ABSTRACT
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
Subject(s)
Apolipoproteins E/genetics , Chromosomes, Human, Pair 19/genetics , Genetic Linkage , Parkinson Disease/genetics , Alleles , Apolipoprotein E4 , Family Health , Gene Frequency , Genotype , Humans , Linkage Disequilibrium , Lod Score , Microsatellite Repeats , SiblingsABSTRACT
Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.