ABSTRACT
OBJECTIVE: Chronic pain is frequently irreversible, representing a major health problem. A survey has shown that 19% of European adults experience chronic pain which is not adequately managed. Innovative interventional techniques for the treatment of chronic pain have been developed, as a further step beyond the three-layer WHO analgesic ladder. Among these techniques, continuous and pulsed radiofrequency (RF) are very effective in the management of radicular pain syndrome. Usually, these techniques are associated with a pharmacologic approach with a wide-spectrum analgesic. Tapentadol has a double mechanism of action, as a µ-opioid receptor agonism (MOR) and noradrenaline reuptake inhibitor (NRI), contributing synergistically to its analgesic efficacy on both nociceptive and neuropathic pain. PATIENTS AND METHODS: We aimed to test the efficacy of tapentadol prolonged release (PR) combined with pulsed RF in improving neuropathic symptoms and disability in 50 patients with moderate-to-severe chronic pain due to lumbar radiculopathy. RESULTS: The responders to treatment, showing at least a 30% reduction in pain intensity on the Numerical Rating Scale (NRS), were 38 (76%). Both average NRS at rest and during loading were statistically significantly reduced compared with baseline (p<0.0001). Other parameters investigated (sleep quality, neuropathic symptoms, the degree of disability) were all statistically better with tapentadol PR. Patients requiring RF intervention dropped dramatically from 98% at baseline to 10% at the end of the study (p<0.01). Adverse events were reported in 14 patients (28%), four of which required therapy discontinuation. However, patients' satisfaction and overall tolerability of tapentadol PR treatment were high. CONCLUSIONS: Tapentadol PR is effective in reducing pain intensity at rest and during loading, with a favorable safety and tolerability profile. Moreover, the use of tapentadol PR decreases the degree and severity of disability, as well as the intensity of neuropathic symptoms.
Subject(s)
Analgesics, Opioid/administration & dosage , Chronic Pain/therapy , Lumbar Vertebrae , Neuralgia/therapy , Radiofrequency Therapy/methods , Tapentadol/administration & dosage , Adult , Aged , Aged, 80 and over , Chronic Pain/diagnosis , Combined Modality Therapy , Female , Humans , Low Back Pain/diagnosis , Low Back Pain/therapy , Male , Middle Aged , Neuralgia/diagnosis , Prospective Studies , Radiculopathy/diagnosis , Radiculopathy/therapy , Treatment OutcomeABSTRACT
AIM: The aim of the study was to investigate the utility of NT-proBNP measurement for the stratification of presurgical cardiac risk. METHODS: Cardiac risk before elective non-cardiac surgery was evaluated in 82 consecutive patients. From each patient a venous blood sample was drawn to determinate NT-proBNP levels. Patients were followed up over three months in order to detect the occurrence of cardiac adverse events. RESULTS: NT-proBNP was positively correlated (P<0.0001) with age, days of hospitalization (P=0.001) and ASA class (P=0.001). High surgical risk (P<0.0001), diabetes (P=0.004), dyslipidemia (P=0.006) and elevated levels of NT-proBNP (P<0.0001) were significantly correlated with events. Using a logistic regression analysis we found an independent association between pre-operative elevated NT-proBNP and postoperative cardiac events (OR 1.2, 95% CI 1.0-1.4, P=0.01). CONCLUSION: Measuring NT-proBNP before non cardiac surgery in clinical practice could be useful to better stratify patients' risk.
Subject(s)
Cardiovascular Diseases/etiology , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Surgical Procedures, Operative/adverse effects , Aged , Biomarkers/blood , Cardiovascular Diseases/blood , Chi-Square Distribution , Elective Surgical Procedures , Female , Humans , Italy , Logistic Models , Male , Middle Aged , Odds Ratio , Predictive Value of Tests , Preoperative Period , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , Up-RegulationSubject(s)
Brugada Syndrome/complications , Wolff-Parkinson-White Syndrome/complications , Brugada Syndrome/diagnosis , Brugada Syndrome/physiopathology , Defibrillators, Implantable , Diabetes Complications/diagnosis , Diabetes Complications/physiopathology , Dyslipidemias/complications , Electric Countershock/methods , Electrocardiography , Female , Humans , Middle Aged , Obesity/complications , Risk Factors , Treatment Outcome , Wolff-Parkinson-White Syndrome/diagnosis , Wolff-Parkinson-White Syndrome/physiopathologySubject(s)
Friedreich Ataxia/physiopathology , Hypertrophy, Left Ventricular/diagnosis , Adolescent , Adult , Antihypertensive Agents/therapeutic use , Antioxidants/therapeutic use , Female , Follow-Up Studies , Friedreich Ataxia/complications , Friedreich Ataxia/drug therapy , Friedreich Ataxia/epidemiology , Friedreich Ataxia/genetics , Humans , Hypertrophy, Left Ventricular/drug therapy , Hypertrophy, Left Ventricular/epidemiology , Hypertrophy, Left Ventricular/genetics , Incidence , Male , Middle Aged , Prevalence , Retrospective Studies , Sampling Studies , Sicily/epidemiologySubject(s)
Arrhythmias, Cardiac/complications , Syncope/etiology , Adolescent , Adult , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/epidemiology , Atrioventricular Block/complications , Child , Child, Preschool , Humans , Incidence , Infant , Infant, Newborn , Long QT Syndrome/complications , Retrospective Studies , Sicily/epidemiology , Syncope/diagnosis , Syncope/epidemiology , Tachycardia, Supraventricular/complicationsABSTRACT
AIM: Heart failure with normal left ventricle (LV) ejection fraction is commonly understood as diastolic heart failure because this expression implies the presence of LV diastolic dysfunction diagnosed by specific echocardiographic findings, such as slow LV relaxation and increased LV stiffness. In this work the authors propose a new parameter named Motion Index, which is measurable by M-Mode technique and it is likely linked to diastolic dysfunction. METHODS: A patient population composed by 134 subjects was enrolled. They all were in New York Heart Association (NYHA) functional class II. Echocardiogram carried out in all patients allowed the authors to distinguish 2 patient arms depending on the presence or absence of diastolic dysfunction, evaluated by flow Doppler and tissue Doppler. RESULTS: After carrying out every echocardiographic examination, the authors also measured the new parameter that called Motion Index, and found that it had an average value of 46 in patients with normal diastolic function and 33.5 in patients with diastolic dysfunction. This parameter did not depend on systolic dysfunction. CONCLUSIONS: Data obtained showed a statistically significant correlation between Motion Index and means of diastolic function assessed by both flow and tissue Doppler.
Subject(s)
Echocardiography, Doppler, Color/methods , Heart Failure, Diastolic/diagnostic imaging , Stroke Volume , Adult , Algorithms , Heart Failure, Diastolic/physiopathology , Heart Function Tests , Humans , Middle Aged , Predictive Value of Tests , Sensitivity and Specificity , Ventricular Dysfunction, Left/diagnostic imagingSubject(s)
Electrocardiography , Heart Conduction System , Magnetic Resonance Imaging , Tachycardia, Ventricular/diagnosis , Adolescent , Arrhythmogenic Right Ventricular Dysplasia/diagnosis , Heart Conduction System/pathology , Heart Conduction System/physiopathology , Humans , Predictive Value of Tests , Sensitivity and Specificity , Tachycardia, Ventricular/physiopathologySubject(s)
Acute Coronary Syndrome/etiology , Growth Hormone/deficiency , Adult , Humans , Male , Risk FactorsSubject(s)
Arrhythmias, Cardiac/virology , Heart Conduction System/physiopathology , Myocarditis/complications , Paramyxoviridae Infections/complications , Paramyxoviridae , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/physiopathology , Arrhythmias, Cardiac/therapy , Child , Diagnosis, Differential , Electric Countershock/methods , Electrocardiography , Humans , Male , Myocarditis/diagnosis , Myocarditis/physiopathology , Myocarditis/therapy , Myocarditis/virology , Paramyxoviridae/isolation & purification , Paramyxoviridae Infections/diagnosis , Paramyxoviridae Infections/physiopathology , Paramyxoviridae Infections/therapy , Treatment OutcomeABSTRACT
OBJECTIVE: To describe the longitudinal course of physical functioning in children with juvenile idiopathic arthritis (JIA) and identify predictors of long-term functional impairment. METHODS: Between January 1987 and December 2002, 227 patients had two or more functional ability questionnaires completed by a parent. The total number of questionnaires was 1356 and the follow-up between first and last questionnaire administration was 949.7 patient years. At each questionnaire administration, patients were assigned to one of three functional disability states (1 = no disability; 2 = mild to moderate disability; 3 = severe disability), based on their functional ability score. Predictor variables included sex, onset age, JIA category, age at visit, disease duration, presence of antinuclear antibodies, joint counts, acute phase reactants and initial disability state. RESULTS: Despite patient variability in the course of physical functioning, the following three longitudinal patterns were observed: (1) a stable state of disability throughout the entire study period, with continued absence of disability in 27.8% of patients and persistently moderate disability in 3.5% of patients; (2) a steady improvement (22.9% of patients) or deterioration (5.7% of patients) in disability over time; (3) a fluctuating course of disability, with deterioration and improvement (40.1% of patients). Younger age at disease onset and a greater restricted joint count were the strongest predictors of long-term functional impairment. CONCLUSION: A wide within-patient and between-patient variability in the longitudinal course of functional disability was found. Children with early disease onset and a greater number of restricted joints had the highest risk of developing long-term physical disability.
Subject(s)
Arthritis, Juvenile/physiopathology , Disability Evaluation , Joints/physiopathology , Age of Onset , Area Under Curve , Child , Child, Preschool , Disease Progression , Female , Health Status , Humans , Infant , Logistic Models , Longitudinal Studies , Male , Prognosis , Quality of Life , Range of Motion, ArticularABSTRACT
BACKGROUND: The aim of the study was to determine whether caudal S-ketamine or clonidine prolonged analgesia together with ropivacaine. METHODS: Sixty-three boys, aged 1-5 years, who were undergoing minor surgery, were allocated in order to receive one of three solutions for caudal anaesthesia. Group R received 2 mg x kg(-1) 0.2% ropivacaine; group C, 2 mg x kg(-1) 0.2% ropivacaine + clonidine 2 microg x kg(-1); and group K, 2 mg x kg(-1) 0.2% ropivacaine + S-ketamine 0.5 mg x kg(-1). RESULTS: Postoperative analgesia assessed by CHEOPS lasted 701 min in group K (P < 0.05) compared with 492 min in group C and 291 min in group R. There were no significant differences between the groups for incidence of haemodynamic and respiratory alterations, motor block or sedation. CONCLUSIONS: This study demonstrates that S-ketamine 0.5 mg x kg(-1) when added to 0.2% caudal ropivacaine provides better postoperative analgesia than clonidine without any clinically significant side-effect.
Subject(s)
Adrenergic alpha-Agonists/therapeutic use , Amides , Analgesia, Epidural , Anesthetics, Dissociative/therapeutic use , Anesthetics, Local , Clonidine/therapeutic use , Ketamine/therapeutic use , Pain, Postoperative/prevention & control , Adrenergic alpha-Agonists/adverse effects , Amides/adverse effects , Analgesia, Epidural/adverse effects , Anesthesia Recovery Period , Anesthetics, Dissociative/adverse effects , Anesthetics, Local/adverse effects , Child , Child, Preschool , Clonidine/adverse effects , Double-Blind Method , Female , Hemodynamics/drug effects , Humans , Infant , Ketamine/adverse effects , Prospective Studies , Respiratory Mechanics/drug effects , RopivacaineABSTRACT
UNLABELLED: Epidurally administered clonidine enhances the quality and duration of postoperative analgesia when it is used as an adjunct to local anesthetics in children. We investigated the dose-response relationship for epidural clonidine when added to a continuous postoperative epidural infusion of ropivacaine. By use of an observer-blinded design, 55 pediatric patients (1-4 yr old) were randomly given a postoperative epidural infusion of plain ropivacaine 0.1% 0.2 mg. kg(-1). h(-1) (Group R), ropivacaine 0.08% 0.16 mg. kg(-1). h(-1) plus clonidine 0.04 microg. kg(-1). h(-1) (Group RC1), ropivacaine 0.08% 0.16 mg. kg(-1). h(-1) plus clonidine 0.08 microg. kg(-1). h(-1) (Group RC2), or ropivacaine 0.08% 0.16 mg. kg(-1). h(-1) plus clonidine 0.12 microg. kg(-1). h(-1) (Group RC3). A clear dose-response relationship could be identified for a continuous infusion of epidural clonidine, with clonidine dosages in the 0.08-0.12 microg. kg(-1). h(-1) range providing improved postoperative analgesia (reduced Children's Hospital of Eastern Ontario pain score, increased time to first supplemental analgesic demand, and a reduced total number of doses of supplemental analgesics during the first 48 h after surgery). Analgesia was improved without any signs of increased sedation or other side effects. The adjunct use of epidural clonidine in the dosage range of 0.08-0.12 microg. kg(-1). h(-1) appears effective and safe for use in children. IMPLICATIONS: The addition of clonidine (0.08-0.12 microg.kg(-1).h(-1))to a continuous epidural infusion of ropivacaine was found to improve postoperative pain relief in children. No clinically significant signs of sedation or other side effects were observed.
Subject(s)
Adrenergic alpha-Agonists/therapeutic use , Amides , Analgesia, Epidural , Anesthetics, Local , Clonidine/therapeutic use , Pain, Postoperative/drug therapy , Adrenergic alpha-Agonists/adverse effects , Anesthesia , Child, Preschool , Clonidine/adverse effects , Conscious Sedation , Dose-Response Relationship, Drug , Drug Therapy, Combination , Humans , Infant , Male , RopivacaineABSTRACT
Objetivos: La finalidad de este estudio fue evaluar la eficacia y la seguridad de la administración epidural de ropivacaína 0,2 por ciento frente a bupivacaína 0,25 por ciento en niños sometidos a procedimientos urológicos (reparaciones del hipospadias).Materiales y métodos: En un estudio prospectivo, randomizado y doble ciego, 72 niños con edades entre 2 y 7 años sometidos a reparaciones del hipospadias fueron asignados aleatoriamente a recibir 1 ml.kg' de ropivacaina 0,2 por ciento o bupivacaína 0,25 por ciento tras la inducción de ligera anestesia general. Se registraron los parámetros vitales durante y después de la intervención. También se evaluaron el tiempo transcurrido hasta la aparición del bloqueo y la duración de la analgesia en el postoperatorio.Resultados: Los grupos eran similares en cuanto a edad, peso, parámetros vitales, tiempo transcurrido hasta la aparición de la anestesia y duración de la intervención quirúrgica. No se observó bloqueo motor al despertar de la anestesia en ninguno de los dos grupos. Las valoraciones del dolor postoperatorio fueron inferiores en el grupo que recibió ropivacaína; el tiempo medio transcurrido hasta solicitar el primer analgésico fue de 300 min en el grupo de la ropivacaína y 225 en el grupo de la bupivacaína. No se observaron efectos adversos.Conclusiones: La administración de 1 ml.kg-' de ropivacaína 0,2° por ciento fue tan eficaz para anestesia epidural en niños como la bupivacaína 0,2_5 por ciento. No obstante, la ropivacaína proporcionó una analgesia superior, no sólo en términos de duración, sino también de calidad (AU)
Subject(s)
Child, Preschool , Child , Humans , Bupivacaine/pharmacology , Anesthesia, Conduction/methods , Hypospadias/surgery , Bupivacaine/administration & dosage , Prospective Studies , Double-Blind Method , Treatment Outcome , Injections, Epidural , Pain, Postoperative/prevention & controlABSTRACT
OBJECTIVE: The purpose of this study was to examine the conversational skills of preschool and school-age children with cleft lip and palate. DESIGN: The children were audio- and videotaped during interactions with an unfamiliar adult. In addition, standardized measures of speech and language were administered, and ratings of resonance were obtained. Comparisons were made between the children with cleft lip and palate and their same-age peers on measures of conversational participation and a standardized test of pragmatic skills. PARTICIPANTS: Participants were 20 children with unilateral cleft lip and palate (10 preschoolers and 10 school-age children) recruited from the Craniofacial Team at Rainbow Babies and Children's Hospital, Cleveland (OH) and 20 noncleft peers matched for gender, age, and socioeconomic status. MAIN OUTCOME MEASURES: Separate comparisons were made for the preschool children with cleft lip and palate and their noncleft peers, and the school-age children with cleft lip and palate and their noncleft peers on eight measures of conversational assertiveness/responsiveness and the standardized tests of pragmatics. Next, each child with cleft lip and palate was classified for level of conversational participation. RESULTS: Paired t tests revealed no significant differences between the preschool and school-age children with cleft lip and palate and their noncleft peers in level of conversational participation. However, individual child comparisons revealed less assertive profiles of conversational participation for 50% of the preschool and 20% of the school-age children with cleft lip and palate. CONCLUSIONS: Children with cleft lip and palate may show a less assertive style of conversational participation, at least during the preschool years. Therefore, craniofacial team evaluations should include examination of conversational competency, particularly for children who are demonstrating difficulty with other aspects of speech, language, or social development.
