Evaluation and Clinical Characterization of Hypersensitivity Reactions Following Administration of 5% Human Serum Albumin in 73 Ill Dogs.

In this prospective study the presence of clinically detectable hypersensitivity reactions following intravenous administration of 5% human serum albumin (HSA) was evaluated in 73 critically ill dogs both during the infusion, within the initial 24 hours afterwards, and at 7, 14, 21 and 28 days. A dose range of 2.0-20.56 mL/kg of 5% HSA was administered at a standard rate of 2.0 ml/kg/h IV in the critically ill dogs. No clinical signs consistent with types I and III hypersensitivity reactions were noted at days 0, 7, 14, 21 and 28. Previous studies have recorded types I and III hypersensitivity reactions following HSA infusion with variable concentrations, rates and volumes infused. This study demonstrated the safe administration of 5% HSA at a standard rate of administration with no reactions.

Prospective Review of Clinical Hypersensitivity Reactions After Administration of 5% Human Serum Albumin in 40 Critically Ill Cats.

This prospective study assesses the presence of immediate and delayed clinical hypersensitivity reactions in 40 hypoalbuminemic critically ill cats during and after an intravenous administration of 5% human serum albumin (HSA). Twenty hypoalbuminemic critically ill cats with no known exposure to HSA (control group) were also checked in order to highlight any clinical signs related to the underlying disease which could mimic hypersensitivity reactions. The administration of 10-20 mL/kg of 5% HSA at 2 mL/kg/h in critically ill cats did not lead to clinical signs of types I and III hypersensitivity reactions at days 0, 7, 14, 21, and 28, unlike previous findings with 25% HSA in this species.

Acute Hypoxemic Respiratory Failure With Hemoptysis in a Dog Exposed to Copper Sulfate Powder.

A 2-year-old male mongrel dog was presented because of the onset of dry cough. About 16 hours before, the dog had been exposed to the pesticide that the owner was spraying in the vineyard. Approximately 3 hours later an acute respiratory failure, with a rapid evolution, began. Hemoptysis and regenerative normocytic normochromic anemia arose within hours, and a pulmonary hemorrhage was diagnosed. Pulmonary hemorrhage fast led to pneumonia, as evidenced by the serial CXR findings and the developing of leukocytosis. The hypothesis that we believe more likely is that the dog inhaled an amount of copper sulfate powder enough to determine respiratory tree damage, extending from the trachea to the pulmonary alveoli. Oxygen supplementation, antibiotics, antioxidant, and gastroprotective medications had been administered. After 4 days of hospitalization the dog was discharged. After a follow-up of more than 2 years later, the dog is still alive and in good health. To the authors knowledge no evidences of acute pulmonary involvement after copper sulfate inhalation exist in any species. This report is a contribution to the knowledge of copper poisoning, scarcely mentioned both in human and veterinary literature, and which has never been described in companion animals.

A New and Easy Procedure to Place an Esophagostomy Tube into Dogs and Cats.

Enteral nutrition improves survival rates and hospitalization times. Some diseases affecting the oral cavity can hinder spontaneous nutrition; in these cases the use of an esophagostomic tube can resolve nutritional problems. The innovative method described in this study is easier and more rapid than those currently known because the end of the tube does not need to be extracted from the oral cavity and then be reinserted with a number of maneuvers into the esophagus. The procedure does not require specific instruments, endotracheal intubation, and nor does it require the head to be moved or lifted. In addition, it can be carried out without the support of an assistant even with big or giant dogs. The new method involves the introduction of hemostatic forceps into the oral cavity, which pass through the esophagus wall and skin, then the distal extremity of the tube is firmly held between the extremity of the forceps and oriented caudally. The forceps, holding the tube, need to be retracted in the esophagus and then pushed ventrally and aborally in order to pass the esophagus stoma, without needing to extract the tube from the oral cavity and thus the risk of tube kinking.

Administration of 5% human serum albumin in critically ill small animal patients with hypoalbuminemia: 418 dogs and 170 cats (1994-2008).

OBJECTIVES: To describe the administration of 5% human serum albumin (HSA) in 588 critically ill hypoalbuminemic dogs and cats, and report outcome to discharge, changes in albumin concentration, and adverse effects during hospitalization. DESIGN: Retrospective clinical study. SETTING: Private emergency and general veterinary center. ANIMALS: Client-owned dogs and cats. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The medical records of 588 critically ill hypoalbuminemic animals (418 dogs and 170 cats) were reviewed. All animals had hypoalbuminemia (serum albumin<20 g/L [2.0 mg/dL]) at admission, received an infusion of 5% HSA, and received no other colloid infusion. The HSA solution was administered through a peripheral vein at 2 mL/kg/h for 10 h/d (total volume 20 mL/kg/d) until albumin reached 20 g/L. The number of days of HSA infusion (median and range) was 4 days (2-11 d) for dogs and 3 days (2-7 d) for cats. Three hundred and sixteen dogs (75.6%) survived to discharge; 56 of 418 (13.4%) died in hospital. One hundred and twenty-three cats (72.3%) survived to discharge; 21 of 170 (12.4%) died in hospital. Severe hypersensitivity reactions such as anaphylaxis, angioedema, and urticaria were not noted. Interruption of albumin infusion and specific treatment of reactions were not required in any animal. CONCLUSIONS: In this study, administration of 5% HSA appeared to be safe in a large group of critically ill, hypoalbuminemic dogs and cats. The results should be interpreted with caution due to the retrospective, descriptive nature of the study, the absence of control groups and the lack of follow-up data, as well as the potentially life-threatening complications of HSA administration.