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1.
Occup Med (Lond) ; 72(2): 81-90, 2022 02 22.
Article in English | MEDLINE | ID: mdl-34729607

ABSTRACT

BACKGROUND: First responders (FRs) are frequently exposed to potentially traumatic events, including terror attacks, and may consequently be at risk of developing mental health disorders. Prior research suggests that FRs with mental health disorders often do not receive appropriate treatment. More knowledge is needed about their use of mental health care (MHC). AIMS: This study aimed to identify factors associated with receiving immediate support, post-immediate support and engagement in MHC among FRs of the November 2015 terror attacks in Paris. METHODS: A web-based study was conducted 8-12 months after the attacks on 663 FRs who were mobilized during the night and/or the aftermath of the attacks. Logistic regression was performed to analyse factors associated with MHC. RESULTS: Overall, 44 FRs sought MHC. Among FRs with post-traumatic stress disorder (PTSD), partial PTSD or depression (n = 60), 38% sought MHC (n = 23). Post-immediate support was associated with immediate support, and both were associated with knowing someone who could help regarding the potential psychological risks following a traumatic event. MHC engagement was associated with a history of MHC, post-immediate support and the presence of PTSD, partial PTSD or depression. CONCLUSIONS: Among FRs with PTSD, partial PTSD or depression, few sought MHC. Improved access to MHC for FRs after terror attacks is essential. Knowing someone who could help regarding potential psychological risks may facilitate immediate and/or post-immediate support. Furthermore, post-immediate support could encourage engagement in MHC. Efforts should be made before and after potentially traumatic events to ensure mental health education for FR.


Subject(s)
Emergency Responders , Stress Disorders, Post-Traumatic , Terrorism , Humans , Paris/epidemiology , Patient Acceptance of Health Care , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/therapy , Terrorism/psychology
2.
BMC Public Health ; 20(1): 754, 2020 May 24.
Article in English | MEDLINE | ID: mdl-32448209

ABSTRACT

BACKGROUND: HIV prevalence in correctional facilities may be 2 to 10 times higher than in the general adult population. Antiretroviral therapy (ART) interruption is frequent after an incarceration. This, in combination with post-release high-risk behaviors, may have detrimental consequences on the epidemic. Although return to care after release from correctional facilities has been described in many North American settings, data from South America seemed scarce. French Guiana is the only French territory located in South America. In 2014, HIV prevalence was estimated at 1.2% among pregnant women and oscillated around 4% in the only correctional facility. METHOD: HIV-infected adults released from the French Guiana correctional facility between 2007 and 2013 were included in a retrospective cohort survey. The first objective was to describe the cascade of care in the 4 years following release. The secondary objectives were to describe contacts with care and to identify factors associated with return to HIV care, 1 year after release. RESULTS: We included 147 people, mostly males (81.6%). The median time before the first ambulatory consultation was 1.8 months. Within 1 year after release, 27.9% came for unscheduled emergency consultations, 22.4% were hospitalized. Within 4 years after release, 40.0-46.5% were in care, 22.4% archieved virological success. Being on ART when incarcerated was associated with HIV care (aIRR: 2.0, CI: 1.2-3.0), whereas being HIV-diagnosed during the last incarceration was associated with poor follow-up (aIRR: 0.3, CI: 0.1-0.9). CONCLUSION: The risk of HIV-follow-up interruption is high, after an incarceration with HIV. ART supply should be sufficient to cover the timespan following release, several months if possible. Those not on ART at the time of incarceration may require special attention, especially those newly HIV-diagnosed while in custody. Comprehensive programs are necessary to support ex-offenders to stay on ART after incarceration.


Subject(s)
Continuity of Patient Care/statistics & numerical data , Emergency Service, Hospital/statistics & numerical data , HIV Infections/therapy , Patient Acceptance of Health Care/psychology , Patient Acceptance of Health Care/statistics & numerical data , Prisoners/psychology , Prisoners/statistics & numerical data , Adult , Cohort Studies , Female , French Guiana/epidemiology , HIV Infections/epidemiology , Humans , Male , Pregnancy , Prevalence , Retrospective Studies
3.
J Affect Disord ; 229: 314-321, 2018 03 15.
Article in English | MEDLINE | ID: mdl-29329065

ABSTRACT

PURPOSE: Women are disproportionately likely to suffer from depression. This is especially true for those who experience socioeconomic hardship, such as homelessness. In France, among homeless mothers many are migrant. However, it is not clear whether risk factors associated with depression are specific for this group or the same as in the general population. Our objective was to describe socio-demographic, relational, living and housing conditions and health factors associated with depression among homeless mothers. METHODS: The ENFAMS survey, conducted via face-to-face bilingual interviews with a representative sample of homeless families in the Paris region (January-May 2013, n = 733 mothers). Mothers reported their socio-demographic characteristics, housing conditions including residential mobility, as well as physical and mental health. Depression was ascertained using the Composite International Diagnostic Interview (CIDI). Factors associated with mother's depression were studied in weighted Poisson regression models with robust error variance. RESULTS: The prevalence of depression among participating mothers was 28.8%. In multivariate analyses, depression was associated with fluency in French (PR = 1.88 95% CI 1.40; 2.51), suicide risk (PR = 2.26, 95% CI 1.82; 2.82), post-traumatic stress disorder (PR = 1.97, 95% CI 1.50; 2.60), and unmet health needs (PR = 1.68, 95% CI 1.09; 2.57). CONCLUSIONS: Homeless mothers have high levels of depression and associated psychiatric comorbidities. Associated risk factors appear to be both specific for this group and shared with mothers in the general population. Improvements in the monitoring of mental health difficulties as well as access to appropriate medical care in this vulnerable population may help improve health and social outcomes.


Subject(s)
Depression/epidemiology , Ill-Housed Persons/psychology , Ill-Housed Persons/statistics & numerical data , Mothers/psychology , Mothers/statistics & numerical data , Surveys and Questionnaires , Adult , Female , France/epidemiology , Housing , Humans , Male , Middle Aged , Prevalence , Vulnerable Populations/psychology , Vulnerable Populations/statistics & numerical data , Young Adult
4.
Epidemiol Infect ; 145(16): 3455-3467, 2017 12.
Article in English | MEDLINE | ID: mdl-29168445

ABSTRACT

Introduction An unprecedented outbreak of Ebola virus diseases (EVD) occurred in West Africa from March 2014 to January 2016. The French Institute for Public Health implemented strengthened surveillance to early identify any imported case and avoid secondary cases. METHODS: Febrile travellers returning from an affected country had to report to the national emergency healthcare hotline. Patients reporting at-risk exposures and fever during the 21st following day from the last at-risk exposure were defined as possible cases, hospitalised in isolation and tested by real-time polymerase chain reaction. Asymptomatic travellers reporting at-risk exposures were considered as contact and included in a follow-up protocol until the 21st day after the last at-risk exposure. RESULTS: From March 2014 to January 2016, 1087 patients were notified: 1053 were immediately excluded because they did not match the notification criteria or did not have at-risk exposures; 34 possible cases were tested and excluded following a reliable negative result. Two confirmed cases diagnosed in West Africa were evacuated to France under stringent isolation conditions. Patients returning from Guinea (n = 531; 49%) and Mali (n = 113; 10%) accounted for the highest number of notifications. CONCLUSION: No imported case of EVD was detected in France. We are confident that our surveillance system was able to classify patients properly during the outbreak period.


Subject(s)
Disease Outbreaks , Hemorrhagic Fever, Ebola , Public Health Surveillance , Travel , Adolescent , Adult , Africa, Western/ethnology , Aged , Aged, 80 and over , Disease Outbreaks/prevention & control , Disease Outbreaks/statistics & numerical data , Ebolavirus , Female , France/epidemiology , Hemorrhagic Fever, Ebola/epidemiology , Hemorrhagic Fever, Ebola/ethnology , Hemorrhagic Fever, Ebola/prevention & control , Humans , Infant , Male , Middle Aged , Young Adult
5.
Eur Psychiatry ; 38: 51-60, 2016 10.
Article in English | MEDLINE | ID: mdl-27664530

ABSTRACT

PURPOSE: Children growing up in homeless families are disproportionately more likely to experience health and psychological problems. Our objective was to describe social, environmental, individual and family characteristics associated with emotional and behavioral difficulties among homeless children living in the Paris region. METHODS: Face-to-face interviews with a representative sample of homeless families were conducted by bilingual psychologists and interviewers between January and May 2013 (n=343 children ages 4-13 years). Mothers reported children's emotional and behavioral difficulties (Strength and Difficulties Questionnaire [SDQ]), family socio-demographic characteristics, residential mobility, and parents' and children's physical and mental health. Children were interviewed regarding their perception of their living arrangements, friendships and school experiences. We studied children's SDQ total score in a linear regression framework. RESULTS: Homeless children had higher SDQ total scores than children in the general population of France, (mean total score=11.3 vs 8.9, P<0,001). In multivariate analyses, children's difficulties were associated with parents' region of birth (beta=1.74 for Sub-Saharan Africa, beta=0.60 for Eastern Europe, beta=3.22 for other countries, P=0.020), residential mobility (beta=0.22, P=0.012), children's health (beta=3.49, P<0.001) and overweight (beta=2.14, P=0.007), the child's sleeping habits (beta=2.82, P=0.002), the mother's suicide risk (beta=4.13, P<0.001), the child's dislike of the family's accommodation (beta=3.59, P<0.001) and the child's experience of bullying (beta=3.21, P=0.002). CONCLUSIONS: Children growing up homeless experience high levels of psychological difficulties which can put them at risk for poor mental health and educational outcomes long-term. Access to appropriate screening and medical care for this vulnerable yet underserved group are greatly needed.


Subject(s)
Child Behavior Disorders/epidemiology , Child Health/statistics & numerical data , Health Status , Ill-Housed Persons/psychology , Child , Child Behavior , Child Behavior Disorders/psychology , Child, Preschool , Europe, Eastern , Family Characteristics , Female , France , Ill-Housed Persons/statistics & numerical data , Humans , Male
6.
Br J Dermatol ; 174(1): 104-12, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26473766

ABSTRACT

BACKGROUND: Dermatological infections constitute the most common health problem in the homeless population. OBJECTIVES: To estimate the prevalences of scabies and pediculosis corporis and to identify associated factors in the homeless population. METHODS: Two randomized cross-sectional surveys were performed, one on the homeless population sleeping in public places in Paris, and the other on the homeless population in various shelters in the Ile-de-France administrative region. Overall 341 and 667 people, respectively, were interviewed about sociodemographic characteristics, lifestyle and hygiene practices, and were examined by a nurse. RESULTS: In individuals sleeping in public places the prevalence of scabies was estimated at 6·5% [95% confidence interval (CI) 0·5-12·5] and for pediculosis corporis at 5·4% (95% CI 1·7-9·1). For those sleeping in shelters these values were 0·4% (95% CI 0·1-1·8) and 0·15% (95% CI 0·0-9·7), respectively (P < 0·01 in both cases). In public places, after multivariate analysis, being a woman, citing squats among the three main types of accommodation and not possessing a sleeping bag were significantly associated with diagnosis of scabies. Likewise, begging, a history of pubic lice, and not taking showers in municipal baths were associated with pediculosis corporis in public places. CONCLUSIONS: Firstly, this study highlights the real existence of two distinct subpopulations having different sociodemographic characteristics, with specific lifestyles and practices, and with different prevalences of ectoparasitism. Secondly, the results of the multivariate analyses will help the implementation of specific actions targeting the group of people who sleep in public places.


Subject(s)
Ill-Housed Persons/statistics & numerical data , Lice Infestations/epidemiology , Scabies/epidemiology , Animals , Cross-Sectional Studies , Female , Humans , Hygiene , Male , Paris/epidemiology , Pediculus , Prevalence , Scalp Dermatoses/epidemiology
9.
Euro Surveill ; 19(38)2014 Sep 25.
Article in English | MEDLINE | ID: mdl-25306877

ABSTRACT

In March 2014, a person in their eighties who was diagnosed with extensive cellulitis due to toxigenic Corynebacterium ulcerans died from multiple organ failure. Environmental investigation also isolated C. ulcerans in biological samples from two stray cats in contact with the case. This finding provides further evidence that pets can carry toxigenic C. ulcerans and may be a source of the infection in humans.


Subject(s)
Cat Diseases/transmission , Cellulitis/diagnosis , Corynebacterium Infections/transmission , Corynebacterium/isolation & purification , Pets/microbiology , Aged, 80 and over , Animals , Anti-Bacterial Agents/therapeutic use , Cat Diseases/microbiology , Cats , Cellulitis/drug therapy , Cellulitis/microbiology , Corynebacterium Infections/diagnosis , Corynebacterium Infections/drug therapy , Corynebacterium Infections/microbiology , Fatal Outcome , France , Humans , Male
10.
Int J Hyg Environ Health ; 216(3): 271-9, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23394847

ABSTRACT

The ubiquitous use of phthalate esters in plastics, building material, medical devices, personal care products and food packaging materials results in a widespread exposure of general population. This study reports measurement of urinary concentration of phthalate metabolites in France and provides a first assessment of the exposure of French pregnant women to this chemical class. For the majority of the phthalate metabolites, concentrations measured in urine were similar to those reported in previous studies except for two phthalates that were characterized by high concentrations of metabolites if compared to previous European and American studies: DiNP (Di-iso-nonylphthalate) and DEHP (Di(2-ethylhexyl)phthalate). In a second part of the study, a pharmacokinetic model was used in order to gain understanding on exposure to DEHP. A high concentration of the primary metabolite of DEHP, MEHP (Mono(2-ethylhexyl)phthalate), was thus identified probably because of a very recent exposure to perfusion materials at the hospital. Pharmacokinetics modelling highlighted that gathering data on the time gap between exposure and biomonitoring is an essential information requirement for reconstructing the dose of non persistent pollutants. Information about exposure pathway is also crucial for conducting effective reverse dosimetry.


Subject(s)
Environmental Pollutants/urine , Phthalic Acids/urine , Pregnancy/urine , Environmental Monitoring , Environmental Pollutants/blood , Environmental Pollutants/pharmacokinetics , Female , France , Humans , Models, Biological , Phthalic Acids/blood , Phthalic Acids/pharmacokinetics , Pilot Projects
11.
Eur J Public Health ; 16(6): 583-91, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17028103

ABSTRACT

The August 2003 heat wave in France resulted in many thousands of excess deaths particularly of elderly people. Individual and environmental risk factors for death among the community-dwelling elderly were identified. We conducted a case-control survey and defined cases as people aged 65 years and older who lived at home and died from August 8 through August 13 from causes other than accident, suicide, or surgical complications. Controls were matched with cases for age, sex, and residential area. Interviewers used questionnaires to collect data. Satellite pictures provided profiles of the heat island characteristics around the homes. Lack of mobility was a major risk factor along with some pre-existing medical conditions. Housing characteristics associated with death were lack of thermal insulation and sleeping on the top floor, right under the roof. The temperature around the building was a major risk factor. Behaviour such as dressing lightly and use of cooling techniques and devices were protective factors. These findings suggest people with pre-existing medical conditions were likely to be vulnerable during heat waves and need information on how to adjust daily routines to heat waves. In the long term, building insulation and urban planning must be adapted to provide protection from possible heat waves.


Subject(s)
Aged, 80 and over/statistics & numerical data , Heat Stroke/etiology , Heat Stroke/mortality , Housing/statistics & numerical data , Temperature , Air Conditioning , Case-Control Studies , City Planning , Comorbidity , Female , France , Geriatric Assessment , Health Education , Health Services Needs and Demand , Heat Stroke/prevention & control , Humans , Male , Meteorological Concepts , Mobility Limitation , Multivariate Analysis , Public Health Practice , Residence Characteristics/statistics & numerical data , Risk Assessment , Risk Factors , Socioeconomic Factors , Surveys and Questionnaires , Urban Health/statistics & numerical data
12.
Euro Surveill ; 10(7): 153-6, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16088047

ABSTRACT

France experienced a record-breaking heat wave between 2 and 15 August 2003. All the French regions were affected by this heat wave, which resulted in an excess of 14 800 deaths between 1 and 20 August. The increase in the number of excess deaths followed the same pattern as the increase in temperatures. No deviance from the normal death rate was observed in the month of August during the last third of the month, nor during the following three months. There was a clear discrepancy in the impact of the heat wave from city to city. If the effect of duration of consecutive days with high minimal temperatures and deviance with the seasonal normal temperature was patent, this could not explain all of the observed variability of the death incidence. The victims were mainly elderly women older than 75 years. In terms of relative risk and contribution to the global toll, deaths linked to heat were the most important. Based on these results, the French government developed a Heat Health Watch Warning System and set up a preventive action plan for each region in 2004.


Subject(s)
Heat Stress Disorders/mortality , Hot Temperature/adverse effects , Weather , Aged , Aged, 80 and over , Death Certificates , Epidemiologic Methods , Female , France/epidemiology , Humans , Middle Aged , Mortality/trends , Seasons
13.
Occup Environ Med ; 62(7): 453-60, 2005 Jul.
Article in English | MEDLINE | ID: mdl-15961621

ABSTRACT

AIMS AND METHODS: Long term effects of air pollution on mortality were studied in 14,284 adults who resided in 24 areas from seven French cities when enrolled in the PAARC survey (air pollution and chronic respiratory diseases) in 1974. Daily measurements of sulphur dioxide, total suspended particles, black smoke, nitrogen dioxide, and nitric oxide were made in 24 areas for three years (1974-76). Cox proportional hazards models controlling for individual confounders (smoking, educational level, body mass index, occupational exposure) were applied, and frailty models used to take into account spatial correlation. Indicators of air pollution were the mean concentration. RESULTS: Models were run before and after exclusion of six area monitors influenced by local traffic (NO/NO2 >3 in ppb). After exclusion of these areas, analyses showed that adjusted risk ratios (95% CI) for TSP, BS, NO2, and NO for non-accidental mortality were 1.05 (1.02 to 1.08), 1.07 (1.03 to 1.10), 1.14 (1.03 to 1.25), and 1.11 (1.05 to 1.17) for 10 microg/m3 respectively. Consistent patterns for lung cancer and cardiopulmonary causes were observed. CONCLUSIONS: Urban air pollution assessed in the 1970s was associated with increased mortality over 25 years in France.


Subject(s)
Air Pollution/adverse effects , Environmental Monitoring/methods , Mortality , Adult , Age Distribution , Body Mass Index , Cardiovascular Diseases/etiology , Cause of Death , Environmental Exposure , Epidemiologic Methods , Epidemiological Monitoring , Female , France/epidemiology , Humans , Lung Neoplasms/etiology , Male , Sex Distribution , Smoking/adverse effects , Urban Population , Vehicle Emissions
14.
Sante Publique ; 17(1): 47-56, 2005 Mar.
Article in French | MEDLINE | ID: mdl-15835215

ABSTRACT

At the request of the Service of Academic Preventative Medicine (APM) in Bordeaux, this study was carried out in the year 2000 and aimed to identify the health information needs of the university's student population. The questionnaire, which was completed by the students themselves, mainly explored health information needs, health status and the students' living conditions. Of the 370 total students coming from all University disciplines who participated in this study, a majority of them were women (61%), with the median age of 21 years old. The majority of students (69%) said that they were stressed and/or depressed and more than one-third were tired. Nearly 20% of the students were smokers, 9% declared that they regularly drank alcohol and 7% of them reported that they never consulted a physician. When asked specifically about their health information needs, they expressed a preference for receiving information on sexually transmitted diseases, how to stay in good health and on issues like psychology, depression and suicide. These themes differed according to gender and risk behaviour. These results permitted a better understanding of the students' health information needs and provided the knowledge necessaryin order to streamline and appropriately adapt the APM's activities for the following academic year in order to be more focused to respond to these needs.


Subject(s)
Information Services , Needs Assessment , Student Health Services , Adult , Communication , Female , France , Health Promotion , Health Surveys , Humans , Male , Mental Health Services , Patient Education as Topic , Smoking , Universities
15.
Eur Respir J ; 21(3): 462-7, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12662002

ABSTRACT

The Pollution Atmosphérique et Affections Respiratoires Chroniques (PAARC; Air Pollution and Chronic Respiratory Diseases) study provided the opportunity to examine the 25-yr mortality of 940 asthmatic adults drawn from a large population-based sample of 14,267 adults investigated during 1974-1976 in seven French cities. Vital statistics were collected in 2001 for the whole population. Multivariate survival analysis was used to assess exact survival rates in asthmatics and nonasthmatics taking relevant confounders into account. On average, the mortality rates obtained were 10.4 and 6.9 deaths 1,000 person-yrs-in asthmatics and nonasthmatics, respectively. On univariate analysis, asthma increased the relative risk (RR) of death by 1.48 (95% confidence interval (CI) 1.29-1.69). The association between asthma and death had an RR of 1.16 (95% CI 0.99-1.37) when age, sex, educational level, smoking habits, occupational exposure and forced expiratory volume in one second (FEV1) were taken into account. FEV1 was an important contributive factor causing increased risk of death in both smokers and nonsmokers. For instance, in asthmatics, the numbers of deaths due to respiratory disease and cancer appeared excessive. The present study suggests that asthmatics exhibit a higher risk of mortality.


Subject(s)
Asthma/diagnosis , Asthma/mortality , Cause of Death , Adult , Age Distribution , Analysis of Variance , Case-Control Studies , Cohort Studies , Confidence Intervals , Environmental Pollutants/adverse effects , Female , France/epidemiology , Humans , Male , Middle Aged , Prevalence , Probability , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/mortality , Reference Values , Respiratory Function Tests , Risk Factors , Severity of Illness Index , Sex Distribution , Smoking/adverse effects , Survival Analysis
16.
Eur J Epidemiol ; 17(1): 7-10, 2001.
Article in English | MEDLINE | ID: mdl-11523579

ABSTRACT

OBJECTIVE: To describe trends in the evolution of causes of death in a cohort of HIV-infected patients before and after the introduction of highly active antiretroviral treatment (HAART). METHODS: This descriptive study concerned all the patients of the Aquitaine cohort who died between 1995 and 1997. Causes of deaths were grouped into 13 'deaths due to an AIDS-defining underlying cause', and eight 'non AIDS' categories. Comparisons were performed between two comparable periods of 18 months, January 1995-June 1996 and July 1996-December 1997 to focus on changes introduced by the prescription of HAART in June 1996. RESULTS: Five hundred and thirty-two deaths were notified in 36 months for a total of 3687 patients. The comparison between causes of deaths before and after June 1996 showed a significant difference between the two periods with a decreasing proportion of AIDS causes of death, from 82.7% to 72.2% (p = 0.007). CONCLUSION: HAART treatment has reduced the number and percentage of deaths due to AIDS-related causes among persons who died with HIV infection in South-western France.


Subject(s)
HIV Infections/epidemiology , HIV-1 , Antiretroviral Therapy, Highly Active , Cause of Death/trends , Cohort Studies , France/epidemiology , HIV Infections/drug therapy , Humans
18.
AIDS ; 13(17): F115-21, 1999 Dec 03.
Article in English | MEDLINE | ID: mdl-10597772

ABSTRACT

OBJECTIVE: To study hepatic cytolysis in patients treated by highly active antiretroviral therapy (HAART) with protease inhibitor or with two nucleoside reverse transcriptase inhibitors (NRTIs). METHODS: We selected patients of the Aquitaine Cohort who initiated HAART or two NRTIs before 1 January 1998, had alanine amino-transferase (ALT) < or = 200 IU/I at baseline and at least one follow-up measure. Cox model was used to study the association between occurrence of severe hepatic cytolysis (ALT>200 IU/l) and age, gender, HIV transmission group, baseline CD4 and CD8 cell count, history of hepatic cytolysis, antiretroviral drug, baseline liver enzymes (WHO classification level 0: < or = 50 IU/l, level 1: 51 to 100, level 2: 101 to 200), hepatitis B and C co-infection. RESULTS: Sixty-four of 748 (8.5%) patients treated with HAART and 71 of 1249 (5.7%) treated with two NRTIs developed cytolysis. The probability of occurrence was 7.9% after 1 year [95% confidence interval (CI), 5.9-10.4] for patients treated with HAART and 4.8% (95% CI, 3.6-6.4) for patients treated with two NRTIs (log-rank test, P = 0.01). The median time to occurrence was 164 days for HAART-treated patients and 252 days for those treated with two NRTIs. In multivariate analysis, the history of cytolysis [hazard ratio (HR) = 2.3; 95% CI, 1.2-4.4], baseline value of ALT (HR = 2.4; 95% CI, 1.2-4.8 and HR = 3.3; 95% CI, 1.4-7.4 for levels 1 and 2, respectively), hepatitis B (HR = 3.0; 95% CI, 1.4-6.2) and C co-infections (HR = 3.2; 95% CI, 1.7-6.2) remained significantly associated with the occurrence of severe hepatic cytolysis among HAART-treated patients. History of cytolysis, hepatitis B and C were associated with cytolysis in patients treated with two NRTIs (HR = 14.8, 2.6 and 2.7, respectively). CONCLUSION: Hepatic cytolysis is more frequent among patients treated with HAART than with two NRTIs. Hepatitis B and C are the major risk factors after initiation of HAART or treatment with NRTIs. Co-infections with hepatitis B virus or hepatitis C virus may modify the management of HIV-infected patients treated by HAART.


Subject(s)
Anti-HIV Agents/adverse effects , Chemical and Drug Induced Liver Injury , HIV Infections/drug therapy , Adolescent , Adult , Aged , Anti-HIV Agents/administration & dosage , Cohort Studies , Drug Therapy, Combination , Female , France , HIV Protease Inhibitors/administration & dosage , HIV Protease Inhibitors/adverse effects , Humans , Male , Middle Aged , Prospective Studies , Reverse Transcriptase Inhibitors/administration & dosage , Reverse Transcriptase Inhibitors/adverse effects , Risk Factors
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