Adult , Humans , Female , Middle Aged , Male , Anti-Asthmatic Agents/adverse effects , Retrospective Studies , Disease Progression , Asthma/diagnosis , Asthma/drug therapy , Asthma/epidemiology , Pulmonary Eosinophilia/diagnosis , Pulmonary Eosinophilia/drug therapy , Pulmonary Eosinophilia/epidemiology , Chronic Disease , Adrenal Cortex Hormones/therapeutic use , Sinusitis/complicationsABSTRACT
No disponible
Subject(s)
Humans , Aspergillosis, Allergic Bronchopulmonary/diagnosis , Aspergillosis, Allergic Bronchopulmonary/therapyABSTRACT
Entre el 15 y el 27% de los pacientes que ingresan en los hospitales españoles son consumidores de tabaco. La hospitalización es un momento idóneo para que el fumador se plantee el abandono del tabaco. Se ha realizado una búsqueda bibliográfica en MEDLINE entre el 1 de enero de 2002 y el 30 de septiembre de 2015, de estudios, controlados y aleatorizados u observacionales, relacionados con la ayuda para dejar de fumar a pacientes ingresados en el hospital. Basándose en los resultados de dichos estudios se han emitido unas recomendaciones para el tratamiento del tabaquismo en pacientes hospitalizados. Las recomendaciones han sido formuladas de acuerdo con el sistema GRADE. Ofrecer al fumador asesoramiento psicológico más tratamiento farmacológico mientras está ingresado en el hospital y prolongar el seguimiento durante al menos 4 semanas después del alta es la recomendación más efectiva para ayudar a dejar de fumar a los pacientes ingresados (AU)
Between 15 and 27% of patients admitted to Spanish hospitals are smokers. Hospitalization is an ideal time for a smoker to decide to quit. We performed a MEDLINE search of controlled, randomized or observational studies associated with helping hospitalized patients quit smoking, published between January 1, 2002 and September 30, 2015. On the basis of the results of those studies, we have issued some recommendations for the treatment of smoking in hospitalized patients. The recommendations were drawn up according to the GRADE system. Offering the smoker psychological counselling and prolonging follow-up for at least 4 weeks after discharge is the most effective recommendation for helping hospitalized patients to quit (AU)
Subject(s)
Humans , Smoking/therapy , Smoking Cessation/methods , Tobacco Use Cessation Devices , Psychotherapy/methods , Smoking Prevention , Hospitalization , Comprehensive Health Care/trends , Practice Patterns, Physicians'ABSTRACT
Between 15 and 27% of patients admitted to Spanish hospitals are smokers. Hospitalization is an ideal time for a smoker to decide to quit. We performed a MEDLINE search of controlled, randomized or observational studies associated with helping hospitalized patients quit smoking, published between January 1, 2002 and September 30, 2015. On the basis of the results of those studies, we have issued some recommendations for the treatment of smoking in hospitalized patients. The recommendations were drawn up according to the GRADE system. Offering the smoker psychological counselling and prolonging follow-up for at least 4 weeks after discharge is the most effective recommendation for helping hospitalized patients to quit.
