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1.
Farm Hosp ; 46(6): 380-381, 2022 Nov 26.
Article in Spanish | MEDLINE | ID: mdl-36520579
7.
J. negat. no posit. results ; 5(3): 246-258, mar. 2020. tab, graf
Article in Spanish | IBECS | ID: ibc-194036

ABSTRACT

Este artículo especial desgrana los mecanismos y aspectos centrales relacionados con tres moléculas: la eritropoyetina, el factor inducible por hipoxia (HIF) y la proteína von Hippel-Lindau (pVHL) que han dado lugar tras múltiples investigaciones a galardonar con el Peremio Nobel de Fisiología y Medicina 2019 a los científicos William G. Kaelin, Gregg L. Semenza y Peter J. Ratcliffe. Se señalan los mecanismos moleculares que tiene lugar en situación de normoxia, hipoxia y pseudohipoxia. El artículo termina señalando las perspectivas farmacológicas que ha abierto la relación investigadora de estos científicos en el campo del cáncer y de muchas enfermedades degenerativas


This special article discusses the mechanisms and central aspects related to three molecules: erythropoietin, hypoxia-induced factor (HIF) and von Hippel-Lindau protein (pVHL) that have led after multiple investigations to win the Nobel Prize in Physiology and Medicine 2019 to scientists William G. Kaelin, Gregg L. Semenza and Peter J. Ratcliffe. The molecular mechanisms taking place in a situation of normoxia, hypoxia and pseudohypoxia are indicated. The article ends by pointing out the pharmacological perspectives that the research of these scientists has opened in the field of cancer and many degenerative diseases


Subject(s)
Humans , Hypoxia/physiopathology , Neoplasms/genetics , Hypoxia-Inducible Factor 1/genetics , Von Hippel-Lindau Tumor Suppressor Protein/genetics , Periodicals as Topic/statistics & numerical data , Biomedical Research/statistics & numerical data , Antineoplastic Agents/pharmacology , Neurodegenerative Diseases/genetics , Molecular Diagnostic Techniques/methods , Nobel Prize
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