Psychiatric disorders in pregnant women admitted to the high-risk obstetric service in a Colombian university clinic between 2013 and 2017.

OBJECTIVE: To determine the psychiatric diagnoses and treatments of patients admitted to the high-risk obstetric service who underwent a consultation with a liaison psychiatrist. METHODS: A descriptive observational study that included pregnant women from the high-risk obstetric service of a highly specialised clinic in Medellín, who had a liaison psychiatry consultation between 2013 and 2017. The main variables of interest were psychiatric and obstetric diagnoses and treatments, in addition to biopsychosocial risk factors. RESULTS: A total of 361 medical records were screened, with 248 patients meeting the inclusion criteria. The main prevailing psychiatric diagnosis was major depressive disorder (29%), followed by adaptive disorder (21.8%) and anxiety disorders (12.5%). The pharmacologic treatments most used by the psychiatry service were SSRI antidepressants (24.2%), trazodone (6.8%) and benzodiazepines (5.2%). The most common primary obstetric diagnosis was spontaneous delivery (46.4%), and the predominant secondary obstetric diagnoses were hypertensive disorder associated with pregnancy (10.4%), gestational diabetes (9.2%) and recurrent abortions (6.4%). Overall, 71.8% of the patients had a high biopsychosocial risk. CONCLUSIONS: The studied population's primary psychiatric disorders were major depressive disorder, adjustment disorder and anxiety disorders, which implies the importance of timely recognition of the symptoms of these perinatal mental pathologies, together with obstetric and social risks, in the prenatal consultation. Psychiatric intervention should be encouraged considering the negative implications of high biopsychosocial risk in both mothers and children.

Epoxy resin-based root canal sealers: An integrative literature review.

The correct obturation of the root canal system achieved by means of a core and a cement is essential for the success of endodontic treatment. There are several root canal cements (RCCs) on the market; however, because of their excellent characteristics, epoxy resin-based sealers (ERBSs) have been widely used. The main aim of this review was to analyze and integrate the available information on different ERBSs. An electronic search was performed in the PubMed and Scopus databases, using "epoxy resin" AND "root canal treatment", and "epoxy resin" AND "endodontics" as search terms. In general, ERBSs have good flow properties, film thickness, solubility, dimensional stability, sealing capacity, and radiopacity. They are also able to adhere to dentin while exhibiting low toxicity and some antibacterial effects. However, their main disadvantage is the lack of bioactivity and biomineralization capability. A large number of ERBSs are available on the market, and AH Plus keeps being the gold standard RCC. Yet, information on many of them is limited or non-existent, which could be due to the fact that some of them are relatively new. The latter emphasizes the need for relevant research on the physicochemical and biological properties of some ERBSs, with the aim of supporting their clinical use with sufficient evidence via prospective and long-term studies.

Delirium in oncological palliative care and clinical cardiology units: A comparative analysis.

OBJECTIVE: The aim of this study was to compare the sociodemographic and clinical characteristics of delirium in patients treated in a clinical cardiology unit (CCU) and an oncological palliative care unit (OPCU) at a high-complexity institution. CONTEXT: Delirium is a neuropsychiatric syndrome with multicausal etiology, associated with increased morbidity and mortality. METHOD: This was a cross-sectional, analytical observational study. CCU and OPCU patients were evaluated for 480 days. The diagnosis was made according to DSM-V. Sociodemographic characteristics, the Karnofsky index, and the Charlson index were evaluated. Possible etiologies were verified. Severity was assessed with the Delirium Severity Scale (DRS-R98). RESULTS: A total of 1,986 patients were evaluated, 205 were eligible, and 110 were included in the study (CCU: 61, OPCU: 49). Delirium prevalence was 11.35% in the CCU and 9.87% in the OPCU. CCU patients were 12 years older (p < 0.03) and a history of dementia (41 vs. 8.2%; p < 0.001). Organ failure was the most frequent etiology of delirium in the CCU (41.0%), and in the OPCU, the etiologies were neoplasms (28.6%), side effect of medication (22.4%), and infections (2.5%). Differences were found in the clinical characteristics of delirium evaluated by DRS-R98, with the condition being more severe and with a higher frequency of psychotic symptoms in OPCU patients. CONCLUSION: Delirium was a common condition in hospitalized patients in the CCU and the OPCU. The clinical characteristics were similar in both groups; however, significant differences were found in OPCU patients in terms of age, personal history of dementia, and opioid use, as well as the severity of delirium and a greater association with psychotic symptoms. These findings have implications for the early implementation of diagnostic and therapeutic strategies.

Chest tomography for COVID-19 screening in head and neck cancer elective surgery. Is it enough?

INTRODUCTION: Head and neck cancer patients are at high risk of SARS-CoV-2 infection; surgery in them involves risk for patients, surgeons, health personnel, medical institutions and society, since it is associated with prolonged and inadvertent production of aerosols and emergency procedures that facilitate the breach of protective measures by health personnel. OBJECTIVE: To find out if pulmonary tomographic findings are sufficient to preoperatively identify patients with COVID-19. METHODS: Retrospective, cross-sectional, analytical study of patients with cervical-facial neoplasms who were candidates for surgery, preoperatively evaluated by simple chest computed tomography based on the CO-RADS classification. In CO-RADS ≥ 3 patients, surgery was suspended and PCR was performed using nasopharyngeal swab. RESULTS: 322 patients were included, all without COVID-19 symptoms. Tomography was positive in 35 (10.87%); in 30, nasopharyngeal swab was performed: 28 were negative and two were positive; none developed COVID-19 symptoms. CONCLUSIONS: Chest tomography is not useful as the only preoperative screening procedure for COVID-19, since its findings are nonspecific, with a high rate of false-positive results. Clinical evaluation, with PCR and tomography, is the best form of preoperative screening.

INTRODUCCIÓN: Los pacientes con cáncer de cabeza y cuello tienen alto riesgo de infección por SARS-CoV-2; la cirugía en ellos implica riesgo para pacientes, cirujanos, personal de salud, institución médica y sociedad, ya que se asocia a aerosolización prolongada e inadvertida y a procedimientos de urgencia que facilitan la ruptura de las medidas de protección del personal de salud. OBJETIVO: Conocer si los hallazgos tomográficos pulmonares son suficientes para identificar en forma preoperatoria a los pacientes con COVID-19. MÉTODOS: Estudio retrospectivo, transversal y analítico de pacientes con neoplasias cervicofaciales candidatos a cirugía, evaluados preoperatoriamente mediante tomografía axial computarizada simple de tórax con base en la clasificación CO-RADS. En los pacientes CO-RADS ≥ 3 se suspendió la cirugía y se realizó PCR por hisopado nasofaríngeo. RESULTADOS: Se incluyeron 322 pacientes, todos sin síntomas de COVID-19. La tomografía fue positiva en 35 (10.87 %); en 30 se efectuó hisopado nasofaríngeo: 28 fueron negativos y dos, positivos; ninguno desarrolló síntomas de COVID-19. CONCLUSIONES: La tomografía torácica no es útil como procedimiento único de tamizaje preoperatorio de COVID-19, ya que sus hallazgos son inespecíficos, con tasa alta de resultados falsos-positivos. La evaluación clínica, con PCR y tomografía es la mejor forma de pesquisa preoperatoria.

La tomografía de tórax para tamizaje de COVID-19 en cirugía electiva de cáncer de cabeza y cuello. ¿Es suficiente? / Chest tomography for COVID-19 screening in head and neck cancer elective surgery. Is it enough?

Resumen Introducción: Los pacientes con cáncer de cabeza y cuello tienen alto riesgo de infección por SARS-CoV-2; la cirugía en ellos implica riesgo para pacientes, cirujanos, personal de salud, institución médica y sociedad, ya que se asocia a aerosolización prolongada e inadvertida y a procedimientos de urgencia que facilitan la ruptura de las medidas de protección del personal de salud. Objetivo: Conocer si los hallazgos tomográficos pulmonares son suficientes para identificar en forma preoperatoria a los pacientes con COVID-19. Métodos: Estudio retrospectivo, transversal y analítico de pacientes con neoplasias cervicofaciales candidatos a cirugía, evaluados preoperatoriamente mediante tomografía axial computarizada simple de tórax con base en la clasificación CO-RADS. En los pacientes CO-RADS ≥ 3 se suspendió la cirugía y se realizó PCR por hisopado nasofaríngeo. Resultados: Se incluyeron 322 pacientes, todos sin síntomas de COVID-19. La tomografía fue positiva en 35 (10.87 %); en 30 se efectuó hisopado nasofaríngeo: 28 fueron negativos y dos, positivos; ninguno desarrolló síntomas de COVID-19. Conclusiones: La tomografía torácica no es útil como procedimiento único de tamizaje preoperatorio de COVID-19, ya que sus hallazgos son inespecíficos, con tasa alta de resultados falsos-positivos. La evaluación clínica, con PCR y tomografía es la mejor forma de pesquisa preoperatoria.

Abstract Introduction: Head and neck cancer patients are at elevated risk of SARS-CoV-2 infection; surgery in them involves risk for patients, surgeons, health personnel, medical institutions and society, since it is associated with prolonged and inadvertent production of aerosols and emergency procedures that facilitate the breach of protective measures by health personnel. Objective: To find out if pulmonary tomographic findings are sufficient to preoperatively identify patients with COVID-19. Methods: Retrospective, cross-sectional, analytical study of patients with cervical-facial neoplasms who were candidates for surgery, preoperatively evaluated by simple chest computed tomography based on the CO-RADS classification. In CO-RADS ≥ 3 patients, surgery was suspended and PCR was performed using nasopharyngeal swab. Results: 322 patients were included, all without COVID-19 symptoms. Tomography was positive in 35 (10.87%); in 30, nasopharyngeal swab was performed: 28 were negative and two were positive; none developed COVID-19 symptoms. Conclusions: Chest tomography is not useful as the only preoperative screening procedure for COVID-19, since its findings are nonspecific, with a high rate of false-positive results. Clinical evaluation, with PCR and tomography, is the best form of preoperative screening.

Not the same, but is it the same? Cycling of biologic agents in rheumatoid arthritis. Experience in the Instituto Mexicano del Seguro Social.

INTRODUCTION: Available data for biocomparable drugs are not enough to make clear decisions with respect to the potential consequences of a change for non-medical reasons in efficacy, security and inmunogenicity in patients. In the near future, options on biological treatments, biocomparable drugs, non biocomparable drugs and new chemical synthesis options will grow. Therefore, it is important to know how patients behave in persistence of treatment after a change for non- medical reasons, which already happens on a regular basis in social security institutions in Mexico. This information will help us to better understand the standard of treatment for patients with chronic immunomediated conditions. OBJECTIVE: The primary objective was to measure the impact of change for non-medical reasons in patients with rheumatoid arthritis (RA) treated with an innovative biological on persistence of treatment after changing to a biocomparable drug or a non-biocomparable drug, compared with those patients staying with the innovative biological. STUDY DESIGN: This is an observational study (non-interventionist) of paired cohorts, where an historic cohort obtained by review of clinical records of stable patients in which no modifications to treatment were made for at least six months is compared with two cohorts of patients whose treatments were switched to another treatment with the same therapeutic mechanism for-non-medical reasons (cycling). RESULTS: We included 264 RA patients (ACR/EULAR, 2010); 132 were switched for non-medical reasons, and 132 were not switched. Two-hundred and thirty (87.1%) were female. Average age was 53.9 years, ranging from 16 to 84 years. Two-hundred and sixty-three patients were Latino (99.6%); one was Caucasian. Persistence of treatment 12 months after the change was 84.8% (85.8% in Enbrel/Infinitam, 78.9% for Remicade/Remsima). No statistical difference was found with respect to RA clinical activity measured by DAS28 12 months after the switch (P > .05). In the 134 switched patients, 20 discontinued the new treatment due to lack of efficacy of the new drug and were changed to a different drug with a different biologic target. Although no differences were found in the cohorts of switched patients with respect to DAS 28 after 12 months of use, we did find differences in the frequency of adverse events. Forty-two patients had an adverse event in the drug switch cohorts: 33 in the Enbrel-Infinitam group and 9 in the Remicade-Remsima group. CONCLUSIONS: The persistence of treatment after switching from an innovative drug to a biocomparable or a non- biocomparable in RA patients did not show statistically significative differences in our cohorts, but we did find a higher number of adverse events when comparing those who were changed with those who continued on an innovative drug. Twenty patients in the switch groups had to receive a new drug with a different biological target due to lack of efficacy of the switched drug.

Failures of the Fontan System in Univentricular Hearts and Mortality Risk in Heart Transplantation: A Systematic Review and Meta-Analysis.

The Fontan procedure (FP) is the standard surgical treatment for Univentricular heart diseases. Over time, the Fontan system fails, leading to pathologies such as protein-losing enteropathy (PLE), plastic bronchitis (PB), and heart failure (HF). FP should be considered as a transitional step to the final treatment: heart transplantation (HT). This systematic review and meta-analysis aims to establish the risk of death following HT according to the presence of FP complications. There was a total of 691 transplanted patients in the 18 articles, immediate survival 88% (n = 448), survival from 1 to 5 years of 78% (n = 427) and survival from 5.1 to 10 years of 69% (n = 208), >10 years 61% (n = 109). The relative risk (RR) was 1.12 for PLE (95% confidence interval [CI] = 0.89-1.40, p = 0.34), 1.03 for HF (0.7-1.51, p = 0.88), 0.70 for Arrhythmias (0.39-1.24, p = 0.22), 0.46 for PB (0.08-2.72, p = 0.39), and 5.81 for CKD (1.70-19.88, p = 0.005). In patients with two or more failures, the RR was 1.94 (0.99-3.81, p = 0.05). After FP, the risk of death after HT is associated with CKD and with the presence of two or more failures.

Caracterización sociodemográfica y clínica en menores de 18 años con maltrato infantil atendidos entre los años 2011 a 2016 en la Clínica Universitaria Bolivariana de Medellín, Colombia / Social-demographic and clinical characterization in children under 18 years of age with child abuse treated between 2011 and 2016 at the Bolivariana University Clinic of Medellin, Colombia

Resumen Introducción: El maltrato infantil es definido por la Organización Mundial de la Salud como todo abuso y desatención que sufren niños, niñas y adolescentes. Si bien en Colombia existen informes generales sobre menores víctimas de maltrato, hay pocos estudios acerca de la frecuencia, tipos y características a nivel departamental o municipal, información importante para enfocar acciones de salud colectiva e individual. Objetivo: Realizar una caracterización sociodemográfica, clínica y según el tipo de maltrato en una población de menores de 18 años con antecedente de maltrato infantil, atendidos entre los años 2011 a 2016, en la Clínica Universitaria Bolivariana de Medellín, Colombia. Materiales y métodos: Estudio descriptivo, retrospectivo y transversal, realizado en el período de tiempo entre enero de 2011 a diciembre de 2016. Se usaron fuentes secundarias de información tipo historia clínica. Se seleccionó una muestra de 29 menores de 18 años tras aplicar criterios de elegibilidad. Resultados: El sexo femenino y la tipología familiar monoparental materna fueron los más frecuentes. El abuso sexual, fue el tipo más común de maltrato, seguido por maltrato físico y psicológico, con diferentes distribuciones según el sexo. Discusión: Las características de salud de las víctimas de maltrato infantil son variables, pero al parecer el sexo y la edad son características que influyen en el tipo del maltrato. Conclusiones: Se realizó un acercamiento desde una visión médica, respecto a la complejidad de una problemática de origen y alcance intersectorial que abarca diferentes formas, las cuales varían por condiciones sociales, familiares y del agresor. MÉD.UIS.2021;34(3): 19-27.

Abstract Introduction: Child abuse is defined by the World Health Organization as all abuse and neglect suffered by children and adolescents. Although in Colombia there are general reports on child victims of abuse, there are few studies on the frequency, types, and characteristics at the departmental or municipal level, important information to focus collective and individual health actions. Objective: To carry out a sociodemographic, clinical characterization and according to the type of abuse in a population of children under 18 years of age with a history of child abuse, attended between 2011 and 2016, at the Bolivariana University Clinic of Medellin, Colombia. Materials and methods: Descriptive, retrospective, and cross-sectional study, carried out in the period from January 2011 to December 2016. Secondary sources of information such as clinical history was used. A sample of 29 children under 18 years of age was selected after applying eligibility criteria. Results: The female sex and the maternal single-parent family type were the most frequent. Sexual abuse was the most common type of abuse, followed by physical and psychological abuse, with different distributions according to sex. Discussion: The health characteristics of victims of child abuse vary, but apparently the sex and age of the victim are characteristics that influence the type of abuse. Conclusions: An approach was made from a medical perspective, regarding the complexity of a problem of intersectoral origin and scope that encompasses different forms, which vary by social, family and aggressor conditions. MED.UIS.202i;34(3): 19-27.

Detection of Persistent Viruses by High-Throughput Sequencing in Tomato and Pepper from Panama: Phylogenetic and Evolutionary Studies.

High-throughput sequencing from symptomatic tomato and pepper plants collected in Panama rendered the complete genome of the southern tomato virus (isolate STV_Panama) and bell pepper endornavirus (isolate BPEV_Panama), and almost-complete genomes of three other BPEV isolates. Tomato chlorosis virus, tomato mosaic virus, and impatiens necrotic spot virus were also detected. Analysis of the complete genome of STV and BPEV worldwide isolates revealed nucleotide diversities of 0.004246 and 0.070523, respectively. Bayesian phylogenetic analysis showed two main groups for each virus (I and II), and several subgroups for BPEV (IA, IB, IC, IIA and IIB). Isolate STV_Panama clustered with NC_12-03-08 from USA and Tom3-T from France (99.97% nucleotide identity) in Group I and BPEV_Panama was close to the Canadian isolate BPEV_Ontario (99.66% nucleotide identity) in Subgroup IB. No correlation was observed between geographic and genetic distances for both viruses. Panamanian BPEV isolates were divergent, belonging to Groups I and II (nucleotide identities > 87.33%). Evolutionary analysis showed purifying selection in all encoding regions of both viruses, being stronger in the overlapping region of both STV genes. Finally, recombination was detected in BPEV but not in STV. This is the first report of STV and BPEV in Panama.

Beliefs of parents of children with mental disorders in a university hospital out-patient clinic in Colombia.

OBJECTIVE: Describe the beliefs of parents about the mental disorders of their children who attended a paediatric outpatient clinic at a university hospital. METHODS: This was a descriptive study with parents of children with mental disorders seen from January to May of 2018 at a high complexity hospital in Medellin, Colombia. Ninety-eight (98) parents of children and adolescents attending their first outpatient consultation with Paediatric Psychiatry were studied. An instrument designed by the investigators was applied to obtain demographic variables and beliefs about the origin of their child's mental disorder, treatment and adjuvants. RESULTS: 49.9% of the 98 parents believed that their child had a mental disorder. 43.9% believed the disorder was inherited and 41.8% believed its cause was organic. 95.9% of the parents believed the child needed treatment, including psychotherapy (90.4%) and medication (58.51%). Among the alternative treatments the parents believed the child needed, healing was the most commonly cited by 27.5% of the parents. Of the adjuvant methods, the most commonly cited were reinforcing positive behaviour (82.7%) and correcting with words and setting a good example (72.4%). CONCLUSIONS: Nearly half of the parents believed their child had a mental disorder, the treatment that was most commonly considered was psychotherapy above medication, and the best adjuvant methods cited by parents were reinforcing positive behaviour, correcting with words and setting a good example.

Creencias de los padres acerca de los trastornos mentales de sus hijos en una consulta universitaria en Colombia / Beliefs of parents of children with mental disorders in a university hospital out-patient clinic in Colombia

RESUMEN Objetivo: Describir las creencias de los padres acerca de los trastornos mentales de sus hijos que asistieron a consulta externa infantil en una clínica universitaria. Métodos: Estudio descriptivo transversal realizado en padres de niños con trastornos mentales de una clínica de cuarto nivel de Medellín, Colombia, durante el periodo comprendido entre enero y mayo del 2018. Se estudió a 98 padres de niños y adolescentes que consultaron por primera vez a Psiquiatría Infantil. Se aplicó un instrumento elaborado por los investigadores con variables demográficas y de creencias sobre: el origen del trastorno mental, del tratamiento y sus coadyuvantes. Resultados: El 49,9% de los 98 padres evaluados creyeron que su hijo tenía un trastorno mental; en cuanto al origen de este, el 43,9% creía que era heredado y 41,8% por causas orgánicas. El 95,9% de los padres creía que sus hijos necesitaban tratamiento, de ellos, el 90,4% estimó la psicoterapia y el 58,51%, la medicación. Entre los tratamientos alternativos el más frecuente fue la sanación, con un 27,5%. De los métodos coadyuvantes en el tratamiento, los más frecuentes fueron estimular comportamientos positivos con el 82,7%, y corregir con palabras y dar buen ejemplo con el 72,4%. Conclusiones: En este estudio casi la mitad de los padres pensaba que sus hijos tenían una enfermedad mental. El tratamiento más considerado por los participantes fue la psicoterapia, por encima del uso de psicofármacos. En cuanto a los métodos coadyuvantes, los padres consideraron principalmente el estimular comportamientos positivos, corregir con palabras y dar buen ejemplo.

ABSTRACT Objective: Describe the beliefs of parents about the mental disorders of their children who attended a paediatric outpatient clinic at a university hospital. Methods: This was a descriptive study with parents of children with mental disorders seen from January to May of 2018 at a high complexity hospital in Medellin, Colombia. Ninety-eight (98) parents of children and adolescents attending their first outpatient consultation with Paediatric Psychiatry were studied. An instrument designed by the investigators was applied to obtain demographic variables and beliefs about the origin of their child's mental disorder, treatment and adjuvants. Results: 49.9% of the 98 parents believed that their child had a mental disorder. 43.9% believed the disorder was inherited and 41.8% believed its cause was organic. 95.9% of the parents believed the child needed treatment, including psychotherapy (90.4%) and medication (58.51%). Among the alternative treatments the parents believed the child needed, healing was the most commonly cited by 27.5% of the parents. Of the adjuvant methods, the most commonly cited were reinforcing positive behaviour (82.7%) and correcting with words and setting a good example (72.4%). Conclusions: Nearly half of the parents believed their child had a mental disorder, the treatment that was most commonly considered was psychotherapy above medication, and the best adjuvant methods cited by parents were reinforcing positive behaviour, correcting with words and setting a good example.

Not the same, but ¿is it the same? Cycling of biologic agents in rheumatoid arthritis. Experience in the Instituto Mexicano del Seguro Social. / No es el mismo pero ¿es igual? Cycling de agentes biológicos en artritis reumatoide. Experiencia en el Instituto Mexicano del Seguro Social.

INTRODUCTION: Available data for biocomparable drugs are not enough to make clear decisions with respect to the potential consequences of a change for non-medical reasons in efficacy, security and inmunogenicity in patients. In the near future, options on biological treatments, biocomparable drugs, non biocomparable drugs and new chemical synthesis options will grow. Therefore, it is important to know how patients behave in persistence of treatment after a change for non-medical reasons, which already happens on a regular basis in social security institutions in Mexico. This information will help us to better understand the standard of treatment for patients with chronic immunomediated conditions. OBJECTIVE: The primary objective was to measure the impact of change for non-medical reasons in patients with rheumatoid arthritis (RA) treated with an innovative biological on persistence of treatment after changing to a biocomparable drug or a non-biocomparable drug, compared with those patients staying with the innovative biological. STUDY DESIGN: This is an observational study (non-interventionist) of paired cohorts, where an historic cohort obtained by review of clinical records of stable patients in which no modifications to treatment were made for at least six months is compared with two cohorts of patients whose treatments were switched to another treatment with the same therapeutic mechanism for-non-medical reasons (cycling). RESULTS: We included 264 RA patients (ACR/EULAR, 2010); 132 were switched for non-medical reasons, and 132 were not switched. Two-hundred and thirty (87.1%) were female. Average age was 53.9years, ranging from 16 to 84years. Two-hundred and sixty-three patients were Latino (99.6%); one was Caucasian. Persistence of treatment 12months after the change was 84.8% (85.8% in Enbrel/Infinitam, 78.9% for Remicade/Remsima). No statistical difference was found with respect to RA clinical activity measured by DAS28 12months after the switch (P>.05). In the 134 switched patients, 20 discontinued the new treatment due to lack of efficacy of the new drug and were changed to a different drug with a different biologic target. Although no differences were found in the cohorts of switched patients with respect to DAS28 after 12months of use, we did find differences in the frequency of adverse events. Forty-two patients had an adverse event in the drug switch cohorts: 33 in the Enbrel-Infinitam group and 9 in the Remicade-Remsima group. CONCLUSIONS: The persistence of treatment after switching from an innovative drug to a biocomparable or a non-biocomparable in RA patients did not show statistically significative differences in our cohorts, but we did find a higher number of adverse events when comparing those who were changed with those who continued on an innovative drug. Twenty patients in the switch groups had to receive a new drug with a different biological target due to lack of efficacy of the switched drug.

Beliefs of parents of children with mental disorders in a university hospital out-patient clinic in Colombia. / Creencias de los padres acerca de los trastornos mentales de sus hijos en una consulta universitaria en Colombia.

OBJECTIVE: Describe the beliefs of parents about the mental disorders of their children who attended a paediatric outpatient clinic at a university hospital. METHODS: This was a descriptive study with parents of children with mental disorders seen from January to May of 2018 at a high complexity hospital in Medellin, Colombia. Ninety-eight (98) parents of children and adolescents attending their first outpatient consultation with Paediatric Psychiatry were studied. An instrument designed by the investigators was applied to obtain demographic variables and beliefs about the origin of their child's mental disorder, treatment and adjuvants. RESULTS: 49.9% of the 98 parents believed that their child had a mental disorder. 43.9% believed the disorder was inherited and 41.8% believed its cause was organic. 95.9% of the parents believed the child needed treatment, including psychotherapy (90.4%) and medication (58.51%). Among the alternative treatments the parents believed the child needed, healing was the most commonly cited by 27.5% of the parents. Of the adjuvant methods, the most commonly cited were reinforcing positive behaviour (82.7%) and correcting with words and setting a good example (72.4%). CONCLUSIONS: Nearly half of the parents believed their child had a mental disorder, the treatment that was most commonly considered was psychotherapy above medication, and the best adjuvant methods cited by parents were reinforcing positive behaviour, correcting with words and setting a good example.

Uncertainty analysis of a non-automatic weighing instrument from calibration data on scales according to the SIM guide.

This research was motivated by technical-economic challenges imposed by mass metrology, specifically, in matters concerning calibration methods of non-automatic type weighing instruments (i.e.: digital scales). In order to contextualize the problem detected, in the industry there are different processes of mass measurement that are controlled by digital scales, such as: mass of liquids, chemicals, food, body mass of a person. In these processes, the scale is used in the following four conditions for mass measurement: (i) ascending and descending load, returned to zero; (ii) ascending and descending load, without the need to return to zero; (iii) only with ascending load and (iv) only with descending load. In this context and, maintaining the principles for the calibration of a measurement instrument in which it must be carried out under the same operating conditions as the instrument, metrology laboratories must knowing the metrological reliability (i.e.: errors and uncertainties) for each situation. This is exactly the main motivation for the development of the research. Thus, the experimental data obtained in a research laboratory under controlled environmental conditions allowed obtaining a minimum expanded uncertainty associated with the mass measurement of 0.0012 kg (k=2; confidence level: 95%).

Evaluation of the metrological reliability of a graduated cylinder from experimental data from an in-situ calibration.

This work presents the data experimentally collected in a chemical laboratory for the calibration of a graduated cylinder. There are several factors that can influence the volume measurement using this type of instrument and, consequently, its metrological reliability, for example: the internal geometry, the environmental conditions (ambient temperature, atmospheric pressure and relative humidity), the acceleration of gravity, the density of the air, among others. For the data collection it was necessary to use a glass liquid thermometer (Range: 0-10 °C), a digital thermohygrometer (Range: 0-100 °C and 0-99%RH) and a digital barometer (Range: 0-9999 mbar). Additionally, an analytical scale (Range: 0-220 g) was used for mass measurement. From the measurements obtained, it was possible to determine the in-situ air density and the buoyancy factor that influences the mass measurement. The data, rigorously obtained, present a potential use to determine the metrological reliability of a graduated cylinder for laboratory use and, additionally, contribute to perform a metrological validation of alternative methods for the calibration of graduated cylinder.

Experiencia y resultados de un proceso educativo interdisciplinario para la promoción de salud en universitarios / Experience and results of an interdisciplinary educational process for the promotion of health with university students / Experiência e resultados dum processo educativo interdisciplinario para a promoção de saúde em universitarios

Objetivo: Capacitar a un grupo interdisciplinario de estudiantes de pregrado como promotores universitarios de salud y evaluar los resultados. Metodología: Investigación acción participativa con 13 estudiantes de pregrado de la Pontificia Universidad Católica del Ecuador durante el periodo 2012-2014. El proceso se desarrolló en cuatro fases: 1) capacitación en promoción de salud del grupo; 2) diagnóstico de la situación de salud general de los estudiantes; 3) diseño, planificación e implementación de un proyecto ejecutado por los estudiantes capacitados; y 4) evaluación de la intervención. En cada fase se aplicaron técnicas cualitativas y cuantitativas para el diagnóstico y evaluación de resultados. Resultados: Fase 1: 100% de los estudiantes completaron el proceso de capacitación. Fase 2: se identificó como principales problemas de salud en la población estudiantil universitaria a los relacionados con salud mental (estrés, ansiedad, depresión), alimentación inadecuada y violencia. Fase 3: Se diseñó y ejecutó un proyecto de intervención a partir del diagnóstico realizado, que benefició a 2916 pares. Fase 4: Como resultado de la intervención, el 76,2% de los beneficiarios manifestaron enfrentar los problemas cotidianos, 90,6% lo consideraron importante para su desarrollo personal espiritual, afectivo y corporal, 94% mejoró las relaciones con sus compañeros, 68,9% aprendieron sobre sus derechos y 38% reconocieron que modificaron sus hábitos de vida. Conclusiones: La metodología implementada otorgó a los estudiantes herramientas para diseñar, ejecutar y evaluar proyectos interdisciplinarios de promoción de salud. La investigación-acción posibilita transformaciones de las realidades en salud en entornos universitarios y es factible de ser aplicada en otros contextos.

Objective: To train an interdisciplinary group of undergraduate students as university health promoters and evaluate their results. Methodology: Participatory action research with 13 undergraduate students of the Pontificia Universidad Católica de Ecuador during the period 2012-2014. The process was developed in four phases: 1) training in health promotion of the group; 2) diagnosis of the general health situation of the students; 3) design, planning and implementation of a project executed by trained students; and 4) evaluation of the intervention. Qualitative and quantitative techniques were applied in each phase for the diagnosis and evaluation of results. Results: Phase 1: 100% of the students completed the training process; Phase 2: The main health problems in the university student population were identified as related to mental health (stress, anxiety, and depression), inadequate diet and violence; Phase 3: An intervention project was designed and executed based on the diagnosis made, which benefited 2916 peers; Phase 4: As a result of the intervention, 76.2% of the beneficiaries stated that they faced daily problems, 90.6% considered it important for their personal spiritual, emotional and corporal development, 94% improved relations with their peers, 68, 9% learned about their rights and 38% acknowledged that they modified their life habits. Conclusions: The methodology implemented gave students tools to design, execute and evaluate interdisciplinary health promotion projects. Action research enables transformations of realities in health in university settings and is feasible to be applied in other contexts.

Objetivo: Capacitar a um grupo interdisciplinares de estudantes de formatura como promotores universitários de saúde e avaliar os resultados. Metodologia: Pesquisa ação participativa com 13 estudantes de formatura da Pontifícia Universidade Católica do Equador durante o período 2012-2014. O processo de desenvolvimento em quatro fases: 1) capacitação em promoção de saúde do grupo; 2) diagnóstico da situação de saúde geral dos estudantes; 3) design, planificação e execução dum projeto executado pelos estudantes capacitados; e 4) avaliação da intervenção. Em cada fase se aplicação técnicas qualitativas e quantitativas para o diagnóstico e avaliação de resultados. Resultados: Fase 1: 100% dos estudantes terminaram o processo de capacitação. Fase 2: Identificou- se como principais problemas de saúde na população estudantil universitária aos relacionados com saúde mental (estresse, ansiedade, depressão), alimentação inadequada e violência. Fase 3: Desenhou-se e executou um projeto de intervenção a partir do diagnóstico realizado, que beneficiou a 2916 pares. Fase 4: Como resultado da intervenção, o 76,2% dos beneficiários manifestaram enfrentar os problemas cotidianos, 90,6% o consideraram importante para seu desenvolvimento pessoal espiritual, afetivo e corporal, 94% melhorou as relações com seus colegas, 68,9% aprenderam sobre seus direitos e 38% reconheceram que modificaram seus hábitos de vida. Conclusões: A metodologia executada deu aos estudantes ferramentas para desenhar, executar e avaliar projetos interdisciplinares de promoção de saúde. A pesquisa-ação possibilita transformações das realidades em saúde em entornos universitários e é possível de ser aplicada em outros contextos.

Experiencia y resultados de un proceso educativo interdisciplinario para la promoción de salud en universitarios / Experience and results of an interdisciplinary educational process for the promotion of health with university students / Experiência e resultados dum processo educativo interdisciplinario para a promoção de saúde em universitarios

Resumen Objetivo: Capacitar a un grupo interdisciplinario de estudiantes de pregrado como promotores universitarios de salud y evaluar los resultados. Metodología: Investigación acción participativa con 13 estudiantes de pregrado de la Pontificia Universidad Católica del Ecuador durante el periodo 2012-2014. El proceso se desarrolló en cuatro fases: 1) capacitación en promoción de salud del grupo; 2) diagnóstico de la situación de salud general de los estudiantes; 3) diseño, planificación e implementación de un proyecto ejecutado por los estudiantes capacitados; y 4) evaluación de la intervención. En cada fase se aplicaron técnicas cualitativas y cuantitativas para el diagnóstico y evaluación de resultados. Resultados: Fase 1: 100% de los estudiantes completaron el proceso de capacitación. Fase 2: se identificó como principales problemas de salud en la población estudiantil universitaria a los relacionados con salud mental (estrés, ansiedad, depresión), alimentación inadecuada y violencia. Fase 3: Se diseñó y ejecutó un proyecto de intervención a partir del diagnóstico realizado, que benefició a 2916 pares. Fase 4: Como resultado de la intervención, el 76,2% de los beneficiarios manifestaron enfrentar los problemas cotidianos, 90,6% lo consideraron importante para su desarrollo personal espiritual, afectivo y corporal, 94% mejoró las relaciones con sus compañeros, 68,9% aprendieron sobre sus derechos y 38% reconocieron que modificaron sus hábitos de vida. Conclusiones: La metodología implementada otorgó a los estudiantes herramientas para diseñar, ejecutar y evaluar proyectos interdisciplinarios de promoción de salud. La investigación-acción posibilita transformaciones de las realidades en salud en entornos universitarios y es factible de ser aplicada en otros contextos.

Abstract Objective: To train an interdisciplinary group of undergraduate students as university health promoters and evaluate their results. Methodology: Participatory action research with 13 undergraduate students of the Pontificia Universidad Católica de Ecuador during the period 2012-2014. The process was developed in four phases: 1) training in health promotion of the group; 2) diagnosis of the general health situation of the students; 3) design, planning and implementation of a project executed by trained students; and 4) evaluation of the intervention. Qualitative and quantitative techniques were applied in each phase for the diagnosis and evaluation of results. Results: Phase 1: 100% of the students completed the training process; Phase 2: The main health problems in the university student population were identified as related to mental health (stress, anxiety, and depression), inadequate diet and violence; Phase 3: An intervention project was designed and executed based on the diagnosis made, which benefited 2916 peers; Phase 4: As a result of the intervention, 76.2% of the beneficiaries stated that they faced daily problems, 90.6% considered it important for their personal spiritual, emotional and corporal development, 94% improved relations with their peers, 68, 9% learned about their rights and 38% acknowledged that they modified their life habits. Conclusions: The methodology implemented gave students tools to design, execute and evaluate interdisciplinary health promotion projects. Action research enables transformations of realities in health in university settings and is feasible to be applied in other contexts.

Resumo Objetivo: Capacitar a um grupo interdisciplinares de estudantes de formatura como promotores universitários de saúde e avaliar os resultados. Metodologia: Pesquisa ação participativa com 13 estudantes de formatura da Pontifícia Universidade Católica do Equador durante o período 2012-2014. O processo de desenvolvimento em quatro fases: 1) capacitação em promoção de saúde do grupo; 2) diagnóstico da situação de saúde geral dos estudantes; 3) design, planificação e execução dum projeto executado pelos estudantes capacitados; e 4) avaliação da intervenção. Em cada fase se aplicação técnicas qualitativas e quantitativas para o diagnóstico e avaliação de resultados. Resultados: Fase 1: 100% dos estudantes terminaram o processo de capacitação. Fase 2: Identificouse como principais problemas de saúde na população estudantil universitária aos relacionados com saúde mental (estresse, ansiedade, depressão), alimentação inadequada e violência. Fase 3: Desenhou-se e executou um projeto de intervenção a partir do diagnóstico realizado, que beneficiou a 2916 pares. Fase 4: Como resultado da intervenção, o 76,2% dos beneficiários manifestaram enfrentar os problemas cotidianos, 90,6% o consideraram importante para seu desenvolvimento pessoal espiritual, afetivo e corporal, 94% melhorou as relações com seus colegas, 68,9% aprenderam sobre seus direitos e 38% reconheceram que modificaram seus hábitos de vida. Conclusões: A metodologia executada deu aos estudantes ferramentas para desenhar, executar e avaliar projetos interdisciplinares de promoção de saúde. A pesquisa-ação possibilita transformações das realidades em saúde em entornos universitários e é possível de ser aplicada em outros contextos.