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Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India.
Argimón, Silvia; Nagaraj, Geetha; Shamanna, Varun; Sravani, Dharmavaram; Vasanth, Ashwini Kodlipet; Prasanna, Akshatha; Poojary, Aruna; Bari, Anurag Kumar; Underwood, Anthony; Kekre, Mihir; Baker, Stephen; Aanensen, David M; Lingegowda, Ravikumar Kadahalli.
Clin Infect Dis ; 74(12): 2234-2237, 2022 07 06.
Article in English | MEDLINE | ID: mdl-34626469

ABSTRACT

We report the persistent circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, linked to the acquisition and maintenance of a previously characterized IncX3 plasmid carrying the ESBL gene blaSHV-12 and the fluoroquinolone resistance gene qnrB7 in the genetic context of a triple mutant also associated with fluoroquinolone resistance.


Subject(s)
Anti-Bacterial Agents , Drug Resistance, Bacterial , Salmonella typhi , Anti-Bacterial Agents/pharmacology , Cephalosporins/pharmacology , Fluoroquinolones , Humans , India/epidemiology , Microbial Sensitivity Tests , Salmonella typhi/drug effects , Salmonella typhi/genetics , beta-Lactamases/genetics
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