ABSTRACT
This report describes the project to identify the global distribution of extended HLA haplotypes, a component of 16th International HLA and Immunogenetics Workshop (IHIW), and summarizes the initial analyses of data collected. The project aims to investigate extended HLA haplotypes, compare their distribution among different populations, assess their frequency in hematopoietic stem cell unrelated donor registries and initiate an international family studies database and DNA repository to be made publicly available. HLA haplotypes compiled in immunogenetics laboratories during the evaluation of transplant candidates and related potential donors were analysed. Haplotypes were determined using the pedigree analysis tool publicly available from the National Marrow Donor Program (NMDP) website. Nineteen laboratories from 10 countries (11 laboratories from North America, five from Asia, two from Latin America and one from Australia) contributed data on a total of 1719 families comprised of 7474 individuals. We identified 10393 HLA haplotypes, of which 1682 haplotypes included high-resolution typing at HLA-A, B, C, DRB1 and DQB1 loci. We also present haplotypes containing MICA and other HLA loci and haplotypes containing rare alleles seen in these families. The project will be extended through the 17th IHIW, and investigators interested in joining the project may communicate with the first author.
Subject(s)
Genetic Variation , HLA Antigens/genetics , Haplotypes , Population Groups/genetics , Australia , Gene Frequency , Genetics, Population , Genotype , HLA Antigens/classification , Histocompatibility Antigens Class I/genetics , Humans , North AmericaABSTRACT
We present a comparative trial between Sandimmun, the original cyclosporine presentation, and a modified one, called Neoral, in microemulsion, to increase the blood absortion and stability of the product. We built for each product, an absorption kinetic curve and we applied it to three patients with stable renal function, using the same dosage that was used for ciclosporine. We observed a greater absorption and stability in the blood levels of Neoral. We analyzed hundred blood samples in 25 patients and we found a higher level of this product; this lead us to make possible that in 72% of the patients we could diminish the daily dosis in 5 to 10%. The patient's renal function was stable and no complications or secondary effects were present with Neoral.
Subject(s)
Cyclosporine/therapeutic use , Immunosuppressive Agents/therapeutic use , Kidney Transplantation/methods , Adult , Female , Graft Rejection/prevention & control , Humans , Male , Treatment OutcomeABSTRACT
We present a comparative trial between Sandimmun, the original cyclosporine presentation, and a modified one, called Neoral, in microemulsion, to increase the blood absortion and stability of the product. We built for each product, an absorption kinetic curve and we applied it to three patients with stable renal function, using the same dosage that was used for ciclosporine. We observed a greater absorption and stability in the blood levels of Neoral. We analyzed hundred blood samples in 25 patients and we found a higher level of this product; this lead us to make possible that in 72% of the patients we could diminish the daily dosis in 5 to 10%. The patient's renal function was stable and no complications or secondary effects were present with Neoral.
Subject(s)
Humans , Male , Female , Adult , Cyclosporine/therapeutic use , Immunosuppressive Agents/therapeutic use , Kidney Transplantation/methods , Graft Rejection/prevention & control , Treatment OutcomeABSTRACT
Con el fin de comparor lo déscrito en la literatura mundial sobre numero y sitio de la toma de la biopsia en lesiones gástricas sospechosas de malignidad realizamos en 41 pacientes un estudio prospéctivo,abierto,a los cuales se les tomaron 9 fragmentos,analizados en grupos de tres.Con la información obtenida se clasificaron los apacientes y se establecio que la sensibilidad de la biopsia gástrica aumenta en la medida que se toma un mayor número de fragmentos del area sospechosa
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Endoscopy, Gastrointestinal , Stomach Neoplasms/diagnosis , Biopsy , Prospective Studies , Stomach Neoplasms/pathologyABSTRACT
El lipoma de colon es el más frecuente de su tipo en el tubo digestivo y es la segunda entidad benigna en el colon. Y puede presentarse como origen de invaginación. Se presentan tres casos de invaginación de colon causadas por lipomas del mismo. Se hace una Revisión del tema
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Colonic Neoplasms , Lipoma , Colonic Neoplasms/diagnosis , Colonic Neoplasms/epidemiology , Lipoma/diagnosis , Lipoma/epidemiologyABSTRACT
The authors report the results of the immunological studies carried out on 246 individuals infected with the human immunodeficiency virus (HIV) in order to compare these data with those obtained in a previous study. They demonstrate an appreciable increase in the number of women with HIV infection and the change of the major cause of infection, in men as well as in women, from transfusions to heterosexual relations with promiscuous and/or bisexual men. They emphasize the danger of HIV infection in pregnant women because of the possibility of infection in their children.
Subject(s)
Acquired Immunodeficiency Syndrome/immunology , Acquired Immunodeficiency Syndrome/mortality , Acquired Immunodeficiency Syndrome/transmission , Adult , Female , Humans , Male , Middle Aged , Panama , Sexual BehaviorABSTRACT
En el presente trabajo se estudiaron 16 pacientes con sintomatología clínica de reflujo gastroesofágico, mediante esofagogastroscopia, biopsia de las zonas de esofagitis y gamagrafía para reflujo. Posteriormente se les administró Cisapride 10 mg antes de cada comida y se revaluaron con igual metodología 4 semanas después, anotándose todos los síntomas durante el estudio. Se recurrió a la prueba de Wilcoxon para análisis estadístico. Se analizan los resultados y finalmente se hace una comparación descriptiva con otros fármacos de efecto análogo
Subject(s)
Humans , Gastroesophageal Reflux/drug therapyABSTRACT
Se presentan dos casos de esofagitis aguda severa relacionada con la ingestión de doxiciclina y se lleva a cabo una revisión breve de la literatura, hacindo énfasis en algunas recomendaciones para evitar esta entidad severa
Subject(s)
Humans , Administration, Buccal , Esophagitis/chemically inducedSubject(s)
Acquired Immunodeficiency Syndrome/immunology , HIV , Acquired Immunodeficiency Syndrome/epidemiology , Acquired Immunodeficiency Syndrome/transmission , Adult , Antibody Formation , Complement System Proteins/analysis , Female , Homosexuality , Humans , Immunity, Cellular , Leukocyte Count , Lymphocytes/classification , Lymphocytes/immunology , Male , Panama , Sexual Behavior , Transfusion ReactionABSTRACT
El cáncer primario del duodeno es un tumor muy raro. La fibroendoscopia gastrointestinal alta de uso incrementado en los últimos anos, puede contribuir al diagnóstico temprano. Se presentan en esta publicacion cuatro casos de carcinoma primario del duodeno estudiados en el Hospital Universitario del Valle entre 1958 y 1986, analizándose sus características clínicas y comparandolas con otros casos presentados en diferentes poblaciones
Subject(s)
Humans , Duodenal Neoplasms/diagnosis , Duodenal Neoplasms/surgery , Adenocarcinoma , Endoscopy, GastrointestinalABSTRACT
Se presenta la experiencia del Servicio de Endoscopia Digestiva del Hospital Universitario del Valle durante 4 anos, en los que se utilizo la endoscopia como metodo diagnostico en los pacientes que consultaron a la istitucion, o que fueron remitidos a ella, por presentar hemorragia gastrointestinal superior. Se estudiaron 726 historias clinicas correpondientes a la totalidad de los pacientes con hemorragia digestiva alta, y se encontro la ulcera duodenal como la causa mas frecuente del sangrado. Tambien se evidenciaron lesiones que no se hubieran podido diagnosticar sin la endoscopia. Finalmente se sugiere no utilizar el estudio radiologico como metodo diagnostico en la hemorragia gastrointestinal superior
