1.
Blood Transfus
; 22(3): 246-252, 2024 May.
Article
in English
| MEDLINE
| ID: mdl-38315531
Subject(s)
Platelet Factor 4 , Purpura, Thrombocytopenic, Idiopathic , Thrombosis , Humans , Thrombosis/etiology , Thrombosis/immunology , Thrombosis/blood , Female , Purpura, Thrombocytopenic, Idiopathic/immunology , Purpura, Thrombocytopenic, Idiopathic/blood , Purpura, Thrombocytopenic, Idiopathic/chemically induced , Male , Platelet Factor 4/immunology , Middle Aged , Adult , Autoantibodies/blood , Autoantibodies/immunology , Aged
2.
Transfus Apher Sci
; 60(1): 103010, 2021 Feb.
Article
in English
| MEDLINE
| ID: mdl-33223471
ABSTRACT
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare condition mainly characterized by microangiopathic hemolytic anemia, thrombocytopenia, reported in approximately three cases per one million adults per year. Some reports describing co-occurrence of aTTP and other autoimmune disorders, as Graves' thyroiditis, are reported. To the best of our knowledge this is the first report describing co-occurrence of subacute thyroiditis and aTTP. The patient was refractory to conventional therapy with plasma exchange, steroids and rituximab but was successfully treated with the addition of caplacizumab, an anti-VWF bivalent variable-domain-only immunoglobulin fragment that inhibits interaction between VWF multimers and platelets.