ABSTRACT
CASE REPORT: A young female patient with systemic lupus erithematosus, inactive for a long period, is described. She develops bilateral serous detachments of the retinal pigment epithelium and neurosensory retina after corticosteroid therapy for a residual nephritis. DISCUSSION: This unusual chorioretinopathy has been reported in association with systemic lupus erithematosus and during corticosteroid therapy in many disorders. This patient, with low activity erithematosus lupus, develops serous retinal detachments after receiving corticosteroid therapy that damage the coriocapillary-pigment epithelium barrier, disordered in lupus patients.
Subject(s)
Glucocorticoids/adverse effects , Lupus Erythematosus, Systemic/drug therapy , Prednisone/adverse effects , Retinal Detachment/chemically induced , Adult , Female , Fluorescein Angiography , Fundus Oculi , Glucocorticoids/administration & dosage , Humans , Prednisone/administration & dosage , Retinal Detachment/surgery , Treatment Outcome , Visual AcuityABSTRACT
CASE REPORT: We report the case of a patient who was surgically treated in his right eye because of an uncontrollable glaucoma and a retinal detachment without retinal break. Ultrasound and computed tomography showed diffuse choroidal thickening. During 6 years of follow-up, he developed a major ocular and orbitary invasion and bone marrow infiltration. He was treated by enucleation and chemotherapy with apparent total remission. DISCUSSION: Reactive lymphoid hyperplasia of the uvea consists of a lymphocytic proliferation that primarily involves the uveal tract. This process is regarded as a low malignant condition, but this case of late diagnosis showed a tendency to orbital and systemic extension.
Subject(s)
Choroid Diseases/pathology , Choroid Neoplasms/pathology , Glaucoma, Open-Angle/etiology , Lymphoma, B-Cell/pathology , Lymphoma, Non-Hodgkin/pathology , Pseudolymphoma/pathology , Retinal Detachment/etiology , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow/pathology , Choroid Diseases/surgery , Choroid Neoplasms/drug therapy , Choroid Neoplasms/surgery , Cyclophosphamide/administration & dosage , Disease Progression , Doxorubicin/administration & dosage , Eye Enucleation , Glaucoma, Neovascular/etiology , Glaucoma, Open-Angle/surgery , Humans , Immunoglobulin kappa-Chains/blood , Lymphoma, B-Cell/blood , Lymphoma, B-Cell/drug therapy , Lymphoma, B-Cell/surgery , Lymphoma, Non-Hodgkin/blood , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/surgery , Male , Neoplasm Invasiveness , Orbital Neoplasms/secondary , Paraproteins , Prednisone/administration & dosage , Pseudolymphoma/surgery , Remission Induction , Retinal Detachment/surgery , Vincristine/administration & dosageABSTRACT
Caso clínico: Se describe el caso de un paciente, intervenido en ojo derecho de glaucoma incontrolable y de desprendimiento de retina sin rotura aparente, que presenta un engrosamiento coroideo en ecografía y en la tomografía computerizada. A lo largo de 6 años desarrolló una gran invasión ocular, orbitaria e infiltración de médula ósea y fue tratado mediante enucleación y quimioterapia con aparente remisión completa. Discusión: La hiperplasia linfoide reactiva de la úvea consiste en una proliferación linfocitaria que se inicia primariamente en el tracto uveal. Aunque se considera un proceso poco maligno, este caso de diagnóstico tardío demuestra su tendencia a la extensión orbitaria y sistémica (AU)
