ABSTRACT
The functional changes of retina morphological parameters of macular zone were investigated under condition of long term action of fenofibrate, 145 mg in patients with diabetes mellitus type 2. Dynamic observation of certain ophthalmologic (visual acuity, macular thickness zone) and system functional parameters (lipid fractions content in serum) in long-term use of this medical drug in 20 patients with diabetes type 2 and DMO for 8 months. In this period we revealed some positive changes in the functional state of the macular area: increase of visual acuity, decrease of macula thickness and the improvement of the lipid profile in blood serum.
Subject(s)
Diabetes Mellitus, Type 2/drug therapy , Diabetic Retinopathy/drug therapy , Fenofibrate/therapeutic use , Hypolipidemic Agents/therapeutic use , Macula Lutea/drug effects , Aged , Biguanides/therapeutic use , Cholesterol/blood , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/diagnostic imaging , Diabetes Mellitus, Type 2/pathology , Diabetic Retinopathy/blood , Diabetic Retinopathy/diagnostic imaging , Diabetic Retinopathy/pathology , Female , Humans , Hypoglycemic Agents/therapeutic use , Lipid Metabolism/drug effects , Lipoproteins, HDL/blood , Lipoproteins, LDL/blood , Macula Lutea/diagnostic imaging , Macula Lutea/metabolism , Macula Lutea/pathology , Male , Middle Aged , Tomography, Optical , Visual Acuity/drug effectsABSTRACT
Conducted a comparative analysis of functional changes in tear production in patients with dry eye syndrome and endocrine ophthalmopathy in the conditions of the long-term acting of preservative free medications based on natural substances. A total of 30 people, aged 35 to 53 years old with clinical manifestations of DES on the background of EO were divided on two groups. In I group eye drops of ectoine and in II - artificial tears were administered. The examination included general and specific methods. The term of follow up - 30 days. It was found that long-term use of preservative free eye drops based on ectoine leads to more expressive positive changes in the condition of the anterior surface of the eye and the secretion and quality of the tear.
