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1.
Semin Cutan Med Surg ; 37(4): 242-246, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30475930

ABSTRACT

Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, and connective tissue fibrosclerosis.


Subject(s)
Adipose Tissue/surgery , Cellulite , Cosmetic Techniques , Laser Therapy/methods , Adipose Tissue/diagnostic imaging , Cellulite/diagnosis , Cellulite/etiology , Cellulite/surgery , Female , Humans , Magnetic Resonance Imaging , Obesity/complications
2.
Semin Cutan Med Surg ; 36(4): 155-163, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29224032

ABSTRACT

Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. This is a review of the literature on microneedling in the treatment of textural abnormalities, specifically rhytides, scars, and striae.


Subject(s)
Cicatrix/therapy , Cosmetic Techniques , Skin Aging , Striae Distensae/therapy , Administration, Cutaneous , Cosmetic Techniques/instrumentation , Humans , Needles , Rejuvenation
3.
JAMA Dermatol ; 153(8): 802-809, 2017 08 01.
Article in English | MEDLINE | ID: mdl-28658462

ABSTRACT

Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy. Evidence Review: A panel of national experts in pediatric dermatology, procedural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convened. A systematic PubMed review of English-language articles published from 1982 to 2017 was performed using the following search terms: isotretinoin, 13-cis-retinoic acid, Accutane, retinoids, acitretin, surgery, surgical, laser, ablative laser, nonablative laser, laser hair removal, chemical peel, dermabrasion, wound healing, safety, scarring, hypertrophic scar, and keloid. Evidence was graded, and expert consensus was obtained. Findings: Thirty-two relevant publications reported 1485 procedures. There was insufficient evidence to support delaying manual dermabrasion, superficial chemical peels, cutaneous surgery, laser hair removal, and fractional ablative and nonablative laser procedures for patients currently receiving or having recently completed isotretinoin therapy. Based on the available literature, mechanical dermabrasion and fully ablative laser are not recommended in the setting of systemic isotretinoin treatment. Conclusions and Relevance: Physicians and patients may have an evidence-based discussion regarding the known risk of cutaneous surgical procedures in the setting of systemic isotretinoin therapy. For some patients and some conditions, an informed decision may lead to earlier and potentially more effective interventions.


Subject(s)
Cicatrix/etiology , Dermatologic Agents/adverse effects , Isotretinoin/adverse effects , Wound Healing/drug effects , Cicatrix/pathology , Dermatologic Agents/administration & dosage , Dermatologic Surgical Procedures/methods , Humans , Isotretinoin/administration & dosage , Skin/drug effects , Skin/metabolism , Time Factors
4.
Semin Cutan Med Surg ; 35(4): 183, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27917998

ABSTRACT

The ethnic and racial composition of the US population is changing rapidly. There is a continuous rise of individuals with mixed ethnic backgrounds comprising skin of color. It is important for physicians to be comfortable addressing and treating the needs of this population, as it differs significantly from the white population.


Subject(s)
Plastic Surgery Procedures , Humans , Racial Groups
5.
J Investig Dermatol Symp Proc ; 17(2): 47-9, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26551947

ABSTRACT

There is insufficient data in the literature concerning optimal intralesional kenalog (ILK) dosing for the treatment of alopecia areata (AA). The purpose of this pilot study was to evaluate the utility of using the ratio of ILK received to initial Severity of Alopecia Tool (SALT) score to guide ILK dosing in patients with AA. Using photographic data from patients at baseline and 4-months follow-up, hair loss in 15 patients treated with AA was retrospectively graded using the SALT scores. The ILK received/initial SALT score (ILK index) was calculated for each patient, and the mean ILK index for patients who experienced significant (≥50%) and suboptimal (<50%) hair regrowth at 4 months follow-up were compared. Patients who experienced suboptimal hair regrowth had a lower ILK index on average than patients who experienced significant improvement. Although the difference did not meet significance (<0.1), the trend suggests that the ILK index, a novel calculation, may be a useful tool for guiding ILK dosing in the treatment of AA.


Subject(s)
Alopecia Areata/drug therapy , Anti-Inflammatory Agents/administration & dosage , Severity of Illness Index , Triamcinolone Acetonide/administration & dosage , Adult , Female , Follow-Up Studies , Hair/growth & development , Humans , Injections, Intralesional , Male , Middle Aged , Photography , Pilot Projects , Retrospective Studies
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