Comparison of vaginal birth outcomes in midwifery-led versus physician-led setting: A propensity score-matched analysis.

BACKGROUND: Experts in many countries are recommending a scaling up midwifery-led care as a model to improve maternal and newborn outcomes, reduce rates of unnecessary interventions, realise cost savings, and facilitate normal spontaneous vaginal birth. OBJECTIVE: The aim of this study was to compare midwifery-led and obstetrician-gynaecologist-led care-related vaginal birth outcomes. PARTICIPANTS: Pregnant women in Kaunas city maternity care facilities. METHODS: A propensity score-matched case-control study of midwifery-led versus physician-led low-risk birth outcomes. Patient characteristics and outcomes were compared between the groups. Continuous variables are presented as mean ± standard deviation and analysed using the Mann-Whitney U test. Categorical and binary variables are presented as frequency (percentage), and differences were analysed using the chi-square test. Analyses were conducted separately for the unmatched (before propensity score matched [PSM]) and matched (after PSM) groups. RESULTS: After adjusting groups for propensity score, postpartum haemorrhage differences between physician-led and midwifery-led labours were significantly different (169.5 and 152.6 mL; p = 0.026), same for hospital stay duration (3.3 and 3.1 days, p = 0.042). Also, in matched population, significant differences were seen for episiotomy rates (chi2 = 4.8; p = 0.029), newborn Apgar 5 min score (9.58 and 9.76; p = 0.002), and pain relief (chi2 = 14.9; p = 0.002). Significant differences were seen in unmatched but not confirmed in matched population for obstetrical procedures used during labour, breastfeeding, birth induction, newborn Apgar 1 min scores, and successful vaginal birth as an overall spontaneous vaginal birth success measure. CONCLUSION: The midwifery-led care model showed significant differences from the physician-led care model in episiotomy rates, hospital stay duration and postpartum haemorrhage, and newborn Apgar 5 min scores. Midwifery-led care is as safe as physician-led care and does not influence the rate of successful spontaneous vaginal births.

Does treatment impact health outcomes for patients after acute coronary syndrome?

BACKGROUND: Mortality rates for acute coronary syndrome (ACS) patients are still very high all over the world. Our study aimed to investigate the impact of ACS treatment on cardiovascular (CV) mortality eight years following ACS. METHODS: A retrospective cohort study with a total of 613 patients was used. The data was collected from databases and medical records. An evidence-based treatment (EBT) algorithm was used based on the ESC guidelines. Logistic regression analysis and standardized odds ratios with 95% confidence interval (CI) were used for the risk assessment, with a p level<0.05 considered as significant. RESULTS: The median follow-up time in this study was 7.6 years. During follow-up 48.9% of the patients (n=300) died from CV and 207 (69%) for a relevant reason. For monotherapy ACE inhibitors and ß-blockers, and for fixed dose combined drugs ACE inhibitors and diuretics, were most frequently used. EBT was provided to 37.8% of patients. The EBT use (HR 0.541, CI 0.394-0.742, p<0.001) during follow-up period was important for reducing CV mortality in ACS patients. CONCLUSIONS: The combined use of EBT significantly improved outcomes. The recurrent myocardial infarction and percutaneous coronary intervention patients were more frequent in EBT and it was beneficial for reducing CV mortality.

Does illness perception explain quality of life of patients with prostate cancer?

BACKGROUND: It is licely that illness perceptions can explain variations in quality of life of patients with prostate cancer across different treatment methods and stages. Therefore, the aim of this study was to determine if illness perception can explain variations in quality of life of patients with prostate cancer. MATERIAL AND METHODS: The cross-sectional national-level study was carried out. Quality of life was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Visual Analogue Scale. Illness perceptions were measured by the revised Illness Perception Questionnaire. RESULTS: The response rate was 77.1% (N=501). The variation in global quality of life was explained (32.0%) by levels of emotional representation (ß=-0.126; P=0.023) and consequences (ß=-0.209; P<0.01); physical functioning (27.0%), by consequences (ß=-0.203; P<0.01) and chemotherapy (ß=-2.911; P=0.007); role functioning (37.0%), by emotional representations (ß=-0.198; P<0.01), timeline cyclical (ß=-0.209; P=0.014), and stage of the disease (ß=-0.779; P=0.007); emotional functioning (43.0%), by emotional representations (ß=-0.361; P<0.01) and education level (ß=-0.566; P=0.025); cognitive functioning (34.0%), by educational level (ß=0.714; P=0.005), emotional representations (ß=-0.118; P=0.019), illness coherence (ß=-0.167; P=0.030), consequences (ß=-0.187; P=0.001), and hormonal therapy (ß=-0.778; P=0.049); and social functioning (39.0%), by consequences (ß=-0.320; P<0.01) and combined treatment (ß=-1.492; P=0.016). CONCLUSIONS: Illness perceptions may be important while investigating quality of life in patients with prostate cancer. It may underlie quality-of-life differences in this group of patients and could inform decision makers about the importance of the provision of psychosocial services to patients with prostate cancer.

Does quality of life of prostate cancer patients differ by stage and treatment?

BACKGROUND: The lack of consensus amongst experts delineate how important it is for patients diagnosed with prostate cancer (PCa) to make an informed decision on available treatment options through an objective discussion of the risks and benefits. One of important benefits could be seen as patient's quality of life (QoL) after treatment. We aimed to assess QoL differences in prostate cancer patients by stage and treatment for a population-based sample. METHODS: The cross-sectional PCa patient population-based national level study for a prostate cancer patient population was performed. QoL was investigated with EORTC QLQ-C30. The analysis includes descriptive statistics and evaluation of differences in functional and symptom scales by stage and treatment group by predictors in the model. RESULTS: Response rate was 79.1% (N=514). The highest QoL scores were observed in localised PCa, active surveillance treatment group. The lowest scores were observed in advanced stages, chemotherapy treatment group. Between cancer stages, statistically significant differences were observed only in scales of emotional functioning (p<0.001) and social functioning (p<0.001). Between treatment groups, statistically significant differences were observed in scales of physical functioning (p<0.001), role functioning (p<0.001), emotional functioning (p<0.001), and social functioning (p<0.001). CONCLUSIONS: Our study highlighted statistically significant differences in QoL between cancer stages and treatment. Understanding how the QoL changes in relation with the selected treatment option can be important to the urologist and individual patient to have realistic expectations as well as to optimise treatment decisions for the prostate cancer patient when exist several alternatives.

Factors affecting electronic health information needs in primary care patients.

BACKGROUND: Electronic health information is a new concept in the Lithuanian healthcare system. It gives the possibility of obtaining accurate medical information online by quick, convenient, and private access and presents to the patients the opportunity for better-informed decisions on their own health and greater participation in healthcare processes. The aim of this study is to assess the availability of health information for patients and to assess the factors affecting a patient's health-related information needs on the Internet. SUBJECTS AND METHODS: A cross-sectional study design was used. Self-perceived needs for health-related information and health-related information on the Internet were evaluated by means of a questionnaire. The questionnaires were distributed to the patients during on-site visits to primary care physician. Cumulative numbers of health information searches were calculated. RESULTS: The Internet was used by 63.2% of the respondents. Electronic health information search indicated 47.3% were Internet users. Internet users were statistically significantly more satisfied and informed about available electronic health services: registration for physician services (p<0.001), health information portal (p<0.001), electronic health record (p<0.001), clinical investigations (p=0.001), medical consultations (p=0.009), patient health education services (p=0.019), and patient self-help groups. A higher frequency of health information searches on the Internet was more associated with female patients (odds ratio [OR], 3.1; p=0.012), patients having chronic disease (p=0.013), living in couples (OR, 14.8; p=0.031), having e-health service experience (OR, 7.0; p<0.001), daily Internet user (OR, 6.7; p=0.054), and longer duration of Internet use per day (OR, 1.3; p=0.046). CONCLUSIONS: The Internet is an important source of health information. Internet users are more satisfied with available health information. Female patients, those having chronic disease, living as couples, and having e-health service experience, and daily Internet users are the most frequent users of health information on the Internet.

Changes in caries prevalence and oral hygiene skills among preschool-aged children in Lithuania between 2000 and 2010.

UNLABELLED: The aim of the study was to evaluate the factors associated with the prevalence and severity of dental caries as well oral hygiene habits among 4- to 6-year-old children in Kaunas (Lithuania) in 2000 and 2010. MATERIAL AND METHODS: A repeated cross-sectional study was carried out to reveal the changes in dental caries prevalence in 2000 and 2010. The study population comprised 4- to 6-year-old children living in Kaunas city and attending kindergartens. The study consisted of two parts: questionnaires on oral health behavior and clinical examination of children's teeth by the World Health Organization methodology. RESULTS: A total of 941 4-6-year-old children were examined in 2000 and 2010. The prevalence of dental caries increased from 85.4% in 2000 to 88.4% in 2010; however, the difference was not significant (P=0.28). A significant increase in the dmf-t index, describing the severity of dental caries, was observed (from 7.42 in 2000 to 12.03 in 2010, P<0.001). The percentage of 4- to 5-year-old girls and 5-year-old boys brushing their teeth regularly decreased in 2010. During the period of the study, a significant change in the accumulation of plaque on children's tooth surfaces was documented (P=0.001). CONCLUSIONS: Comparing 2000 and 2010, no significant difference in the prevalence of dental caries among 4- to 6-year-old children in Kaunas was observed; however, the severity of dental caries differed significantly. A significant decrease in regular toothbrushing skills was documented for 4- and 5-year-old girls and 5-year-old boys. The Silness-Loe oral hygiene index was assessed as satisfactory.

Effectiveness of telemedicine and distance learning applications for patients with chronic heart failure. A protocol for prospective parallel group non-randomised open label study.

INTRODUCTION: Chronic heart failure in Baltic Sea Region is responsible for more hospitalisations than all forms of cancer combined and is one of the leading causes of hospitalisations in elderly patients. Frequent hospitalisations, along with other direct and indirect costs, place financial burden on healthcare systems. We aim to test the hypothesis that telemedicine and distance learning applications is superior to the current standard of home care. METHODS AND ANALYSIS: Prospective parallel group non-randomised open label study in patients with New York Heart Association (NYHA) II-III chronic heart failure will be carried out in six Baltic Sea Region countries. The study is organised into two 6-month follow-up periods. The first 6-month period is based on active implementation of tele-education and/or telemedicine for patients in two groups (active run period) and one standard care group (passive run period). The second 6-month period of observation will be based on standard care model (passive run period) to all three groups. Our proposed practice change is based on translational research with empirically supported interventions brought to practice and aims to find the home care model that is most effective to patient needs. ETHICS AND DISSEMINATION: This study has been approved by National Bioethics Committee (2011-03-07; Registration No: BE-2-11). TRIAL REGISTRATION: This study has been registered in Australian New Zealand Clinical Trials Registry (ANZCTR) with registration number ACTRN12611000834954.

Survival of women with breast cancer in Kaunas Region, Lithuania.

OBJECTIVE. The assessment of breast cancer survival rates and comparison with those of other countries may help to deepen knowledge among decision makers in the health care system and to improve the inequalities in accessibility to early detection and effective treatment. The aim of this study was to evaluate breast cancer survival rates in Kaunas region, Lithuania, and to compare them with those in the selected European countries. MATERIAL AND METHODS. A retrospective study was carried out using medical records and data gathered from the Lithuanian Cancer Registry. A group of 240 patients with primary breast cancer diagnosed in 2008 in Kaunas region was analyzed. All causes of death were included in the analysis. The closing date of follow-up was September 30, 2010. Survival was determined using the life-table method and the Kaplan-Meier method. Cox proportional hazard models were used to estimate the effects of prognostic risk factors on survival. RESULTS. The median age of the patients was 63 years (range, 28-95). The 1-year and 2-year cumulative survival for breast cancer patients in Kaunas region, Lithuania, was 94.2% and 90.1%, respectively. As expected, the survival of patients with diagnosed advanced disease (stage III and IV) was significantly worse than that of patients with stage I (P<0.001) and II (P=0.003) disease. The screening group (aged 50-69 years) showed better survival in comparison with the group older than 69 years. Age, T4 tumor, and distant metastasis were the prognostic factors significantly associated with an increased relative mortality risk of breast cancer. CONCLUSIONS. Compared to the European survival rates, the 1-year and 2-year survival of patients with breast cancer in Lithuania was found to be similar to most European countries.

Healthcare spending in the case of a HPV16/18 population-wide vaccination programme.

BACKGROUND: The policy of population-wide human papillomavirus (HPV) vaccination has been debated as the introduction of such a programme in a low-resource country faces the risk of insufficient cost-effectiveness. OBJECTIVES: To assess the potential healthcare spending changes after the introduction of a HPV16/18 population-wide vaccination programme in Lithuania. STUDY DESIGN: For a cost-effectiveness analysis, we used mathematical simulation and epidemiological data modelling based on a Lithuanian female population. We performed comparative analysis of an annual 12-year-old girls population-wide vaccination programme combined with cervical cancer screening programme compared to the screening programme strategy only. RESULTS: HPV vaccination would gain an average of 35.6 life years per death avoided or up to 284.8 thousand life years would be gained over 90 years in total. The programme costs would be 2932.58 EUR per life year gained. All costs associated with the introduction of the vaccination programme could be recovered in 48 years. The HPV vaccination programme in Lithuania has the potential to generate up to 40.07 million EUR of economic returns annually compared with the current practice of the cervical screening alone. CONCLUSIONS: In Lithuania the HPV16/18 vaccination programme would be economically effective only in the long term. The investment costs of HPV16/18 vaccination have the potential to be recovered.

Factors affecting health-related quality of life in prostate cancer patients.

OBJECTIVE: Prostate cancer is the most common cancer among men in Lithuania. Quality of life (QoL) assessment plays a key role in the evaluation and treatment of cancer patients. The aim of this study was to evaluate factors affecting the QoL of patients with prostate cancer in Lithuania. MATERIAL AND METHODS: A cross-sectional national-level study was performed. QoL was investigated with the EORTC QLQ-C30 questionnaire. Statistical analysis included descriptive statistics, interrelationship analysis between characteristics and multivariate logistic regression to estimate predictors and odds ratios (ORs) for each of the independent variables in the model. RESULTS: The response rate was 74.8% (N = 486). One-quarter of respondents with prostate cancer indicated high QoL scores. Higher QoL scores were given for prostate cancer patients with lower education level [OR = 3.092, 95% confidence interval (CI) 1.007-9.491, p = 0.049], having lower monthly expenses for treatment (OR = 3.653, CI 1.318-10.128, p = 0.013), disease stage II (by patient conveyance) (OR = 10.053, CI 1.015-99.534, p = 0.048), disease stage I (by medical record) (OR = 2.19E + 08, CI 218514200.17-218514200.17, p < 0.001) and in those with undisclosed disease stage (OR = 9.220, CI 1.251-67.965, p = 0.029). CONCLUSIONS: Significant predictors for higher QoL scores were education level, own monthly expenses for treatment and disease stage. Patients with undisclosed disease stage more often had higher QoL scores.

The relation between oral hygiene skills and the prevalence of dental caries among 4 - 6-year-old children.

AIM OF THE STUDY. To evaluate the tooth brushing skills and the prevalence of dental caries as well as its intensity in relation to oral hygiene skills among 4 - 6-year-old children. MATERIAL AND METHODS. The cross-sectional study was performed from November 16, 2009 to January 12, 2010. 235 children (4 - 6-year old) were randomly selected from kindergartens in Plunge and Jonava in Lithuania. The results of study were registered in the special forms prepared in accordance with the recommendations of WHO. Parents of the children were asked to fill in the questionnaires. RESULTS. The results of the study show that 91% (Plunge) and 90% (Jonava) of 4 - 6-year-old children have caries in their primary teeth. The prevalence of caries is different in relation to age: 78.7% of 4-year-old children, 97.3% of 5-year-old children, and 95.3% of 6-year-old children. The intensity of caries is as follows: 4.9 (SN=±4.9), 7.5 (SN=±4.5), and 8.2 (SN=±4.7). CONCLUSIONS. There is the high prevalence of caries, particularly of not treated forms, among 4 - 6-year-old children. The oral hygiene index is just satisfactory.

Willingness to use eHealth services in Lithuanian healthcare institutions. Countrywide survey.

BACKGROUND: Lithuania started to implement its own National eHealth Service System (NESS) in 2005. In May 2007, an eHealth system development strategy for the period 2007-2015 was prepared. In general, it is expected that these processes will lead to a higher level of citizens' awareness and involvement in protecting their health, as well as more effective use of available resources for provision and expansion of healthcare services, based on modern IT technologies. However, the implementation of the system is very slow and difficult. We aimed to assess competence and willingness of healthcare institutions (HCIs) to implement the NESS in primary care healthcare institutions in Lithuania. METHODS: A cross-sectional study design was used. Questionnaires with letters of invitation to participate in the study were sent to 150 Lithuanian HCIs by mail. Only one questionnaire per HCI was sent. HCI head administrative staff (e.g., director, medical director, head of administration) was asked to answer the questionnaires. RESULTS: A total of 68 replies from all HCIs were received. Response rate to the survey was 45.3%. The eHealth system implementation was mostly expected in eAdministration (77.9%), eReimbursement (47.1%) and Institutional EPR systems (47.1%). There was a lower willingness to start implementing ePrescriptions (4.4%), a picture archiving and communication system (PACS, 8.8%), eLaboratory (11.8%) and Telemedicine (13.2%) services. A lack of competence and knowledge in eHealth system implementation was recorded in the following: digital data protection (p=0.006), IT (p=0.028), health technology (p=0.032) and National eHealth Strategy (p=0.036). CONCLUSIONS: Most Lithuanian HCIs are planning to participate in the implementation of NESS. HCIs are mostly willing to use eAdministration, eReimbursement and Institutional electronic patient record systems. HCIs highlighted a lack of key competences in eHealth system implementation.

Cost-effectiveness of 12- and 15-year-old girls' human papillomavirus 16/18 population-based vaccination programmes in Lithuania.

BACKGROUND: There is a large difference in the prevalence of cervical cancer between European countries. Between European Union countries, cervical cancer is the most prevalent in Lithuania. Currently we have available vaccines for different types of human papillomavirus virus (HPV), but we lack evidence on how the vaccination would be cost-effective in low-resource Eastern European countries like Lithuania. OBJECTIVES: To create a simulation model for the Lithuanian population; to estimate epidemiological benefits and cost-effectiveness for a HPV16/18 vaccination programme in Lithuania. STUDY DESIGN: For the cost-effectiveness analysis, we used Lithuanian population mathematical simulation and epidemiological data modelling. We performed comparative analysis of annual vaccination programmes of 12-year-old or 15-year-old girls at different vaccine penetration levels. POPULATION: Lithuanian female population at all age groups. RESULTS: A vaccination programme in Lithuania would gain an average of 35.6 life years per death avoided. Vaccinated girls would experience up to 76.9% overall reduction in incidence of cervical cancers, 80.8% reduction in morbidity and 77.9% reduction in mortality over their lifetime. Cost per life year gained with different vaccine penetration levels would range from 2167.41 Euros to 2999.74 Euros. CONCLUSIONS: HPV vaccination in Lithuania would have a very positive impact on the epidemiological situation and it would be cost-effective at all ranges of vaccine penetration. Vaccination in Lithuania in the long term potentially could be more cost-effective due to avoiding early disease onset and lower accumulation of period costs.

Cost-utility analysis of methadone maintenance treatment in Lithuania.

BACKGROUND: Economic evaluations in health care involve the identification, measurement, valuation, and then comparison of the costs (inputs) and outcomes of treatments or preventive activities. The aim was to analyze the cost-utility of six-month methadone maintenance treatment program in a Lithuanian primary health care setting. METHODS: A prospective study design was used. All the information was obtained through the validated questionnaires at the baseline and 3- and 6-month follow-ups. WHOQOL-BREF was used to assess the quality of life; the costs were assessed using the DATCAP methodology from the perspective of a patient and outpatient clinic during follow-up period. RESULTS: A total of 102 opioid-dependent patients were recruited in the study; 512 follow-up patient-months were obtained. The methadone maintenance treatment has significantly improved physical, psychological, and environmental components of quality of life during follow-up. Total program costs were 61 288.87 EUR. Cost paid by a patient comprised about 31% of total program costs. Cost per quality-adjusted life-month (QALM) for physical domain was 2227.55 EUR; for psychological domain, 1879.50 EUR; for social domain, 5467.64 EUR; and for environmental domain, 4626.47 EUR. Costs per QALM and quality-adjusted life-year (QALY) for total quality of life in the maintenance program were 2864.00 EUR and 34 368.00 EUR, respectively. CONCLUSIONS: Our results showed that 6-month methadone maintenance program was effective in the terms of quality-of-life improvement. Methadone maintenance treatment program was less effective in terms of cost per QALY.

Cost-effectiveness and cost-utility of the treatment of chronic hepatitis B with peginterferon alfa-2a, interferon alfa, and lamivudine in Lithuania.

BACKGROUND: Chronic hepatitis B infection is an important health care problem worldwide. According to the World Health Organization, 10% to 15% of population is infected with hepatitis B virus. Nearly 100 new cases of acute hepatitis B are annually registered in Lithuania, but official statistics covers only 8-25% of all disease incidence. The aim of this study was to evaluate the cost-effectiveness of the treatment of chronic hepatitis B with peginterferon alfa-2a and compare it to treatment with interferon alfa and lamivudine in Lithuania. MATERIAL AND METHODS: A Markov model was used to evaluate long-term cost-effectiveness of the treatment with peginterferon alfa-2a and to compare it with treatment with interferon alfa and lamivudine. Peginterferon alfa-2a was administered by subcutaneous injections at a dosage of 180 µg every week for 48 weeks; interferon alfa, 6 million IU three times a week for 24 weeks; and lamivudine, 100 mg per day from 48 weeks to 5 years for HBeAg-positive chronic hepatitis B and 100 mg per day up to 5 years in HBeAg-negative chronic hepatitis B. RESULTS: Treatment with peginterferon alfa-2a gained 1.179 life years as compared to 0.658 life years gained with treatment with interferon alfa; incremental costs per incremental life-year gained (LYG) were 51,256.92 Lt (14,845.03 €). Treatment with peginterferon alfa-2a gained 0.545 quality-adjusted life-years (QALYs) with incremental costs per incremental QALY of 48,980.08 Lt (14,185.61 €). Treatment with peginterferon alfa-2a had twice higher cost-effectiveness than treatment with interferon alfa: 50,4167.00 Lt (146,016.85 €) vs. 954,020.08 Lt (276,303.31 €), respectively. Costs for a complete response were also twice lower. Treatment with peginterferon alfa-2a gained 0.757 incremental LYG more compared to lamivudine (48-week course). Comparing incremental cost-effectiveness using peginterferon alfa-2a for treatment, incremental costs per incremental LYG were 41,993.67 Lt (12,162.21 €); additionally there was a gain of 0.792 incremental QALYs, while incremental costs for incremental QALY were 40,096.19 Lt (11,612.66 €). Complete response costs were 83,515.98 Lt (24,187.89 €) less compared to lamivudine (48-week course). CONCLUSIONS: Treatment of chronic hepatitis B prolongs patients' overall survival and quality-adjusted life. Peginterferon alfa-2a was the most effective drug registered in Lithuania for CHB treatment.

Associations between parental skills and their attitudes toward importance to develop good oral hygiene skills in their children.

BACKGROUND: For many years, poor oral hygiene and frequent consumption of sugars is known as key behavioral risk factors for oral diseases, such as dental caries and periodontal disease. Parental attitudes toward children's oral health could be associated with their own oral health skills. We aimed to analyze associations between parental skills and attitudes toward caries development and possibilities to control positive oral health behavior in their children. MATERIAL AND METHODS: A cross-sectional study involved 550 parents of 3- to 4-year-old children. A 40-item questionnaire was developed from the Theory of Planned Behavior, Health Belief Model and the Health Locus of Control model, and parental attitudes toward dental caries in their children were analyzed. RESULTS: A total of 397 filled-in questionnaires were collected; the response rate was 72%. Parents with good own oral hygiene skills significantly more often understood the importance of brushing their children's teeth (chi(2)=29.8; df=1; P<0.001). Study results highlighted also significant differences in importance to prevent tooth decay (chi(2)=3.1; df=1; P=0.051), importance to control sugar snacking (chi(2)=10.6; df=1; P=0.001), and parental perceived seriousness of tooth decay in children (chi(2)=9.2; df=1; P=0.002) comparing parents with poor and good oral hygiene skills. Differences in parental efficacy to control proper toothbrushing and parental efficacy to control sugar snacking in children were not significant comparing both groups. CONCLUSIONS: More than half (61%) of the parents have reported appropriate own oral hygiene skills. Parental attitudes toward children's oral health were significantly associated with their own oral health behavior and understanding the importance of development of oral hygiene skills in their children.